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Demyelinating Disease 

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  1. 19-08-2023 | Multiple Sclerosis | Letter

    Frequency of demyelinating disease activity following immune checkpoint inhibitor cancer immunotherapy

  2. Open Access 01-12-2023 | Polyneuropathy | OriginalPaper

    Introducing electronic monitoring of disease activity in patients with chronic inflammatory demyelinating polyneuropathy (EMDA CIDP): trial protocol of a proof of concept study

    Chronic inflammatory demyelinating polyneuropathy (CIDP) is one of the most common immune neuropathies [ 11 ]. It is characterized by a progressive or relapsing disease course developing for more than 8 weeks, often leading to severe restriction of …

  3. 09-05-2023 | Multiple Sclerosis | OriginalPaper

    Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease

    Resveratrol is a natural polyphenol which may be useful for treating neurodegenerative diseases such as multiple sclerosis (MS). To date, current immunomodulatory treatments for MS aim to reduce inflammation with limited effects on the …

  4. Open Access 01-12-2023 | Neuromyelitis Optica Spectrum Disease | OriginalPaper

    Distinct features of B cell receptors in neuromyelitis optica spectrum disorder among CNS inflammatory demyelinating diseases

    CNS inflammatory demyelinating diseases (CIDDs) encompass a group of disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) [ 1 ].

  5. Open Access 01-12-2023 | Multiple Sclerosis | OriginalPaper

    The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies

    Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On January 30, 2020, the World Health Organization declared COVID-19 an international public health emergency …

  6. Open Access 01-12-2022 | Multiple Sclerosis | OriginalPaper

    B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseases

    Multiple sclerosis (MS) is a prevalent demyelinating autoimmune disease of the central nervous system (CNS) [ 1 ]. While many treatments allow to decrease peripheral activation and CNS infiltration of autoreactive lymphocytes [ 2 ], treatments …

  7. Open Access 04-02-2023 | OriginalPaper

    The phenotypic spectrum of pathogenic ATP1A1 variants expands: the novel p.P600R substitution causes demyelinating Charcot–Marie–Tooth disease

    Charcot–Marie–Tooth (CMT) disease is a group of hereditary motor and sensory neuropathies (HMSN) characterized by high genetic and phenotypic heterogeneity [ 1 ]. CMT is the most common inherited neuropathy, with a reported global incidence of 1 in …

  8. 01-01-2022 | Colchicine | ReviewPaper

    Familial coexistence of demyelinating diseases and familial Mediterranean fever

    Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by fever and serositis attacks caused by mutations in the MEditerranean FeVer (MEFV) gene encoding the pyrin gene. Gain of the function mutations of the pyrin …

  9. Open Access 01-12-2021 | Polyneuropathy | OriginalPaper

    A de novo variant of POLR3B causes demyelinating Charcot-Marie-Tooth disease in a Chinese patient: a case report

    Charcot-Marie-Tooth (CMT) disease is a group of inherited peripheral neuropathies clinically characterized by progressive distal muscle weakness and atrophy, sensory loss, areflexia and skeletal deformities. By virtue of electrophysiological …

  10. 01-12-2020 | Cranial MRI | Case Study

    Central nervous system Cryptococcoma mimicking demyelinating disease: a case report

    Central nervous system (CNS) cryptococcosis results from infection with the yeast fungus cryptococcus. A large proportion of patients with CNS cryptococcosis are immunosuppressed individuals, such as those with AIDS. Meningitis or …

  11. 01-12-2020 | Demyelinating Disease | Original Research

    Endothelin-1 contributes to the development of virus-induced demyelinating disease

    Theiler’s murine encephalomyelitis virus (TMEV) causes a chronic progressive demyelinating disease in susceptible mice [ 1 , 2 ]. Development of this virally induced demyelinating disease appears to be immune-mediated and primarily involves CD4 + T …

  12. 01-11-2020 | SARS-CoV-2 | BriefCommunication

    First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease

    The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease

  13. Open Access 01-12-2020 | Multiple Sclerosis | ReviewPaper

    Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice

    Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI …

  14. 22-06-2022 | Multiple Sclerosis | Letter

    Relapse of myelin oligodendrocyte glycoprotein antibody-associated demyelinating disease in an elderly patient after long-term remission

  15. Open Access 01-12-2019 | Filgrastim | OriginalPaper

    Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

    More than 50% of acquired demyelinating syndromes (ADS) in children are associated to myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Abs). Anti-MOG-Abs are frequent in optic neuritis (ON), transverse myelitis (TM), acute demyelinating

  16. 14-06-2022 | Myasthenia Gravis | ReviewPaper

    Cross-syndrome: myasthenia gravis and the demyelinating diseases of the central nervous system combination. Systematic literature review and case reports

    Nowadays the problem of comorbidity is still relevant. In this review, we describe clinical cases of the disease of the neuromuscular junction (myasthenia gravis (MG) generalized form) and the demyelinating disease of the central nervous system …

  17. Open Access 01-12-2021 | Magnetic Resonance Imaging | OriginalPaper

    Multi-parametric MRI phenotype with trustworthy machine learning for differentiating CNS demyelinating diseases

    Multiple sclerosis (MS) and Neuromyelitis optica (NMO) are demyelinating diseases of the central nervous system (CNS), which are the most common causes of neurological disability in young people [ 1 ]. In the pathogenesis of these two diseases, a …

  18. Open Access 01-12-2020 | OriginalPaper

    A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease

    Autosomal dominant mutations in LITAF are responsible for the rare demyelinating peripheral neuropathy, Charcot–Marie–Tooth disease type 1C (CMT1C). The LITAF protein is expressed in many human cell types and we have investigated the consequences …

  19. 01-12-2021 | Multiple Sclerosis | ReviewPaper

    Demyelinating disease (multiple sclerosis) in a patient with psoriatic arthritis treated with adalimumab: a case-based review

    Over the past two decades, tumor necrosis factor-α (TNF-α) inhibitors became one of the most important drugs in the treatment of patients with psoriatic arthritis. Unfortunately, some of the patients exhibit unwanted side effects of the treatment.

  20. Open Access 01-01-2021 | Guillain-Barré Syndrome | OriginalPaper

    A Global Survey of Disease Burden in Patients Who Carry a Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy

    This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article’s associated Figshare page. To view digital features for this article go to …

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