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Thrombotic Thrombocytopenic Purpura 

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  1. Open Access 27-04-2024 | Fatigue | Online First

    Long-term health-related quality of life and mental health in patients with immune thrombotic thrombocytopenic purpura

    Immune thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially life-threatening disorder. Treatment advances have lowered morbidity rates, but past acute events can still cause long-term consequences, reducing health-related quality …

  2. Open Access 01-12-2024 | Thrombotic Thrombocytopenic Purpura | OriginalPaper

    Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients

    Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with a global annual incidence of approximately 1.5–6 per million people and a female predominance [ 1 ]. It has a rapid progression with a mortality rate of untreated …

  3. 09-01-2024 | Thrombotic Microangiopathy | BriefCommunication

    Immune-mediated thrombotic thrombocytopenic purpura: don’t miss the boat

  4. 14-02-2024 | Thrombotic Thrombocytopenic Purpura | Online First

    Importance of Prenatal Genetic Counselling: An Experience with Hereditary Thrombotic Thrombocytopenic Purpura

    Thrombotic thrombocytopenic purpura (TTP) can be explained as very rare and lethal thrombotic microangiopathy which can be characterized by acute thrombocytopenia, microangiopathic haemolytic anaemia, organ ischemia, and a severe deficiency in …

  5. 27-01-2024 | Thrombotic Thrombocytopenic Purpura | OriginalPaper

    Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut

    It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical …

  6. Open Access 01-12-2023 | Systemic Lupus Erythematosus | OriginalPaper

    Concurrence of immune thrombocytopenic purpura and thrombotic thrombocytopenic purpura: a case report and review of the literature

    Immune thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP) are distinct diseases that cause thrombocytopenia. ITP is defined as a platelet count below 100,000 platelets per cubic millimeter, excluding known causes of …

  7. Open Access 01-12-2023 | Stroke | OriginalPaper

    Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI

    Thrombotic thrombocytopenic purpura (TTP) is a rare and fatal thrombotic microangiopathy-based hematologic disease characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, and end organ ischemia (particularly brain, heart and …

  8. Open Access 01-12-2023 | Laser | OriginalPaper

    Reversible skin microvascular hyporeactivity in patients with immune-mediated thrombocytopenic thrombotic purpura

    Acquired or immune-mediated thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by thrombocytopenia and hemolytic anemia [ 1 – 3 ]. Immune TTP is due to the presence of neutralizing anti-ADAMTS-13 …

  9. Open Access 01-12-2023 | Anemia | OriginalPaper

    Two ischemic stroke events within 48 h: a case report of an unusual presentation of thrombotic thrombocytopenic purpura

    Coagulation disorders account for less than 5% of ischemic strokes (IS) [ 1 ]. Thrombotic thrombocytopenic purpura (TTP) is a rare, though severe, inherited or acquired disease caused by severe deficiency of the Von Willebrand factor-cleaving …

  10. 23-10-2023 | Thrombotic Thrombocytopenic Purpura | OriginalPaper

    Magnesium sulphate in patients with thrombotic thrombocytopenic purpura (MAGMAT): a randomised, double-blind, superiority trial

    Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi [ 1 ]. TTP …

  11. Open Access 01-12-2023 | Hepatitis E | OriginalPaper

    A case of acquired thrombotic thrombocytopenic purpura induced by acute severe hepatitis E: successfully treated by plasma exchange and rituximab

    With its low morbidity and high mortality rates, thrombotic thrombocytopenic purpura (TTP) has imposed a critical physical and economic burden on both society and individuals. Thrombocytopenia commonly occurs in severe liver failure, and a variety …

  12. 11-10-2023 | Thrombotic Thrombocytopenic Purpura | OriginalPaper

    The challenging follow-up of pregnancy in women with known thrombotic thrombocytopenic purpura: a single-center experience of a preemptive management protocol

    The family of thrombotic microangiopathies (TMAs) includes a set of rare and potentially life-threatening diseases [ 1 , 2 ]. Within this family, thrombotic thrombocytopenic purpura (TTP) is related to the severe functional deficiency of a …

  13. Open Access 10-09-2023 | Rituximab | OriginalPaper

    Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in Japan 2023

    Thrombotic thrombocytopenic purpura (TTP) can rapidly become a life-threatening condition, and the importance of its appropriate diagnosis and treatment cannot be overstated. Until recently, TTP has mainly been diagnosed by clinical findings such …

  14. 01-07-2023 | Thrombotic Thrombocytopenic Purpura | OriginalPaper

    Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome

    Thrombotic thrombocytopenic purpura (TTP) and the hemolytic and uremic syndrome (HUS) are two forms of thrombotic microangiopathy (TMA). Their clinical and biological presentation includes mechanical hemolytic anemia and consumptive …

  15. Open Access 28-12-2022 | Thrombotic Thrombocytopenic Purpura | ReviewPaper

    Secondary immune-mediated thrombotic thrombocytopenic purpura in idiopathic inflammatory myopathy: a case-based review

    Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal acquired thrombotic microangiopathy syndrome that frequently develops in the context of infectious diseases or systemic autoimmune conditions including connective …

  16. 13-12-2022 | Stroke | OriginalPaper

    Large vessel stroke and isolated thrombocytopenia as presenting features of thrombotic thrombocytopenic purpura

  17. Open Access 01-12-2022 | Venous Thrombosis | OriginalPaper

    Complete recovery of deep venous thrombosis from Coombs (+) thrombotic thrombocytopenic purpura: case report

    Thrombotic thrombocytopenic purpura (TTP) is a rare and potentially fatal hematologic disease. Fifty years ago, before the era of effective treatment, the diagnosis of TTP was based on the progressive appearance of the “pentad” of clinical …

  18. 28-11-2022 | Thrombotic Thrombocytopenic Purpura | Letter

    Real-world experience and considerations on concomitant caplacizumab and anticoagulation in thrombotic thrombocytopenic purpura

  19. 12-08-2022 | Systemic Lupus Erythematosus | ReviewPaper

    Upfront rituximab therapy for thrombotic thrombocytopenic purpura in systemic lupus erythematosus: a case-based review

    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies and deposition of immune complexes on tissues. Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening …

  20. 12-05-2023 | Thrombotic Thrombocytopenic Purpura | OriginalPaper

    N-Acetylcistein for thrombotic thrombocytopenic purpura: an observational case series study

    Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder. N-Acetylcysteine (NAC) rapidly degrades ultra-large von Willebrand factor multimers by disrupting the disulfide bonds. We report a series of twelve consecutive …

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