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Neuropathic Pain 

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  1. Open Access 01-12-2024 | ReviewPaper

    Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain

    Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of the insular cortex (IC) is thought to involve several neuroplastic changes in multiple brain …

  2. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    Platelet-rich plasma alleviates neuropathic pain in osteoarthritis by downregulating microglial activation

    Knee osteoarthritis (KOA) is a common chronic degenerative disease characterized by articular cartilage degeneration, synovitis, subchondral bone remodeling, and joint muscle atrophy. KOA has the highest prevalence among all types of arthritis and …

  3. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain

    Neuropathic pain (NP) largely arises from a pathological imbalance between excitatory and inhibitory controls of pain transmission, especially at the level of the dorsal spinal cord [ 1 – 4 ]. Together with a persistent neuroinflammation, this …

  4. 08-05-2024 | Neuropathic Pain | Online First

    Epitranscriptomic Regulation of NMDA Receptors Rears its Ugly Head in Chemotherapy-Induced Neuropathic Pain

  5. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain

    Chronic neuropathic pain (CNP) is a common sequela of peripheral nerve injury and abnormal nervous system function [ 1 ]. With a prevalence ranging from 6.9 to 10% of the general population, CNP is a major contributor to the global disease burden [ …1

  6. Open Access 16-04-2024 | Neuropathic Pain | Online First

    Neuropathic and Nociplastic Pain Profiles are Common in Adult Chronic Nonbacterial Osteitis (CNO)

    Chronic nonbacterial osteitis (CNO) is a rare musculoskeletal disease causing chronic bone pain. It is known that chronic musculoskeletal pain may involve other mechanisms than nociceptive pain only. We investigate the prevalence of neuropathic

  7. 01-12-2024 | Neuropathic Pain | OriginalPaper

    Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway

    The role of circular RNAs (circRNAs) in neuropathic pain is linked to the fundamental physiological mechanisms involved. However, the exact function of circRNAs in the context of neuropathic pain is still not fully understood. The functional …

  8. Open Access 10-04-2024 | Neuropathic Pain | OriginalPaper

    Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial

    Chronic pain is one of the most common problems encountered in healthcare [ 1 ]. Normally, pain perception is modulated by an array of biological, environmental, cognitive and affective factors that heavily influence the subjective experience of …

  9. Open Access 01-12-2024 | Neuropathic Pain | Erratum

    Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

  10. 02-05-2024 | Neuropathic Pain | Online First

    All available diagnostic and therapeutic options should be fully exploited in order to quickly identify and optimally treat neuropathic pain in long-COVID

  11. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    Assessment of neuropathic pain management knowledge, attitudes, and practices among urology trainees and consultants in prostate cancer care: a survey-based study

    Prostate cancer is the most common non-cutaneous malignancy in men, with presentations that can range from mild disease to advanced metastasis [ 1 , 2 ]. Advanced prostate cancer patients frequently grapple with the burden of pain as a complication …

  12. 29-02-2024 | Pain in MS | ReviewPaper

    Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis

    Neuropathic pain is a major concern in multiple sclerosis, but treatments have poor efficacy and unpleasant side effects. What options for pain control are available?

  13. Open Access 16-02-2024 | Neuropathic Pain | Report

    Corneal Neuropathic Pain: A Patient and Physician Perspective

    Corneal neuropathic pain (CNP) is a debilitating condition characterized by pain in the absence of a noxious stimulus. Symptoms such as ocular stinging, burning, photophobia, irritation, and a deep aching pain can be severe despite a seemingly …

  14. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion

    Trigeminal nerve injury is one of the most serious complications in clinical orofacial operations, with an incidence of 0.5% to 37% [ 1 ]. About 50% of patients with trigeminal nerve injury have orofacial neuropathic pain (NP), which seriously …

  15. Open Access 01-12-2024 | OriginalPaper

    SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury

    Neuropathic pain (NP) is an intractable pain caused by a lesion or disease affecting the somatosensory system [ 1 ]. Traditional analgesics have poor efficacy and are prone to adverse reactions, such as overdose toxicity and opioid dependence.

  16. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    Chronic temporomandibular disorder pain patients with a history of neuropathic pain treatment: a narrative research on their diagnosis and treatment history

    The aims of this qualitative research were (1) to gain more insight in the diagnostic and treatment history of patients with chronic temporomandibular disorder (TMD) pain; (2) to get a deeper understanding of possible factors that are involved in …

  17. Open Access 01-12-2024 | Neuropathic Pain | OriginalPaper

    Analgesic effect of neuromodulation using the AT-04 portable magnetic field-generating device in a patient with neuropathic pain: a case report

    The neuromodulation produced by electrical therapies such as transcutaneous electrical nerve stimulation (TENS) and spinal cord stimulation (SCS) can alleviate neuropathic pain [ 1 , 2 ]. A previous clinical trial has reported that neuromodulation …

  18. 14-12-2023 | Neuropathic Pain | ReviewPaper

    Phytocannabinoids for the Treatment of Neuropathic Pain: A Scoping Review of Randomised Controlled Trials Published Between 2012 and 2023

    Neuropathic pain (NP) is defined by the International Association for the Study of Pain (IASP) as pain that arises from lesion or disease to the somatosensory nervous system [ 1 ] which can occur centrally or peripherally [ 2 ]. NP is estimated to …

  19. Open Access 28-08-2023 | Neuropathic Pain | OriginalPaper

    Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain

    The cytochrome P450 proteins (CYP450s) have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases. CYP26A1, a member of the CYP450 family, carries out the oxidative metabolism of retinoic …

  20. 04-01-2024 | Deep Brain Stimulation | OriginalPaper

    Somatotopic organization of the ventral nuclear group of the dorsal thalamus: deep brain stimulation for neuropathic pain reveals new insights into the facial homunculus

    Deep Brain Stimulation (DBS) is an experimental treatment for medication-refractory neuropathic pain. The ventral posteromedial (VPM) and ventral posterolateral (VPL) nuclei of the thalamus are popular targets for the treatment of facial and limb …

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