Reactions Weekly 1/2020

Developmental Disorder News item

Educational materials updated for valproate in the UK

News item

EMA to regularly publish DHPCs on its website

News item

Healthcare professionals can use EMIS Web to report ADRs to MHRA

News item

MHRA launches social media campaign on reporting adverse effects

Meningioma News item

PRAC recommends cyproterone restrictions due to meningioma risk

Psoriatic Arthritis News item

Tofacitinib increases risk of VTE and serious infections

Propranolol News item

Toxicity of propranolol overdose under-recognised

Cancer Therapy Clinical study

Cardiovascular adverse events with contemporary cancer therapies

Chlorthalidone Clinical study

Chlorthalidone, hydrochlorothiazide cardiovascular outcomes and safety

Premature Birth Clinical study

Duloxetine increases risk of postpartum haemorrhage

Postpartum Depression Clinical study

General anaesthesia linked with severe postpartum depression

Folic Acid Clinical study

Low-dose methotrexate: risk of skin cancer and GI and pulmonary AEs

Clinical study

Pregnancy and birth outcomes with MenACWY-CRM vaccine

News item

Other adverse reaction research

Human Alphaherpesvirus 3 Case report

Aciclovir

Uveitis Case report

Adalimumab

Aphthous Ulcer Case report

Adalimumab

Isoniazid Case report

Adalimumab

Erythema Nodosum Case report

Adalimumab

Adalimumab Case report

Adalimumab

Crohn's Disease Case report

Adalimumab

Infliximab Case report

Adalimumab/infliximab

Doxycycline Case report

Adalimumab/prednisone

Entecavir Case report

Adefovir/teriparatide

Multiple Sclerosis Case report

Alemtuzumab

Gout Case report

Allopurinol

Gout Case report

Allopurinol

Endocarditis Case report

Allopurinol

Angiography Case report

Allopurinol/everolimus/prednisolone

Ulcerative Colitis Case report

Allopurinol/mercaptopurine interaction

Alteplase Case report

Alteplase

Stroke Case report

Alteplase

Metronidazole Case report

Amikacin/ceftriaxone/metronidazole

Hepatic Encephalopathy Case report

Amiodarone

Metoprolol Case report

Amiodarone

Atrial Fibrillation Case report

Amiodarone

Ventricular Tachycardia Case report

Amiodarone

Shock Case report

Amiodarone/flecainide/sodium-bicarbonate

Magnetic Resonance Cholangio Pancreatography Case report

Amoxicillin

Stevens-Johnson Syndrome Case report

Amoxicillin

Anaphylactic Shock Case report

Amoxicillin/clavulanic-acid

Hepatitis A Case report

Amoxicillin/clavulanic-acid

Vomiting Case report

Amoxicillin/clavulanic-acid

Constipation Case report

Amoxicillin/clavulanic-acid/rifampicin

Ileus Case report

Amoxicillin/cotrimoxazole

Tremor Case report

Amphetamines/serotonin-uptake-inhibitors

Cervical Cancer Case report

Amrubicin

Testosterone Case report

Anabolic steroids abuse

Portal Vein Thrombosis Case report

Anastrozole

Filgrastim Case report

Antiarrhythmics/antineoplastics

Edoxaban Case report

Anticoagulants

Pantoprazole Case report

Antihypertensives

SCLC Case report

Antineoplastics

Patent Ductus Arteriosus Case report

Antineoplastics

Breast Cancer Case report

Antineoplastics

NSCLC Case report

Antineoplastics

Adrenocortical Carcinoma Case report

Antineoplastics

Myelodysplastic Syndrome Case report

Antineoplastics

Metastasis Case report

Antineoplastics

Pleural Effusion Case report

Antineoplastics

Acute Myeloid Leukemia Case report

Antineoplastics

Hyperpigmentation Case report

Antineoplastics/antithymocyte globulin

Insulin Glargine Case report

