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Neurology

Susac syndrome: diverse presentations, tailored treatment

Less than a third of patients present the classic triad – encephalopathy, vision loss, and hearing loss. This case series highlights heterogeneity of symptoms and the effectiveness of personalized immunosuppressive therapy.

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Editor's Choice

AI-driven nerve stimulation device improves upper limb essential tremor

AI-driven transcutaneous peripheral nerve stimulation device improves upper limb function in people with essential tremor compared with a sham device.

What makes ublituximab stand out in RMS?

Ublituximab, a novel anti-CD20 therapy, is substantially advancing the treatment landscape for relapsing multiple sclerosis, offering rapid B-cell depletion, twice-yearly dosing, and strong efficacy.

Liraglutide may reduce recurrent stroke risk in people with type 2 diabetes

Liraglutide may reduce recurrent stroke risk versus placebo in people with type 2 diabetes with minor acute ischemic stroke or high-risk transient ischemic attack.

Methotrexate mitigates immune reaction to tofersen in ALS

Tofersen can trigger an autoinflammatory response in SOD1 amyotrophic lateral sclerosis, but this case indicates that concomitant immunomodulatory therapy could allow patients to continue long-term treatment.

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Keynote webinar | Spotlight on functional neurological disorder

FND perplexes and frustrates patients and physicians alike. Limited knowledge and insufficient awareness delays diagnosis and treatment, and many patients feel misunderstood and stigmatized. How can you recognize FND and what are the treatment options?

Prof. Mark Edwards
Developed by: Springer Medicine
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Video

Case Studies

Susac syndrome: diverse presentations, tailored treatment

Less than a third of patients present the classic triad – encephalopathy, vision loss, and hearing loss. This case series highlights heterogeneity of symptoms and the effectiveness of personalized immunosuppressive therapy.

Methotrexate mitigates immune reaction to tofersen in ALS

Tofersen can trigger an autoinflammatory response in SOD1 amyotrophic lateral sclerosis, but this case indicates that concomitant immunomodulatory therapy could allow patients to continue long-term treatment.

Sudden onset of arm movements in a woman with diabetes

What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?

Episode 21: Moving towards migraine freedom?

Newcomer PACAP could make the difference in migraine control

Anti-CGRP therapy has dramatically improved migraine treatment for many patients since its introduction in 2018. However, 30–40% of patients do not respond adequately to these drugs.

Prof. Messoud Ashina talks to us about PACAP and why targeting this pathway could offer a new future option for such patients.

Prof. Messoud Ashina
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Podcast

Current Reviews

Endovascular coiling vs. microsurgical clipping for ruptured anterior circulation aneurysms: an updated meta-analysis with meta-regression

Subarachnoid hemorrhage (SAH) is a major cause of stroke, accounting for 10% of cases [ 1 ]. Ruptured saccular cerebral aneurysm is the leading cause of spontaneous SAH [ 2 ], accounting for 75% of cases. Approximately 85% arise in the anterior …

A systematic review of organophosphorus pesticides detection in biological matrices

Pesticides are widely used chemical agents designed to control agricultural pests and improve crop yield. Based on their chemical composition, they are commonly classified into organochlorines, organophosphates, carbamates, and pyrethroids [ 1 – 3 …

The cure hit a nerve: a case of immune checkpoint inhibitor-induced mononeuritis multiplex

A 74-year-old gentleman with a background of early stage melanoma presented with subacute onset of asymmetric sensorimotor symptoms, involving all four limbs. This had progressed over the preceding three-months - he had become severely debilitated …

Gut Microbiota in the Treatment of Migraine with Acupuncture: A Review

Migraine is one of the most common nervous system diseases in the world, which is characterized by recurrent severe headache, accompanied by gut microbiota imbalance and gut–brain axis dysfunction, seriously affecting the quality of life of …

How can you integrate PET into your practice? (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)™

PET imaging is playing an increasingly critical role in managing AD. Our expert-led program will empower you with practical strategies and real-world case studies to effectively integrate it into clinical practice.

