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Interferon 

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  1. 01-04-2024 | Sorafenib | News

    Interferon/sorafenib

    Lack of efficacy and intracranial haemorrhage
  2. 01-04-2024 | Autoimmune Hepatitis | News

    Interferon

    Autoimmune hepatitis
  3. 07-05-2024 | Interferon | Online First

    Esaxerenone Inhibits Interferon-γ Induced Pyroptosis of Macrophages in the Lungs of Aldosterone-treated Mice

    Lung immune cells such as lymphocytes and macrophages can induce an inflammatory response due to the activation of mineralocorticoid receptor (MR), which is manifested by the infiltration of inflammatory cells and the secretion of inflammatory …

  4. Open Access 01-12-2024 | Human Papillomavirus | OriginalPaper

    Interferon-γ-induced GBP1 is an inhibitor of human papillomavirus 18

    Human papillomavirus (HPV) is a non-enveloped circular double-stranded DNA virus [ 1 ]. The genome can be divided into early protein coding region (E region), late protein coding region (L region) and long control region (LCR). More than 200 HPV …

  5. Open Access 25-04-2024 | Hemophagocytic Lymphohistiocytosis | Online First

    Population Pharmacokinetics of the Anti-Interferon-Gamma Monoclonal Antibody Emapalumab: An Updated Analysis

    Hemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive, and potentially fatal syndrome characterized by excessive, uncontrolled immune activation and systemic hyperinflammation [ 1 – 3 ]. Primary HLH is associated with genetic defects and …

  6. 01-03-2024 | Interferon | News

    Interferon-beta-1a/methylprednisolone

    Retinopathy and lack of efficacy
  7. 01-03-2024 | Human interferon beta | News

    Interferon-beta-1

    Thrombotic microangiopathy
  8. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants

    Disease progression among antiretroviral treatment (ART) naïve people living with HIV (PLWH) differs substantially [ 1 ], with both viral and host genetic factors (and their interaction) known to play an important role [ 2 – 4 ]. Human leukocyte …

  9. Open Access 01-04-2024 | Interferon | OriginalPaper

    Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients

    Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although most COVID-19 patients show mild disease, some suffer from severe symptoms, leading to death due to …

  10. Open Access 29-04-2024 | Human Papillomavirus | Online First

    Comparing the effects of argon plasma coagulation and interferon therapy in patients with vaginal intraepithelial neoplasia: a single-center retrospective study

    Vaginal intraepithelial neoplasia (VaIN) is defined as atypical hyperplasia of different levels limited to the vaginal intraepithelial tissue. VaIN is precancerous lesion that could potentially lead to vaginal carcinoma. In 1952, Graham and Meigs …

  11. Open Access 16-04-2024 | Mycobacterium Tuberculosis | Online First

    Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling

    Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a worldwide disease that affects one-third of the world's population [ 1 ]. Mtb is an intracellular pathogen living in macrophage, which is the first line of host defense …

  12. 01-03-2024 | Interferon | News

    Interferon-alpha-2a/ipilimumab/nivolumab

    Various toxicities
  13. 03-01-2024 | Hepatocellular Carcinoma | OriginalPaper

    Interferon-Gamma-Inducible Protein 16 Inhibits Hepatocellular Carcinoma via Interferon Regulatory Factor 3 on Chemosensitivity

    Hepatocellular carcinoma (HC) is a type of cancer that typically occurs later in life and progresses rapidly. It's the second leading cause of tumor-related deaths worldwide, with the highest incidences of this disease include East Asia and …

  14. Open Access 01-12-2024 | Tuberculosis | OriginalPaper

    Impact of immune checkpoint inhibitors (ICIs) therapy on interferon-γ release assay (IGRA) and diagnostic value in non-small cell lung cancer (NSCLC) patients

    Tuberculosis (TB) is a highly contagious respiratory disease that presents a grave global threat. The 2022 report from the World Health Organization (WHO) reveals an unsettling change in the TB incidence trend, which had been declining over the …

  15. 17-04-2024 | Respiratory Syncytial Virus Infection | Online First

    TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I

    Innate immune response is the first line of defense for the host against virus invasion. One important response is the synthesis and secretion of type I interferon (IFN-I) in the virus-infected host cells. Here, we found that respiratory syncytial …

  16. Open Access 01-03-2024 | Interferon | OriginalPaper

    Prevalence of Neutralizing Autoantibodies Against Type I Interferon in a Multicenter Cohort of Severe or Critical COVID-19 Cases in Shanghai

    The recent declaration by the World Health Organization (WHO) that COVID-19 no longer represents a public health emergency represents a significant turning point in worldwide efforts to address the ongoing pandemic. Nevertheless, it is imperative …

  17. 01-04-2024 | Pancreatic Cancer | ReviewPaper

    Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer

    Human interferon-induced transmembrane protein family (IFITMs) consists of five main proteins. IFITM1, IFITM2, and IFITM3 can be induced by interferon, while IFITM5 and IFITM10 are insensitive to interferon. IFITMs has various functions, including …

  18. 01-12-2024 | Interferon | ReviewPaper

    Efficacy, safety and cost-effectiveness of 5-fluorouracil versus interferon α-2b as adjuvant therapy after surgery in ocular surface squamous neoplasia in a southern European tertiary hospital

    Ocular surface squamous neoplasia (OSSN) includes a wide spectrum of conjunctival and corneal epithelium lesions presenting an abnormal growth of dysplastic squamous epithelial cells, histologically classified into carcinoma in situ I (CINI), CIN …

  19. 26-02-2024 | Type 1 Diabetes | OriginalPaper

    Interferons are key cytokines acting on pancreatic islets in type 1 diabetes

    Type 1 diabetes is caused by severe insulin deficiency due to an immune-mediated assault on the pancreatic beta cells, leading to islet inflammation (insulitis) and loss of beta cells in genetically susceptible individuals submitted to …

  20. 11-03-2024 | Stroke | Online First

    Type I Interferon Signalling and Ischemic Stroke: Mechanisms and Therapeutic Potentials

    Type I interferon (IFN-I) signalling is intricately involved in the pathogenesis of multiple infectious diseases, autoimmune diseases, and neurological diseases. Acute ischemic stroke provokes overactivation of IFN-I signalling within the injured …

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