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A rare, late side effect of radiotherapy

Open Access Breast Cancer Case Study

A woman developed sudden painless ecchymosis (bruising) of her breast, which was thought to be related to the radiotherapy she received for early-stage breast cancer a year and a half earlier.

Genetic causes of polyhydramnios

Open Access Polyhydramnions Case Study

Amniocentesis is not routine for isolated polyhydramnios in the absence of key structural defects. But these two cases show that polyhydramnios can be caused by rare genetic conditions that benefit from early diagnosis and intervention.

Update on menopausal HRT and type 2 diabetes

Open Access Type 2 Diabetes Review

Menopausal HRT may reduce the risk of type 2 diabetes developing and improve glycemic control. Individual risk factors must be considered when deciding a treatment plan.

Current Reviews

Progress in medical therapy in aplastic anemia: why it took so long?

Aplastic Anemia Progress in Hematology

The treatment of aplastic anemia (AA) has significantly advanced in the last 50 years, evolving from a fatal condition to one where survival rates now exceed 80–85%. Hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy …

A systematic review of therapeutic enoxaparin dosing in obesity

Enoxaparin is a hydrophilic drug with obesity having little effect on its apparent volume of distribution, therefore patients with obesity receiving standard 1 mg/kg dosing may be at a higher risk of supratherapeutic dosing. Conversely, dose …

Efanesoctocog alfa in hemophilia A: a profile of its use

Hemophilia Adis Drug Q&A

Efanesoctocog alfa [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl; ALTUVIIIO®], indicated for routine prophylaxis, on-demand treatment of bleeding episodes, and perioperative management of bleeding, is a useful addition to …

Inferior Vena Cava Filter Retrieval: Simple to Complex

Retrievable inferior vena cava filters were designed to provide mechanical prophylaxis from pulmonary embolism with the intent for retrieval once no longer indicated, and have been utilized at a high rate since their introduction. Unfortunately …

Case Studies

Successful management of ATO-induced acute pericarditis

Free for a limited time Acute Promyelocytic Leukemia Case Study

A patient receiving arsenic trioxide for acute promyelocytic leukemia developed drug-induced acute pericarditis that was successfully treated with colchicine.

How to recognise rare Kawasaki disease in neonates

Open Access Kawasaki Disease Case Study

When newborns present with clinical signs such as rash, distal extremity desquamation, and cervical lymph adenitis, and simultaneous increases in peripheral blood leukocyte count and platelets, clinicians should be highly alert to KD even without fever.

Obinutuzumab-induced acute thrombocytopenia

Open Access Lymphoma Case Study

A case series of three patients suggests that obinutuzumab-induced acute thrombocytopenia is a frequent, possibly non-relapsing, and unique adverse event that deserves more attention than it currently receives.

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eLearning | Interviews (Link opens in a new window)

This independent educational program aims to highlight advances in the diagnosis, treatment, and management of patients with hemophilia that have the potential to improve patients’ outcomes and quality of life.

Supported by:
  • Sanofi
Developed by: Springer Healthcare IME

Case-based insights: Oncology and hematology

Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.

Developed by: Springer Medizin

Further Reading

COVID-19 in the Netherlands: lessons from a nationwide query of dutch autopsy, histology, and cytology pathological reports


Since the onset of the COVID-19 pandemic, autopsies have played a valuable role in understanding the pathophysiology of COVID-19. In this study, we have analyzed COVID-19-related pathology reports from autopsies, histology, and cytology on a …

Recurrent miscarriage and low-titer antiphospholipid antibodies

Open Access Miscarriage ORIGINAL ARTICLE

Recurrent miscarriage (RM) occurs in 0.4 to 2% of couples attempting conception, as determined by various criteria [ 1 ]. It is associated with anatomical, hormonal, and chromosomal abnormalities, as well as antiphospholipid syndrome (APS), a …

Effect of ferric citrate hydrate on fibroblast growth factor 23 and platelets in non-dialysis-dependent chronic kidney disease and non-chronic kidney disease patients with iron deficiency anemia

Open Access Chronic Kidney Disease Original article

Iron deficiency anemia (IDA) is the most frequent type of anemia and is highly prevalent among women. Anemia due to iron deficiency is found in 29.6% of non-pregnant women of reproductive age and 36.5% of pregnant women [ 1 ]. IDA also frequently …

Pharmacokinetic–Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate

Open Access Hemophilia Original Research Article

Hemophilia A is characterized by a deficiency of coagulation factor (F) VIII leading to recurrent spontaneous and trauma-induced bleeding [ 1 ]. Current guidelines recommend treatment with prophylactic FVIII replacement therapy [ 2 ], bypassing …