Antithymocyte-globulin/ciclosporin/prednisolone

Splenectomy Case report

Apixaban

Hematemesis Case report

Apixaban/aspirin

Nausea Case report

Apomorphine

Acetylsalicylic Acid Case report

Aspirin

Tarry Feces Case report

Aspirin

Laryngoscopy Case report

Aspirin/clopidogrel

Anticoagulant Case report

Aspirin/clopidogrel/enoxaparin-sodium

Fentanyl Case report

Aspirin/heparin

Ticagrelor Case report

Aspirin/ticagrelor

Stroke Case report

Atorvastatin

Atorvastatin Case report

Atorvastatin

Atorvastatin Case report

Atorvastatin

Atorvastatin Case report

Atorvastatin

Atorvastatin Case report

Atorvastatin

Magnetic Resonance Cholangio Pancreatography Case report

Atorvastatin/cassia

Magnetic Resonance Cholangio Pancreatography Case report

Atorvastatin/cefazolin

Atorvastatin Case report

Atorvastatin/rosuvastatin

Antiphospholipid Syndrome Case report

Axicabtagene ciloleuce

Azathioprine Case report

Azathioprine

Sarcoidosis Case report

Azathioprine

Azathioprine Case report

Azathioprine

Infliximab Case report

Azathioprine

Tuberculosis Case report

Azathioprine/infliximab

Itraconazole Case report

Azathioprine/infliximab/coticosteroids

Azathioprine Case report

Azathioprine/tacrolimus

Tarry Feces Case report

Azathioprine/tacrolimus

Azathioprine Case report

Azathioprine/tofacitinib

Azithromycin Case report

Azithromycin/ceftriaxone

Lubiprostone Case report

Baclofen

Acute Kidney Injury Case report

Baclofen/vancomycin

Ulcerative Colitis Case report

Balsalazide

Methotrexate Case report

Baricitinib

Kawasaki Disease Case report

BCG vaccine

Everolimus Case report

Belatacept

Cyanosis Case report

Benzocaine

Acute Pancreatitis Case report

Bevacizumab

Bevacizumab Case report

Bevacizumab

Bevacizumab Case report

Bevacizumab

Magnetic Resonance Cholangio Pancreatography Case report

Bictegravir/emtricitabine/tenofovir

Nausea Case report

Bictegravir/emtricitabine/tenofovir-alafenamide

Acute Lymphoblastic Leukemia Case report

Blinatumomab

Hematuria Case report

Botulinum-toxin-A

Crohn's Disease Case report

Budesonide

Adalimumab Case report

Budesonide

Budesonide Case report

Budesonide/corticosteroids/methylprednisolone

Fluconazole Case report

Budesonide/formoterol

Spinal Anesthesia Case report

Bupivacaine

Icterus Case report

Bupivacaine

Ovarian Hyperstimulation Syndrome Case report

Buserelin/urofollitropin

Migraine Case report

Butalbital/paracetamol/caffeine

Case report

Cabazitaxel

Gastroesophageal Reflux Disease Case report

Calcium-carbonate

Diarrhea Case report

Capecitabine

Acute Kidney Injury Case report

Capecitabine

Breast Cancer Case report

Capecitabine/doxorubicin

Gastric Ulcer Case report

Capecitabine/gemcitabine

Metabolic Acidosis Case report

Capecitabine/oxaliplatin

Trigeminal Neuralgia Case report

Carbamazepine

Lung Cancer Case report

Carboplatin/gemcitabine/pembrolizumab

Fifth Disease Case report

Cardiotonics/epinephrine/immune globulin

Sexually Transmitted Infection Case report

Ceftriaxone

Tuberculosis Case report

Certolizumab pegol/infliximab

Piperazine Case report

Chlorphenamine

Ciclosporine Case report

Ciclosporin/mycophenolate-mofetil/prednisone

Ciprofloxacin Case report

Ciprofloxacin

Nausea Case report

Cisplatin/fluorouracil/antiretrovirals

Tachyarrythmia Case report

Cisplatin/gemcitabine/irinotecan

Propranolol Case report

Citalopram/propranolol overdose

Tarry Feces Case report

Clopidogrel

Giant Cell Arteritis Case report

