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Open Access Lipedema Review

Physical exercise as a therapeutic tool for lipedema

Lipedema is a complex condition that requires a multidisciplinary management approach. Structured exercise training is a promising intervention, offering physiological and psychological benefits.

Editor's Choice

Rethinking adolescent obesity (Link opens in a new window)

Pediatric Obesity Independent Medical Education

Incidence of adolescent obesity is at an all-time high. Discover the unique challenges faced by adolescents with obesity, and learn effective strategies to help young people overcome this disease.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Severe cobalamin C deficiency

Open Access Metabolic Disease in Childhood Case Study

Nephrotic syndrome is usually caused by primary renal disorders, but you should consider metabolic diseases in atypical cases. This 7-month-old presented with nephrotic syndrome, malignant hypertension, and hemolytic anemia.

Adrenal insufficiency caused by immunotherapy

Three patients receiving tislelizumab immunotherapy for NSCLC developed adrenal insufficiency, highlighting the need for awareness of pituitary–adrenal axis dysfunction as an immune-related adverse event.

The lower the better for blood pressure treatment

17-07-2024 Hypertension News

Reducing systolic blood pressure to less than 120 mmHg versus 140 mmHg prevents major vascular events in patients at high cardiovascular risk, suggests the ESPRIT trial.

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Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Using CGM to optimize type 2 diabetes management with non-intensive insulin treatment in primary care

With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report. 

Supported by: Abbott Diabetes Care

Prof. Samuel Seidu
Developed by: Adis

Case Studies

Severe cobalamin C deficiency

Open Access Metabolic Disease in Childhood Case Study

Nephrotic syndrome is usually caused by primary renal disorders, but you should consider metabolic diseases in atypical cases. This 7-month-old presented with nephrotic syndrome, malignant hypertension, and hemolytic anemia.

Adrenal insufficiency caused by immunotherapy

Three patients receiving tislelizumab immunotherapy for NSCLC developed adrenal insufficiency, highlighting the need for awareness of pituitary–adrenal axis dysfunction as an immune-related adverse event.

Necrotizing myopathy in a woman with type 1 diabetes

Open Access Diabetes-associated Diseases Case Study

Identifying the cause of muscle necrosis can be a diagnostic challenge, as shown by this case of diabetic myonecrosis complicated by pyomyositis and abscess caused by Escherichia coli.

Episode 10: Disease-modifying therapy for type 1 diabetes

Reducing the burden of type 1 diabetes

Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.

Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.

Prof. Chantal Mathieu

Current Reviews

The effect of BMI on survival outcome of breast cancer patients: a systematic review and meta-analysis

Breast Cancer REVIEW ARTICLE

Breast cancer remains the most prevalent cancer type and the primary cause of cancer-related deaths among women worldwide [ 1 ]. The latest global cancer statistics from 2022 reveal a shift where female breast cancer has surpassed lung cancer …

Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism?

Open Access Obesity REVIEW

Atherosclerotic cardiovascular disease (ASCVD) is a prominent contributor to cardiovascular disease (CVD), which is one of the primary contributors of morbidity and mortality in modern society [ 1 ]. In Europe, it claims the lives of approximately …

Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives

A metabolic disorder is a condition that disrupts the body's normal metabolism, leading to changes in how it processes and distributes macronutrients like lipids, carbohydrates, and proteins. Metabolic disorders may occur as a result of typical …

The Pattern of Thyroid Cancers in Nigeria: a Systematic Review and Meta-analysis

Thyroid Cancer Review Article

Thyroid cancer is the most common endocrine cancer. There are various histopathological types requiring different therapeutic approaches and having variable prognoses. The objective of this study was to determine the pattern of thyroid cancers in …

Insulins Clinical Trial Summary

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.

Developed by: Springer Medicine

CME & eLearning

Videos | Case Scenarios | Infographics (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Expert Interviews | Videos (Link opens in a new window)

With adolescent obesity at an all-time high, greater understanding of the individual cost and societal burden is crucial. Discover the unique challenges faced by adolescents with obesity, and learn effective strategies to help young people to overcome this disease.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Tweetorials | Vodcasts | Infographics (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)

Stay up to date with the rapidly changing CGM landscape. Learn how to implement and integrate CGM into diabetes management to improve patient care and outcomes.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Further Reading

Safety and feasibility of single-incision laparoscopic distal gastrectomy in overweight and obese gastric cancer patients: a propensity score-matched analysis

Open Access Gastrectomy Original Article

Laparoscopic gastrectomy has been established as a safe and effective approach for gastric cancer and is widely accepted worldwide [ 1 – 4 ]. The introduction of transumbilical single-incision laparoscopic distal gastrectomy (SIDG) in 2011 marked a …

17α Hydroxylase/17,20 lyase deficiency: clinical features and genetic insights from a large Turkey cohort

Open Access Congenital Adrenal Hyperplasia Original Article

17α Hydroxylase/17–20 lyase deficiency (17OHD) is a rare autosomal recessive form of congenital adrenal hyperplasia (CAH) caused by biallelic mutations in the CYP17A1 gene, encoding cytochrome p450c17. It accounts for about 1% of all CAH forms …

Thyroid dysfunction in Hashimoto’s thyroiditis: a pilot study on the putative role of miR-29a and TGFβ1

Open Access Hashimoto Thyroiditis Original Article

Hashimoto’s thyroiditis (HT) is one of the most common causes of hypothyroidism in iodine sufficient worldwide areas. The pathogenesis of this autoimmune disorder is due to a combination of genetic and environmental factors [ 1 ]. HT is …

Bone Fragility in High Fat Diet-induced Obesity is Partially Independent of Type 2 Diabetes in Mice

Open Access Type 2 Diabetes Original Research

Obesity and type 2 diabetes (T2D) are risk factors for fragility fractures. It is unknown whether this elevated risk is due to a diet favoring obesity or the diabetes that often occurs with obesity. Therefore, we hypothesized that the fracture …

Related topics

Strumal carcinoid tumor of the ovary

Salpingo-oophorectomy was performed after 15 years’ surveillance of an ovarian dermoid cyst in a female with type 2 diabetes. The removed ovary contained a mature cystic teratoma and a discrete solid nodule.

Read more

Physical exercise as a therapeutic tool for lipedema

Open Access Lipedema Review

Lipedema is a complex condition that requires a multidisciplinary management approach. Structured exercise training is a promising intervention, offering physiological and psychological benefits.

Read more