ESC Congress 2023

Long-term mavacamten helps patients with symptomatic obstructive hypertrophic cardiomyopathy avoid septal reduction therapy, but may be linked to left ventricular systolic dysfunction.

Is too much atrial pacing associated with atrial fibrillation? The DANPACE II study argues it isn't.

Should loop diuretics be dosed in acute heart failure based on urinary sodium levels? The PUSH-AHF study has investigated this and provides interesting results.

Randomized trial findings show no survival advantage for expedited transfer to a specialist cardiac center for non-ST elevation out-of-hospital cardiac arrest.

Treatment with acoramidis in people with transthyretin-mediated amyloidosis yielded a significant reduction in all-cause mortality, cardiovascular hospitalizations, and an improvement in NT-proBNP.

Those with low levels of physical activity during childhood and adolescence may be creating an environment susceptible to heart attack and stroke later in life. 

Patients with congestive heart failure who face food insecurity in daily life have been found to have a higher mean BMI and lower albumin levels than those who are food secure.

Icosapent-ethyl lowers the number of major adverse cardiovascular events in patients with atherosclerotic cardiovascular disease and elevated triglyceride levels.

Alirocumab every 2 or 4 weeks is a safe and effective treatment in children and adolescents with heterozygous familial hypercholesterolemia inadequately controlled with statins.

Cancer patients treated with immune checkpoint inhibitors have an increased risk of major adverse cardiovascular events if they have a history of atherosclerotic cardiovascular disease or hypertension.

A comprehensive analysis shows that people who consume the most ultra-processed foods have a 24% higher risk of heart attack or stroke.

The ONCO DVT trial supports extended anticoagulation with edoxaban for cancer patients with isolated distal deep vein thrombosis.

Serum lipoprotein (a) concentrations appear to be a risk factor for bioprosthetic aortic valve degeneration. The next step in investigating the role of lipoprotein (a) would be whether lowering it could delay bioprosthetic valve degradation.

A focused update of the ESC's heart failure guidelines will embed the results of major new studies into current practice.

In the Netherlands, only a very small proportion of patients start a PCSK9 inhibitor within 365 days of myocardial infarction. 

The low incidence of chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary embolism, in a German real-world cohort, suggests that there is low awareness around this syndrome. There also seems to be a lack of protocols for systematic follow-up for people who have had an acute PE.

Immediate multivessel PCI is noninferior to a staged approach in patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease.

Results of a single-center trial suggest that patients with end-stage heart failure and symptomatic atrial fibrillation could benefit from catheter ablation.

The use of extracorporeal life support alongside medical therapy does not mitigate the risk for 30-day mortality in patients with acute myocardial infarction complicated by cardiogenic shock.

Anticoagulation with edoxaban does not reduce the risk for stroke and increases the incidence of bleeding in individuals with atrial high-rate episodes.

Anterior protrusion of the lower sternum may develop in infants and toddlers following cardiac surgery with midline sternotomy. This protrusion has not been a priority treatment target because it rarely causes significant symptoms. The protrusion …

Catheter ablation is currently the most effective treatment option for ventricular arrhythmias. However, in some circumstances, classic radiofrequency ablation cannot effectively eliminate some deeply located intramural arrhythmias. Thus, novel …

In the last decade, it has emerged that intestinal permeability may be a risk factor for cardiometabolic diseases, contributing to inflammatory sequalae and subsequent disease progression [ 1 ]. The intestinal wall is lined by a monolayer of …

Determination of blood flow, i.e., stroke volume (SV) and cardiac output (CO), is an integral part of hemodynamic monitoring in intensive care medicine. Despite the availability of less- or non-invasive technologies, intermittent CO monitoring …