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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2020

01-12-2020 | Alzheimer's Disease | Research

Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

Authors: Maralinde R. Abbink, Janssen M. Kotah, Lianne Hoeijmakers, Aline Mak, Genevieve Yvon-Durocher, Bram van der Gaag, Paul J. Lucassen, Aniko Korosi

Published in: Journal of Neuroinflammation | Issue 1/2020

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Abstract

Background

Early-life stress (ES) is an emerging risk factor for later life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model. Because astrocytes are key players in the pathogenesis of AD, we studied here if and how ES affects astrocytes in wildtype (WT) and APP/PS1 mice and how these relate to the previously reported amyloid pathology and microglial profile.

Methods

We induced ES by limiting nesting and bedding material from postnatal days (P) 2–9. We studied in WT mice (at P9, P30, and 6 months) and in APP/PS1 mice (at 4 and 10 months) (i) GFAP coverage, cell density, and complexity in hippocampus (HPC) and entorhinal cortex (EC); (ii) hippocampal gene expression of astrocyte markers; and (iii) the relationship between astrocyte, microglia, and amyloid markers.

Results

In WT mice, ES increased GFAP coverage in HPC subregions at P9 and decreased it at 10 months. APP/PS1 mice at 10 months exhibited both individual cell as well as clustered GFAP signals. APP/PS1 mice when compared to WT exhibited reduced total GFAP coverage in HPC, which is increased in the EC, while coverage of the clustered GFAP signal in the HPC was increased and accompanied by increased expression of several astrocytic genes. While measured astrocytic parameters in APP/PS1 mice appear not be further modulated by ES, analyzing these in the context of ES-induced alterations to amyloid pathology and microglial shows alterations at both 4 and 10 months of age.

Conclusions

Our data suggest that ES leads to alterations to the astrocytic response to amyloid-β pathology.
Appendix
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Metadata
Title
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Authors
Maralinde R. Abbink
Janssen M. Kotah
Lianne Hoeijmakers
Aline Mak
Genevieve Yvon-Durocher
Bram van der Gaag
Paul J. Lucassen
Aniko Korosi
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2020
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-020-01762-z

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