Issue 1/2020
Content (373 Articles)
IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis
Hugo Charles-Messance, Guillaume Blot, Aude Couturier, Lucile Vignaud, Sara Touhami, Fanny Beguier, Lourdes Siqueiros, Valérie Forster, Nour Barmo, Sébastien Augustin, Serge Picaud, José-Alain Sahel, Alvaro Rendon, Antje Grosche, Ramin Tadayoni, Florian Sennlaub, Xavier Guillonneau
TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus
Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo, Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang, Jianliang Fu
MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries
You-Quan Ding, Han Luo, Jian-Guo Qi
Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice
Yan Liu, John Man Tak Chu, Tim Yan, Yan Zhang, Ying Chen, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Neuroinflammation trajectories precede cognitive impairment after experimental meningitis—evidence from an in vivo PET study
Vijayasree V. Giridharan, Allan Collodel, Jaqueline S. Generoso, Giselli Scaini, Rico Wassather, Sudhakar Selvaraj, Rodrigo Hasbun, Felipe Dal-Pizzol, Fabricia Petronilho, Tatiana Barichello
Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs
Alejandra Vargas-Caraveo, Aline Sayd, Javier Robledo-Montaña, Javier R. Caso, José L. M. Madrigal, Borja García-Bueno, Juan C. Leza
The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction
Elzbieta Klimiec-Moskal, Marcin Piechota, Joanna Pera, Kazimierz Weglarczyk, Agnieszka Slowik, Maciej Siedlar, Tomasz Dziedzic
Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
Dibyadeep Datta, Shannon N. Leslie, Yury M. Morozov, Alvaro Duque, Pasko Rakic, Christopher H. van Dyck, Angus C. Nairn, Amy F. T. Arnsten
Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis
Lisa Thiele née Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese, Andrew Chan
Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
Rashmi Das, Abhishek Ankur Balmik, Subashchandrabose Chinnathambi
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease
Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang
Serum dickkopf-3 is associated with death and vascular events after ischemic stroke: an observational study from CATIS
Zhengbao Zhu, Daoxia Guo, Chongke Zhong, Aili Wang, Tan Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang, Jiang He
Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression
Shuai Shao, Huan Xia, Min Hu, Chengjuan Chen, Junmin Fu, Gaona Shi, Qinglan Guo, Yu Zhou, Wenjie Wang, Jiangong Shi, Tiantai Zhang
Sepsis-associated encephalopathy: a vicious cycle of immunosuppression
Chao Ren, Ren-qi Yao, Hui Zhang, Yong-wen Feng, Yong-ming Yao
HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia
Shutian Zhang, Li Hu, Jialun Jiang, Hongji Li, Qin Wu, Kokwin Ooi, Jijiang Wang, Yi Feng, Danian Zhu, Chunmei Xia
Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage
Pengyu Pan, Hengli Zhao, Xuan Zhang, Qiang Li, Jie Qu, Shilun Zuo, Fan Yang, Guobiao Liang, John H. Zhang, Xin Liu, Haiyang He, Hua Feng, Yujie Chen
Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
Xin-Chun Ye, Qi Hao, Wei-Jing Ma, Qiu-Chen Zhao, Wei-Wei Wang, Han-Han Yin, Tao Zhang, Miao Wang, Kun Zan, Xin-Xin Yang, Zuo-Hui Zhang, Hong-Juan Shi, Jie Zu, Hafiz Khuram Raza, Xue-Ling Zhang, De-Qin Geng, Jin-Xia Hu, Gui-Yun Cui
Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation
Xiaoxia Ye, Mingming Zhu, Xiaohang Che, Huiyang Wang, Xing-Jie Liang, Chunfu Wu, Xue Xue, Jingyu Yang
BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis
Honglu Ding, Jialiang Chen, Minzhi Su, Zhijun Lin, Hailun Zhan, Fei Yang, Wenbiao Li, Juncong Xie, Yong Huang, Xianguo Liu, Bolong Liu, Xiangfu Zhou
Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members
Jennifer Rusiecki, Lynn I. Levin, Li Wang, Celia Byrne, Jayasree Krishnamurthy, Ligong Chen, Zygmunt Galdzicki, Louis M. French
Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients
Naiara Celarain, Jordi Tomas-Roig
Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
Fernando Bartolome, Desiree Antequera, Macarena de la Cueva, Marcos Rubio-Fernandez, Nerea Castro, Consuelo Pascual, Antoni Camins, Eva Carro
Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice
Li-Li Qiu, Wei Pan, Dan Luo, Guang-Fen Zhang, Zhi-Qiang Zhou, Xiao-Yun Sun, Jian-Jun Yang, Mu-Huo Ji
Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli
Sandra Ribes, Christa Arcilla, Martina Ott, Sandra Schütze, Uwe-Karsten Hanisch, Stefan Nessler, Roland Nau
The progress of gut microbiome research related to brain disorders
Sibo Zhu, Yanfeng Jiang, Kelin Xu, Mei Cui, Weimin Ye, Genming Zhao, Li Jin, Xingdong Chen
Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia
Urs Fisch, Catherine Brégère, Florian Geier, Laurie Chicha, Raphael Guzman
Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling
Leon G. Coleman Jr, Jian Zou, Fulton T. Crews
MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation
Dongxu Yue, Juanjuan Zhao, Huizi Chen, Mengmeng Guo, Chao Chen, Ya Zhou, Lin Xu
White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model
Nadezda Ivanova, Qingfan Liu, Cansu Agca, Yuksel Agca, Earl G. Noble, Shawn Narain Whitehead, David Floyd Cechetto
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception
Yongwoo Jang, Minseok Kim, Sun Wook Hwang
Neuroprotective effect of microglia against impairments of auditory steady-state response induced by anti-P IgG from SLE patients in naïve mice
Xuejiao Wang, Yingzhuo Li, Zijie Li, Jinhong Li, Jingyi Xu, Pingting Yang, Ling Qin
Correction to: C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
Kevin G. Young, Keqin Yan, David J. Picketts
Crosstalk between stressed brain cells: direct and indirect effects of ischemia and aglycemia on microglia
Monika Rabenstein, Sabine Ulrike Vay, Stefan Blaschke, Helene Luise Walter, Anne Ladwig, Gereon Rudolf Fink, Maria Adele Rueger, Michael Schroeter
Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats
Hongjie Yuan, Shibin Du, Liping Chen, Xiaoqing Xu, Yufeng Wang, Fuhai Ji
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy
Antonio Heras-Garvin, Violetta Refolo, Markus Reindl, Gregor K. Wenning, Nadia Stefanova
Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy
Bereketeab Haileselassie, Amit U. Joshi, Paras S. Minhas, Riddhita Mukherjee, Katrin I. Andreasson, Daria Mochly-Rosen
The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge
Andrea Crespo-Castrillo, Luis-Miguel Garcia-Segura, Maria-Angeles Arevalo
Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer’s mouse model
Sitara B. Sankar, Carmen Infante-Garcia, Laura D. Weinstock, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Cecilia Fernandez-Ponce, Levi B. Wood, Monica Garcia-Alloza
Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure
Tamara S. Bodnar, Charlis Raineki, Wladimir Wertelecki, Lyubov Yevtushok, Larisa Plotka, Irina Granovska, Natalya Zymak-Zakutnya, Alla Pashtepa, Alan Wells, Gordon Honerkamp-Smith, Claire D. Coles, Julie A. Kable, Christina D. Chambers, Joanne Weinberg
Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation
Seiya Takada, Harutoshi Sakakima, Takahiro Matsuyama, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Yuki Itashiki, Akira Tani, Kiyoshi Kikuchi
Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis
Nickoleta Delivanoglou, Marina Boziki, Paschalis Theotokis, Evangelia Kesidou, Olga Touloumi, Nikolina Dafi, Evangelia Nousiopoulou, Roza Lagoudaki, Nikolaos Grigoriadis, Ioannis Charalampopoulos, Constantina Simeonidou
A comparison study of metabolic profiles, immunity, and brain gray matter volumes between patients with bipolar disorder and depressive disorder
Ya-Mei Bai, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Pei-Chi Tu, Wan-Chen Chang, Tung-Ping Su, Cheng Ta Li, Wei-Chen Lin, Shih-Jen Tsai
Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model
Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang
Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs
Michael R. Grovola, Nicholas Paleologos, Kathryn L. Wofford, James P. Harris, Kevin D. Browne, Victoria Johnson, John E. Duda, John A. Wolf, D. Kacy Cullen
G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense
Ning Bai, Quanguang Zhang, Wenli Zhang, Bin Liu, Fang Yang, Darrell Brann, Ruimin Wang
RETRACTED ARTICLE:Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway
Kun Hou, Guichen Li, Jinchuan Zhao, Baofeng Xu, Yang Zhang, Jinlu Yu, Kan Xu
Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization
Wei Liu, Yuluo Rong, Jiaxing Wang, Zheng Zhou, Xuhui Ge, Chengyue Ji, Dongdong Jiang, Fangyi Gong, Linwei Li, Jian Chen, Shujie Zhao, Fanqi Kong, Changjiang Gu, Jin Fan, Weihua Cai
CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation
Yeomyeong Kim, Sungwoon Lee, Haiying Zhang, Sunghye Lee, Hyejeong Kim, Yeaji Kim, Moo-Ho Won, Young-Myeong Kim, Young-Guen Kwon
Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis
