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Hematology

12-06-2024 Multiple Myeloma News

DREAMM-8 supports use of novel ADC in multiple myeloma

A combination incorporating the antibody–drug conjugate belantamab mafodotin significantly improves the outcomes of people with relapsed or refractory multiple myeloma.

Digital interventions in hematologic malignancies

Learn how digital technology via the use of web-based and smart device apps, remote monitoring devices, and patient portals, can improve the care of adult and pediatric patients with hematologic cancers.

Choosing the best anticoagulant after aortic valve replacement

Open Access Aortic Valve Replacement Review

Is it time for direct oral anticoagulants to replace vitamin K antagonist therapy after mechanical aortic valve replacement?

Blastocystis hominis infection presenting as immune thrombocytopenia

Open Access Thrombocytopenia in Children Case Study

Screening for potential predisposing factors is essential in patients with ITP who have poor response to first-line treatment. This unusual case was related to parasitic infection.

A new frontline option for Ph-positive ALL?

Trial data suggest a role for ponatinib plus reduced-intensity chemotherapy in the treatment of newly diagnosed Philadelphia chromosome-positive ALL.

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Episode 9: The gut microbiome and CAR T-cell therapy

How do nutrition, supplements and antibiotics impact patient outcomes?

Recent research suggests that the gut microbiome could be an important modulator of response to CAR T-cell therapy in patients with hematologic cancers.

Prof. Marion Subklewe takes us through the latest evidence, highlighting the impact of antibiotics, nutrition, and dietary supplements, and discusses how to devise interventions to improve patient outcomes.

Prof. Marion Subklewe

Case Studies

Blastocystis hominis infection presenting as immune thrombocytopenia

Open Access Thrombocytopenia in Children Case Study

Screening for potential predisposing factors is essential in patients with ITP who have poor response to first-line treatment. This unusual case was related to parasitic infection.

An atypical adverse reaction to iron infusion

Anemia Case Study

A person receiving a blood transfusion for severe anemia developed acute respiratory distress with hypoxia that resolved after treatment with steroids and supplemental oxygen.

Anti-PF4 antibody-related disorder initially presenting as ICH

Open Access Cerebral Hemorrhage Case Study

Anti-platelet factor (PF4) disorders are severe and diagnosis may be challenging. Intracranial hemorrhage could present first but usually develops secondary to cerebral venous sinus thrombosis.

Current Reviews

Underlying Mechanisms of Thrombosis Associated with Cancer and Anticancer Therapies

Cancer-associated thrombosis (CAT) has been identified as the second most prevalent cause of death after cancer itself. Moreover, the risk of thrombotic events in cancer patients increases due to anticancer drugs, such as tyrosine kinase …

Patient Blood Management for the Critically-Ill Patient

Open Access Anemia Blood Management (KA Tanaka, Section Editor)

Anemia is common and associated with poor outcomes in patients with and recovering from critical illness [ 1 ]. Exacerbation of anemia can lead to red blood cell (RBC) transfusion. RBC transfusion has been identified as an independent predictor of …

Efficacy and safety of fostamatinib in refractory immune thrombocytopenia: a meta-analysis from randomized controlled trials

Open Access Thrombocytopenia Review

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count, which can lead to an increased risk of bleeding and other complications [ 1 ]. The incidence of ITP was reported to be 3.3 adults per 100,000 per year [ …

Inflammatory diseases causing joint and bone destruction: rheumatoid arthritis and hemophilic arthropathy

Open Access Rheumatoid Arthritis Invited Review

Various diseases and conditions cause joint disorders. Osteoarthritis (OA) is characterized by the degeneration of articular cartilage, synovitis, and anabolic changes in surrounding bone tissues. In contrast, rheumatoid arthritis (RA) and …

Case-Based Insights: Oncology and Hematology (Link opens in a new window)


Refresh your knowledge in Oncology and Hematology: 

  • 45 clinical cases across different topics with relevant clinical images
  • Written by renowned experts 
  • Knowledge-check questions with answers
Try the first set of cases now
SPONSORED

Webinar

In this live webinar, Professor Martin Dreyling and an esteemed, international panel of CAR-T experts will discuss the very latest data on the safety, efficacy and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL, as presented at ASH 2023, EU CAR-T 2024, and EHA 2024. 

Please note, this webinar is not intended for healthcare professionals based in the US and UK. 

Sponsored by:
  • Novartis Pharma AG
Developed by: Springer Healthcare
SPONSORED

Webinar

1.5 European CME credits (ECMEC®s), 2.0 NVVP and NIV CME points

A series of patient cases underpin this interactive webinar that aims to provide practical guidance on a multidisciplinary approach to managing patients with cutaneous T-cell lymphoma.

Sponsored by:
  • Kyowa Kirin
Developed by: Springer Healthcare

eLearning | Interviews (Link opens in a new window)

This independent educational program aims to highlight advances in the diagnosis, treatment, and management of patients with hemophilia that have the potential to improve patients’ outcomes and quality of life.

Supported by:
  • Sanofi
Developed by: Springer Healthcare IME

Further Reading

Patient Blood Management for the Critically-Ill Patient

Open Access Anemia Blood Management (KA Tanaka, Section Editor)

Anemia is common and associated with poor outcomes in patients with and recovering from critical illness [ 1 ]. Exacerbation of anemia can lead to red blood cell (RBC) transfusion. RBC transfusion has been identified as an independent predictor of …

Obesity is associated with adverse outcomes in primary immune thrombocytopenia - a retrospective single-center study

Open Access Obesity Research

The pathophysiology of immune thrombocytopenia (ITP) involves immune-mediated platelet destruction. The presence of adipose tissue in obese individuals creates an inflammatory environment that could potentially impact the clinical course and …

In vitro blood sample assessment: investigating correlation of laboratory hemoglobin and spectral properties of dual-energy CT measurements (ρ/Z)

Open Access Computed Tomography Computed Tomography

Attenuation measurements in single energy computed tomography (SECT) for tissue identification and discrimination are recognized to possess substantial technical limitations. The overlap in attenuation of various tissue types is attributed to the …

Efficacy and safety of fostamatinib in refractory immune thrombocytopenia: a meta-analysis from randomized controlled trials

Open Access Thrombocytopenia Review

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count, which can lead to an increased risk of bleeding and other complications [ 1 ]. The incidence of ITP was reported to be 3.3 adults per 100,000 per year [ …