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Targeted therapy in pediatric ALL

Targeted therapies could transform the treatment of pediatric acute lymphoblastic leukemia. Take a deep dive into the mechanistic aspects of the agents, ongoing and recent clinical trial results and approvals, and the side effects of each modality.

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Editor's Choice

Ectopic Cushing syndrome caused by renal neuroendocrine tumor

A challenging case of Cushing syndrome with aggressive clinical manifestations. Ectopic Cushing syndrome was diagnosed and the source identified as an ACTH-negative and likely CRH-secretory renal neuroendocrine tumor.

TTP as a complication of pembrolizumab

A patient with suspected advanced renal cell carcinoma developed thrombotic thrombocytopenic purpura after receiving a single dose of pembrolizumab, underscoring the need for clinician vigilance.

Adjuvant imatinib may be beneficial for GIST with KIT exon 9 mutations

Postoperative treatment with imatinib could significantly delay recurrence and improve survival among individuals with gastrointestinal stromal tumors carrying KIT exon 9 mutations.

Neoadjuvant therapy in cisplatin-ineligible MIBC

Discover the two conceptually distinct paradigms that could transform the neoadjuvant treatment of cisplatin-ineligible patients with muscle-invasive bladder cancer, and understand how they might be selected and sequenced.

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Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
Watch now
COMMISSIONED

How-to guide for healthcare professionals: understanding genomic reports

This educational activity was initiated, funded and co-developed by Boehringer Ingelheim and is intended for healthcare professionals in the UK and Ireland only. 

Genomic testing helps inform cancer diagnosis, prognosis, and treatment. A genomic report is generated by the laboratory carrying out next-generation sequencing to analyze biopsy samples. Access this educational microsite to learn more about typical genomic report content and how to interpret test results for patients with cancer.

NP-GB-106631 | Jan 2026

Commissioned by:
  • Boehringer Ingelheim
Learn more

Case Studies

Ectopic Cushing syndrome caused by renal neuroendocrine tumor

A challenging case of Cushing syndrome with aggressive clinical manifestations. Ectopic Cushing syndrome was diagnosed and the source identified as an ACTH-negative and likely CRH-secretory renal neuroendocrine tumor.

TTP as a complication of pembrolizumab

A patient with suspected advanced renal cell carcinoma developed thrombotic thrombocytopenic purpura after receiving a single dose of pembrolizumab, underscoring the need for clinician vigilance.

Etoposide dosing challenges

This case of a testicular cancer patient with cystic fibrosis and liver cirrhosis shows that monitoring of etoposide concentrations can be beneficial in complex scenarios involving organ dysfunction and/or potential drug–drug interactions.

Episode 25: Therapeutic cancer vaccines

The next frontier in cancer treatment?

Recently there has been a renewed interest in the prospect of therapeutic cancer vaccines. But what exactly does it mean to vaccinate against cancer, where are vaccines showing the most promise, and what are the challenges of making such vaccines a reality?

Dr. Elias Sayour answers these questions and more in this episode.

Dr. Elias Sayour
Listen now
Podcast

Current Reviews

Gastrointestinal cancers in women: The role of sex hormones

Gastrointestinal (GI) cancers remain a leading cause for global cancer-related morbidity and mortality, affecting both—men and women. Recent research highlights significant differences between the sexes in terms of incidence, development and …

Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects

Triple-negative breast cancer (TNBC) remains a major clinical challenge owing to its inherent resistance to treatment, immune-competent tumor microenvironment, and early metastasis. Sonodynamic therapy (SDT), which generates reactive oxygen …

Evidence-based Interventions for Cancer Screening Access among People with Physical and/or Sensory Disability: a Systematic Review of the Evidence

People with physical and/or sensory disability have lower uptake of breast, cervical, and colorectal cancer screening than those without disability. This systematic review aims to identify evidence-based interventions designed to positively …

A narrative review of mutant isocitrate dehydrogenase AML in Japan based on experience with ivosidenib in AGILE

Ivosidenib is a mutant IDH1 (mIDH1) inhibitor that demonstrated clinical benefit in combination with azacitidine for treatment of mIDH1 acute myeloid leukemia (AML) in the phase 3 AGILE trial. Results from AGILE led to the approval of ivosidenib …

Aplastic anemia: managing special patient subgroups and challenging cases (Link opens in a new window)

Learn more about the importance of adapting treatment approaches for special patient populations (eg, elderly or pregnant patients) in this third module of our interactive e-Learning program on diagnosing and treating aplastic anemia.

Independent Medical Education Grant:
  • Pfizer
Learn more TODO (Link opens in a new window)

CME & eLearning

COMMISSIONED

How-to guide for healthcare professionals: understanding genomic reports

This educational activity was initiated, funded and co-developed by Boehringer Ingelheim and is intended for healthcare professionals in the UK and Ireland only.

Genomic testing helps inform cancer diagnosis, prognosis, and treatment. Access this educational microsite to learn more about typical genomic report content and how to interpret test results for patients with cancer.

