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Internal Medicine Gastroenterology and Hepatology

Gastroenterology and Hepatology

Cilofexor shows no liver fibrosis benefits for patients with PSC

The FXR agonist cilofexor does not slow down fibrosis progression in patients with noncirrhotic primary sclerosing cholangitis.

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Editor's Choice

Sigmoid volvulus in a healthy young woman

A high index of suspicion for sigmoid volvulus is needed in young women with abdominal symptoms as the overlap of gastrointestinal and gynecological symptoms can easily lead to misdiagnosis.

Enteritis and peritonitis as first presentation of SLE

Another case report contributing to the growing body of literature on gastrointestinal involvement in systemic lupus erythematosus, and underscoring the importance of early recognition and targeted treatment.

Managing dual primary liver metastases

The treatment strategy for liver metastases is predominantly determined by the primary cancer site, which made this patient with metastases from breast and colorectal cancer quite challenging to manage.

Chronic hepatitis B: combination therapy with novel drugs

Combination therapies involving novel drugs hold promise for improving chronic hepatitis B outcomes, particularly in achieving a functional cure. What are these novel drugs and how might they be combined to improve efficacy?

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Keynote webinar | Spotlight on addressing alcohol-associated liver disease

  • Live
  • Webinar | 19-11-2025 | 18:00 (CET)

The global burden of ALD is growing and compounded by frequent late-stage diagnosis and undertreatment. Get the latest insights into patient risk and identification, treatment and management, and the arrival of MetALD.

Watch it live: 19 November 2025, 18:00-19:30 (CET)

Prof. Helena Cortez-Pinto
Prof. Mark Thursz
Dr. Juan Pablo Arab
Developed by: Springer Medicine
Register now
Webinar
SPONSORED

Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by:
  • Viatris
Developed by: Springer Health+
Watch now
Video

Case Studies

Sigmoid volvulus in a healthy young woman

A high index of suspicion for sigmoid volvulus is needed in young women with abdominal symptoms as the overlap of gastrointestinal and gynecological symptoms can easily lead to misdiagnosis.

Enteritis and peritonitis as first presentation of SLE

Another case report contributing to the growing body of literature on gastrointestinal involvement in systemic lupus erythematosus, and underscoring the importance of early recognition and targeted treatment.

Managing dual primary liver metastases

The treatment strategy for liver metastases is predominantly determined by the primary cancer site, which made this patient with metastases from breast and colorectal cancer quite challenging to manage.

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

Current Reviews

Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan

Obesity is now firmly recognized as a complex, chronic, relapsing, and progressive disease, affecting over 650 million adults worldwide. It is a major driver of type 2 diabetes (T2D), atherosclerotic cardiovascular disease (ASCVD), heart failure …

Reappraising appendicitis: a systematic review and meta-analysis of evolving treatment paradigms

The management of acute appendicitis has undergone a substantial transformation in recent years, transitioning from mandatory surgical intervention to more individualized treatment strategies. This systematic review and meta-analysis aim to …

Insights into the Mechanism of Action of Tirzepatide: A Narrative Review

Tirzepatide is the first dual long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist indicated for the treatment of type 2 diabetes in adults, for reducing excess body weight and maintaining …

Keynote series | Spotlight on managing health in obesity

Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.

Prof. Eva L. Feldman
Prof. Jonette Keri
Developed by: Springer Medicine
Watch now
Video

CME and eLearning

Unveiling the spectrum (Link opens in a new window)

Update your awareness of the phenotypes and clinical presentations of late-onset genetic cholestasis. Learn how to integrate consensus recommendations and diagnostic tools for accurate diagnosis, and discover treatment advances.

Supported by:
  • Ipsen
Developed by: Springer Health+ IME

Amyloidosis action (Link opens in a new window)

Experts from established amyloidosis centers offer you specialized guidance to support your mission to set up a local center. Roundtable insights allow you to network with other HCPs in your locality to discuss region-specific challenges in establishing amyloidosis centers. 

Supported by:
  • AstraZeneca and Alexion
Developed by: Springer Health+ IME
SPONSORED

Chronic pancreatitis pain: A multidisciplinary approach and practical solutions

1.5 European CME credits (ECMEC®s)

Severe pain is the most common symptom of chronic pancreatitis. In this live webinar, experts shared the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discussed pertinent cases and provided practical suggestions for use within clinical practice.

Sponsored by:
  • Viatris
Developed by: Springer Health+

Further Reading

Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer

Colorectal cancer (CRC) is the third most common malignant tumor globally exhibiting a rising incidence rate-particularly among younger populations under 50, where rates increased annually in recent years [ 1 ]. According to the World Health …

Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer

Approximately 5% of all colorectal cancers have a strong genetic component and are classified as hereditary colorectal cancer (HCRC). Some of the unique features commonly seen in HCRC cases include early age of onset, synchronous/metachronous …

Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan

Obesity is now firmly recognized as a complex, chronic, relapsing, and progressive disease, affecting over 650 million adults worldwide. It is a major driver of type 2 diabetes (T2D), atherosclerotic cardiovascular disease (ASCVD), heart failure …

Related topics

Sigmoid volvulus in a healthy young woman

A high index of suspicion for sigmoid volvulus is needed in young women with abdominal symptoms as the overlap of gastrointestinal and gynecological symptoms can easily lead to misdiagnosis.

Read more
Image Credits
Missed target, wrong direction, failure, cancellation, or mistake concept image/© mohd izzuan / iStock / Getty Images Plus, Erect abdominal radiograph consistent with sigmoid volvulus/© 2025, Hana Girma Abera et al, J Med Case Reports, CT scan of patient with enteritis and peritonitis as first presentation of SLE/© 2025, Bashar Kamal Ali Douden et al, BMC Rheumatol, 3D reconstruction of liver metastases from breast and colorectal cancer/© 2025, Ryota Ito et al, under exclusive licence to Japanese Society of Gastroenterology, Clin J Gastroenterol, Red jigsaw house on blue background/© Westend61 / Westend61 / Getty Images, Abstract low poly wireframe illustration of the liver/© (M) Yevhen Lahunov / iStock / Getty Images Plus, Girl with abdominal pain at medical appointment/© LuxeShutter24/peopleimages.com / stock.adobe.com (symbolic image with models), Chronic pancreatitis 3D concept image/© Rasi Bhadramani, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Spotlight on obesity series 4x3 image/© smartboy10 / Getty Images / iStock, Unveiling the Spectrum: A Deep Dive into Late-Onset Cholestasis (PFIC)/© Springer Healthcare IME, Amyloidosis Action: expanding the global center network/© Springer Healthcare IME, Artificial intelligence in healthcare concept/© Parradee / stock.adobe.com, Papercraft Venn diagram composed of two overlapping circles/© MirageC / Moment / Getty Images, Three darts in a dart board with one hitting the bull's-eye/© Richard Drury / Getty, Papercraft arrow hitting a bullseye/© MirageC / Moment / Getty Images, Question mark made of pills/© Nadzeya / stock.adobe.com, Syringe and multicolored pills on red background/© VlaDee / Getty Images / iStock, Fresh eels at market/© urbancow / Getty Images / iStock