Yee Ming Khaw, Claire Cunningham, Abigail Tierney, Mayandi Sivaguru, Makoto Inoue
Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
Xiong Zhang, Lan-Bing Zhu, Jia-Hui He, Hong-Qiu Zhang, Shu-Ya Ji, Chao-Nan Zhang, Na-Na Hou, Chen-Ping Huang, Jian-Hong Zhu
Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1+ stem cells from young donors
Lukasz Wlodarek, Feng Cao, Faisal J. Alibhai, Adam Fekete, Nima Noyan, Stephanie W. Tobin, Tina B. Marvasti, Jun Wu, Shu-Hong Li, Richard D. Weisel, Lu-Yang Wang, Zhengping Jia, Ren-Ke Li
Glial remodeling enhances short-term memory performance in Wistar rats
Simone N. De Luca, Alita Soch, Luba Sominsky, Thai-Xinh Nguyen, Abdulhameed Bosakhar, Sarah J. Spencer
Clozapine reduces infiltration into the CNS by targeting migration in experimental autoimmune encephalomyelitis
Katharina Robichon, Vimal Patel, Bronwen Connor, Anne Camille La Flamme
Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression
Chun-Hong Liu, Ming-Hao Yang, Guang-Zhong Zhang, Xiao-Xu Wang, Bin Li, Meng Li, Marie Woelfer, Martin Walter, Lihong Wang
Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
Neta Lax, Nina Fainstein, Yossi Nishri, Ayal Ben-Zvi, Tamir Ben-Hur
Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway
Di Xie, Xiaoli Ge, Yanli Ma, Jialong Tang, Yang Wang, Yajie Zhu, Chengjin Gao, Shuming Pan
Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert
Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease
Marta Moreno-Rodriguez, Sylvia E. Perez, Muhammad Nadeem, Michael Malek-Ahmadi, Elliott J. Mufson
Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
Giovanna Casili, Marika Lanza, Alessia Filippone, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
The association of neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio with 3-month clinical outcome after mechanical thrombectomy following stroke
Danielle Lux, Vafa Alakbarzade, Luke Bridge, Camilla N. Clark, Brian Clarke, Liqun Zhang, Usman Khan, Anthony C. Pereira
Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
Lei Li, Xiang-Hui Wu, Xiao-Jing Zhao, Lu Xu, Cai-Long Pan, Zhi-Yuan Zhang
Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury
Fan-Qi Kong, Shu-Jie Zhao, Peng Sun, Hao Liu, Jian Jie, Tao Xu, An-Di Xu, Ya-Qing Yang, Ye Zhu, Jian Chen, Zheng Zhou, Ding-Fei Qian, Chang-Jiang Gu, Qi Chen, Guo-Yong Yin, Han-Wen Zhang, Jin Fan
Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
Yunjie Yang, Zitian He, Zhiwei Xing, Zejie Zuo, Lifang Yuan, Yingying Wu, Mei Jiang, Fangfang Qi, Zhibin Yao
A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration
Zhan Zhao, Yubao Wang, Ran Zhou, Yi Li, Yun Gao, Dezhen Tu, Belinda Wilson, Sheng Song, Jing Feng, Jau-Shyong Hong, Jerrel L. Yakel
The association between serum adipocyte fatty acid–binding protein and 3-month disability outcome after aneurysmal subarachnoid hemorrhage
Yong-Gang Luo, Bing Han, Tong-Wen Sun, Xianzhi Liu, Jun Liu, Jun Zhang
ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis
Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang, Yuwu Zhao
c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells
Mahdia Benkhoucha, Isis Senoner, Patrice H. Lalive
Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons
Gabriel M. S. Janach, Olivia Reetz, Noah Döhne, Konstantin Stadler, Sabine Grosser, Egor Byvaltcev, Anja U. Bräuer, Ulf Strauss
Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway
Tiziano Balzano, Yaiza M. Arenas, Sherry Dadsetan, Jerónimo Forteza, Sara Gil-Perotin, Laura Cubas-Nuñez, Bonaventura Casanova, Francisco Gracià, Natalia Varela-Andrés, Carmina Montoliu, Marta Llansola, Vicente Felipo
Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury
Lun Li, Li Ni, Robert F. Heary, Stella Elkabes
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease
Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice
Niansheng Lai, Degang Wu, Tianyu Liang, Pengjie Pan, Guiqiang Yuan, Xiang Li, Haiying Li, Haitao Shen, Zhong Wang, Gang Chen
The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors
Evhy Apryani, Usman Ali, Zi-Ying Wang, Hai-Yun Wu, Xiao-Fang Mao, Khalil Ali Ahmad, Xin-Yan Li, Yong-Xiang Wang
Pathological modeling of TBEV infection reveals differential innate immune responses in human neurons and astrocytes that correlate with their susceptibility to infection
Mazigh Fares, Marielle Cochet-Bernoin, Gaëlle Gonzalez, Claudia N. Montero-Menei, Odile Blanchet, Alexandra Benchoua, Claire Boissart, Sylvie Lecollinet, Jennifer Richardson, Nadia Haddad, Muriel Coulpier
Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice
Hongli Shi, Qiao Wang, Mingxuan Zheng, Shanshan Hao, Jeremy S. Lum, Xi Chen, Xu-Feng Huang, Yinghua Yu, Kuiyang Zheng
Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy
Xiaoyue Zhu, Joshua Hatfield, Joseph K. Sullivan, Feng Xu, William E. Van Nostrand
Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease
Clemens Gödel, Birgit Kunkel, Alireza Kashani, Hans Lassmann, Manimozhiyan Arumugam, Gurumoorthy Krishnamoorthy
Autonomic nervous system and inflammation interaction in endometriosis-associated pain
Yajing Wei, Yanchun Liang, Haishan Lin, Yujing Dai, Shuzhong Yao
DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke
Li Peng, Yang Zhou, Ning Jiang, Tingting Wang, Jin Zhu, Yanlin Chen, Linyu Li, Jinyan Zhang, Shanshan Yu, Yong Zhao
Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase
Toru Koda, Akiko Namba, Makoto Kinoshita, Yuji Nakatsuji, Tomoyuki Sugimoto, Kaori Sakakibara, Satoru Tada, Mikito Shimizu, Kazuya Yamashita, Kazushiro Takata, Teruyuki Ishikura, Syo Murata, Shohei Beppu, Atsushi Kumanogoh, Hideki Mochizuki, Tatsusada Okuno
Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord
Lijuan Wang, Cui Yin, Tianya Liu, Mannan Abdul, Yan Zhou, Jun-Li Cao, Chen Lu
A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer’s disease
Kritleen K. Bawa, Saffire H. Krance, Nathan Herrmann, Hugo Cogo-Moreira, Michael Ouk, Di Yu, Che-Yuan Wu, Sandra E. Black, Krista L. Lanctôt, Walter Swardfager
Antinociceptive effect of intrathecal injection of miR-9-5p modified mouse bone marrow mesenchymal stem cells on a mouse model of bone cancer pain
Chao Zhu, Kun Wang, Zhi Chen, Yingchao Han, Hao Chen, Quan Li, Zude Liu, Lie Qian, Jun Tang, Hongxing Shen
Increased serum neurofilament light chain concentration indicates poor outcome in Guillain-Barré syndrome
Patrick Altmann, Desiree De Simoni, Alexandra Kaider, Birgit Ludwig, Jakob Rath, Fritz Leutmezer, Fritz Zimprich, Romana Hoeftberger, Michael P. Lunn, Amanda Heslegrave, Thomas Berger, Henrik Zetterberg, Paulus Stefan Rommer
Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo
Anna Simon, Ming Yang, Joanne L. Marrison, Andrew D. James, Mark J. Hunt, Peter J. O’Toole, Paul M. Kaye, Miles A. Whittington, Sangeeta Chawla, William J. Brackenbury
Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis
Miriam Mecha, Natalia Yanguas-Casás, Ana Feliú, Leyre Mestre, Francisco Javier Carrillo-Salinas, Kristoffer Riecken, Diego Gomez-Nicola, Carmen Guaza
Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury
Xiaobing Long, Xiaolong Yao, Qian Jiang, Yiping Yang, Xuejun He, Weidong Tian, Kai Zhao, Huaqiu Zhang
Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury
Zhongyuan Liu, Xinqiang Yao, Wangsheng Jiang, Wei Li, Siyuan Zhu, Congrui Liao, Lin Zou, Ruoting Ding, Jianting Chen
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Maralinde R. Abbink, Janssen M. Kotah, Lianne Hoeijmakers, Aline Mak, Genevieve Yvon-Durocher, Bram van der Gaag, Paul J. Lucassen, Aniko Korosi
Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep
Robert Galinsky, Simerdeep K. Dhillon, Justin M. Dean, Joanne O. Davidson, Christopher A. Lear, Guido Wassink, Fraser Nott, Sharmony B. Kelly, Mhoyra Fraser, Caroline Yuill, Laura Bennet, Alistair Jan Gunn
Role of dietary fatty acids in microglial polarization in Alzheimer’s disease
Smita Eknath Desale, Subashchandrabose Chinnathambi
Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes
Carolyn A. Thomson, Alison McColl, Gerard J. Graham, Jonathan Cavanagh
Mutant Huntingtin affects toll-like receptor 4 intracellular trafficking and cytokine production in mast cells
Marian Jesabel Pérez-Rodríguez, Alfredo Ibarra-Sánchez, Abraham Román-Figueroa, Francisca Pérez-Severiano, Claudia González-Espinosa
Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation
Karina Barbosa de Queiroz, Vanessa Cavalcante-Silva, Flávia Lombardi Lopes, Gifone Aguiar Rocha, Vânia D’Almeida, Roney Santos Coimbra
Transcriptomic profiling of microglia and astrocytes throughout aging
Jie Pan, Nana Ma, Bo Yu, Wei Zhang, Jun Wan
Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology
Julie C. Savage, Marie-Kim St-Pierre, Micaël Carrier, Hassan El Hajj, Sammy Weiser Novak, Maria Gabriela Sanchez, Francesca Cicchetti, Marie-Ève Tremblay
Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats
