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A 6-year-old girl with early onset, severe obesity fulfilling the criteria for ROHHAD syndrome was found to have variants in PLXNA3 and PCSK1, genes involved in the leptin‒melanocortin pathway and associated with monogenic obesity.
A practical overview of how changing physiological needs across life stages, from puberty to after menopause, shape selection of the most effective multiple sclerosis therapies to optimize long‑term outcomes.
Premature neonates are particularly vulnerable to fungemia due to factors such as low birth weight, prolonged empirical antibiotic treatment, and immune suppression due to steroid use. This case series outlines the challenges of diagnosis and how to approach treatment.
Cyclic exclusive enteral nutrition offers greater long-term remission rates than continuous partial enteral nutrition in children with Crohn's disease who have responded to nutritional induction therapy.
Recently there has been a renewed interest in the prospect of therapeutic cancer vaccines. But what exactly does it mean to vaccinate against cancer, where are vaccines showing the most promise, and what are the challenges of making such vaccines a reality?
Dr. Elias Sayour answers these questions and more in this episode.
A 6-year-old girl with early onset, severe obesity fulfilling the criteria for ROHHAD syndrome was found to have variants in PLXNA3 and PCSK1, genes involved in the leptin‒melanocortin pathway and associated with monogenic obesity.
Premature neonates are particularly vulnerable to fungemia due to factors such as low birth weight, prolonged empirical antibiotic treatment, and immune suppression due to steroid use. This case series outlines the challenges of diagnosis and how to approach treatment.
Echocardiography revealed a 3 mm type I aortopulmonary window with minor hypertension in a 3-year-old girl. Transcatheter coil occlusion was successful in closing the defect, highlighting its role as an alternative to surgical repair.
What can we do to reduce mounting myopia prevalence?
Global prevalence of myopia in children and adolescents is set to reach 40% by 2050, exceeding 740 million cases.
Reducing incidence and slowing progression is essential, as myopia is linked to sight-threatening complications like retinal detachment, myopic macular degeneration, and glaucoma. Dr. Annegret Dahlmann-Noor explores the reasons behind this increase and what we can do to halt the trend.
Acute kidney injury (AKI) represents a critical diagnostic challenge in pediatric medicine, with incidence rates exceeding 25% in intensive care populations and associated mortality approaching 15% even with modern supportive care [ 1 , 2 ]. Unlike …
Lung ultrasound (LUS) and targeted neonatal echocardiography (TNE) are employed in some neonatal intensive care units throughout the hospital stay to monitor heart- and lung-related morbidities. However, preterm infants are at risk of increased …
Intra-amniotic inflammation and infection are common intrapartum conditions at term and represent a major cause of fetal and neonatal morbidity independent of hypoxia. These conditions trigger the fetal inflammatory response syndrome (FIRS) …
This study aimed to compare neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) between asthmatic and healthy children and to investigate the predictive role of PLR and NLR for asthma exacerbation. Web of Science, PubMed …
Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.
Improve your ECG interpretation skills with this comprehensive, rapid, interactive course. Expert advice provides detailed feedback as you work through 50 ECGs covering the most common cardiac presentations to ensure your practice stays up to date.
Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.
Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver news, cases and expert reviews covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.
Disorders of gut–brain interaction (DGBI) are common in pediatrics, affecting between 10% and 23% of the population [ 1 ]. Though the very name clearly implies a neural contribution to these disorders, the role of the autonomic nervous system …
Neurofeedback (NFB) therapy based on spectral neuromarkers of Attention-Deficit/Hyperactivity Disorder (ADHD) has faced challenges regarding its efficacy and replicability. In this study, we investigate whether a microstate-based EEG marker …
Ultra-short celiac disease (USCD) represents a histopathological variant with selective involvement of the duodenal bulb. The mechanisms underlying the sparing of the second duodenal portion remain unclear. The histopathological progression of …
Phototherapy is the mainstay of treatment for neonatal jaundice since the 1950s. It involves rapid photoisomerization of bilirubin resulting in faster excretion [ 1 ]. Traditionally, phototherapy is given until the serum bilirubin level reaches …
Pattern visual evoked potentials can objectively measure the effects of retinal gene therapy on retinogeniculostriate function in young children with early-onset inherited retinal dystrophies.
Premature neonates are particularly vulnerable to fungemia due to factors such as low birth weight, prolonged empirical antibiotic treatment, and immune suppression due to steroid use. This case series outlines the challenges of diagnosis and how to approach treatment.
Echocardiography revealed a 3 mm type I aortopulmonary window with minor hypertension in a 3-year-old girl. Transcatheter coil occlusion was successful in closing the defect, highlighting its role as an alternative to surgical repair.
Two-year findings from the Early Surveillance for Autoimmune Diabetes (ELSA) study demonstrate that screening for type 1 diabetes in children is feasible in the UK.
Improved survival in pediatric oncology has highlighted the growing burden of cancer treatment-related cardiotoxicity. Delve into the recent advances and emerging priorities.
Exocrine pancreatic insufficiency has various causes that differ with age, and diagnosis is challenging due to the lack of reliable diagnostic testing approaches. A high index of suspicion based on clinical history should inform testing.
