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Immune thrombocytopenia in connective tissue disease

What are the clinical and pathological features of immune thrombocytopenia secondary to systemic lupus erythematosus and Sjögren syndrome? And how can current and emerging therapeutic strategies improve outcomes?

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Editor's Choice

Community-acquired respiratory infections in cancer patients

Updated guideline from the German Society for Hematology and Medical Oncology on the prevention, diagnosis, and management of community-acquired respiratory virus infections in people with cancer.

Portal hypertension following inotuzumab treatment

Long-term monitoring for portal hypertension is important – even after resolution of acute sinusoidal obstruction syndrome and achievement of leukemia remission – to optimize outcomes in inotuzumab ozogamicin-treated patients.

Revisiting the use of steroids in oncology

Glucocorticoids are cornerstone agents in oncology due to their potent anti-inflammatory, immunosuppressive, and antitumor properties. But it is crucial to strike a balance between therapeutic benefit and harm.

Baseline fatigue linked to worse toxicity from cancer treatments

Among people with cancer, the presence of fatigue before starting treatment is associated with an increased risk for severe, life-threatening, or fatal adverse events.

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Aplastic anemia: managing special patient subgroups and challenging cases (Link opens in a new window)

Learn more about the importance of adapting treatment approaches for special patient populations (eg, elderly or pregnant patients) in this third module of our interactive e-Learning program on diagnosing and treating aplastic anemia.

Supported by:
  • Pfizer
Developed by: Springer Health+ IME
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Are you up to date on targeted therapies for relapsed/refractory AML? 

Join Prof. Amer Zeidan and his expert guests to hear about innovations in molecular testing, emerging therapies, and IDH-targeted treatments, and get practical advice for improving your patient care.

Supported by: independent educational grant from Rigel

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SPONSORED

Updated guidelines for the treatment of anemia in chronic kidney disease

This podcast summarises updated European Renal Best Practice and UK Kidney Association guidelines on treating anemia in CKD. With a focus on hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) as an alternative to erythropoiesis‐stimulating agents, and key considerations for clinical practice.

Sponsored by:
  • Astellas Pharma, Inc.
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Podcast

Case Studies

Portal hypertension following inotuzumab treatment

Long-term monitoring for portal hypertension is important – even after resolution of acute sinusoidal obstruction syndrome and achievement of leukemia remission – to optimize outcomes in inotuzumab ozogamicin-treated patients.

Macrophage activation syndrome following varicella

Common infections can trigger macrophage activation syndrome. This case of a 10-year-old girl developing MAS during the convalescence period after varicella highlights the complexities of MAS diagnosis.

Hodgkin lymphoma in a patient with Behçet disease

A case illustrating a rare but important association between Behçet disease and Hodgkin lymphoma, possibly mediated by immune dysregulation and chronic immunosuppression.

Episode 22: Celebrating 25 years of TKIs in CML

Marking a major milestone in chronic myeloid leukemia treatment

Tyrosine kinase inhibitors have transformed the treatment of chronic myeloid leukemia, a condition that had limited therapeutic options before.

In this 25th year since the first phase 2 trials of the first TKI, we speak to a researcher and clinician who has been involved since the early days. Dr. Jorge Cortes shares his experience and talks about the impact of these drugs, not only in the treatment of CML but also more widely.

Dr. Jorge Cortes
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Podcast

Current Reviews

Efficacy and safety of trilaciclib to prevent chemotherapy-induced myelosuppression in advanced solid tumors: a systematic review and meta-analysis

Chemotherapy remains a mainstay in managing advanced and metastatic solid tumors, but its hematologic toxicity may restrict its application [ 1 ]. Chemotherapy-induced myelosuppression (CIM) is one of the common side effects of systemic …

Differences in adult eosinophilic esophagitis between Japan and Western countries

Several similarities and differences have been reported in the epidemiology and clinical characteristics of adult eosinophilic esophagitis (EoE) between Japan and Western countries. To review the similarities and differences in adult EoE between …

Varicose veins and venous thromboembolism in inflammatory rheumatic diseases: vascular complications and rehabilitation approaches

Inflammatory rheumatic diseases (IRDs) compromise vascular integrity through systemic inflammation and (auto) immune reactions, which are associated with an increased risk of vascular complications. Venous stasis, endothelial dysfunction, and …

The emerging role of heparanase in cardiovascular diseases: Pathophysiology, clinical outcomes, and therapeutic perspectives

Endothelial dysfunction, inflammation, atherosclerosis, thrombosis, and extracellular matrix remodeling represent the key pathophysiological processes underlying cardiovascular diseases. Heparanase, the sole mammalian endo-β-D-glucuronidase that …

Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
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Video

CME & eLearning

SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Professor Joy Ho and a panel of Asia-Pacific-based experts will examine real-life patient cases in this Masterclass, exchanging insights into their clinical experiences of using CAR T-cell therapy to treat patients with R/R DLBCL or R/R FL.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
SPONSORED

CAR T-cell therapy medical education hub

This hub presents a curated selection of educational materials focused on the latest clinically relevant topics related to the use of chimeric antigen receptor (CAR) T‑cell therapy for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and R/R follicular lymphoma (FL).