Jia-Liang Chen, Xin Zhou, Bo-Long Liu, Xu-Hong Wei, Hong-Lu Ding, Zhi-Jun Lin, Hai-Lun Zhan, Fei Yang, Wen-Biao Li, Jun-Cong Xie, Min-Zhi Su, Xian-Guo Liu, Xiang-Fu Zhou
The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model
Na Jing, Bo Fang, Zhe Li, Ayong Tian
Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity
Jing Ruan, Dirk Schlüter, Xu Wang
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury
Jyoti Gautam, Lingling Xu, Abhijit Nirwane, Benjamin Nguyen, Yao Yao
The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target
William T. O’Brien, Louise Pham, Georgia F. Symons, Mastura Monif, Sandy R. Shultz, Stuart J. McDonald
Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease
Mei-Ling Xia, Xia-Hong Xie, Jian-Hua Ding, Ren-Hong Du, Gang Hu
Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion—possible amelioration of cognitive function by AT2 receptor activation
Li-Juan Min, Jun Iwanami, Masachika Shudou, Hui-Yu Bai, Bao-Shuai Shan, Akinori Higaki, Masaki Mogi, Masatsugu Horiuchi
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke
Xinyu Zhang, Lu Wang, Zhenxiang Han, Jing Dong, Defang Pang, Yuan Fu, Longxuan Li
The role of Toll-like receptor signaling pathways in cerebrovascular disorders: the impact of spreading depolarization
Rezan Ashayeri Ahmadabad, Maryam Khaleghi Ghadiri, Ali Gorji
Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Dongliang Li, Mingming Chen, Tao Meng, Jianchun Fei
Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits
Jing Wu, Jian-Jun Yang, Yan Cao, Huihui Li, Hongting Zhao, Shuofei Yang, Kuanyu Li
Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice
Shunichiro Tsuji, Elena Di Martino, Takeo Mukai, Shoko Tsuji, Takashi Murakami, Robert A. Harris, Klas Blomgren, Ulrika Åden
Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disorder
Saranya Canchi, Mary K. Swinton, Robert A. Rissman, Jerel Adam Fields
Independent and inter-dependent immunoregulatory effects of NCF1 and NOS2 in experimental autoimmune encephalomyelitis
Jianghong Zhong, Anthony C. Y. Yau, Rikard Holmdahl
TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection
Amy L. Aldrich, Cortney E. Heim, Wen Shi, Rachel W. Fallet, Bin Duan, Tammy Kielian
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice
Alexandria N. Early, Amy A. Gorman, Linda J. Van Eldik, Adam D. Bachstetter, Josh M. Morganti
Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring
Sanoji Wijenayake, Mouly F. Rahman, Christine M. W. Lum, Wilfred C. De Vega, Aya Sasaki, Patrick O. McGowan
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
Marina Leardini-Tristão, Giulia Andrade, Celina Garcia, Patrícia A. Reis, Millena Lourenço, Emilio T. S. Moreira, Flavia R. S. Lima, Hugo C. Castro-Faria-Neto, Eduardo Tibirica, Vanessa Estato
The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury
Jing Wang, Ming Zhao, Peng Jia, Fang-Fang Liu, Kun Chen, Fei-Yang Meng, Jiang-Hao Hong, Ting Zhang, Xiao-Hang Jin, Juan Shi
Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain
Jinar Rostami, Grammatiki Fotaki, Julien Sirois, Ropafadzo Mzezewa, Joakim Bergström, Magnus Essand, Luke Healy, Anna Erlandsson
Glioblastoma hijacks microglial gene expression to support tumor growth
Sybren L. N. Maas, Erik R. Abels, Lieke L. Van De Haar, Xuan Zhang, Liza Morsett, Srinjoy Sil, Joana Guedes, Pritha Sen, Shilpa Prabhakar, Suzanne E. Hickman, Charles P. Lai, David T. Ting, Xandra O. Breakefield, Marike L. D. Broekman, Joseph El Khoury
CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy
Elizabeth M. Runge, Abhirami K. Iyer, Deborah O. Setter, Felicia M. Kennedy, Virginia M. Sanders, Kathryn J. Jones
Spinal cord NLRP1 inflammasome contributes to dry skin induced chronic itch in mice
Jun-Juan Fan, Bo Gao, Ao-Qi Song, Ya-Jing Zhu, Jun Zhou, Wei-Zu Li, Yan-Yan Yin, Wen-Ning Wu
Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
Elín I. Magnúsdóttir, Mirjana Grujic, Jessica Bergman, Gunnar Pejler, Malin C. Lagerström
Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL
Chih-Hao Chen, Yu-Wen Cheng, Ya-Fang Chen, Sung-Chun Tang, Jiann-Shing Jeng
Suppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root ganglia
Xiao-Tao He, Xiao-Fan Hu, Chao Zhu, Kai-Xiang Zhou, Wen-Jun Zhao, Chen Zhang, Xiao Han, Chang-Le Wu, Yan-Yan Wei, Wei Wang, Jian-Ping Deng, Fa-Ming Chen, Ze-Xu Gu, Yu-Lin Dong
NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice
Dongping Li, Ying Wang, Xinrong Jin, Die Hu, Chunlei Xia, Hanmei Xu, Jialiang Hu
MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia
Ioanna Plastira, Eva Bernhart, Lisha Joshi, Chintan N. Koyani, Heimo Strohmaier, Helga Reicher, Ernst Malle, Wolfgang Sattler
Outcome and risk of recurrence in a large cohort of idiopathic longitudinally extensive transverse myelitis without AQP4/MOG antibodies
Elisabeth Maillart, Françoise Durand-Dubief, Céline Louapre, Bertrand Audoin, Bertrand Bourre, Nathalie Derache, Jonathan Ciron, Nicolas Collongues, Jérome de Sèze, Mikael Cohen, Christine Lebrun-Frenay, Nawel Hadhoum, Hélène Zéphir, Romain Deschamps, Clarisse Carra-Dallière, Pierre Labauge, Philippe Kerschen, Alexis Montcuquet, Sandrine Wiertlewski, David Laplaud, Gwenaëlle Runavot, Sandra Vukusic, Caroline Papeix, Romain Marignier
Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats
Yu Abekura, Isao Ono, Akitsugu Kawashima, Katsumi Takizawa, Hirokazu Koseki, Haruka Miyata, Kampei Shimizu, Mieko Oka, Mika Kushamae, Susumu Miyamoto, Hiroharu Kataoka, Akira Ishii, Tomohiro Aoki
DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage
Yang Xu, Derek Nowrangi, Hui Liang, Tian Wang, Lingyan Yu, Tai Lu, Zhengyang Lu, John H. Zhang, Benyan Luo, Jiping Tang
Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease
Nicole Schröder, Anja Schaffrath, Josua A. Welter, Tim Putzka, Angelika Griep, Patrick Ziegler, Elisa Brandt, Sebastian Samer, Michael T. Heneka, Hannes Kaddatz, Jiangshan Zhan, Eugenia Kipp, Thomas Pufe, Simone C. Tauber, Markus Kipp, Lars-Ove Brandenburg
Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis
Madhu Sudhana Saddala, Anton Lennikov, Anthony Mukwaya, Yan Yang, Michael A. Hill, Neil Lagali, Hu Huang
The cerebrovascular and neurological impact of chronic smoking on post-traumatic brain injury outcome and recovery: an in vivo study
Farzane Sivandzade, Faleh Alqahtani, Ali Sifat, Luca Cucullo
LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3
Jiahui Zhou, Zhiyue Li, Tianding Wu, Qun Zhao, Qiancheng Zhao, Yong Cao
Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis
Eleni Christoforidou, Greig Joilin, Majid Hafezparast
Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy
Haihan Jiao, Laura E. Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J. Keenan, Laura H. Jacobson, Holly R. Chinnery
Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke
Ladonya Jackson, Selin Dumanli, Maribeth H. Johnson, Susan C. Fagan, Adviye Ergul
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Dennis A. Brown, Pei-Yu Wang, I-Chen Yu, Jui-Hung Yen
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
M. Brittany Johnson, Justin R. Halman, Amanda R. Burmeister, Saralynn Currin, Emil F. Khisamutdinov, Kirill A. Afonin, Ian Marriott
PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
Stal Shrestha, Min-Jeong Kim, Mark Eldridge, Michael L. Lehmann, Michael Frankland, Jeih-San Liow, Zu-Xi Yu, Michelle Cortes-Salva, Sanjay Telu, Ioline D. Henter, Evan Gallagher, Jae-Hoon Lee, J. Megan Fredericks, Chelsie Poffenberger, George Tye, Yanira Ruiz-Perdomo, Fernanda Juarez Anaya, Jose A. Montero Santamaria, Robert L. Gladding, Sami S. Zoghbi, Masahiro Fujita, James D. Katz, Victor W. Pike, Robert B. Innis
Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions
Kohki Toriuchi, Hiroki Kakita, Tetsuya Tamura, Satoru Takeshita, Yasumasa Yamada, Mineyoshi Aoyama
The neuroregenerative effects of topical decorin on the injured mouse cornea
Mengliang Wu, Laura E. Downie, Liam M. Grover, Richard J. A. Moakes, Saaeha Rauz, Ann Logan, Haihan Jiao, Lisa J. Hill, Holly R. Chinnery
IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis
Haritha L. Desu, Melanie Plastini, Placido Illiano, Helen M. Bramlett, W. Dalton Dietrich, Juan Pablo de Rivero Vaccari, Roberta Brambilla, Robert W. Keane
Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats
Umut Ocak, Pinar Eser Ocak, Lei Huang, Weilin Xu, Yuchun Zuo, Peng Li, Marcin Gamdzyk, Gang Zuo, Jun Mo, Guangyu Zhang, John H. Zhang
Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells
Thomas Grüter, Alina Blusch, Jeremias Motte, Melissa Sgodzai, Hussein Bachir, Rafael Klimas, Björn Ambrosius, Ralf Gold, Gisa Ellrichmann, Kalliopi Pitarokoili
Embryonic microglia influence developing hypothalamic glial populations
Candace M. Marsters, Dinushan Nesan, Rena Far, Natalia Klenin, Quentin J. Pittman, Deborah M. Kurrasch
Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4+ T cell apoptosis
Ke An, Meng-Jiao Xue, Jia-Ying Zhong, Sheng-Nan Yu, Tian-Shu Lan, Zhong-Quan Qi, Jun-Jie Xia
Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson’s disease model
Liyan Hou, Xingyue Qu, Xiaofei Qiu, Ruixue Huang, Xiulan Zhao, Qingshan Wang
Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain
Gloria Donninelli, Inbar Saraf-Sinik, Valentina Mazziotti, Alessia Capone, Maria Grazia Grasso, Luca Battistini, Richard Reynolds, Roberta Magliozzi, Elisabetta Volpe
High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats
Ye Hong, Qian Liu, Mengna Peng, Maosheng Bai, Juanji Li, Rui Sun, Hongquan Guo, Pengfei Xu, Yi Xie, Yunzi Li, Ling Liu, Juan Du, Xinfeng Liu, Bin Yang, Gelin Xu
The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study
Rola Ismail, Peter Parbo, Lasse Stensvig Madsen, Allan K. Hansen, Kim V. Hansen, Jeppe L. Schaldemose, Pernille L. Kjeldsen, Morten G. Stokholm, Hanne Gottrup, Simon F. Eskildsen, David J. Brooks
IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model
Juan Huang, Weitian Lu, Desislava Met Doycheva, Marcin Gamdzyk, Xiao Hu, Rui Liu, John H. Zhang, Jiping Tang
Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier
M. H. Sheikh, S. M. Henson, R. A. Loiola, S. Mercurio, A. Colamatteo, G. T. Maniscalco, V. De Rosa, S. McArthur, E. Solito
Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia
Hao Yang, Lingmin Wu, Huimin Deng, Yuanli Chen, Huanping Zhou, Meiyun Liu, Shaochen Wang, Li Zheng, Lina Zhu, Xin Lv
A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
Noah Goshi, Rhianna K. Morgan, Pamela J. Lein, Erkin Seker
Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats
Jung-Shun Lee, Yu-Hsiang Hsu, Yi-Shu Chiu, I-Ming Jou, Ming-Shi Chang
Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice
Aimee N. Winter, Meena S. Subbarayan, Bethany Grimmig, Jason A. Weesner, Lauren Moss, Melinda Peters, Edwin Weeber, Kevin Nash, Paula C. Bickford
NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats
Tianyi Wang, Junyi Zhang, Peng Li, Yan Ding, Jiping Tang, Gang Chen, John H. Zhang
Mitigation of helium irradiation-induced brain injury by microglia depletion
Barrett D. Allen, Amber R. Syage, Mattia Maroso, Al Anoud D. Baddour, Valerie Luong, Harutyun Minasyan, Erich Giedzinski, Brian L. West, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch, Munjal M. Acharya
Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation
Maria Pilar Blasco, Anjali Chauhan, Pedram Honarpisheh, Hilda Ahnstedt, John d’Aigle, Arunkumar Ganesan, Sriram Ayyaswamy, Frank Blixt, Susan Venable, Angela Major, David Durgan, Anthony Haag, Julia Kofler, Robert Bryan, Louise D. McCullough, Bhanu Priya Ganesh
Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis
Ana Zabalza, Andrea Vera, Elisenda Alari-Pahissa, Elvira Munteis, Antía Moreira, Jose Yélamos, Mireia Llop, Miguel López-Botet, Jose E. Martínez-Rodríguez
Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses
Ruixiang Chen, Chengyu Yin, Qimiao Hu, Boyu Liu, Yan Tai, Xiaoli Zheng, Yuanyuan Li, Jianqiao Fang, Boyi Liu
Intermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice
Hui-Ting Huang, Po-See Chen, Yu-Min Kuo, Shun-Fen Tzeng
Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice
Hui-Min Shan, Minhua Zang, Qi Zhang, Ru-Bing Shi, Xiao-Jing Shi, Muyassar Mamtilahun, Chang Liu, Long-long Luo, Xiaoying Tian, Zhijun Zhang, Guo-Yuan Yang, Yaohui Tang, Jun Pu, Yongting Wang
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage
Yucong Peng, Jianfeng Zhuang, Guangyu Ying, Hanhai Zeng, Hang Zhou, Yang Cao, Huaijun Chen, Chaoran Xu, Xiongjie Fu, Hangzhe Xu, Jianru Li, Shenglong Cao, Jingyin Chen, Chi Gu, Feng Yan, Gao Chen
Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat
Hetao Bian, Gaohua Wang, Junjie Huang, Liang Liang, Yage Zheng, Yanyan Wei, Hui Wang, Ling Xiao, Huiling Wang
Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain
Clémence Disdier, Fares Awa, Xiaodi Chen, Simerdeep K. Dhillon, Robert Galinsky, Joanne O. Davidson, Christopher A. Lear, Laura Bennet, Alistair J. Gunn, Barbara S. Stonestreet
TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice
Shengpan Chen, Jianhua Peng, Prativa Sherchan, Yongjie Ma, Sishi Xiang, Feng Yan, Hao Zhao, Yong Jiang, Ning Wang, John H. Zhang, Hongqi Zhang
ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4+ T cells
Ru-Yi Luo, Cong Luo, Feng Zhong, Wei-Yun Shen, Hui Li, Zhao-Lan Hu, Ru-Ping Dai
TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain
Shih-Ping Dai, Wei-Shan Hsieh, Chien-Hua Chen, Yueh-Hao Lu, Hsu-Shan Huang, Der-Ming Chang, Shir-Ly Huang, Wei-Hsin Sun
The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
Hao Sun, Xinran He, Xia Tao, Tingting Hou, Mingming Chen, Meijun He, Hong Liao
Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats
Elisabeth G. Vichaya, Sajida Malik, Luba Sominsky, Bianca G. Ford, Sarah J. Spencer, Robert Dantzer
Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses
Lihong Gong, Linyuan Yu, Xiaohong Gong, Cheng Wang, Naihua Hu, Xuyang Dai, Cheng Peng, Yunxia Li
IL-33 and its decoy sST2 in patients with Alzheimer’s disease and mild cognitive impairment
Marina Saresella, Ivana Marventano, Federica Piancone, Francesca La Rosa, Daniela Galimberti, Chiara Fenoglio, Elio Scarpini, Mario Clerici
Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment
Sarah Schram, Jeffrey A. Loeb, Fei Song
Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression
Gayathri Sundaram, Chai K. Lim, Bruce J. Brew, Gilles J. Guillemin
Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal
Tsong-Hai Lee, Jiun-Liang Chen, Pei-Shan Liu, Ming-Ming Tsai, Su-Jane Wang, Hsi-Lung Hsieh
NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice
Ao-Qi Song, Bo Gao, Jun-Juan Fan, Ya-Jing Zhu, Jun Zhou, Yu-Ling Wang, Li-Zhong Xu, Wen-Ning Wu
High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism
Anni Fan, Oladayo Oladiran, Xiang Qun Shi, Ji Zhang
A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)
Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie
Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model
Xiao-Hui Tang, Guang-Fen Zhang, Ning Xu, Gui-Fang Duan, Min Jia, Ru Liu, Zhi-Qiang Zhou, Jian-Jun Yang
Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE
Xiao Hu, Shirong Li, Desislava Met Doycheva, Lei Huang, Cameron Lenahan, Rui Liu, Juan Huang, Shucai Xie, Jiping Tang, Gang Zuo, John H. Zhang
Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain
Mohammed Shaqura, Li Li, Doaa M. Mohamed, Xiongjuan Li, Sascha Treskatsch, Constanze Buhrmann, Mehdi Shakibaei, Antje Beyer, Shaaban A. Mousa, Michael Schäfer
The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome
Brandon C. Smith, Maksim Sinyuk, Julius E. Jenkins III, Morgan W. Psenicka, Jessica L. Williams
CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats
Chiu-Yi Ho, Yu-Te Lin, Hsin-Hung Chen, Wen-Yu Ho, Gwo-Ching Sun, Michael Hsiao, Pei-Jung Lu, Pei-Wen Cheng, Ching-Jiunn Tseng
Myelination- and immune-mediated MR-based brain network correlates
Manuela Cerina, Muthuraman Muthuraman, Marco Gallus, Nabin Koirala, Andre Dik, Lydia Wachsmuth, Petra Hundehege, Patrick Schiffler, Jan-Gerd Tenberge, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Venu Narayanan, Julia Krämer, Cornelius Faber, Thomas Budde, Sergiu Groppa, Sven G. Meuth
Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice
Tao Li, Weilin Xu, Jinsong Ouyang, Xiaoyang Lu, Prativa Sherchan, Cameron Lenahan, Giselle Irio, John H. Zhang, Jianhua Zhao, Yongfa Zhang, Jiping Tang
Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury
Han Wang, Xiao-Ming Zhou, Ling-Yun Wu, Guang-Jie Liu, Wei-Dong Xu, Xiang-Sheng Zhang, Yong-Yue Gao, Tao Tao, Yan Zhou, Yue Lu, Juan Wang, Chu-Lei Deng, Zong Zhuang, Chun-Hua Hang, Wei Li
Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis
Wendy Gilmore, Brett T. Lund, Peili Li, Alex M. Levy, Eve E. Kelland, Omid Akbari, Susan Groshen, Steven Yong Cen, Daniel Pelletier, Leslie P. Weiner, Adil Javed, Jeffrey E. Dunn, Anthony L. Traboulsee
Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma
Xu Ding, Wei Yang, Qinghua Ren, Jiajian Hu, Shen Yang, Wei Han, Jing Wang, Xu Wang, Huanmin Wang
Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway
Sichen Li, Yuan Shi, Peixi Liu, Yaying Song, Yingjun Liu, Lingwen Ying, Kai Quan, Guo Yu, Zhiyuan Fan, Wei Zhu
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
Neuroinflammatory mechanisms of post-traumatic epilepsy
Sanjib Mukherjee, Gabriel M. Arisi, Kaley Mims, Gabriela Hollingsworth, Katherine O’Neil, Lee A. Shapiro
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Natalia Kolosowska, Maria Gotkiewicz, Hiramani Dhungana, Luca Giudice, Rosalba Giugno, Daphne Box, Mikko T. Huuskonen, Paula Korhonen, Flavia Scoyni, Katja M. Kanninen, Seppo Ylä-Herttuala, Tiia A. Turunen, Mikko P. Turunen, Jari Koistinaho, Tarja Malm
Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation
Sungho Jin, Kwang Kon Kim, Byong Seo Park, Dong Hee Kim, Bora Jeong, Dasol Kang, Tae Hwan Lee, Jeong Woo Park, Jae Geun Kim, Byung Ju Lee
Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants
Elisabeth Mulazzani, Danny Wagner, Joachim Havla, Miriam Schlüter, Ingrid Meinl, Lisa-Ann Gerdes, Tania Kümpfel
Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells
Syed Faaiz Enam, Sajidur Rahman Kader, Nicholas Bodkin, Johnathan G. Lyon, Mark Calhoun, Cesar Azrak, Pooja Munnilal Tiwari, Daryll Vanover, Haichen Wang, Philip J. Santangelo, Ravi Venkat Bellamkonda
Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis
Ye Gong, Ya-ling Zhang, Zhen Wang, Huan-huan Song, Yuan-chu Liu, Ao-wei Lv, Li-li Tian, Wen-li Zhu, Ying Fu, Xiao-li Ding, Lang-jun Cui, Ya-ping Yan
27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction
Ying Wang, Yu An, Weiwei Ma, Huiyan Yu, Yanhui Lu, Xiaona Zhang, Yushan Wang, Wen Liu, Tao Wang, Rong Xiao
A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment
He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu, Xiao-Xia Jiang
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis
Ayan Mondal, Dipro Bose, Punnag Saha, Sutapa Sarkar, Ratanesh Seth, Diana Kimono, Muayad Albadrani, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterjee
Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model
Wen-Kai Chen, Lin-Juan Feng, Qiao-Dan Liu, Qing-Feng Ke, Pei-Ya Cai, Pei-Ru Zhang, Li-Quan Cai, Nian-Lai Huang, Wen-Ping Lin
Correction to: Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway
Kun Hou, Guichen Li, Jinchuan Zhao, Baofeng Xu, Yang Zhang, Jinlu Yu, Kan Xu
TREM2 ectodomain and its soluble form in Alzheimer’s disease
Jiaolong Yang, Zhihui Fu, Xingyu Zhang, Min Xiong, Lanxia Meng, Zhentao Zhang
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou, Zengqiang Yuan, Jinbo Cheng
Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod
Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Masami Tanaka, Ayako Sakoda, Fumie Hayashi, Yuji Kawano, Ryo Yamasaki, Takuya Matsushita, Jun-ichi Kira
CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons
Guo-Qing Chang, Olga Karatayev, Devi Sai Sri Kavya Boorgu, Sarah F. Leibowitz
Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning
Florian Eckenweber, Jose Medina-Luque, Tanja Blume, Christian Sacher, Gloria Biechele, Karin Wind, Maximilian Deussing, Nils Briel, Simon Lindner, Guido Boening, Barbara von Ungern-Sternberg, Marcus Unterrainer, Nathalie L. Albert, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Paul Cumming, Axel Rominger, Günter U. Höglinger, Jochen Herms, Matthias Brendel
CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage
Xiao Chen, Ming Jiang, Haiying Li, Yang Wang, Haitao Shen, Xiang Li, Yunhai Zhang, Jiang Wu, Zhengquan Yu, Gang Chen
BDNF reverses aging-related microglial activation
Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yi-Ting Chiang, Bu-Miin Huang, Fan-E Mo, Yu-Min Kuo
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain
Ting Li, Tongtong Liu, Xuhui Chen, Li Li, Miaomiao Feng, Yue Zhang, Li Wan, Chuanhan Zhang, Wenlong Yao
Oxidized cell-free DNA as a stress-signaling factor activating the chronic inflammatory process in patients with autism spectrum disorders
Galina V. Shmarina, Elizaveta S. Ershova, Natalia V. Simashkova, Svetlana G. Nikitina, Julia M. Chudakova, Natalia N. Veiko, Lev N. Porokhovnik, Anna Y. Basova, Antonina F. Shaposhnikova, Daria A. Pukhalskaya, Vladimir M. Pisarev, Natalia J. Korovina, Natalia L. Gorbachevskaya, Olga A. Dolgikh, Marina Bogush, Sergey I. Kutsev, Svetlana V. Kostyuk
Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice
Katharine M. von Herrmann, Faith L. Anderson, Eileen M. Martinez, Alison L. Young, Matthew C. Havrda
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
Michiyo Iba, Changyoun Kim, Michelle Sallin, Somin Kwon, Anjali Verma, Cassia Overk, Robert A. Rissman, Ranjan Sen, Jyoti Misra Sen, Eliezer Masliah
Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker, Cynthia Shannon Weickert
Comparison of different optomotor response readouts for visual testing in experimental autoimmune encephalomyelitis-optic neuritis
Christina Hecker, Michael Dietrich, Andrea Issberner, Hans-Peter Hartung, Philipp Albrecht
Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats
Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian, Hong-Quan Dong
Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer’s disease
Adham Fani Maleki, Giulia Cisbani, Marie-Michèle Plante, Paul Préfontaine, Nataly Laflamme, Jean Gosselin, Serge Rivest
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury
Yuan Chang, Juan Zhu, Di Wang, Hua Li, Yihua He, Kewei Liu, Xiaoqiang Wang, Yuqin Peng, Suyue Pan, Kaibin Huang
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
Annie Pu, Manoj K. Mishra, Yifei Dong, Samira Ghorbanigazar, Erin L. Stephenson, Khalil S. Rawji, Claudia Silva, Hiroshi Kitagawa, Stephen Sawcer, V. Wee Yong
Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Anne Murphy, Daniel N. Cox, Javier E. Stern
Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?
Tamara L. Baker, Mujun Sun, Bridgette D. Semple, Shiraz Tyebji, Christopher J. Tonkin, Richelle Mychasiuk, Sandy R. Shultz
A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy
Xavier Taylor, Pablo Cisternas, Yanwen You, Yingjian You, Shunian Xiang, Yamil Marambio, Jie Zhang, Ruben Vidal, Cristian A. Lasagna-Reeves
CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation
Elien Grajchen, Elien Wouters, Britt van de Haterd, Mansour Haidar, Kévin Hardonnière, Tess Dierckx, Jana Van Broeckhoven, Celine Erens, Sven Hendrix, Saadia Kerdine-Römer, Jerome J. A. Hendriks, Jeroen F. J. Bogie
NF-κB p65-dependent transcriptional regulation of histone deacetylase 2 contributes to the chronic constriction injury-induced neuropathic pain via the microRNA-183/TXNIP/NLRP3 axis
Jiamin Miao, Xuelong Zhou, Tianjiao Ji, Gang Chen
A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
Hina Singh, Daniel Ojeda-Juárez, Ricky Maung, Rohan Shah, Amanda J. Roberts, Marcus Kaul
Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
Sudeshna Das, Zhaozhi Li, Ayush Noori, Bradley T. Hyman, Alberto Serrano-Pozo
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
Giovanni Ferrara, Andrea Benzi, Laura Sturla, Daniela Marubbi, Davide Frumento, Sonia Spinelli, Elena Abbotto, Federico Ivaldi, Maria von Holtey, Maximilien Murone, Alessio Nencioni, Antonio Uccelli, Santina Bruzzone
The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome
Xiangming Liu, Yiming Ma, Ruoyun Ouyang, Zihang Zeng, Zijie Zhan, Huanhuan Lu, Yanan Cui, Zhongshang Dai, Lijuan Luo, Chenjie He, Herui Li, Dandan Zong, Yan Chen
Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use
Hannah A. Wang, Hua-Jun Liang, Thomas M. Ernst, Kenichi Oishi, Linda Chang
Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports
Souhel Najjar, Amanda Najjar, Derek J. Chong, Bidyut K. Pramanik, Claudia Kirsch, Ruben I. Kuzniecky, Steven V. Pacia, Salman Azhar
Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation
Anu Mary Varghese, Mausam Ghosh, Savita Kumari Bhagat, K. Vijayalakshmi, Veeramani Preethish-Kumar, Seena Vengalil, Pradeep-Chandra-Reddy Chevula, Saraswati Nashi, Kiran Polavarapu, Meenakshi Sharma, Rupinder Singh Dhaliwal, Mariamma Philip, Atchayaram Nalini, Phalguni Anand Alladi, Talakad N. Sathyaprabha, Trichur R. Raju
Neurocognitive impacts of arbovirus infections
Marion Clé, Patrick Eldin, Laurence Briant, Annie Lannuzel, Yannick Simonin, Philippe Van de Perre, André Cabié, Sara Salinas
Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration
Ione O. C. Woollacott, Christina E. Toomey, Catherine Strand, Robert Courtney, Bridget C. Benson, Jonathan D. Rohrer, Tammaryn Lashley
GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ
Hasan Onur Dikmen, Marc Hemmerich, Andrea Lewen, Jan-Oliver Hollnagel, Bruno Chausse, Oliver Kann
Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders
Leung-Wah Yick, Chi-Ho Tang, Oscar Ka-Fai Ma, Jason Shing-Cheong Kwan, Koon-Ho Chan
Prognostic significance of plasma IL-2 and sIL-2Rα in patients with first-ever ischaemic stroke
Haiping Zhao, Fangfang Li, Yuyou Huang, Sijia Zhang, Lingzhi Li, Zhenhong Yang, Rongliang Wang, Zhen Tao, Ziping Han, Junfen Fan, Yangmin Zheng, Qingfeng Ma, Yumin Luo
Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail Woolums, Donna M. Wilcock
Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury
Guang-Jie Liu, Tao Tao, Han Wang, Yan Zhou, Xuan Gao, Yong-Yue Gao, Chun-Hua Hang, Wei Li
Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching
Tzu-Chieh Huang, Hua-Lin Wu, Szu-Han Chen, Yun-Ting Wang, Chia-Ching Wu
Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve
Siming Wang, Tamaki Ishima, Jiancheng Zhang, Youge Qu, Lijia Chang, Yaoyu Pu, Yuko Fujita, Yunfei Tan, Xingming Wang, Kenji Hashimoto
T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease
Meena S. Subbarayan, Charles Hudson, Lauren D. Moss, Kevin R. Nash, Paula C. Bickford
