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Polyneuropathy 

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  1. 25-04-2024 | Guillain-Barré Syndrome | Online First

    Differentiating recurrent Guillain–Barre syndrome and acute-onset chronic inflammatory polyneuropathy: literature review

    Guillain–Barre syndrome (GBS) is an acute-onset immune-mediated polyneuropathy characterized by ascending symmetrical muscle weakness, diminished reflexes, and sensory symptoms. While GBS typically follows a monophasic course, some patients …

  2. Open Access 03-05-2024 | Small Fiber Neuropathy | Online First

    Serum neurofilament light chain levels correlate with small fiber related parameters in patients with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN)

    Hereditary transthyretin amyloidosis (ATTRv, v for ‘variant’) is an adult-onset, autosomal-dominant disease, caused by pathogenic variants in the TTR gene, encoding the transthyretin protein. Diffuse extracellular deposition of misfolded …

  3. Open Access 02-04-2024 | Polyneuropathy | Online First

    Progressive demyelinating polyneuropathy after hematopoietic cell transplantation in metachromatic leukodystrophy: a case series

    Metachromatic leukodystrophy (MLD) is a neuro-metabolic disorder due to arylsulfatase A deficiency, causing demyelination of the central and peripheral nervous system. Hematopoietic cell transplantation (HCT) can provide a symptomatic and survival …

  4. 01-02-2024 | Amyloidosis | ReviewPaper

    Update on Amyloid Polyneuropathy and Treatment

    Systemic amyloidoses are a group of rare conditions associated with tissue deposition of insoluble deposits of misfolded protein leading to tissue injury and dysfunction [ 1 ]. Two most common types are light-chain amyloidosis (AL) and …

  5. 18-03-2024 | Paraneoplastic Neurologic Syndrome | Online First

    Sequential onset of anti-HU-related paraneoplastic sensory polyneuropathy and limbic encephalitis in pancreatic neuroendocrine tumour: a case report

    A 64-year-old woman presented to the ED complaining progressive postural instability and unsteady gait. Symptoms had started 3 months earlier after an episode of serology-proven herpes zoster-associated painful cervical radiculopathy extending to …

  6. Open Access 01-12-2024 | Acupuncture | OriginalPaper

    Electroacupuncture efficacy in diabetic polyneuropathy: Study protocol for a double-blinded randomized controlled multicenter clinical trial

    T2DM is a public health problem, according to the International Diabetes Federation (IDF) it was estimated that 537 million people had diabetes in 2021 [ 1 , 2 ], which occurs nearly in an 80% in low-income and middle-income countries [ 2 ], such …

  7. 25-01-2024 | Amyloidosis | Online First

    Quantitative muscle ultrasound as a disease biomarker in hereditary transthyretin amyloidosis with polyneuropathy

    Hereditary transthyretin amyloidosis (ATTRv) is an autosomal dominant disorder caused by a point mutation of the transthyretin (TTR) gene, resulting in deposition of mutated amyloid fibrils in the peripheral nerves, heart, and other organs …

  8. 07-07-2023 | Polyneuropathy | Letter

    Hereditary polyneuropathy with conduction block associated with SORD mutation in three siblings

    SORD-related neuropathy is one of the most common causes of autosomal recessive CMT2 and dHMN [ 4 ].

  9. 19-12-2023 | OriginalPaper

    The Role of Inflammation in the Development of Diabetic Polyneuropathy and the Potential for Its Correction

    Objectives. To study the efficacy of the drug Cytoflavin in patients with diabetic polyneuropathy (DPN) by assessing the blood tumor necrosis factor-α (TNF-α) concentration. Materials and methods. An open, comparative, prospective observation of …

  10. 21-12-2023 | Polyneuropathy | Online First

    Corticosteroid responsive anti-contactin-1 antibody seropositive chronic inflammatory demyelinating polyneuropathy: report of two cases

    A 71-year-old man presented to the Emergency Department of our hospital with progressive imbalance, gait difficulty and numbness in all extremities, over the last three months. He had a medical history of smoking (30 pack years) and hypertension …