This content is intended for healthcare professionals outside of the UK.

Supported by:
  • Lilly
Developed by: Springer Health+ IME
Learn more

CME & eLearning

Alzheimer disease in the biomarker era (Link opens in a new window)

0.5 AMA PRA Category 1 Credit(s)

How can your team use biomarkers to improve diagnosis and management of AD? Explore the use of biomarker testing to interpret results and guide treatment strategies with these expert videos and unique educational escape room.

This content is intended for healthcare professionals outside of the UK.

Supported by:
  • Lilly
Developed by: Springer Health+ IME

Navigating neuroimaging in AD care (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)™

PET imaging is playing an increasingly critical role in early diagnosis of Alzheimer disease, disease staging, and guiding treatment decisions. But how can you effectively integrate it into clinical practice? Our expert-led program will empower you with practical strategies and real-world case studies.

This content is intended for healthcare professionals outside of the UK.

Supported by:
  • Lilly
Developed by: Springer Health+ IME

Awareness, advances, action in myasthenia gravis (Link opens in a new window)

1.75 AMA PRA Category 1 Credit(s)

The unpredictable nature of generalized myasthenia gravis can feel overwhelming for many patients. Explore strategies for effective communication and shared decision-making,  latest advances in treatment options, and how to develop patient-centric treatment plans using our multiformat educational programme.

Supported by:
  • Merck KGaA, Darmstadt, Germany and UCB Inc.
Developed by: Springer Health+ IME

Further Reading

Comparison of visual evoked potential variability in eyes affected by optic neuritis and fellow eyes

The visual evoked potential (VEP) provides objective functional assessment of the visual pathway, and since its first clinical usage [ 1 ], it has proven to be a useful tool for both clinical and experimental investigations of visual pathways [ 2 …

Clinical features of varicella-zoster virus meningitis diagnosed by polymerase chain reaction without abnormal routine cerebrospinal fluid analysis

This study aimed to investigate the clinical features of varicella-zoster virus (VZV) meningitis cases diagnosed by polymerase chain reaction (PCR) despite normal routine cerebrospinal fluid (CSF) testing. A retrospective review was performed on …

Intraoperative neuromonitorig alert risks in patients submitted to anterior cervical decompression and fusion for cervical spondylotic myelopathy: a single institution cohort-study

Cervical spondylotic myelopathy (CSM) is the most common cause of non-traumatic spinal cord dysfunction, with an estimated hospitalization rate of 4 cases per 100.000 people per year, mostly affecting males and elderly people [ 1 ]. CSM can be …

Evaluation of meningeal lymphatic vessels with delayed contrast enhanced vessel-wall MRI in cerebral infarction

Delayed-phase contrast-enhanced (CE) MRI, typically acquired 1–6 h after gadolinium-based contrast agents (GBCA) administration, enables the visualization of slow-moving or retained contrast agents in interstitial fluid (ISF) clearance of the …

Image Credits
Abstract blood vessels/© iStock / Getty Images Plus, Close-up of a woman's hands/© Ratirath / stock.adobe.com (symbolic image with model), Illustration of monoclonal antibodies/© Alena Butusava / Getty Images / iStock, Downward arrows/© akinbostanci / Getty Images / iStock, Methotrexate pills/© Ray Geiger / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images, Amyloid-beta peptide accumulating into amyloid fibrils/© selvanegra / iStock / Getty Images Plus, Hyperdense lesion in the left putamen/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Navigating neuroimaging in Alzheimer’s care: Practical applications and strategies for integration/© Springer Healthcare IME, Alzheimer’s disease in the biomarker era: preparing the multidisciplinary care team/© Springer Healthcare IME, Awareness, Advances, and Action: Optimizing Outcomes for Patients With Generalized Myasthenia Gravis/© Springer Healthcare IME