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Subarachnoid Hemorrhage 

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  1. 01-12-2024 | Subarachnoid Hemorrhage | OriginalPaper

    Hematocrit drift and outcomes in surgical patients with aneurysmal subarachnoid hemorrhage

    Anemia is pervasive among individuals afflicted with aneurysmal subarachnoid hemorrhage (aSAH), with an estimated 50% of patients manifesting anemic states during the course of their hospitalization [ 29 ]. Substantial evidence suggests that anemia …

  2. Open Access 01-12-2024 | Subarachnoid Hemorrhage | OriginalPaper

    Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation

    Cerebrovascular diseases often lead to the occurrence of subarachnoid hemorrhage (SAH), which is associated with high rates of fatality and morbidity. This condition also results in unfavorable outcomes, especially in individuals with …

  3. Open Access 01-12-2024 | Hydrocephalus | OriginalPaper

    Comparison of sex differences on outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis

    Aneurysmal subarachnoid hemorrhage (aSAH) is more prevalent in women than in men compared with other types of stroke [ 1 , 2 ]. Several studies have shown that females are associated with a poorer prognosis after aSAH compared to males [ 3 – 5 ].

  4. Open Access 01-12-2024 | OriginalPaper

    FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway

    Subarachnoid hemorrhage (SAH) is a critical medical emergency initiated by the rupture of aneurysms within the subarachnoid space [ 1 , 2 ]. SAH gives rise to devastating neurological deficits and leads to mortality rates as high as 35% among …

  5. Open Access 30-04-2024 | Subarachnoid Hemorrhage | Online First

    All Three Supersystems—Nervous, Vascular, and Immune—Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage

    The recently published DISCHARGE-1 trial supports the observations of earlier autopsy and neuroimaging studies that almost 70% of all focal brain damage after aneurysmal subarachnoid hemorrhage are anemic infarcts of the cortex, often also …

  6. 29-04-2024 | Simvastatin | Online First

    Statins in Subarachnoid Hemorrhage to Prevent Delayed Cerebral Ischemia: Old Drugs for New Strategies?

  7. Open Access 04-05-2024 | Central Nervous System Trauma | Online First

    The Optimal pressure reactivity index range is disease-specific: A comparison between aneurysmal subarachnoid hemorrhage and traumatic brain injury

    Cerebral blood flow (CBF) disturbances including ischemia and hyperemia are common following acute brain injuries such as aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) [ 23 ]. Traditionally, cerebral perfusion pressure …

  8. Open Access 01-12-2024 | Aneurysm | OriginalPaper

    Trends in incidence and treatments of spontaneous subarachnoid hemorrhage- a 10 year hospital based study

    The most important thing when treating a patient with a spontaneous subarachnoid haemorrhage (SAH) is to find and occlude the ruptured aneurysm as quickly as possible. The two main treatment strategies for this- neurointervention and microsurgery- …

  9. 23-04-2024 | Epigenetics | Online First

    Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage

    Vasospasm is a potentially preventable cause of poor prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH). Epigenetics might provide insight on its molecular mechanisms. We aimed to analyze the association between differential DNA …

  10. 11-04-2024 | Subarachnoid Hemorrhage | Online First

    Three Pillars of Recovery After Aneurysmal Subarachnoid Hemorrhage: A Narrative Review

    Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurologic disease with high mortality and disability. There have been global improvements in survival, which has contributed to the prevalence of patients living with long-term sequelae …

  11. Open Access 01-12-2024 | Subarachnoid Hemorrhage | OriginalPaper

    One-year survival of aneurysmal subarachnoid hemorrhage after airplane transatlantic transfer – a monocenter retrospective study

    Worldwide incidence of spontaneous aneurysmal subarachnoid hemorrhage (aSAH) is about 6.1 per 100,000 person-years, depending on the country [ 1 ]. Despite advances in the management of this disease [ 2 ], early case-fatality remains high, with …

  12. Open Access 01-12-2024 | Subarachnoid Hemorrhage | ReviewPaper

    Differential DNA methylation associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review

    Recent studies suggest that differential DNA methylation could play a role in the mechanism of cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Considering the significance of this …

  13. Open Access 15-04-2024 | Intracranial Hypertension | Online First

    Analysis of Cerebral Spinal Fluid Drainage and Intracranial Pressure Peaks in Patients with Subarachnoid Hemorrhage

    Subarachnoid hemorrhage (SAH) caused by a rupture of an intracranial aneurysm (aSAH) is a severe life-threatening emergency that is characterized by an acute onset of symptoms and is associated with considerable rates of morbidity and mortality [ 1 …–

  14. 08-04-2024 | Nimodipine | Online First

    The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model

    Brain injury caused by subarachnoid hemorrhage (SAH) after rupture of a cerebral aneurysm is divided into early brain injury and delayed brain injury [ 1 , 2 ]. The pathophysiologic mechanisms of early brain damage are known to be an immediate …

  15. 02-04-2024 | Simvastatin | Online First

    Effect of Statin Treatment in Patients with Aneurysmal Subarachnoid Hemorrhage: A Network Meta-Analysis

    Subarachnoid hemorrhage (SAH) occurs in approximately 9 per 100,000 people yearly, mainly due to the rupture of intracranial aneurysms [ 1 , 2 ]. About half of patients with SAH are younger than 55 years old, with an inferior prognosis. Up to 75% …

  16. Open Access 01-12-2024 | Subarachnoid Hemorrhage | OriginalPaper

    Impaired cerebral autoregulation detected in early prevasospasm period is associated with unfavorable outcome after spontaneous subarachnoid hemorrhage: an observational prospective pilot study

    Spontaneous aneurysmal subarachnoid hemorrhage (SAH) is a severe hemorrhagic stroke associated with the early onset of multiple complications that can lead to poor outcomes [ 1 , 2 ]. The mortality rate after SAH is up to 35%, and more than …

  17. 08-04-2024 | Subarachnoid Hemorrhage | Online First

    Correction to: Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice

  18. 01-12-2024 | Subarachnoid Hemorrhage | Letter

    Letter to editor: Serum concentration–guided intravenous magnesium sulfate administration for neuroprotection in patients with aneurysmal subarachnoid hemorrhage: A retrospective evaluation of a 12-year single-center experience.

    This critique examines a 12-year retrospective study on serum magnesium concentration-guided administration of magnesium sulfate in 548 patients with aneurysmal subarachnoid hemorrhage (aSAH). The study reported that maintaining serum magnesium …

  19. 01-12-2024 | Aneurysm | OriginalPaper

    Sex differences in patients with and without high-risk factors associated with aneurysmal subarachnoid hemorrhage

    Intracranial aneurysms are cerebrovascular lesions estimated to occur in up to 10% of the population [ 14 , 26 , 27 , 42 ]. The overall rate of aneurysmal subarachnoid hemorrhage (aSAH) is thought to be 1% to 2% annually among those with aneurysms …

  20. Open Access 01-12-2024 | Subarachnoid Hemorrhage | OriginalPaper

    Cisternal nicardipine for prevention of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a comparative retrospective cohort study

    Cerebral vasospasm (CV) is a major cause of mortality and morbidity in patients after aneurysmal subarachnoid hemorrhage (aSAH) [ 4 , 8 ]. It is associated with delayed ischemic neurological deficit (DIND) and delayed cerebral ischemia (DCI)[ 45 ] …

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