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Gynecology and Obstetrics

A rare, late side effect of radiotherapy

Open Access Breast Cancer Case Study

A woman developed sudden painless ecchymosis (bruising) of her breast, which was thought to be related to the radiotherapy she received for early-stage breast cancer a year and a half earlier.

Genetic causes of polyhydramnios

Open Access Polyhydramnions Case Study

Amniocentesis is not routine for isolated polyhydramnios in the absence of key structural defects. But these two cases show that polyhydramnios can be caused by rare genetic conditions that benefit from early diagnosis and intervention.

Update on menopausal HRT and type 2 diabetes

Open Access Type 2 Diabetes Review

Menopausal HRT may reduce the risk of type 2 diabetes developing and improve glycemic control. Individual risk factors must be considered when deciding a treatment plan.

Current Reviews

Tattooing to reconstruct Nipple-Areola Complex after oncological breast surgery: a scoping review

Open Access Breast Cancer Review

At the end of 2020, breast cancer was the most prevalent cancer in the world [ 1 ]. If the tumor position is found in the tissues below the areola or on the surrounding skin , Nipple-Areola Complex (NAC) removal may be necessary. This procedure can …

Infrastructural and public health awareness gaps for the diagnosis and treatment of ovarian cancer: aliterature review

Ovarian cancer (OC) is the sixth most common cancer in women. This literature review and thematic analysis presents gaps in Health Literacy including public knowledge on symptoms, risk, and screening for OC. We have identified a strong variation …

Male sexual and reproductive health in multiple sclerosis: a scoping review

Open Access Multiple Sclerosis Review

Multiple sclerosis (MS) is a chronic neuroinflammatory disease that adversely affects physical and mental health and can lead to social dissatisfaction [ 1 , 2 ]. There are 2.8 million people living with MS worldwide [ 3 ]. Newer high-efficacy …

Impact of preterm birth on muscle mass and function: a systematic review and meta-analysis

Individuals born preterm present lower exercise capacity. Along with the cardiopulmonary responses and activity level, muscle strength is a key determinant of exercise capacity. This systematic review aimed to summarize the current knowledge on …

Case Studies

A rare, late side effect of radiotherapy

Open Access Breast Cancer Case Study

A woman developed sudden painless ecchymosis (bruising) of her breast, which was thought to be related to the radiotherapy she received for early-stage breast cancer a year and a half earlier.

Genetic causes of polyhydramnios

Open Access Polyhydramnions Case Study

Amniocentesis is not routine for isolated polyhydramnios in the absence of key structural defects. But these two cases show that polyhydramnios can be caused by rare genetic conditions that benefit from early diagnosis and intervention.

Recurrent stroke in a young woman with patent foramen ovale

Open Access Congenital Heart Anomaly Case Study

A 31-year-old woman taking oral contraceptives presented with repetitive ischemic strokes before a patent foramen ovale was detected and closed. The dual risk of an undiagnosed PFO and common use of oral contraceptives should be considering in young women presenting with stroke symptoms. 

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Knowledge center focusing on improving the individualized management of HR+/HER2- early breast cancer.

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Case-based insights: Oncology and hematology

Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.

Developed by: Springer Medizin

Further Reading

Tattooing to reconstruct Nipple-Areola Complex after oncological breast surgery: a scoping review

Open Access Breast Cancer Review

At the end of 2020, breast cancer was the most prevalent cancer in the world [ 1 ]. If the tumor position is found in the tissues below the areola or on the surrounding skin , Nipple-Areola Complex (NAC) removal may be necessary. This procedure can …

Low-intensity pulsed ultrasound activated the anti-tumor immunity by irradiating the spleen of mice in 4 T-1 breast cancer

Open Access Breast Cancer Research

Tumor immunotherapy is booming around the world. However, strategies to activate the immune system and alleviate the immunosuppression still need to be refined. Here, we demonstrate for the first time that low-intensity pulsed ultrasound (LIPUS …

Distinct profiles of proliferating CD8+/TCF1+ T cells and CD163+/PD-L1+ macrophages predict risk of relapse differently among treatment-naïve breast cancer subtypes

Open Access Breast Cancer Research

Immunophenotypic analysis of breast cancer microenvironment is gaining attraction as a clinical tool improving breast cancer patient stratification. The aim of this study is to evaluate proliferating CD8 + including CD8 + TCF1 + Τ cells along with …

Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cells

Open Access Breast Cancer Research

Breast cancer stands as a formidable global health challenge for women. While neoantigens exhibit efficacy in activating T cells specific to cancer and instigating anti-tumor immune responses, the accuracy of neoantigen prediction remains …