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Internal Medicine Nephrology

Nephrology

Disease-modifying therapies in lupus nephritis

Of the current treatments for lupus nephritis, how many can be classed as disease modifying according to recently proposed criteria? And what are the challenges and considerations for future studies?

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Editor's Choice

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

Reduced infection risk with IL-targeting biologics

Biologics targeting interleukin-12, 23, and 17 are associated with a reduced risk for serious infections among older adults with psoriatic disease.

Managing septic shock in a pediatric AML patient

A 10-year-old boy exhibited persistent pancytopenia following treatment for mucormycosis, with further diagnosis revealing AML. Septic shock soon followed, but was successfully managed with combined CRRT and CytoSorb therapy.

CV efficacy of oral semaglutide confirmed for high-risk type 2 diabetes

Oral semaglutide significantly reduces the risk for major adverse cardiovascular events versus placebo in people with high-risk type 2 diabetes.

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Case Studies

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

Managing septic shock in a pediatric AML patient

A 10-year-old boy exhibited persistent pancytopenia following treatment for mucormycosis, with further diagnosis revealing AML. Septic shock soon followed, but was successfully managed with combined CRRT and CytoSorb therapy.

Is abdominal pain signaling acute intermittent porphyria?

AIP can easily be overlooked in its early stages. When a patient presents with central, peripheral, or autonomic nervous system symptoms and common causes are ruled out, AIP should be considered.

Current Reviews

Association between sodium-glucose cotransporter 2 inhibitors and cancer: a systematic review and meta-analysis of randomized active-controlled trials

SGLT2 inhibitors demonstrated a neutral effect on the overall risk of cancer in T2DM patients compared to active comparators. In subgroup analyses, SGLT2 inhibitors significantly reduced the risk of gastrointestinal cancers compared to metformin …

State of the art review of AI in renal imaging

Renal cell carcinoma (RCC) as a significant health concern, with incidence rates rising annually due to increased use of cross-sectional imaging, leading to a higher detection of incidental renal lesions. Differentiation between benign and …

Contrast-enhanced ultrasound in the evaluation and management of solid renal lesions based on EFSUMB guidelines

Contrast-enhanced ultrasound (CEUS) has become an important tool for the detection and characterization of solid renal lesions, complementing traditional B-mode US, which often struggles to distinguish between solid and cystic masses. CEUS …

Sedentary behavior and risk of chronic kidney disease: a systematic review and meta-analysis

In recent years, with the shift in modern lifestyles, sedentary behavior has become a prevalent phenomenon. Sedentary behavior refers to any awake behavior with an energy expenditure of 1.5 METs or lower while sitting or lying [ 1 ]. Most …

CME & eLearning

Vodcasts | Case Scenarios (Link opens in a new window)

Expert guidance on the multidisciplinary approach to identifying and managing chronic kidney disease in patients with type 2 diabetes, plus patient scenarios to assist your decision-making and put the latest clinical guidelines into context.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Further Reading

Compliance with clinical guidelines: the role of incentives and competition between practitioners

In this study we use a unit record, panel dataset, to examine the behaviour of clinicians under a chronic disease management program (CDMP) that is designed to improve care and slow the progression of chronic kidney disease (CKD). Using 8 years of …

Treatment of Primary Solid Renal Tumours Using Histotripsy: Study Protocol for the CAIN Feasibility Trial

Renal cell carcinoma (RCC) accounts for 2% of global cancer diagnoses and deaths, with an estimated 403,000 people diagnosed with neoplasms of the kidney in 2018, according to GLOBOCAN data [ 1 ]. The incidence of renal cancer has more than doubled …

Renal Arteriography and C-arm CT-Guided Ablation (RenACAGA) for Thermal Ablation of Challenging Renal Tumors

Percutaneous thermal ablation is a well-established minimally invasive alternative to kidney-sparing surgery for T1a renal cell carcinoma (RCC) [ 1 , 2 ]. It can be performed using various techniques, including radiofrequency ablation (RFA) …

Patterns of damage observed on dimercaptosuccinic acid kidney scans and future risk of urinary tract infections or reduced kidney function

99m Technetium dimercaptosuccinic acid scan (DMSA) scintigraphy is used for functional imaging of the kidney parenchyma [ 1 ]. It provides an accurate method for assessing differential kidney function and evaluating regional parenchymal function …