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia
Rafael Rivas-Santisteban, Ana I. Rodriguez-Perez, Ana Muñoz, Irene Reyes-Resina, José Luis Labandeira-García, Gemma Navarro, Rafael Franco
MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling
Meng Mao, Yi Xu, Xin-Yu Zhang, Lin Yang, Xiao-bin An, Yang Qu, Ya-ni Chai, Yan-Ru Wang, Ting-ting Li, Jing Ai
Myeloid Pannexin-1 mediates acute leukocyte infiltration and leads to worse outcomes after brain trauma
Joon Ho Seo, Miloni S. Dalal, Frances Calderon, Jorge E. Contreras
Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice
Ryan J. Worthen, Susan S. Garzon Zighelboim, Camila S. Torres Jaramillo, Eleonore Beurel
The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours
Katarzyna Chamera, Katarzyna Kotarska, Magdalena Szuster-Głuszczak, Ewa Trojan, Alicja Skórkowska, Bartosz Pomierny, Weronika Krzyżanowska, Natalia Bryniarska, Agnieszka Basta-Kaim
Myeloproliferative blood cancers as a human neuroinflammation model for development of Alzheimer’s disease: evidences and perspectives
Hans C. Hasselbalch, Vibe Skov, Lasse Kjær, Torben L. Sørensen, Christina Ellervik, Troels Wienecke
IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice
Yuejin Liang, Panpan Yi, Wenjuan Ru, Zuliang Jie, Hui Wang, Tamer Ghanayem, Xiaofang Wang, Edrous Alamer, Jinjun Liu, Haitao Hu, Lynn Soong, Jiyang Cai, Jiaren Sun
Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model
Peng Li, Gang Zhao, Fanfan Chen, Yan Ding, Tianyi Wang, Shengpeng Liu, Weitian Lu, Weilin Xu, Jerry Flores, Umut Ocak, Tongyu Zhang, John H. Zhang, Jiping Tang
Neuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury
Mengya Jiao, Xiangyong Li, Liying Chen, Xiaodi Wang, Baohong Yuan, Tao Liu, Qun Dong, Hanfang Mei, Hui Yin
Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma
Xiangjun Yang, Qun Zeng, Mine Barış, Gülgün Tezel
Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
Brienne A. McKenzie, Jason P. Fernandes, Matthew A. L. Doan, Laura M. Schmitt, William G. Branton, Christopher Power
Serum amyloid A inhibits astrocyte migration via activating p38 MAPK
Aihua Lin, Jin Liu, Ping Gong, Yanqing Chen, Haibo Zhang, Yan Zhang, Yang Yu
CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment
Yu-Qing Chen, Sai-Nan Wang, Yu-Jiao Shi, Jing Chen, Shu-Qin Ding, Jie Tang, Lin Shen, Rui Wang, Hai Ding, Jian-Guo Hu, He-Zuo Lü
MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation
Maorong Jiang, Ran Li, Jingjun Lyu, Xuan Li, Wei Wang, Zhuoran Wang, Huaxin Sheng, Weiguo Zhang, Jörn Karhausen, Wei Yang
FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages
Wang Dongxue, Liu Fei, Zhu Liyun, Lin Ping, Han Fanyi, Wang Xue, Tan Xianxi, Lin Li, Xiong Ye
Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice
Dan Liu, Yujia Zhao, Yuze Qi, Yun Gao, Dezhen Tu, Yinxi Wang, Hui-Ming Gao, Hui Zhou
Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion
Benjamin R. Cassidy, Miao Zhang, William E. Sonntag, Douglas A. Drevets
Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets
Vaidya Govindarajan, Juan Pablo de Rivero Vaccari, Robert W. Keane
Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients
Sven Jarius, Hannah Pellkofer, Nadja Siebert, Mirjam Korporal-Kuhnke, Martin W. Hümmert, Marius Ringelstein, Paulus S. Rommer, Ilya Ayzenberg, Klemens Ruprecht, Luisa Klotz, Nasrin Asgari, Tobias Zrzavy, Romana Höftberger, Rafik Tobia, Mathias Buttmann, Kai Fechner, Kathrin Schanda, Martin Weber, Susanna Asseyer, Jürgen Haas, Christian Lechner, Ingo Kleiter, Orhan Aktas, Corinna Trebst, Kevin Rostasy, Markus Reindl, Tania Kümpfel, Friedemann Paul, Brigitte Wildemann
Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients
Sven Jarius, Christian Lechner, Eva M. Wendel, Matthias Baumann, Markus Breu, Mareike Schimmel, Michael Karenfort, Adela Della Marina, Andreas Merkenschlager, Charlotte Thiels, Astrid Blaschek, Michela Salandin, Steffen Leiz, Frank Leypoldt, Alexander Pschibul, Annette Hackenberg, Andreas Hahn, Steffen Syrbe, Jurgis Strautmanis, Martin Häusler, Peter Krieg, Astrid Eisenkölbl, Johannes Stoffels, Matthias Eckenweiler, Ilya Ayzenberg, Jürgen Haas, Romana Höftberger, Ingo Kleiter, Mirjam Korporal-Kuhnke, Marius Ringelstein, Klemens Ruprecht, Nadja Siebert, Kathrin Schanda, Orhan Aktas, Friedemann Paul, Markus Reindl, Brigitte Wildemann, Kevin Rostásy
Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury
Xuefei Li, Zhiyuan Yu, Weifeng Zong, Peng Chen, Jia Li, Minghuan Wang, Fengfei Ding, Minjie Xie, Wei Wang, Xiang Luo
Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet
Maude Bordeleau, Chloé Lacabanne, Lourdes Fernández de Cossío, Nathalie Vernoux, Julie C. Savage, Fernando González-Ibáñez, Marie-Ève Tremblay
Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease
Ayelet Vardi, Shifra Ben-Dor, Soo Min Cho, Ulrich Kalinke, Julia Spanier, Anthony H. Futerman
Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis
Nathalia Bernardes Teixeira, Gisele Picolo, Aline Carolina Giardini, Fawzi Boumezbeur, Géraldine Pottier, Bertrand Kuhnast, Denis Servent, Evelyne Benoit
Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
Hila Israelov, Orly Ravid, Dana Atrakchi, Daniel Rand, Shirin Elhaik, Yael Bresler, Rachel Twitto-Greenberg, Liora Omesi, Sigal Liraz-Zaltsman, Fabien Gosselet, Michal Schnaider Beeri, Itzik Cooper
Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments
Flora Reverchon, Vidian de Concini, Vanessa Larrigaldie, Sulayman Benmerzoug, Sylvain Briault, Dieudonnée Togbé, Bernhard Ryffel, Valérie F. J. Quesniaux, Arnaud Menuet
Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway
Yaiza M. Arenas, Andrea Cabrera-Pastor, Nora Juciute, Eloy Mora-Navarro, Vicente Felipo
Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte
Min Liu, Zhipeng Xu, Long Wang, Lixia Zhang, Yi Liu, Jiangbei Cao, Qiang Fu, Yanhong Liu, Hao Li, Jingsheng Lou, Wugang Hou, Weidong Mi, Yulong Ma
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease
Irina Belaya, Mariia Ivanova, Annika Sorvari, Marina Ilicic, Sanna Loppi, Hennariikka Koivisto, Alessandra Varricchio, Heikki Tikkanen, Frederick R. Walker, Mustafa Atalay, Tarja Malm, Alexandra Grubman, Heikki Tanila, Katja M. Kanninen
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein
Na Li, Tessandra Stewart, Lifu Sheng, Min Shi, Eugene M. Cilento, Yufeng Wu, Jau-Syong Hong, Jing Zhang
Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona, Amanda M. Brown
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease
David J. Braun, Edgardo Dimayuga, Josh M. Morganti, Linda J. Van Eldik
Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis
Marc Y. Stevens, Haley C. Cropper, Katherine L. Lucot, Aisling M. Chaney, Kendra J. Lechtenberg, Isaac M. Jackson, Marion S. Buckwalter, Michelle L. James
Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis
Priyanka, Renu Wadhwa, Rituparna Chaudhuri, Tapas Chandra Nag, Pankaj Seth
GM2 ganglioside accumulation causes neuroinflammation and behavioral alterations in a mouse model of early onset Tay-Sachs disease
Seçil Akyıldız Demir, Zehra Kevser Timur, Nurselin Ateş, Luis Alarcón Martínez, Volkan Seyrantepe
Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs
Angela D. A. Cornelius, Shirin Hosseini, Sarah Schreier, David Fritzsch, Loreen Weichert, Kristin Michaelsen-Preusse, Markus Fendt, Andrea Kröger
Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS
Lindsay A. Hohsfield, Allison R. Najafi, Yasamine Ghorbanian, Neelakshi Soni, Edna E. Hingco, Sung Jin Kim, Ayer Darling Jue, Vivek Swarup, Mathew A. Inlay, Kim N. Green
β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology
Daniel C. Shippy, Connor Wilhelm, Patel A. Viharkumar, Thomas J. Raife, Tyler K. Ulland
Site-specific opening of the blood-brain barrier by extracellular histones
Nuria Villalba, Sheon Baby, Byeong J. Cha, Sarah Y. Yuan
Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord
Susana Monteiro, Andreia G. Pinho, Mara Macieira, Cláudia Serre-Miranda, Jorge R. Cibrão, Rui Lima, Carina Soares-Cunha, Natália L. Vasconcelos, José Lentilhas-Graça, Sara Duarte-Silva, Alice Miranda, Margarida Correia-Neves, António J. Salgado, Nuno A. Silva
TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model
Frank Zamudio, Anjanet R. Loon, Shayna Smeltzer, Khawla Benyamine, Nanda K. Navalpur Shanmugam, Nicholas J. F. Stewart, Daniel C. Lee, Kevin Nash, Maj-Linda B. Selenica
The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection
Richard Lindqvist, Ebba Rosendal, Elvira Weber, Naveed Asghar, Sarah Schreier, Annasara Lenman, Magnus Johansson, Gerhard Dobler, Malena Bestehorn, Andrea Kröger, Anna K. Överby
Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease
Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas, Abigail E. Salinero, Charly Abi-Ghanem, Yannick Poitelon, Sophie Belin, Kristen L. Zuloaga
Neurological consequences of COVID-19: what have we learned and where do we go from here?
