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IL-6 shows promise as diagnostic biomarker for sepsis

Interleukin-6 shows promise as a biomarker to diagnose sepsis early in high-risk patient groups such as neonates, children, and pregnant women.

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Editor's Choice

Reduced infection risk with IL-targeting biologics

Biologics targeting interleukin-12, 23, and 17 are associated with a reduced risk for serious infections among older adults with psoriatic disease.

Infective endocarditis as cause of retinal artery occlusion

Retinal artery occlusion is a rare complication of infective endocarditis. Following the diagnosis of bilateral RAO, TEE revealed the presence of mobile vegetation on the mitral leaflet. Blood culture confirmed E. rhusiopathiae endocarditis.

Surprise passenger as cause of severe anemia

  • Open Access
  • Anemia
  • Case Study

Blood-tinged saliva, light-headedness, difficulty speaking and a foreign body sensation in the throat were all reported by a 65-year-old man with severe anemia. The cause? Oropharyngeal leech infestation.

Managing septic shock in a pediatric AML patient

A 10-year-old boy exhibited persistent pancytopenia following treatment for mucormycosis, with further diagnosis revealing AML. Septic shock soon followed, but was successfully managed with combined CRRT and CytoSorb therapy.

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Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME
Learn more

Case Studies

Infective endocarditis as cause of retinal artery occlusion

Retinal artery occlusion is a rare complication of infective endocarditis. Following the diagnosis of bilateral RAO, TEE revealed the presence of mobile vegetation on the mitral leaflet. Blood culture confirmed E. rhusiopathiae endocarditis.

Surprise passenger as cause of severe anemia

  • Open Access
  • Anemia
  • Case Study

Blood-tinged saliva, light-headedness, difficulty speaking and a foreign body sensation in the throat were all reported by a 65-year-old man with severe anemia. The cause? Oropharyngeal leech infestation.

Managing septic shock in a pediatric AML patient

A 10-year-old boy exhibited persistent pancytopenia following treatment for mucormycosis, with further diagnosis revealing AML. Septic shock soon followed, but was successfully managed with combined CRRT and CytoSorb therapy.

Current Reviews

Molecular and ecological determinants of mammalian adaptability in avian influenza virus

The avian influenza virus (AIV) primarily affects birds and poses an increasing concern due to its growing adaptability to other hosts, heightening zoonotic risks. The adaptability is a key factor in AIV to infect multiple non-avian species …

Cellulitis in Pediatric Patients: Recognition and Management in the Era of Evolving Resistance

Cellulitis, a bacterial skin infection most frequently caused by group A streptococci (Streptococcus pyogenes) and less so by Staphylococcus aureus, commonly occurs in pediatric patients. The non-specific clinical presentation of poorly …

Clinic-radiological classification of herpesviral encephalitis in humans (systematic review)

The development of a comprehensive classification for herpesvirus encephalitis remains an urgent task. Distinct clinic-radiological forms of herpesvirus cerebral lesions have been characterized, including findings from histopathological studies.

Abdominal hydatid disease: role of imaging in diagnosis, complications, and management

Hydatid disease is a relatively common parasitic infection. Incidence can reach more than 50 per 100,000 person-years in endemic areas. It can affect all organs but favors the liver and lungs. Presentation is often asymptomatic. Imaging plays a …

CME & eLearning

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME

Further Reading

Clinical Outcome of Inflammatory Bowel Disease with Clostridioides difficile Polymerase Chain Reaction Toxin-Positive/Enzyme Immunoassay Toxin-Negative: A Retrospective Cohort Study

Clostridioides difficile is an anaerobic, spore-forming, gram-positive bacterium that mainly spreads via the fecal–oral route through the ingestion of spores. As a common and noteworthy nosocomial pathogen with steadily increasing prevalence, C.

Advancing Understanding of Cerebrovascular Hemodynamic Perturbations in Pediatric Cerebral Malaria Using a Modified Critical Closing Pressure Evaluation- A Prospective, Observational Study

  • Open Access
  • Malaria
  • Original work

Malaria affects 240 million individuals and results in ~ 620,000 deaths annually, > 80% of which occur in African children [ 1 ]. That equates to > 1300 childhood deaths daily. Cerebral malaria (CM) is a severe form of the disease characterized by …

CLICs Inhibitor IAA94 Alleviates Inflammation and Injury in Septic Liver by Preventing Pyroptosis in Macrophages

Macrophage pyroptosis represents a pivotal mechanism underlying acute liver injury during sepsis. Chloride intracellular channel proteins (CLICs) have been linked to inflammatory reflexes, with IAA94 serving as an inhibitor of channel formation …

Predicting ICU Admission Risk in Children with Respiratory Syncytial Virus

Respiratory syncytial virus (RSV) infection is a prevalent viral illness with a significant impact on the well-being of individuals, particularly young children and older adults. Over the past two decades, the incidence of RSV infection has …

Related topics

Managing septic shock in a pediatric AML patient

A 10-year-old boy exhibited persistent pancytopenia following treatment for mucormycosis, with further diagnosis revealing AML. Septic shock soon followed, but was successfully managed with combined CRRT and CytoSorb therapy.

Read more

Surprise passenger as cause of severe anemia

  • Open Access
  • Anemia
  • Case Study

Blood-tinged saliva, light-headedness, difficulty speaking and a foreign body sensation in the throat were all reported by a 65-year-old man with severe anemia. The cause? Oropharyngeal leech infestation.

Read more