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Androgens 

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  1. 11-11-2023 | Polycystic Ovary Syndrome | OriginalPaper

    Androgens exacerbate hepatic triglyceride accumulation in rats with polycystic ovary syndrome by downregulating MTTP expression

    Polycystic ovary syndrome (PCOS) is one of the most prevalent, complex, and heterogeneous endocrine diseases in women of reproductive age, and its prevalence worldwide ranges from 4% to 21%, depending on the adopted diagnostic criteria [ 1 , 2 ].

  2. 20-02-2024 | Stanolone | OriginalPaper

    Relationship of 5α-reductase and androgens with sperm quality during breeding and non-breeding seasons in Arabi rams

    Seasonal changes in the sperm quality of rams may be influenced by the activity of 5α-reductase (5αR) and androgens, i.e., testosterone and dihydrotestosterone (DHT). The aim of this study was to investigate the variation in the levels of 5αR type …

  3. Open Access 01-12-2023 | Insulins | ReviewPaper

    The interplay between androgens and the immune response in polycystic ovary syndrome

    Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, standardized criteria have been …

  4. Open Access 01-03-2023 | Endometrial Cancer | ReviewPaper

    Androgens in endometrial carcinoma: the killer or helper?

    Endometrial carcinoma (EC) is the most commonly diagnosed gynecological cancer in women and ranked second in gynecological cancer-related deaths [ 1 ]. Risks for EC are associated with an excess-estrogen environment. And the role of unopposed …

  5. 02-12-2022 | Obesity | ReviewPaper

    Aging and androgens: Physiology and clinical implications

    In men >  ~35 years, aging is associated with perturbations in the hypothalamus-pituitary–testicular axis and declining serum testosterone concentrations. The major changes are decreased gonadotropin-releasing hormone (GnRH) outflow and decreased …

  6. Open Access 01-12-2023 | COVID-19 | ReviewPaper

    Association of the androgens with COVID-19 prognostic outcomes: a systematic review

    The novel coronavirus disease 2019 has rapidly spread globally, causing great impacts on human health and the social economy. The severe acute respiratory syndrome coronavirus 2 (SASR-CoV-2) continues to mutate, resulting in a continued increase …

  7. 10-11-2022 | Testosterone | ReviewPaper

    The anabolic applications of androgens in older adults with functional limitations

    Aging is associated with a progressive decrease in skeletal muscle mass, strength and power and impairment of physical function. Serum testosterone concentrations in men decrease with advancing age due to defects at all levels of the …

  8. Open Access 24-06-2022 | Prostate Cancer | ReviewPaper

    Androgens, aging, and prostate health

    Due to late onset hypogonadism (LOH), there is an increased usage of testosterone replacement therapy (TRT) in the aging male population. Since prostate is a target organ for androgens and anti-androgenic strategies are used to treat and palliate …

  9. Open Access 01-12-2022 | Hirsutism | ReviewPaper

    Long-term Prophylaxis with Androgens in the management of Hereditary Angioedema (HAE) in emerging countries

    Hereditary angioedema (HAE) is a rare autosomal dominant genetic disease characterized by repetitive subcutaneous or submucosal angioedema, activation of the kinin system, and increased vascular permeability. C1-inhibitor (C1-INH) deficiency, the …

  10. Open Access 01-12-2022 | Insulins | OriginalPaper

    Ovarian volume, not follicle count, is independently associated with androgens in patients with polycystic ovary syndrome

    Polycystic ovary syndrome (PCOS) has become the common endocrine and metabolic disorder of women of reproductive age worldwide, with an estimated prevalence of 6–15% [ 1 ]. It is widely believed that elevated androgen levels have a negative impact …

  11. 30-08-2022 | Androgens | OriginalPaper

    Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis

    Microscopic colitis (MC) is a chronic inflammatory disease of the colon with a rising incidence [ 1 ]. The etiology of MC is largely unknown, but similar to other chronic inflammatory diseases of the bowel, is thought to be related to inappropriate …

  12. Open Access 01-12-2021 | Polycystic Ovary Syndrome | OriginalPaper

    Comparison of the efficacy of different androgens measured by LC-MS/MS in representing hyperandrogenemia and an evaluation of adrenal-origin androgens with a dexamethasone suppression test in patients with PCOS

    Polycystic ovary syndrome (PCOS), with a prevalence ranging from 6 to 20%, is the most common endocrine disorder that causes infertility in reproductive-aged women, and it is characterized by hyperandrogenemia, chronic anovulation, and polycystic …

  13. Open Access 01-01-2021 | Prostate Cancer | ReviewPaper

    Sex differences in COVID-19: the role of androgens in disease severity and progression

    The novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV2) has evolved into a global pandemic and has affected millions of people worldwide. Two notably consistent findings are the low rates of …

  14. Open Access 01-12-2020 | Autism Spectrum Disorder | OriginalPaper

    Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort

    Autism spectrum disorder (ASD) has an estimated prevalence of 1 in 59 among 8-year-old children in the USA [ 1 – 3 ]. Within this population level estimate, there is a strong sex-dependent bias with a 4:1 male/female ratio, with some groups …

  15. Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role

    The purpose of this paper is to provide an update on various mechanisms of androgens that have bearing on their effects on stress, sex, and other important functions. First, an overview of neurosteroids’ action will be discussed, then the …

  16. 01-12-2020 | Polycystic Ovary Syndrome | OriginalPaper

    Insulin resistance, androgens, and lipids are gradually improved in an age-dependent manner in lean women with polycystic ovary syndrome: insights from a large Caucasian cohort

    Polycystic ovary syndrome (PCOS) constitutes one of the most common endocrine diseases, which, according to the current concept, should be considered as a continuum, having its origins in fetal life, persisting through the reproductive period, and …

  17. 01-08-2019 | Insulins | OriginalPaper

    Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation

    Glucocorticoids are widely used for their unsurpassed immunomodulatory effects. However, their use in humans is limited by significant adverse outcomes, including glucose intolerance, dyslipidaemia, hypertension, central obesity, loss of muscle …

  18. 01-03-2020 | Polycystic Ovary Syndrome | OriginalPaper

    Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome

    Secreted frizzled-related protein 4 (SFRP4) is a peptide hormone which is a member of the SFRPs family. SFRP4 is expressed from various tissues such as adipocytes, pancreas and uterus [ 1 – 3 ]. SFRP4 involves in a diversity of pathophysiological …

  19. 01-01-2020 | Prostate Cancer | OriginalPaper

    Predictors of poor response to first-generation anti-androgens as criteria for alternate treatments for patients with non-metastatic castration-resistant prostate cancer

    Androgen-deprivation therapy (ADT) has been the primary therapy for localized disease and has been widely used in multimodal therapy for more advanced disease, with or without metastasis [ 1 ]. Prostate cancer becomes fatal by progressing to …

  20. 01-08-2019 | Hypertension | OriginalPaper

    Hypotestosteronemia is an important factor for the development of hypertension: elevated blood pressure in orchidectomized conscious rats is reversed by different androgens

    Cardiovascular diseases continue to increase worldwide, a phenomenon that is particularly problematic among the aging population. One of the most relevant cardiovascular diseases is hypertension and is clearly a public global health challenge. In …

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