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Open Access 01-12-2020 | Sleep Apnea | Review

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Authors: Xiangming Liu, Yiming Ma, Ruoyun Ouyang, Zihang Zeng, Zijie Zhan, Huanhuan Lu, Yanan Cui, Zhongshang Dai, Lijuan Luo, Chenjie He, Herui Li, Dandan Zong, Yan Chen

Published in: Journal of Neuroinflammation | Issue 1/2020

Abstract

Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent hypoxia (IH) conditions in OSAS patients elicited neuron injury (especially in the hippocampus and cortex), leading to cognitive dysfunction, a significant and extraordinary complication of OSAS patients. The repeated courses of airway collapse and obstruction in OSAS patients resulted in apnea and arousal during sleep, leading to IH and excessive daytime sleepiness (EDS) and subsequently contributing to the development of inflammation. IH-mediated inflammation could further trigger various types of cognitive dysfunction. Many researchers have found that, besides continuous positive airway pressure (CPAP) treatment and surgery, anti-inflammatory substances might alleviate IH-induced neurocognitive dysfunction. Clarifying the role of inflammation in IH-mediated cognitive impairment is crucial for potentially valuable therapies and future research in the related domain. The objective of this article was to critically review the relationship between inflammation and cognitive deficits in OSAS.

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Title: The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome
Authors: Xiangming Liu
Yiming Ma
Ruoyun Ouyang
Zihang Zeng
Zijie Zhan
Huanhuan Lu
Yanan Cui
Zhongshang Dai
Lijuan Luo
Chenjie He
Herui Li
Dandan Zong
Yan Chen
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Sleep Apnea
Published in: Journal of Neuroinflammation / Issue 1/2020
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/s12974-020-01905-2

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The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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