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Frontotemporal Dementia 

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  1. Open Access 07-05-2024 | Alzheimer's Disease | Online First

    Visuospatial working memory in behavioural variant frontotemporal dementia: a comparative analysis with Alzheimer's disease using the box task

    The memory profile of the behavioural variant of frontotemporal dementia (bvFTD) has been a subject of debate [ 1 – 3 ]. The current consensus criteria for bvFTD describe a neuropsychological profile of relatively intact episodic memory and …

  2. Open Access 24-01-2024 | Frontotemporal Dementia | OriginalPaper

    Longitudinal volumetric changes in amygdala subregions in frontotemporal dementia

    Amygdala atrophy has been found in frontotemporal dementia (FTD), yet the specific changes of its subregions across different FTD phenotypes remain unclear. The aim of this study was to investigate the volumetric alterations of the amygdala …

  3. Open Access 01-12-2024 | Frontotemporal Dementia | OriginalPaper

    Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer’s disease, suspected-LATE and frontotemporal dementia

    There is currently growing interest in the involvement of neuromodulatory subcortical systems in Alzheimer’s disease (AD) and, more broadly, in neurodegenerative pathologies [ 1 ]. The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) …

  4. Open Access 01-06-2024 | Amyotrophic Lateral Sclerosis | OriginalPaper

    Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia

    The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS). While prior studies have focused on STING within immune cells, little is …

  5. Open Access 10-04-2024 | Frontotemporal Dementia | Online First

    Clinical and neuroanatomical characterization of the semantic behavioral variant of frontotemporal dementia in a multicenter Italian cohort

    Frontotemporal dementia (FTD) is a broad term that includes various syndromes characterized by the progressive loss of inhibitory circuits and language pathways and gradual involution of frontotemporal cortex. In addition to the three canonical …

  6. 02-02-2024 | Frontotemporal Dementia | OriginalPaper

    Entorhinal cortex astrocytic atrophy in human frontotemporal dementia

    The pathophysiology of Fronto Temporal Dementia (FTD) remains poorly understood, specifically the role of astroglia. Our aim was to explore the hypothesis of astrocytic alterations as a component for FTD pathophysiology. We performed an in-depth …

  7. Open Access 09-04-2024 | Frontotemporal Dementia | Online First

    Clinical and neuroimaging characterization of the first frontotemporal dementia family carrying the MAPT p.K298E mutation

    We present an in-depth clinical and neuroimaging analysis of a family carrying the MAPT K298E mutation associated with frontotemporal dementia (FTD). Initial identification of this mutation in a single clinical case led to a comprehensive …

  8. Open Access 01-12-2024 | Frontotemporal Dementia | OriginalPaper

    Diagnostic accuracy of research criteria for prodromal frontotemporal dementia

    Frontotemporal dementia (FTD) encompasses a clinically, genetically, and pathologically heterogeneous group of neurodegenerative disorders characterized by predominant degeneration of the frontal and/or temporal lobes. The clinical criteria have …

  9. Open Access 27-11-2023 | Frontotemporal Dementia | OriginalPaper

    Cortical thickness modeling and variability in Alzheimer’s disease and frontotemporal dementia

    During the last two decades, the study of several biomarkers, including neuroimaging, has substantially improved the diagnosis of neurodegenerative dementias. However, there’s still a need for reliable biomarkers to track disease, evaluate the …

  10. Open Access 01-12-2024 | Alzheimer's Disease | OriginalPaper

    The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer’s disease

    Frontotemporal dementia (FTD) is a clinically, genetically, and pathologically heterogeneous disease and the second most common form of young-onset dementia after Alzheimer’s disease (AD) [ 1 ]. The most prevalent form is the behavioral variant of …

  11. Open Access 01-12-2023 | Frontotemporal Dementia | OriginalPaper

    A frontotemporal dementia-like case after high-altitude climbing

    “High-altitude diseases”, a common ailment in mountaineers and mountain hikers, usually manifest themselves with the development of cerebral and pulmonary syndromes in people not acclimatized after climbing above 2500 m [ 1 ]. In a study conducted …

  12. Open Access 05-09-2023 | Frontotemporal Dementia | OriginalPaper

    Application of the mild behavioral impairment checklist in Chinese patients with the behavioral variant of frontotemporal dementia

    Behavioral variant frontotemporal dementia (bvFTD) is the commonest subtype of frontotemporal lobar degeneration, characterized by personality and behavioral changes in the early stages that gradually worsen over the course of the disease and are …

  13. Open Access 01-12-2023 | Frontotemporal Dementia | OriginalPaper

    Peripheral inflammation in behavioural variant frontotemporal dementia: associations with central degeneration and clinical measures

    Behavioural variant frontotemporal dementia (bvFTD) is the most common clinical subtype of frontotemporal dementia (FTD) [ 1 ]. The underlying mechanism of bvFTD is the accumulation and deposition of abnormal pathological proteins, especially in …

  14. Open Access 01-12-2023 | Frontotemporal Dementia | OriginalPaper

    Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

    Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. The triggers for neurodegeneration in FTD with GRN …

  15. Open Access 01-12-2023 | Frontotemporal Dementia | OriginalPaper

    Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

    Frontotemporal dementia (FTD) is one of the most common causes of dementia after Alzheimer's disease with an incidence of 4.1 cases per 100,000 subjects each year [ 32 ]. FTD is a spectrum of different early and progressive disorders characterized …

  16. Open Access 01-12-2023 | Frontotemporal Dementia | OriginalPaper

    Altered metabolic connectivity within the limbic cortico-striato-thalamo-cortical circuit in presymptomatic and symptomatic behavioral variant frontotemporal dementia

    Behavioral variant frontotemporal dementia (bvFTD) is a highly genetic and heterogeneous clinical syndrome characterized by early and prominent deterioration of behavior, which includes impaired social interactions, disinhibition, apathy, and …

  17. Open Access 01-12-2023 | Frontotemporal Dementia | OriginalPaper

    Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer’s disease and frontotemporal dementia

    Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are two of the most prevalent causes of dementia among the elderly. AD is a slow-progressing neurodegenerative disorder that is primarily characterized by memory and cognitive impairments …

  18. 08-05-2023 | Frontotemporal Dementia | OriginalPaper

    New Approaches to the Treatment of Frontotemporal Dementia

    Frontotemporal dementia (FTD) comprises a diverse group of clinical neurodegenerative syndromes characterized by progressive changes in behavior, personality, executive function, language, and motor function. Approximately 20% of FTD cases have a …

  19. Open Access 17-10-2023 | Amyotrophic Lateral Sclerosis | OriginalPaper

    Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

    A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS; C9ORF72-FTD/ALS). The goal of …

  20. Open Access 23-03-2023 | Frontotemporal Dementia | OriginalPaper

    The Behavioural Dysfunction Questionnaire discriminates behavioural variant frontotemporal dementia from Alzheimer’s disease dementia and major depressive disorder

    After Alzheimer’s disease dementia (ADD), frontotemporal dementia (FTD) is the second most common younger-onset dementia, with the behavioural variant (bvFTD) as its most frequent clinical syndrome [ 27 , 31 , 35 ]. BvFTD is a neurodegenerative …

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