Clopidogrel/methylprednisolone

Clopidogrel Case report

Clopidogrel/warfarin

Schizophrenia Case report

Clozapine

Schizophrenia Case report

Clozapine/fluvoxamine

Lymphoma Case report

Cobicistat/darunavir/emtricitabine/tenofovir

Tenofovir Case report

Cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide

Retinal Detachment Case report

Cobimetinib/vemurafenib

Colchicine Case report

Colchicine

Prednisolone Case report

Colecalciferol

Metronidazole Case report

Colistin/tetanus vaccine

Tarry Feces Case report

Corticosteroids/mycophenolate mofetil

Echocardiography Case report

Corticotropin

Pancreatitis Case report

Cotrimoxazole

Hepatic Encephalopathy Case report

Cotrimoxazole

Case report

Cotrimoxazole

Levofloxacin Case report

Cotrimoxazole

Stem Cell Transplantion Case report

Cytarabine

Levofloxacin Case report

Cytarabine/levofloxacin

Dabigatran Case report

Dabigatran etexilate

Dapagliflozin Case report

Dapagliflozin

Dapagliflozin Case report

Dapagliflozin

Ciprofloxacin Case report

Dapsone

Liver Function Test Case report

Daptomycin

Aspergillosis Case report

Daratumumab

Magnetic Resonance Cholangio Pancreatography Case report

Dasatinib

Cushing's Syndrome Case report

Dexamethasone/morphine/nivolumab

Epileptic Seizure Case report

Diazepam/midazolam/phenytoin

Digoxin Case report

Digoxin/midodrine interaction

Tetanus Case report

Diphtheria-tetanus vaccine

Citalopram Case report

Disulfiram

Antibiotic Case report

Docetaxel

Dementia Case report

Donepezil/mirtazapine/trazodone

Varicosis Case report

Doxorubicin

Rasburicase Case report

Doxorubicin

Doxycycline Case report

Doxycycline/simvastatin

Insulin Glargine Case report

Dronabinol

Liver Function Test Case report

Dronedarone

Nausea Case report

Duloxetine

Fibromyalgia Case report

Duloxetine

Conjunctivitis Case report

Dupilumab

Lung Cancer Case report

Durvalumab/tremelimumab

Alopecia Case report

Dutasteride

Tarry Feces Case report

Edoxaban/warfarin

Irritable Bowel Syndrome Case report

Eluxadoline

Tenofovir Case report

Entecavir/lamivudine/tenofovir-disoproxil-fumarate

Esophagogastroduodenoscopy Case report

Epinephrine

Mastectomy Case report

Epinephrine/ropivacaine

Hepatocellular Carcinoma Case report

Epirubicin/ethiodized-oil/oxaliplatin

Tarry Feces Case report

Eptacog-alfa

Migraine Case report

Erenumab

Esophagitis Case report

Erlotinib

Leukocytoclastic Vasculitis Case report

Ertapenem

Antiepileptic Drugs Case report

Eslicarbazepine-acetate

Migraine Case report

Estradiol/sumatriptan interaction

IgA Vasculitis Case report

Etanercept

Etanercept Case report

Etanercept

Hepatic Adenoma Case report

Ethinylestradiol

Hemophagocytic Lymphohistiocytosis Case report

Etoposide/unspecified steroids

Carcinoid Tumor Case report

Everolimus

Endoscopy Case report

Everolimus

Kidney Cancer Case report

Everolimus

Hypoparathyroidism Case report

Famotidine

Hepatic Encephalopathy Case report

Fenofibrate

Linezolid Case report

Fentanyl/linezolid

Gastritis Case report

Ferrous sulfate

Iron Deficiency Case report

Ferrous-sulfate

Nausea Case report

Ferrous-sulfate overdose

Fexofenadine Case report

Fexofenadine/pseudoephedrine/loratadine/pseudoephedrine

Glaucoma Case report

Fluorouracil

Nitroglycerin Case report

Fluorouracil

Infliximab Case report

Fluorouracil

Diarrhea Case report

Fluorouracil

Rasburicase Case report

Fluorouracil/folinic acid/oxaliplatin

Selective Mutism Case report