This content has been developed in collaboration with and funded by the sponsor Novartis Pharma AG and is not intended for healthcare professionals based in the UK and US.

Sponsored by:
  • Novartis Pharma AG

The AML expert series

Hear directly from experts in acute myeloid leukemia about innovations in molecular testing, emerging therapies, and targeted treatments, and get practical advice for improving the care of your patients with relapsed or refractory disease.

Supported by:
  • Rigel Pharmaceuticals, Inc.
Developed by: Springer Health+ IME

Further Reading

Computed tomography-derived Hounsfield units for the differentiation between thrombosis and leaflet fibrosis in bioprosthetic heart valves

Mechanisms of bioprosthetic heart valve (BHV) dysfunction include structural deterioration, non-structural valve dysfunction, endocarditis, and thrombosis. Amongst these, thrombosis and leaflet fibrosis (as a component of structural valve …

Anti-thymocyte globulin-based treatment frequently leads to enduring treatment success in both old and young adult patients with aplastic anaemia: a real-world analysis from the Dutch aplastic anaemia registry

Discussion remains concerning the safety and tolerability of anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) in older patients with aplastic anaemia (AA). Using data of 127 consecutive patients from the Dutch adult AA registry …

Pulmonary thromboembolism in Glanzmann Thrombasthenia: a case report and systematic literature review

Glanzmann Thrombasthenia (GT) is a congenital platelet disorder characterized by a life-long bleeding tendency, historically considered protective against thrombosis. This report describes a rare case of pulmonary embolism (PE) in a patient with …

Machine learning mortality prediction model for cyclosporine therapy in pediatric aplastic anemia

The outcomes of children with aplastic anemia receiving cyclosporine monotherapy vary significantly in terms of mortality risk; therefore, a prognostic model for predicting mortality risk was constructed to optimize risk-stratified treatment …

Related topics

Community-acquired respiratory infections in cancer patients

Updated guideline from the German Society for Hematology and Medical Oncology on the prevention, diagnosis, and management of community-acquired respiratory virus infections in people with cancer.

Read more
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Small reddish spots on skin/© Dr. Hans Schulz, Bergkamen, File folder with guidelines tab/© tang90246 / stock.adobe.com, IV drip/© Trsakaoe / stock.adobe.com, Colorful pills spilling from a bottle/© igoriss / Getty Images / iStock, Older man sitting on the edge of a bed/© andreswd / E+ / Getty Images (symbolic image with model), Aplastic Anemia/© Springer Healthcare IME, Doctor and pregnant woman at hospital/© Syda Productions / stock.adobe.com (symbolic image with models), Map of Europe with glowing details of city and human population density areas/© kasezo / Getty Images / iStock, Close-up of subcutaneous injection syringe/© Laures / Getty Images / iStock, Adis Journal Podcast/© Adis, Confluent hemorrhagic rashes around ankle joint /© 2025, H. Mateiko et al, J Med Case Reports, FDG PET-CT of patient with Behçet disease and Hodgkin lymphoma/© 2025, Matthew Coulter et al, under exclusive licence to International League of Associations for Rheumatology (ILAR), Clin Rheumatol, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Lupus concept/© (M) Vitalii But / stock.adobe.com / Generated with AI, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com, T-cell expressing chimeric antigen receptor (CAR) in the cell membrane; DNA is exposed from the T-cell to highlight the genetic engineering involved in creating CAR T-cells/© LoveLive/stock.adobe.com, Leukemia background in bright colors, including white and red blood cells in realistic style/© Double Brain/Shutterstock.com, Vector illustration of intravenous therapy/© Tarchyshnik / Getty Images / iStock, Rash on the back of patient with VEXAS syndrome/© 2025, Gunjan Rana et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, 3D illustration of the human small intestine/© Kateryna Kon / Science Photo Library / Getty Images, Leech removed from patient/© 2025, Asnake Gibrie et al, J Med Case Reports, Surgically resected colon of a patient with colonic diaphragm disease/© (M) 2025, Yang Tang et al, Dig Dis Sci, Fundus scan in vitreoretinal lymphoma/© 2025, Atsunobu Takeda et al, Jpn J Ophthalmol