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Episode 25: Therapeutic cancer vaccines

The next frontier in cancer treatment?

Recently there has been a renewed interest in the prospect of therapeutic cancer vaccines. But what exactly does it mean to vaccinate against cancer, where are vaccines showing the most promise, and what are the challenges of making such vaccines a reality?

Dr. Elias Sayour answers these questions and more in this episode.

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Medicine Matters keeps practicing doctors informed of key clinical developments, discusses controversial issues in medicine, and helps doctors be sure that their patient care is up to date.

More episodes from Medicine Matters

Episode 0: Introducing Medicine Matters

In this episode, Dr. Jane Godsland & Dr. Erik Heintz introduce the new platform and podcast. 

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Episode 1: From Gray's to Google

We talk to Dr. Nathalie van Havre and Dr. Elsbeth Headley about ongoing medical education in the digital age. 

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Episode 2: Progress in PARP inhibitors

In this episode, Dr. Elena Castro takes us through the latest evidence for PARP inhibitors and their combinations in this setting.

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Episode 3: Unravelling resistant hypertension

In this episode, Professors Morris Brown and Bryan Williams debate the causes of resistant hypertension and explore novel treatment options. 

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Episode 4: Stem cell therapy for PD

Prof. Malin Parmar explains why stem cell therapy is such a good option for patients with Parkinson’s disease and how its safety is being tested in the STEM-PD trial.

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Episode 5: Next-generation sequencing in cancer

Professor Andrew Beggs discusses best practice in the use of next-generational sequencing within thyroid and non-small cell lung cancers

Supported by: Illumina, Inc., and Eli Lilly and Company

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Episode 6: OCT for coronary imaging

Drs Niels Holm and Lene Andreasen bring us up to speed with the latest evidence, and explore whether we should expect to see this technology in use in our clinics in the future.

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Episode 7: A deep dive into ADAURA

A conversation with Dr. Luis Paz-Ares about the key questions raised by the ADAURA trial of adjuvant osimertinib in early-stage NSCLC.

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Episode 8: AI in stroke

Prof. Susanne Wegener discusses her team’s work to develop deep learning models that outperform neurologists in predicting patients’ clinical outcomes after stroke.

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Episode 9: The gut microbiome and CAR T-cell therapy

Prof. Marion Subklewe explores the interplay between the gut microbiota and the efficacy and safety of CAR T-cell therapy in people with hematologic malignancies.

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Episode 10: Disease-modifying therapy for type 1 diabetes

Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape. 

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Episode 11: Cardiac rehabilitation in patients with frailty

Dr. Eduard Shantsila discusses rehabilitation approaches for complex patients with heart disease and comorbid frailty, including those with cognitive vulnerability.

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Episode 12: Defining ARDS

Since publication of the Berlin criteria for ARDS in 2012, several developments have prompted the need for an update. Last year, an international group of experts rose to the challenge. But is the new definition necessary and will it have an impact on clinical practice? Prof. Giacomo Grasselli shares his thoughts.

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Episode 13: Advances in MASLD and MASH

Prof. Vlad Ratziu discusses the updated subclassification and nomenclature for steatotic liver disease, the therapeutic advance of resmetirom, and the future for MASLD and MASH.

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Episode 14: Diagnostic criteria for AD

Dr. Nicolas Villain outlines why it is so important to consider both clinical symptoms and biological findings when diagnosing Alzheimer's disease. 

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Episode 15: Breastfeeding after breast cancer

We talk to Dr. Cristina Saura about the concerns around breastfeeding after a breast cancer diagnosis, and why the POSITIVE results are such good news.

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Episode 16: Sexual health in older age

Dr Holly Thomas helps us unpack the needlessly taboo subject of sex and sexual health in women of older age.

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Episode 17: Challenges of developing DMOADs

Prof. Ali Mobasheri identifies the key issues in developing a successful disease-modifying osteoarthritis drug and how they can be overcome.

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Episode 18: The fight for children's eyesight

Dr. Annegret Dahlmann-Noor explores why the number of children and adolescents with myopia is increasing and what we can do to halt the trend.

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Episode 19: GLP-1 medicines - past, present, and future

We talk with Prof. Daniel Drucker about the early work on GLP-1 medicines for the treatment of diabetes, how they are now impacting the lives of people living with obesity, and their potential use for many other indications.

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Episode 20: Gonorrhea in the modern era

Dr. Hamish Mohammed discusses the rollout of the world’s first vaccination program against gonorrhea.

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Episode 21: Moving towards migraine freedom?

We talk to Prof. Messoud Ashina about PACAP signaling and why targeting it might be the next big breakthrough for sustained migraine control.

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Episode 22: Celebrating 25 years of TKIs in CML

We reflect on a key breakthough in the treatment of CML with Dr. Jorge Cortes, who has been involved in the development of TKIs since the early days.

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Episode 23: Improving dysphagia outcomes

Prof. Edoardo Savarino takes us through the updated UEG and ESNM dysphagia guidelines and the difference they could make to patient outcomes.

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Episode 24: Looking back at 2025

The Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology join us to chat about the exciting advances that caught their attention in 2025.

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Adis Journal Podcasts

Podcast
SPONSORED

Updated guidelines for the treatment of anemia in chronic kidney disease

This podcast summarises updated European Renal Best Practice and UK Kidney Association guidelines on treating anemia in CKD. With a focus on hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) as an alternative to erythropoiesis‐stimulating agents, and key considerations for clinical practice.

Sponsored by:
  • Astellas Pharma, Inc.
Podcast

Navigating the treatment of renal cell carcinoma: Insights on the current treatment landscape and managing patient health

In recent years, tremendous efforts have been made in the medical treatment of metastatic renal cell carcinoma (mRCC), with immune-oncological combinations standing as the current standard of care in the first-line setting of mRCC. In these podcasts, expert authors discuss the current treatment landscape for these new therapies and discuss what should be taken into account when choosing the most appropriate treatment for their patients so as to balance outcomes, adverse events and quality of life.

Supported by:
  • Eisai Europe Limited
Podcast

Using CGM to optimize type 2 diabetes management with non-intensive insulin treatment in primary care

With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report. 

Supported by:
  • Abbott Diabetes Care
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