Fluoxetine

Breast Cancer Case report

Fulvestrant/palbociclib

Metoprolol Case report

Furosemide

Quetiapine Case report

Garcinia cambogia/quetiapine interaction

Acute Liver Failure Case report

Gemcitabine

Simvastatin Case report

Glecaprevir/pibrentasvir/simvastatin interaction

Glimepiride Case report

Glimepiride/levofloxacin/metformin

Esophagogastroduodenoscopy Case report

Haloperidol/haloperidol decanoate

Prostate Cancer Case report

Heparin

Liver Transplantation Case report

Hydralazine

Hepatic Encephalopathy Case report

Hydralazine/iron

Pulmonary Nodule Case report

Hydrazine

Metoprolol Case report

Hydrochlorothiazide/nebivolol/telmisartan

Paracetamol Case report

Hydrocortisone/prednisolone

Case report

Hydrogen peroxide misuse

Aspiration Pneumonia Case report

Hydromorphone/oxycodone

Hydroxychloroquine Case report

Hydroxychloroquine

Giant Cell Arteritis Case report

Hydroxychloroquine/prednisolone/sulfasalazine

Chronic Lymphocytic Leukemia Case report

Ibrutinib

Acute Pancreatitis Case report

Ibuprofen

Tarry Feces Case report

Ibuprofen

Gastrointestinal Stromal Tumor Case report

Imatinib

Actinic Keratosis Case report

Imiquimod

Glioblastoma Case report

Immune-checkpoint inhibitors

Hydroxychloroquine Case report

Immune-globulin

Ampicillin Case report

Immunosuppressant

Kidney Transplantation Case report

Immunosuppressants

Ciclosporine Case report

Immunosuppressants

Vasculitis Case report

Immunosuppressants

Expectoration Case report

Immunosuppressants

Encephalitis Case report

Immunosuppressants

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab

IgA Vasculitis Case report

Infliximab

IgA Vasculitis Case report

Infliximab

Alopecia Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab/mercaptopurine

Infliximab Case report

Infliximab/methotrexate

Angiography Case report

Iohexol

Vasculitis Case report

Ipilimumab

Nephrectomy Case report

Ipilimumab

Infliximab Case report

Ipilimumab/infliximab/nivolumab

Melanoma Case report

Ipilimumab/nivolumab

Endoscopy Case report

Ipilimumab/nivolumab

Myasthenia Gravis Case report

Ipilimumab/nivolumab

Acute Kidney Injury Case report

Ipilimumab/nivolumab/omeprazole

Infliximab Case report

Ipilimumab/pembrolizumab

Suicide Case report

Iron

Case report

Isavuconazole

Hepatic Encephalopathy Case report

Isoniazid/rifampicin

Isoniazid Case report

Isoniazid/rifampicin

Adalimumab Case report

Isotretinoin

Itraconazole Case report

Itraconazole

Plaque Psoriasis Case report

Ixekizumab

Cystitis Case report

Ketamine

Lamotrigine Case report

Lamotrigine/phenobarbital

Paracetamol Case report

Leflunomide

Leflunomide Case report

Leflunomide/steroids

Multiple Myeloma Case report

Lenalidomide

Tooth Extraction Case report

Levamisole

Meningoencephalitis Case report

Levamisole

Tetraparesis Case report

Levamisole

Status Epilepticus Case report

Levetiracetam/phenytoin

Hypoglycemia Case report

Linagliptin

Nausea Case report

Liraglutide

Cholecystitis Case report

Liraglutide

Liver Function Test Case report

Liraglutide

Leg Ulcer Case report

Liraglutide

Nausea Case report

Lisinopril

Granulomatosis with Polyangiitis Case report

Lisinopril

Tympanotomy Case report

Lisinopril

Ultrasound Case report

Lithium

Cefazolin Case report

Lithium overdose

Losartan Case report

Losartan

Mannitol Case report

Mannitol

Mumps Case report

Measles-and-rubella-virus-vaccine/measles-mumps-and-rubella-virus-vaccine/measles-vaccine