  11. 12-01-2024 | Polyneuropathy | Report

    Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10)

    Diabetic symmetric sensorimotor polyneuropathy (DSPN), which is a chronic, symmetrical, length‐dependent sensorimotor polyneuropathy, is recognized as one of the most common microvascular complications in patients with diabetes [ 1 , 2 ]. DSPN …

  12. Open Access 01-12-2023 | Critical Illness Polyneuropathy | ReviewPaper

    Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes

    In 1984, Bolton described the first 5 cases of “critically ill polyneuropathy” in patients with “adult” respiratory distress syndrome (as these syndromes were called at that time) [ 1 ]. Initially, the condition described seemed very rare, as it …

  13. Open Access 01-12-2023 | Polyneuropathy | Erratum

    Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes

  14. Open Access 01-12-2023 | Magnetic Resonance Imaging | OriginalPaper

    Demyelinating polyneuropathy combined with brachial plexopathy after nivolumab therapy for hodgkin lymphoma: a case report

    Tumor cells have various evasion mechanisms to escape the immune system. Immune checkpoints, namely programmed cell death-1 (PD-1) and cytotoxic T lymphocyte antigen-4 (CTLA-4), and their immunologic pathways are well-known immune systems in the …

  15. Open Access 01-12-2023 | Cardiomyopathy | OriginalPaper

    The impact of inotersen on Neuropathy Impairment Score in patients with hereditary transthyretin amyloidosis with polyneuropathy

    Hereditary transthyretin amyloidosis (ATTRv) is a rare, systemic, progressive, and life-threatening disease caused by the misfolding of the transthyretin (TTR) protein and consequent formation of amyloid fibrils, which deposit in organs and …

  16. 29-04-2023 | Secondary Immunodeficiency | OriginalPaper

    Early diagnosis leading to improvement of critical illness polyneuropathy associated with severe Staphylococcus aureus infection in a patient on hemodialysis

    Critical illness polyneuropathy (CIP) is a very rare complication of sepsis and multi-organ failure. Herein, we report the first case of CIP reported in a patient on maintenance hemodialysis, who improved with rehabilitation. A 55-year-old male …

  17. Open Access 01-12-2023 | Affective Disorder | OriginalPaper

    Fatigue, depression, and product tolerability during long-term treatment with intravenous immunoglobulin (Gamunex® 10%) in patients with chronic inflammatory demyelinating polyneuropathy

    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare and often disabling chronic progressive or relapsing immune-mediated neuropathy. The prevalence reported in the literature varies between 0.67 and 7.7 cases per 100,000 …

  18. Open Access 20-09-2023 | Polyneuropathy | OriginalPaper

    Structural changes in Schwann cells and nerve fibres in type 1 diabetes: relationship with diabetic polyneuropathy

    Diabetic polyneuropathy (DPN) is one of the most common complications of diabetes [ 1 , 2 ], and is characterised by sensory dysfunction and in some cases neuropathic pain [ 3 – 5 ]. However, the mechanisms behind DPN and painful DPN are not fully …

  19. Open Access 01-12-2023 | Polyneuropathy | OriginalPaper

    Introducing electronic monitoring of disease activity in patients with chronic inflammatory demyelinating polyneuropathy (EMDA CIDP): trial protocol of a proof of concept study

    Chronic inflammatory demyelinating polyneuropathy (CIDP) is one of the most common immune neuropathies [ 11 ]. It is characterized by a progressive or relapsing disease course developing for more than 8 weeks, often leading to severe restriction of …

  20. Open Access 02-06-2023 | Polyneuropathy | OriginalPaper

    Red flags and adjusted suspicion index for distinguishing hereditary transthyretin amyloid polyneuropathy from idiopathic axonal polyneuropathy

    Hereditary transthyretin amyloidosis (hATTRv) is an autosomal dominant multisystem disorder as a result from misfolding of the destabilized tetrameric transthyretin (TTR) protein. Aggregations of misfolded TTR protein can deposit in multiple …

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