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Acute Lymphoblastic Leukemia 

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  1. 05-04-2024 | Acute Lymphoblastic Leukemia | Online First

    T-cell acute lymphoblastic leukemia with atypical intracytoplasmic inclusions in the blasts

    In this study, we investigate the utility of flow cytometry as a diagnostic tool for identifying T-cell acute lymphoblastic leukemia (T-ALL). Traditional hematopathological examination has limitations, prompting the need for more accurate …

  2. Open Access 25-04-2024 | Blinatumomab | Online First

    Real-world evidence on treatment pattern, effectiveness, and safety of blinatumomab in Chinese patients with B-cell acute lymphoblastic leukemia

    Blinatumomab is efficacious in patients with B-cell acute lymphoblastic leukemia (B-ALL), yet limited real-world data exists in this context. This retrospective study provided real-world data on the treatment pattern, effectiveness, and safety of …

  3. Open Access 01-12-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    Significance and implications of FHIT gene expression and promoter hypermethylation in acute lymphoblastic leukemia (ALL)

    Among different types of leukemia, acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. As per Surveillance, Epidemiology, and End Results (SEER) program, ALL accounts for ~ 25% of all diagnosed cancers in children up to …

  4. Open Access 01-12-2024 | Blinatumomab | Letter

    Chemo-free treatment of adult patients with Ph-positive acute lymphoblastic leukemia: latest updates from the 2023 ASH annual meeting

    The chemo-free concept represents a new direction for managing adult patients with Ph-positive acute lymphoblastic leukemia (Ph + ALL). The tyrosine kinase inhibitors (TKIs), blinatumomab and venetoclax serve as the backbone of chemo-free …

  5. Open Access 01-12-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

    B-cell acute lymphoblastic leukemia (B-ALL) is a prevalent subtype of leukemia characterized by its highly malignant nature, primarily originating from the clonal expansion and abnormal proliferation of B lymphocytes within the hematopoietic …

  6. Open Access 01-12-2024 | Fatigue | OriginalPaper

    Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study

    Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, and most affected children (> 90%) will become long-term survivors [ 1 , 2 ]. With improved survivorship, a focus on quality-of-life outcomes, including the late effects of …

  7. Open Access 01-12-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    Extracellular matrix protein 1 (ECM1) is a potential biomarker in B cell acute lymphoblastic leukemia

    B cell acute lymphoblastic leukemia (ALL) is characterized by the highly heterogeneity of pathogenic genetic background, and there are still approximately 30–40% of patients without clear molecular markers. To identify the dysregulated genes in B …

  8. 29-11-2023 | Acute Kidney Injury | OriginalPaper

    Extramedullary relapsed acute lymphoblastic leukemia presenting as asymptomatic acute kidney injury after hematopoietic stem cell transplantation

    Acute kidney injury (AKI) is a common complication in children with hematological malignancies. Although AKI due to infiltration of tumor cells in children is rare, it negatively impacts treatment outcomes and increases the risk of mortality. We …

  9. Open Access 01-12-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    Diagnostic significance of cerebrospinal fluid flow cytometry in Chinese children with B lineage acute lymphoblastic leukemia

    Central nervous system leukemia (CNSL) is extramedullary leukemia caused by the infiltration of leukemia cells into the meninges, cranial nerves, brain tissue, or spinal cord, which is common in patients with acute leukemia, especially in those …

  10. 29-02-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    Predictive factors for l-asparaginase hypersensitivity in pediatric acute lymphoblastic leukemia

    Acute lymphoblastic leukemia (ALL) is a most common cancer in children, globally accounting for 30% of all childhood cancer [ 1 ]. The Thai Pediatrics Oncology Group (ThaiPOG) has previously reported that an incidence of childhood ALL in Thailand …

  11. 12-04-2024 | Acute Lymphoblastic Leukemia | Online First

    Upfront allogeneic hematopoietic stem cell transplantation for adult T-cell acute lymphoblastic leukemia/lymphoma in first complete remission: a single-center study

    Background: Real-world data on outcomes of upfront allogeneic hematopoietic stem cell transplantation (allo-HCT) for adult T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) patients in first complete remission (CR1) is still lacking. Methods: A …

  12. Open Access 08-03-2024 | Acute Lymphoblastic Leukemia | Letter

    Inotuzumab in Older Patients with Newly Diagnosed Acute Lymphoblastic Leukemia—A Podcast

    Older patients with acute lymphoblastic leukemia (ALL) have historically had poor outcomes (5-year survival rate, 20%) with standard intensive and dose-adjusted chemotherapy regimens, due to a high incidence of adverse biologic features including …

  13. Open Access 01-03-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity

    B-acute lymphoblastic leukemia (B-ALL), the most common malignancy in children, is an affliction of uncontrolled B lymphocyte proliferation in the bone marrow (Terwilliger and Abdul-Hay 2017 ). Although combination chemotherapy has achieved …

  14. Open Access 01-06-2024 | Filgrastim | OriginalPaper

    Associations of granulocyte colony-stimulating factor with toxicities and efficacy of chimeric antigen receptor T-cell therapy in relapsed or refractory B-cell acute lymphoblastic leukemia

    Few studies have reported the associations of granulocyte colony-stimulating factor (G-CSF) with cytokine release syndrome (CRS), neurotoxic events (NEs) and efficacy after chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory …

  15. 25-01-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    TBI, etoposide, and cyclophosphamide conditioning for intermediate-risk relapsed childhood acute lymphoblastic leukemia

    Although treatment outcomes of children with relapsed acute lymphoblastic leukemia (ALL) have improved in recent years, they are still unsatisfactory. Time to relapse, immunophenotype, and relapse site are the well-established prognostic factors …

  16. 13-04-2024 | Blinatumomab | Online First

    Impact of minimal residual disease response and of status of disease on survival after blinatumomab in B-cell acute lymphoblastic leukemia: results from a real-life study

    Blinatumomab is a bispecific T-cell engager approved for relapsed/refractory and minimal residual disease positive B-cell Acute Lymphoblastic Leukemia. We conducted a retrospective study evaluating the outcome of Blinatumomab. The impact of …

  17. 16-03-2024 | Blinatumomab | Online First

    Isolated salivary gland extramedullary relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia during blinatumomab treatment

  18. 07-03-2024 | Acute Lymphoblastic Leukemia | Online First

    Mutations of epigenetic modifier genes predict poor outcome in adult acute lymphoblastic leukemia

    Epigenetic modifier (EM) genes play important roles in the occurrence and progression of acute lymphoblastic leukemia (ALL). However, the prognostic significance of EM mutations in ALL has not yet been thoroughly investigated. This retrospective …

  19. Open Access 01-12-2024 | Acute Lymphoblastic Leukemia | OriginalPaper

    CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia

    Acute Lymphoblastic Leukemia (ALL) is a hematological tumor arising from lymphoid progenitor cells of B-lineage or T-lineage [ 1 ], which due to abnormal growth of CD19 + precursor B cells and subsequent inhibition of normal hematopoiesis …

  20. 18-03-2024 | Acute Lymphoblastic Leukemia | Online First

    Relationship between subtype-specific minimal residual disease level and long-term prognosis in children with acute lymphoblastic leukemia

    Minimal residual disease (MRD) based risk stratification criteria for specific genetic subtypes remained unclear in childhood acute lymphoblastic leukemia (ALL). Among 723 children with newly diagnosed ALL treated with the Chinese Children …

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