Tarry Feces Case report

Meloxicam

Chronic Inflammatory Bowel Disease Case report

Mesalazine

Myocarditis Case report

Mesalazine

Colchicine Case report

Mesalazine

Ulcerative Colitis Case report

Mesalazine

Giant Cell Arteritis Case report

Methotrexate

Abatacept Case report

Methotrexate

Vasculitis Case report

Methotrexate/mycophenolate

Ciclosporine Case report

Methylprednisolone/prednisolone

Giant Cell Arteritis Case report

Methylprednisolone/prednisolone

Epstein-Barr Virus Case report

Methylprednisolone/prednisone

Ulcerative Colitis Case report

Methylprednisolone/prednisone

Hypersensitivity Pneumonitis Case report

Methylprednisolone/rocuronium-bromide

Case report

Methylthioninium-chloride

Metoprolol Case report

Metoprolol

Metoprolol Case report

Metoprolol

Tarry Feces Case report

Metronidazole

Metronidazole Case report

Metronidazole

Fosfomycin Case report

Metronidazole

Acute Myeloid Leukemia Case report

Midostaurin

Case report

Mitomycin

Case report

Mitragyna speciosa

Radiotherapy Case report

Mogamulizumab

Tramadol Case report

Morphine

Epstein-Barr Virus Case report

Multiple drugs

Isoniazid Case report

Multiple drugs

Paracetamol Case report

Multiple drugs

Lymphoma Case report

Multiple drugs

Terbutaline Case report

Multiple drugs

Ciprofloxacin Case report

Multiple drugs

Subarachnoid Hemorrhage Case report

Multiple drugs

Propranolol Case report

Multiple drugs

Antiepileptic Drugs Case report

Multiple drugs

Clonidine Case report

Multiple drugs

Atorvastatin Case report

Multiple drugs interaction

Diarrhea Case report

Mycophenolate

Ultrasound Case report

Mycophenolate mofetil/prednisolone/tacrolimus

Fluconazole Case report

Mycophenolate mofetil/prednisone/tacrolimus

Nausea Case report

Mycophenolate mofetil/tacrolimus

Endoscopy Case report

Mycophenolate/prednisone/tacrolimus

Septicemia Case report

Mycophenolate/tacrolimus

Merkel Cell Carcinoma Case report

Mycophenolate/tacrolimus

Ribavirin Case report

Mycophenolic-acid/sirolimus

Idiopathic Pulmonary Fibrosis Case report

Nintedanib

Nitrofurantoin Case report

Nitrofurantoin

Anaphylaxis Case report

Nitrous oxide/oxygen

Glioblastoma Case report

Nivolumab

Hepatocellular Carcinoma Case report

Nivolumab

Endoscopy Case report

Nivolumab

Streptococci Case report

Nivolumab

Infliximab Case report

Nivolumab

Aphthous Ulcer Case report

Nivolumab

Pantoprazole Case report

Nivolumab

Erythema Case report

Nivolumab

Melanoma Case report

Nivolumab

Budesonide Case report

Nivolumab

Carvedilol Case report

Nivolumab

Kidney Cancer Case report

Nivolumab

Infliximab Case report

Nivolumab

Magnetic Resonance Cholangio Pancreatography Case report

Nivolumab

Case report

Nivolumab

Esophagitis Case report

Nivolumab

Paracetamol Case report

Nivolumab

Rifaximin Case report

Nonsteroidal-anti-inflammatories/omeprazole

Leptospirosis Case report

Norepinephrine

Norethisterone Case report

Norethisterone

Tarry Feces Case report

Olmesartan-medoxomil

Ultrasound Case report

Olmesartan-medoxomil/valsartan

Omalizumab Case report

Omalizumab

Omeprazole Case report

Omeprazole

Angiography Case report

Ondansetron

Magnetic Resonance Cholangio Pancreatography Case report

Oseltamivir

Naloxone Case report

Oxycodone/oxycodone/naloxone

Enalapril Case report

Pantoprazole

Helicobacter Pylori Case report

Pantoprazole

Paracetamol Case report

Paracetamol

Osteoarthrosis Case report

Paracetamol

Suicide Case report

Paracetamol overdose

Paracetamol Case report

Pazopanib

Eosinophilia Case report

Pazopanib

Acute Lymphoblastic Leukemia Case report

Pegaspargase

Acute Lymphoblastic Leukemia Case report

Pegaspargase

Gout Case report

Pegloticase

Eosinophilia Case report

Pembrolizumab