NP-GB-106631 | Jan 2026

Commissioned by:
  • Boehringer Ingelheim
Video
SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Professor Joy Ho and a panel of Asia-Pacific-based experts will examine real-life patient cases in this Masterclass, exchanging insights into their clinical experiences of using CAR T-cell therapy to treat patients with R/R DLBCL or R/R FL.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsor:
  • Novartis Pharma AG
SPONSORED

CAR T-cell therapy medical education hub

This hub presents a curated selection of educational materials focused on the latest clinically relevant topics related to the use of chimeric antigen receptor (CAR) T‑cell therapy for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and R/R follicular lymphoma (FL).

This content has been developed in collaboration with and funded by the sponsor Novartis Pharma AG and is not intended for healthcare professionals based in the UK and US.

Sponsor:
  • Novartis Pharma AG

Further Reading

Immunohistochemical expression of GPNMB in TFEB-rearranged and TFEB-amplified renal cell carcinomas

TFEB-altered renal cell carcinomas (RCCs) display a wide range of morphological features and variable immunohistochemical profiles, often overlapping with other RCC subtypes. This variability poses significant diagnostic challenges. Consequently …

Cost-effectiveness analysis of immune checkpoint inhibitors versus platinum-based doublet chemotherapy in the first-line treatment of advanced non-small-cell lung cancer with High PD-L1 expression in Japan

Lung cancer is the leading cause of cancer-related deaths in Japan, with over 130,000 new cases and approximately 75,000 deaths annually [ 1 ]. Non-small-cell lung cancer (NSCLC) accounts for about 85% of these cases, with most patients presenting …

SCGB1A1 suppresses prostate cancer proliferation and metastasis by modulating the MAPK signaling pathway

Prostate cancer (PCa) is the most common malignant tumor of the male genitourinary system and ranks as the second most frequently diagnosed cancer among men, following lung cancer [ 1 ]. In the United States, PCa holds the highest incidence among …

Evaluation of neoadjuvant chemotherapy followed by radical hysterectomy in cervical cancer: a single-center study

Cervical cancer remains a common gynecologic malignancy worldwide, with approximately 600,000 new cases reported annually [ 1 ]. The principal definitive treatment options for locally advanced cervical cancer include radical hysterectomy (RH) and …

Related topics

Targeted therapy in pediatric ALL

Targeted therapies could transform the treatment of pediatric acute lymphoblastic leukemia. Take a deep dive into the mechanistic aspects of the agents, ongoing and recent clinical trial results and approvals, and the side effects of each modality.

Read more

Ectopic Cushing syndrome caused by renal neuroendocrine tumor

A challenging case of Cushing syndrome with aggressive clinical manifestations. Ectopic Cushing syndrome was diagnosed and the source identified as an ACTH-negative and likely CRH-secretory renal neuroendocrine tumor.

Read more
Image Credits
Dart hitting center of target/© Ramita / Generated with AI / Stock.adobe.com, Imaging of a patient with ectopic Cushing syndrome caused by a renal neuroendocrine tumor./© (M) 2026, Faezeh Sehatpour et al. J Diabetes Metab Disord, under exclusive licence to Tehran University of Medical Sciences, Molecular model of pembrolizumab/© Kateryna_Kon / stock.adobe.com, DNA mutation illustration/© Design Cells / Getty Images / iStock, Syringe, vial and white pills/© Alexander / Stock.adobe.com, Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human heart illustration/© peterschreiber.media / stock.adobe.com, IV drip in hospital/© Kwangmoozaa / stock.adobe.com, Artistic rendering of fecal microbiota transplantation pills/© mbruxelle / Stock.adobe.com, Lab technician loading centrifuge/© sinology / Moment / Getty (symbolic image with model), Assortment of glasses of wine and beer/© MarkWagonerProductions / Getty Images / iStock, DNA double helix structure on a purple background/© 2025 Adobe, Syringe and vial/© Ake Ngiamsanguan / Getty Images / iStock, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Aplastic Anemia/© Springer Healthcare IME, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com, T-cell expressing chimeric antigen receptor (CAR) in the cell membrane; DNA is exposed from the T-cell to highlight the genetic engineering involved in creating CAR T-cells/© LoveLive/stock.adobe.com, IV drip/© Trsakaoe / stock.adobe.com, Older man sitting on the edge of a bed/© andreswd / E+ / Getty Images (symbolic image with model), FDG PET-CT of patient with Behçet disease and Hodgkin lymphoma/© 2025, Matthew Coulter et al, under exclusive licence to International League of Associations for Rheumatology (ILAR), Clin Rheumatol, Fundus scan in vitreoretinal lymphoma/© 2025, Atsunobu Takeda et al, Jpn J Ophthalmol, Paper illustration of multiple brain tumors/© freshidea / Stock.adobe.com, Abdominal CT of patient with ICI-associated gastritis/© 2026, Nozomi Sano et al, under exclusive licence to Japanese Society of Gastroenterology, Clin J Gastroenterol