Abbas Jarrahi, Meenakshi Ahluwalia, Hesam Khodadadi, Evila da Silva Lopes Salles, Ravindra Kolhe, David C. Hess, Fernando Vale, Manish Kumar, Babak Baban, Kumar Vaibhav, Krishnan M. Dhandapani
Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts
Tyler A. Smith, Cameron L. Ghergherehchi, Haley O. Tucker, George D. Bittner
Associations between gut microbiota and Alzheimer’s disease, major depressive disorder, and schizophrenia
Zhenhuang Zhuang, Ruotong Yang, Wenxiu Wang, Lu Qi, Tao Huang
The effect of insomnia on development of Alzheimer’s disease
Shaghayegh Sadeghmousavi, Mahsa Eskian, Farzaneh Rahmani, Nima Rezaei
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin
Julieta Saba, Federico López Couselo, Juan Turati, Lila Carniglia, Daniela Durand, Andrea de Laurentiis, Mercedes Lasaga, Carla Caruso
Molecular patterns from a human gut-derived Lactobacillus strain suppress pathogenic infiltration of leukocytes into the central nervous system
John Michael S. Sanchez, Daniel J. Doty, Ana Beatriz DePaula-Silva, D. Garrett Brown, Rickesha Bell, Kendra A. Klag, Amanda Truong, Jane E. Libbey, June L. Round, Robert S. Fujinami
Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice—role of phosphoinositide 3-kinase gamma
Guang-Ping Lang, Bernadin Ndongson-Dongmo, Trim Lajqi, Michael Brodhun, Yingying Han, Reinhard Wetzker, Martin G. Frasch, Reinhard Bauer
Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis
Ngoc Dung Le, Lukas Muri, Denis Grandgirard, Jens Kuhle, David Leppert, Stephen L. Leib
Decreased expression of miR-29 family associated with autoimmune myasthenia gravis
Mélanie A. Cron, Cloé A. Payet, Odessa-Maud Fayet, Solène Maillard, Frédérique Truffault, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Adrian Liston, Rozen Le Panse
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
Hong Fan, Hai-Bin Tang, Zhe Chen, Hu-Qing Wang, Lei Zhang, Yu Jiang, Tao Li, Cai-Feng Yang, Xiao-Ya Wang, Xia Li, Sheng-Xi Wu, Gui-Lian Zhang
Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations
Patrick P. Lowe, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Abhishek Satishchandran, Istvan Furi, Yeonhee Cho, Benedek Gyongyosi, Donna Catalano, Eric Lefebvre, Laurent Fischer, Star Seyedkazemi, Dorothy P. Schafer, Gyongyi Szabo
Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis
Qin Ma, Atsuko Matsunaga, Brenda Ho, Jorge R. Oksenberg, Alessandro Didonna
The immune system on the TRAIL of Alzheimer’s disease
Chiara Burgaletto, Antonio Munafò, Giulia Di Benedetto, Cettina De Francisci, Filippo Caraci, Rosaria Di Mauro, Claudio Bucolo, Renato Bernardini, Giuseppina Cantarella
The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
Shinrye Lee, Seyeon Kim, Ha-Young Kang, Hye Ryeong Lim, Younghwi Kwon, Myungjin Jo, Yu-Mi Jeon, Sang Ryong Kim, Kiyoung Kim, Chang Man Ha, Seongsoo Lee, Hyung-Jun Kim
PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139
Wissam Beaino, Bieneke Janssen, Esther Kooijman, Ricardo Vos, Robert C. Schuit, James O’Brien-Brown, Michael Kassiou, Bert van het Hof, Danielle J. Vugts, Helga E. de Vries, Albert D. Windhorst
Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia
Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero Jr, Manoocher Soleimani
Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro
Bo Ding, Chengheng Lin, Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Weina Yang
Glycine, the smallest amino acid, confers neuroprotection against d-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain
Rahat Ullah, Myeung Hoon Jo, Muhammad Riaz, Sayed Ibrar Alam, Kamran Saeed, Waqar Ali, Inayat Ur Rehman, Muhammad Ikram, Myeong Ok Kim
A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis
Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Kevin Aguilar, Anna Escrig, Mercedes Giralt, Richard D. Palmiter, Juan Hidalgo
Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer’s disease
Fan’ge Kong, Xue Jiang, Ruochen Wang, Siyu Zhai, Yizhi Zhang, Di Wang
Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa
Wei Yang, Guoyin Xiong, Bin Lin
Endothelin-1 contributes to the development of virus-induced demyelinating disease
Young-Hee Jin, Bongsu Kang, Hyun S. Kang, Chang-Sung Koh, Byung S. Kim
Investigation of reactive astrogliosis effect on post-stroke cognitive impairment
Kuo-Lun Huang, Ing-Tsung Hsiao, Meng-Yang Ho, Jung-Lung Hsu, Yeu-Jhy Chang, Ting-Yu Chang, Chi-Hung Liu, Chien-Hung Chang, Yi-Ming Wu, Kuan-Yi Wu, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Tsong-Hai Lee, Kun-Ju Lin
Neuroprotective effects of verbascoside against Alzheimer’s disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice
Chunyue Wang, Xueying Cai, Ruochen Wang, Siyu Zhai, Yongfeng Zhang, Wenji Hu, Yizhi Zhang, Di Wang
NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel
Meng Liu, Su-Bo Zhang, Yu-Xuan Luo, Yan-Ling Yang, Xiang-Zhong Zhang, Bo Li, Yan Meng, Yuan-Jie Chen, Rui-Xian Guo, Yuan-Chang Xiong, Wen-Jun Xin, Dai Li
Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model
Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan, Wen Wu
Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation
Kohei Kanno, Kohei Shimizu, Masamichi Shinoda, Makoto Hayashi, Osamu Takeichi, Koichi Iwata
RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice
Rina Zilkha-Falb, Tatyana Rachutin-Zalogin, Lakota Cleaver, Michael Gurevich, Anat Achiron
Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents
Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel, Daniela Salvemini
Efficient control of Japanese encephalitis virus in the central nervous system of infected pigs occurs in the absence of a pronounced inflammatory immune response
Valerie Redant, Herman W. Favoreel, Kai Dallmeier, Willem Van Campe, Nick De Regge
Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways
Pongsatorn Meesawatsom, Gareth Hathway, Andrew Bennett, Dumitru Constantin-Teodosiu, Victoria Chapman
The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease
Micheline McCarthy, Ami P. Raval
Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling
Bin Zhang, Miao Bai, Xiaojian Xu, Mengshi Yang, Fei Niu, Fei Gao, Baiyun Liu
Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model
Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan, Sujatha Kannan
Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy
Jialin Yin, Yanan Shen, Yanna Si, Yuan Zhang, Jiayue Du, Xiajuan Hu, Mengmeng Cai, Hongguang Bao, Yan Xing
Regulatory coupling between long noncoding RNAs and senescence in irradiated microglia
Anan Xu, Rong Li, Anbang Ren, Haifeng Jian, Zhong Huang, Qingxing Zeng, Baiyao Wang, Jieling Zheng, Xiaoyu Chen, Naiying Zheng, Ronghui Zheng, Yunhong Tian, Mengzhong Liu, Zixu Mao, Aimin Ji, Yawei Yuan
Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling
Hailong Yu, Xiang Cao, Wei Li, Pinyi Liu, Yuanyuan Zhao, Lilong Song, Jian Chen, Beilei Chen, Wenkui Yu, Yun Xu
Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
Kristina Berve, Brian L. West, Rudolf Martini, Janos Groh
Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis
Juwen C. DuBois, Alex K. Ray, Peter Davies, Bridget Shafit-Zagardo
The formyl peptide receptor agonist Ac2-26 alleviates neuroinflammation in a mouse model of pneumococcal meningitis
Marvin Rüger, Eugenia Kipp, Nadine Schubert, Nicole Schröder, Thomas Pufe, Matthias B. Stope, Markus Kipp, Christian Blume, Simone C. Tauber, Lars-Ove Brandenburg
Microglia dynamics in adolescent traumatic brain injury
Eric Eyolfson, Asher Khan, Richelle Mychasiuk, Alexander W. Lohman
Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration
Amir Saeed Khan, Thomas Langmann
Cellular infiltration in traumatic brain injury
Aftab Alam, Eric P. Thelin, Tamara Tajsic, Danyal Z. Khan, Abdelhakim Khellaf, Rickie Patani, Adel Helmy
Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia
Tingting He, Wanlu Li, Yaying Song, Zongwei Li, Yaohui Tang, Zhijun Zhang, Guo-Yuan Yang
Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury
Rui Sun, Mengna Peng, Pengfei Xu, Feihong Huang, Yi Xie, Juanji Li, Ye Hong, Hongquan Guo, Qian Liu, Wusheng Zhu
Consecutive intra-gingival injections of lipopolysaccharide and butyric acid to mice induce abnormal behavior and changes in cytokine concentrations
Takamitsu Tsukahara, Atsushi Toyoda, Takahiro Kawase, Shin-ichi Nakamura, Kuniyasu Ochiai
