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Schizophrenia 

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  1. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia

    Schizophrenia is a serious psychiatric illness that affects 0.5 -1% of the global population [ 1 ]. The burden of mental illness was estimated to account for 7% of all diseases worldwide in 2016, and nearly 20% of all years lived with disability [ …

  2. 21-04-2024 | Insulinoma | Case Study

    A case of insulinoma misidentified as schizophrenia due to its manifestation in neuropsychiatric symptoms

    Intermittently scanning CGM detected hypoglycemia in a woman previously diagnosed with schizophrenia and treated with antipsychotic medication. Insulinoma was diagnosed and resected, resolving her neuropsychiatric symptoms.

  3. 04-05-2024 | Schizophrenia | Online First

    Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives

    Schizophrenia is a complex and serious brain disorder. Neuroscientists have become increasingly interested in using magnetic resonance-based brain imaging-derived phenotypes (IDPs) to investigate the etiology of psychiatric disorders. IDPs capture …

  4. 16-04-2024 | Schizophrenia | Online First

    Multimorbidity and the Etiology of Schizophrenia

    Medical conditions sometimes co-occur in the same individual. That this co-occurrence is not trivial began to be appreciated several decades ago. The global aging of the world population increased its frequency and hence the interest in this …

  5. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia

    Mental health issues have profound implications for individuals, families, and society, representing a crucial global public health concern [ 1 ]. The ongoing COVID-19 pandemic has heightened these concerns, with emerging evidence indicating an …

  6. 02-04-2024 | Schizophrenia | Online First

    Genetics and Schizophrenia

    Schizophrenia is a polygenic psychotic disorder categorized by positive, negative, and cognitive symptoms. Relative to the general population, individuals with schizophrenia have markedly lower life expectancy, lower reproductive rates, and a …

  7. Open Access 07-05-2024 | Antipsychotics | Online First

    Sex Differences Between Female and Male Individuals in Antipsychotic Efficacy and Adverse Effects in the Treatment of Schizophrenia

    As recommended in guidelines, as well as common clinical practice, antipsychotics are a core component for both the treatment as well as ongoing relapse prevention management of psychotic disorders including schizophrenia [ 1 – 4 ]. While psychotic …

  8. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia

    Evidence suggests that patients with schizophrenia (SCZ) are at a significantly higher risk of violent behavior compared with the general population [ 1 ]. A meta-analysis indicated that the odds ratio (OR) for the comparison of violent behaviors …

  9. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    The role of the immune system in early-onset schizophrenia: identifying immune characteristic genes and cells from peripheral blood

    Schizophrenia (SCZ) is a devastating psychiatric disorder with an unclear etiology and a lifetime prevalence of 1%. It is characterized by significant abnormalities in cognitive function, thinking, emotion, behavior and other aspects of mental …

  10. 25-04-2024 | Schizophrenia | Online First

    Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia

    This study aims to investigate the altered patterns of dynamic functional network connectivity (dFNC) between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS), and further explore the associations with cognitive impairments. 70 DS …

  11. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Longitudinal assessment of ventricular volume trajectories in early-stage schizophrenia: evidence of both enlargement and shrinkage

    Schizophrenia is linked to a wide range of morphometric brain changes in white and gray matter [ 1 , 2 ], with ventricular enlargement being one of the most recognizable macrostructural signatures [ 3 , 4 ]. A recent meta-analysis of …

  12. 12-02-2024 | OriginalPaper

    Hemostasis System in Patients with Schizophrenia and Schizophrenia Spectrum Disorders

    Hemostasis system in patients with schizophrenia and schizophrenia spectrum disorders was examined using “Fibrinodynamics” technology that allows evaluating the overal coagulation, fibrinolysis, and hemostasis potentials. All indices, except for …

  13. Open Access 01-12-2024 | Opioids | OriginalPaper

    Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder

    Opioid analgesic medications have a role in pain management; however, there are potentially serious harms associated with their use [ 1 – 3 ]. Also, there is limited evidence to support their benefit, compared with that of nonopioid medications for …

  14. 15-03-2024 | Schizophrenia | OriginalPaper

    Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia

    Hypofunctioning of NMDA receptors, and the resulting shift in the balance between excitation and inhibition, is considered a key process in the pathophysiology of schizophrenia. One important manifestation of this phenomenon is changes in neural …

  15. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Abnormal ambiguous facial expression recognition in Chinese patients with schizophrenia

    Facial expression recognition is one of the most basic skills of social cognition, serving as the primary means to understand the emotional states of others in daily human interaction [ 1 , 2 ]. Facial expressions represent a complex stimuli that …

  16. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Sex differences in prevalence and clinical correlates of internet addiction among Chinese adolescents with schizophrenia

    Schizophrenia (SCZ) is a severe psychiatric disorder that manifests in several ways, including delusions, hallucinations, disturbed thought processes, cognitive dysfunction, and impairment of social behavior [ 1 ]. SCZ is linked to a considerable …

  17. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    A preliminary metabolomics study of the database for biological samples of schizophrenia among Chinese ethnic minorities

    SCZ is a common, polygenic, and debilitating neurological disease, characterized by chronic psychotic symptoms and socio-psychological impairments [ 1 ]. its prevalence is influenced by race, nationality, and the geographical origins of immigrants …

  18. Open Access 29-03-2024 | Schizophrenia | Online First

    Predictors of adherence to exercise interventions in people with schizophrenia

    Exercise interventions are nowadays considered as effective add-on treatments in people with schizophrenia but are usually associated with high dropout rates. Therefore, the present study investigated potential predictors of adherence from a large …

  19. Open Access 01-12-2024 | Schizophrenia | OriginalPaper

    Clinical experiences of guided tapering of antipsychotics for patients with schizophrenia– a case series

    Antipsychotic medication remains a cornerstone in the management of psychotic symptoms [ 1 , 2 ]. With one in three patients possibly experiencing persistent symptoms despite antipsychotic treatment [ 3 ], the beneficial effect of long-term …

  20. Open Access 01-12-2024 | Clozapine | OriginalPaper

    Multiple serum anti-glutamate receptor antibody levels in clozapine-treated/naïve patients with treatment-resistant schizophrenia

    Approximately 30% of individuals with schizophrenia do not respond to antipsychotic medications, which is known as treatment-resistant schizophrenia (TRS) [ 1 ]. TRS is typically defined as schizophrenia that shows inadequate response to at least …

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