Acute Pancreatitis Case report

Pembrolizumab

Cushing's Syndrome Case report

Pembrolizumab

Budesonide Case report

Pembrolizumab

Gastritis Case report

Pembrolizumab

Doxycycline Case report

Pembrolizumab

Cystitis Case report

Pentosan polysulfate

Case report

Phentermine

Glaucoma Case report

Phentermine/topiramate

Varicosis Case report

Polidocanol

Photodynamic Therapy Case report

Porfimer sodium

Gentamicin Case report

Potassium hydroxide misuse

Candida Balanitis Case report

Potassium-bromide

Herpes Virus Case report

Prednisolone

Diagnostics in Neurology Case report

Prednisolone

Isoniazid Case report

Prednisolone/rifampicin/isoniazid/pyrazinamide interaction

Isoniazid Case report

Prednisone

Colchicine Case report

Prednisone

Tapentadol Case report

Pregabalin

Atrial Fibrillation Case report

Propafenone

Hepatitis B Case report

Propafenone

ANCA-Associated Vasculitis Case report

Propylthiouracil

Acute Liver Failure Case report

Propylthiouracil

Suicide Case report

Pyridostigmine overdose

Thyroidectomy Case report

Regorafenib

Azathioprine Case report

Rituximab

Pleural Effusion Case report

Rivaroxaban

Liver Transplantation Case report

Rosuvastatin

Etanercept Case report

Secukinumab

Leg Ulcer Case report

Secukinumab

Etanercept Case report

Secukinumab

Gastrointestinal Bleeding Case report

Sevelamer

Hemorrhoids Case report

Sevelamer

Thrombotic Microangiopathy Case report

Sirolimus/tacrolimus

Magnetic Resonance Cholangio Pancreatography Case report

Sitosterol

Candidiasis Case report

Sodium picosulfate

Colonoscopy Case report

Sodium polystyrene sulfonate

Endoscopy Case report

Sodium polystyrene sulfonate

Tarry Feces Case report

Sodium polystyrene sulfonate

Aortic Valve Replacement Case report

Sodium polystyrene sulfonate/warfarin

Hemicolectomy Case report

Sodium-polystyrene-sulfonate

Icterus Case report

Sofosbuvir/velpatasvir/voxilaprevir

Hyperpigmentation Case report

Somatrogon

Urea Cycle Disorder Case report

Sorafenib

Acute Pancreatitis Case report

Sorafenib

Hepatocellular Carcinoma Case report

Sorafenib

Thrush Case report

Sorafenib

Ulcerative Colitis Case report

Sulfasalazine

Anakinra Case report

Sulfasalazine

Vascular Stenosis Case report

Sumatriptan

Tarry Feces Case report

Sunitinib

Pyoderma Gangrenosum Case report

Sunitinib

Thrombotic Thrombocytopenic Purpura Case report

Tacrolimus

Kidney Transplantation Case report

Tacrolimus

Key Symptom Case report

Tacrolimus

Amenorrhoea Case report

Tamoxifen

Mastectomy Case report

Tamoxifen

Etoricoxib Case report

Terbinafine

Hepatorenal Syndrome Case report

Terlipressin

Testosterone Case report

Testosterone misuse

Dyscalculia Case report

Thiamazole

Tirofiban Case report

Tirofiban

Anakinra Case report

Tocilizumab

Brainstem Infarction Case report

Tofogliflozin

Topiramate Case report

Topiramate

Glioma Case report

Trametinib

Melanoma Case report

Trametinib

Azathioprine Case report

Trastuzumab

Breast Cancer Case report

Trastuzumab

Suicide Case report

Trazodone overdose

Case report

Tretinoin

Ileus Case report

Trihexyphenidyl

Helicobacter Pylori Case report

Tripotassium-dicitratobismuthate/tetracycline/metronidazole

Etanercept Case report

Tumour necrosis factor-α inhibitors

Uterine Sarcoma Case report

Ulipristal

Orchitis Case report

Ustekinumab

Crohn's Disease Case report

Ustekinumab

Leukocytoclastic Vasculitis Case report

Ustekinumab

Crohn's Disease Case report

Ustekinumab

Rifaximin Case report

Valproate

Lisinopril Case report

Vancomycin

Basalioma Case report

Vismodegib

Warfarin Case report

Warfarin

Gastrostomy Case report

Warfarin

Erythema Nodosum News item

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Reactions Weekly

Content (454 Articles)