Oncology

Since the release of the DESTINY-Breast04 (DB-04) trial findings in June 2022, the field of pathology has seen a renaissance of HER2 as a predictive biomarker in breast cancer. The trial focused on patients with metastatic breast cancer who were …

Traditionally, adipose tissue was thought a passive energy storage depot simply, playing a fundamental role in energy homeostasis. In 1993, Hotamisligil et al. found the expression of TNF-α in adipose tissue, which was thought closely associated …

Improved understanding of TP53 biology and the clinicopathological features of TP53-mutated myeloid neoplasms has led to the recognition of TP53-mutated acute myeloid leukemia/myelodysplastic syndrome (TP53m AML/MDS) as a unique entity …

Osteoporosis is an enormous public health burden that affects men and women of all races. About 50% of women and 20% of men in the USA over the age of 50 years will experience an osteoporotic fracture [ 1 ]. Osteoporosis is characterized by bone …

Since the release of the DESTINY-Breast04 (DB-04) trial findings in June 2022, the field of pathology has seen a renaissance of HER2 as a predictive biomarker in breast cancer. The trial focused on patients with metastatic breast cancer who were …

Leber congenital amaurosis (LCA) is a severe form of inherited retinal dystrophy. It is hallmarked by a rapidly progressing visual impairment which first presents in early childhood and usually leads to complete blindness by the fourth decade of …

In metastatic neuroendocrine tumors (NETs), liver metastases are present in 82% of patients [ 1 ]. In addition to surgical therapy, systemic treatment is often required to maintain the quality of life and prevent unhindered progression of the tumor …

Methotrexate (MTX) is a folate antagonist with anti-inflammatory, immunomodulatory and anti-proliferative capacities. In low doses, MTX has been established as a first-line effective, safe and inexpensive treatment in immune-mediated inflammatory …