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas, Sandra M. Cardoso
Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model
Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu, Dai-Shi Tian
Air pollution as a contributor to the inflammatory activity of multiple sclerosis
Andrea Cortese, Luca Lova, Patrizia Comoli, Elisabetta Volpe, Silvia Villa, Giulia Mallucci, Sabrina La Salvia, Alfredo Romani, Diego Franciotta, Valentina Bollati, Sabrina Basso, Ilaria Guido, Giuseppe Quartuccio, Luca Battistini, Cristina Cereda, Roberto Bergamaschi
Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice
Yanan Shen, Yuan Zhang, Lihai Chen, Jiayue Du, Hongguang Bao, Yan Xing, Mengmeng Cai, Yanna Si
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice
Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John, Gareth R. Howell
Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea
Lin-Jing Gong, Xin-Yuan Wang, Wen-Yu Gu, Xu Wu
Lectin complement pathway initiators after subarachnoid hemorrhage — an observational study
Jeppe Sillesen Matzen, Charlotte Loumann Krogh, Julie Lyng Forman, Peter Garred, Kirsten Møller, Søren Bache
Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury
Susan A. Farr, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo, Michael L. Niehoff, Timothy M. Doyle, Daniela Salvemini
Microglial responses to peripheral type 1 interferon
Ernest Aw, Yingying Zhang, Michael Carroll
Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Steven Droho, Benjamin R. Thomson, Hadijat M. Makinde, Carla M. Cuda, Harris Perlman, Jeremy A. Lavine
Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK
Ying Liu, Lijia Yu, Yaling Xu, Xiaohui Tang, Xijin Wang
Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress
Dongjie Peng, Junyan Li, Yue Deng, Xiaojuan Zhu, Lin Zhao, Yuwen Zhang, Zhaocong Li, Shiyan Ou, Shaojun Li, Yueming Jiang
Correction to: Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona, Amanda M. Brown
Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids
Douglas J. Hermes, Ian R. Jacobs, Megan C. Key, Alexis F. League, Barkha J. Yadav-Samudrala, Changqing Xu, Virginia D. McLane, Sara R. Nass, Wei Jiang, Rick B. Meeker, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Zibo Li, Zhanhong Wu, Hong Yuan, Pamela E. Knapp, Kurt F. Hauser, Sylvia Fitting
Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model
Jee-Wei Emily Chen, Jan Lumibao, Sarah Leary, Jann N. Sarkaria, Andrew J. Steelman, H. Rex Gaskins, Brendan A. C. Harley
Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice
Yu-Kun Feng, Qiong-Li Wu, Yan-Wen Peng, Feng-Yin Liang, Hua-Jing You, Yi-Wei Feng, Ge Li, Xue-Jiao Li, Shu-Hua Liu, Yong-Chao Li, Yu Zhang, Zhong Pei
Correction to: Three-dimensional morphometric analysisreveals time-dependent structural changesin microglia and astrocytes in the centralamygdala and hypothalamicparaventricular nucleus of heart failure rats
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Anne Murphy, Daniel N. Cox, Javier E. Stern
CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis
Michelle Naughton, Jill Moffat, George Eleftheriadis, Nira de la Vega Gallardo, Andrew Young, John Falconer, Kristen Hawkins, Ben Pearson, Bernard Perbal, Andrew Hogan, Paul Moynagh, Sam Loveless, Neil P. Robertson, Bruno Gran, Rachael Kee, Stella Hughes, Gavin McDonnell, Owain Howell, Denise C. Fitzgerald
K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway
Hyeon Joo Ham, Yong Sun Lee, Jaesuk Yun, Dong Ju Son, Hee Pom Lee, Sang-Bae Han, Jin Tae Hong
Diesel exhaust impairs TREM2 to dysregulate neuroinflammation
Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Prasada R. S. Kodavanti, Joyce L. Royland, Urmila P. Kodavanti, Michelle L. Block
Retraction Note: Bone mesenchymal stem cell-derivedexosomal microRNA-29b-3p preventshypoxic-ischemic injury in rat brain byactivating the PTEN-mediated Aktsignaling pathway
Kun Hou, Guichen Li, Jinchuan Zhao, Baofeng Xu, Yang Zhang, Jinlu Yu, Kan Xu
Correction to: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
Yi-wei Wang, Qin Zhou, Xiang Zhang, Qing-qing Qian, Jia-wen Xu, Peng-fei Ni, Yan-ning Qian
The good, the bad, and the opportunities of the complement system in neurodegenerative disease
Nicole D. Schartz, Andrea J. Tenner
Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration
Karis Little, Maria Llorián-Salvador, Miao Tang, Xuan Du, Stephen Marry, Mei Chen, Heping Xu
Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review
Huaping Xu, Xiaoyun Shi, Xin Li, Jiexin Zou, Chunyan Zhou, Wenfeng Liu, Huming Shao, Hongbing Chen, Linbo Shi
Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy
Julia Loos, Samantha Schmaul, Theresa Marie Noll, Magdalena Paterka, Miriam Schillner, Julian T. Löffel, Frauke Zipp, Stefan Bittner
Insulin inhibits inflammation-induced cone death in retinal detachment
Jean-Baptiste Conart, Guillaume Blot, Sébastien Augustin, Géraldine Millet-Puel, Christophe Roubeix, Fanny Beguier, Hugo Charles-Messance, Sara Touhami, José-Alain Sahel, Jean-Paul Berrod, Thierry Léveillard, Xavier Guillonneau, Cécile Delarasse, Florian Sennlaub
An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration
Rabah Dabouz, Colin W. H. Cheng, Pénélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera, Sylvain Chemtob
Immunological classification of gliomas based on immunogenomic profiling
Qiushi Feng, Lin Li, Mengyuan Li, Xiaosheng Wang
Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia
Mariana Mota, Vanessa Porrini, Edoardo Parrella, Marina Benarese, Arianna Bellucci, Sina Rhein, Markus Schwaninger, Marina Pizzi
CCL3 contributes to secondary damage after spinal cord injury
Nicolas Pelisch, Jose Rosas Almanza, Kyle E. Stehlik, Brandy V. Aperi, Antje Kroner
Oleanolic acid ameliorates intestinal alterations associated with EAE
Beatriz Gutierrez, Isabel Gallardo, Lorena Ruiz, Yolanda Alvarez, Victoria Cachofeiro, Abelardo Margolles, Marita Hernandez, Maria Luisa Nieto
NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice
Miao Wang, Xinchun Ye, Jinxia Hu, Qiuchen Zhao, Bingchen Lv, Weijing Ma, Weiwei Wang, Hanhan Yin, Qi Hao, Chao Zhou, Tao Zhang, Weifeng Wu, Yan Wang, Mingyue Zhou, Cong-hui Zhang, Guiyun Cui
Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain
Nahla Zaghloul, Dalibor Kurepa, Mohammad Y. Bader, Nadia Nagy, Mohamed N. Ahmed
Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation
Pedram Honarpisheh, Juneyoung Lee, Anik Banerjee, Maria P. Blasco-Conesa, Parisa Honarpisheh, John d’Aigle, Abdullah A. Mamun, Rodney M. Ritzel, Anjali Chauhan, Bhanu P. Ganesh, Louise D. McCullough
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment
Emma Sigfridsson, Martina Marangoni, Giles E. Hardingham, Karen Horsburgh, Jill H. Fowler
Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells
Aidan Falvey, Fabrice Duprat, Thomas Simon, Sandrine Hugues-Ascery, Silvia V. Conde, Nicolas Glaichenhaus, Philippe Blancou
Reactivity and increased proliferation of NG2 cells following central nervous system infection with Theiler’s murine encephalomyelitis virus
Laura A. Bell, Glenna J. Wallis, Karen S. Wilcox
CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy
Jonathan D. Cherry, Gaoyuan Meng, Sarah Daley, Weiming Xia, Sarah Svirsky, Victor E. Alvarez, Raymond Nicks, Morgan Pothast, Hunter Kelley, Bertrand Huber, Yorghos Tripodis, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection
Jorge Rubén Cabrera, Ignacio Rodríguez-Izquierdo, José Luis Jiménez, María Ángeles Muñoz-Fernández
Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1
Gyu Won Jeong, Hwan Hee Lee, Whaseon Lee-Kwon, Hyug Moo Kwon
Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlie differences in modulation of in vitro myelination
Inge L. Werkman, Marissa L. Dubbelaar, Pieter van der Vlies, Jelkje J. de Boer-Bergsma, Bart J. L. Eggen, Wia Baron
Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases
Gloria Biechele, Nicolai Franzmeier, Tanja Blume, Michael Ewers, Jose Medina Luque, Florian Eckenweber, Christian Sacher, Leonie Beyer, Francois Ruch-Rubinstein, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Paul Cumming, Peter Bartenstein, Axel Rominger, Günter U. Höglinger, Jochen Herms, Matthias Brendel
Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model
Pia Grotegut, Natarajan Perumal, Sandra Kuehn, Andreas Smit, H. Burkhard Dick, Franz H. Grus, Stephanie C. Joachim