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934 search results for:

Chlorthalidone 

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  1. Open Access 01-12-2022 | Chlorthalidone | OriginalPaper

    Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4–5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial

    Approximately 85% of patients with advanced chronic kidney disease (glomerular filtration rate < 30 ml/min) suffer from hypertension mostly as a result of volume increase [ 1 ]. Given that volume overload is the primary contributing factor to the …

  2. 01-02-2022 | Metoprolol | OriginalPaper

    Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study

    Hypertension is a key contributor to the global disease burden and a predominant cause of morbidity and mortality related to cardiovascular diseases [ 1 , 2 ]. In India, a high prevalence of hypertension is observed across all age groups, affecting …

  3. Open Access 01-12-2020 | Chlorthalidone | ReviewPaper

    Combining angiotensin receptor blockers with chlorthalidone or hydrochlorothiazide – which is the better alternative? A meta-analysis

    Hypertension is a major global public-health challenge affecting approximately 1 billion individuals worldwide, with a projection to increase to 1.56 billion by 2025 given the increasingly aging population [ 1 ]. Hypertension is a disease with …

  4. 01-04-2021 | Losartan | Erratum

    Correction to: Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial

    A correction to this paper has been published: https://doi.org/10.1007/s00592-021-01689-8.

  5. 01-02-2021 | Losartan | OriginalPaper

    Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial

    The European Society of Cardiology (ESC)/European Society of Hypertension (ESH) 2018 Guidelines for management of hypertension recommend renin-angiotensin system blockers as preferential agents for the management of hypertension in patients with …

  6. Open Access 01-12-2019 | Chlorthalidone | OriginalPaper

    Efficacy of chlorthalidone and hydrochlorothiazide in combination with amiloride in multiple doses on blood pressure in patients with primary hypertension: a protocol for a factorial randomized controlled trial

    Thiazide diuretics have been commonly used as pharmacological agents for the treatment of hypertension for over five decades [ 1 , 2 ], remaining the cornerstone of antihypertensive treatment due to their favorable blood pressure (BP) lowering …

  7. 01-02-2020 | Chlorthalidone | News

    Chlorthalidone, hydrochlorothiazide cardiovascular outcomes and safety

  8. Open Access 01-12-2018 | Letter

    Chlorthalidone, not hydrochlorothiazide, is the right diuretic for comparison

    We have read the study design “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: …

  9. Open Access 01-12-2014 | Abstract

    PO-09 Spironolactone as Add-On Therapy to Chlorthalidone Improves Endothelial Function, Arterial Stiffness and Insulin Resistance in European and African American Patients with Essential Hypertension — A Double-Blind Placebo-Controlled Randomized Study

    Diuretics have been shown to have a neutral effect on cardiovascular (CV) biomarkers like arterial stiffness and endothelial function despite their blood pressure (BP) lowering effect. Thiazide diuretics generally have harmful effects on glucose …

  10. 01-08-2016 | OriginalPaper

    Evaluation of a Pharmacokinetic Interaction between Telmisartan and Chlorthalidone in Healthy Male Adult Subjects

    Telmisartan, an angiotensin II receptor antagonist, inhibits angiotensin II-induced vasoconstriction and aldosterone-releasing activity by selective binding to the AT 1 receptor in a variety of tissues, including the heart, kidneys, adrenal gland …

  11. 01-09-1997 | Abstract

    Chlorthalidone/furosemide

    Acute tubular necrosis in an elderly patient: case report
  12. 01-08-1998 | Abstract

    Chlorthalidone

    First report of fever: case report
  13. 01-06-2005 | OriginalPaper

    A Randomised Comparison of the Effects of Nebivolol and Atenolol with and without Chlorthalidone on the Sexual Function of Hypertensive Men

    Background and objective: Erectile dysfunction, which is common in men with hypertension, has been reported as a common adverse effect of many antihypertensive drug classes, including β-blockers and diuretics. Atenolol and nebivolol are both …

  14. Open Access 01-12-2018 | OriginalPaper

    S-amlodipine plus chlorthalidone vs. S-amlodipine plus telmisartan in hypertensive patients unresponsive to amlodipine monotherapy: study protocol for a randomized controlled trial

    Hypertension is the most prevalent disease worldwide and a leading cause of cardiovascular mortality and morbidity [ 1 ]. Its treatment has proven prolonging survival and reducing ischemic heart disease and stroke [ 2 ].

  15. 01-10-2013 | ReviewPaper

    Chlorthalidone: Mechanisms of Action and Effect on Cardiovascular Events

    How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may …

  16. 01-08-2008 | OriginalPaper

    Should chlorthalidone be the diuretic of choice for antihypertensive therapy?

    For decades, diuretic therapy has been a cornerstone in treating hypertension, an approach supported by multiple randomized controlled trials demonstrating reduced morbidity and mortality from cardiovascular events. Yet controversy persists …

  17. 01-04-2015 | ReviewPaper

    Not Just Chlorthalidone: Evidence-Based, Single Tablet, Diuretic Alternatives to Hydrochlorothiazide for Hypertension

    Accounting for 15 % of deaths worldwide, hypertension is often treated with hydrochlorothiazide (HCTZ) (50 million prescriptions annually). HCTZ has a <24-h duration of action, is less potent than chlorthalidone and all major antihypertensive drug …

  18. 01-09-2000 | BriefCommunication

    Major cardiovascular events in hypertensive patients randomized to doxazosin versus chlorthalidone

  19. 01-12-2012 | ReviewPaper

    Which Diuretic Is the Preferred Agent for Treating Essential Hypertension: Hydrochlorothiazide or Chlorthalidone?

    Since their introduction over 50 years ago thiazide and thiazide-like diuretics have been a mainstay in the treatment of hypertension. Yet despite outcome evidence with chlorthalidone, the preponderance of usage has been with …

  20. 01-08-2013 | OriginalPaper

    Hydrochlorothiazide compared to chlorthalidone in reduction of urinary calcium in patients with kidney stones

    Prevention of recurrent calcium stone disease includes treatment with thiazide and thiazide-type diuretics to reduce urinary calcium (UCa) levels, with the reduction in UCa correlating with risk of stone recurrence. There has been a recent trend …

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