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A challenging case of Cushing syndrome with aggressive clinical manifestations. Ectopic Cushing syndrome was diagnosed and the source identified as an ACTH-negative and likely CRH-secretory renal neuroendocrine tumor.
Metabolic and renal dysfunctions can influence the disease trajectory, treatment response, and prognosis of cardiomyopathies. A holistic and multidisciplinary approach is key to identifying the appropriate therapies.
SGLT2 inhibitors are linked to lower kidney, cardiovascular, and hepatic risks than DPP-4 inhibitors in patients with type 2 diabetes and liver cirrhosis.
Given the association of MASLD with cardiovascular, renal, and endocrine metabolic disorders, should cardiovascular-kidney-metabolic syndrome evolve to metabolic-associated liver-cardiovascular-kidney syndrome?
Hyponatremia in heart failure reflects specific pathophysiological mechanisms that demand targeted intervention alongside standard decongestion strategies. This review outlines a phenotype-informed management framework to support safe and effective care.
Equip yourself to confidently implement the latest evidence-based strategies for your patients with systemic lupus erythematosus with this program. Expert-led videos on topics including the updated EULAR 2023 guidelines available now.
This podcast summarises updated European Renal Best Practice and UK Kidney Association guidelines on treating anemia in CKD. With a focus on hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) as an alternative to erythropoiesis‐stimulating agents, and key considerations for clinical practice.
A challenging case of Cushing syndrome with aggressive clinical manifestations. Ectopic Cushing syndrome was diagnosed and the source identified as an ACTH-negative and likely CRH-secretory renal neuroendocrine tumor.
A case of immune-related gastritis complicated by subsequent cytomegalovirus gastritis in a patient undergoing combination therapy with ipilimumab and nivolumab for renal cell carcinoma.
An extremely rare case of dermatomyositis concomitant with IgA nephropathy. Although the possibility of coincidental co-occurrence cannot be ruled out, it seems more likely that a common pathologic mechanism plays a role.
In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.
Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.
Chronic kidney disease [CKD] is associated with profound alterations of both gut microbiota composition and functions, commonly referred to as gut dysbiosis. These changes are driven by several factors such as dietary restrictions, medications …
The Research Society for the Study of Diabetes in India (RSSDI) Guidelines for the Management of Diabetes in Older Adults provide evidence-based, India-specific recommendations addressing the growing challenge of type 2 diabetes mellitus (T2DM) in …
In this perspective paper, I re-examine the evidence base behind the common advice that older adults should “ drink plenty of water before feeling thirsty ” especially during heat exposure and exercise. I first discuss the seminal mechanistic …
The performance of semipermeable membranes, and adsorbents incorporated in blood purification devices depends heavily on the design of blood purification devices. No matter how excellent the semipermeable membranes or adsorbents are, if the …
Equip yourself to confidently implement the latest evidence-based strategies for your patients with systemic lupus erythematosus with this program. Expert-led videos on topics including the updated EULAR 2023 guidelines available now.
Experts from established amyloidosis centers offer you specialized guidance to support your mission to set up a local center. Roundtable insights allow you to network with other HCPs in your locality to discuss region-specific challenges in establishing amyloidosis centers.
TFEB-altered renal cell carcinomas (RCCs) display a wide range of morphological features and variable immunohistochemical profiles, often overlapping with other RCC subtypes. This variability poses significant diagnostic challenges. Consequently …
The institutional review board approval for this prospective cohort study was authorized by the Ethics Committee of the Medical Faculty of the University of Cologne (No.: 21-1292_1), and the study was conducted at the surgical department of the …
Chronic kidney disease [CKD] is associated with profound alterations of both gut microbiota composition and functions, commonly referred to as gut dysbiosis. These changes are driven by several factors such as dietary restrictions, medications …
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood [ 1 ]. JIA comprises a heterogeneous group of chronic arthritis with onset before the age of 16 years, persisting for a minimum of 6 weeks, and lacking an …