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Hepatitis B 

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  1. Open Access 21-02-2024 | Hepatitis B | ReviewPaper

    Hepatitis B Virus Elimination Strategies

    Globally, hepatitis B virus (HBV) is a major health problem, with an estimated 257.5 million people infected (3.23% of the population in 2022) and 820,000 deaths in 2019 [ 1 •, 2 ]. Progress in global vaccine distribution and improved antiviral …

  2. 26-02-2024 | Hepatitis B | ReviewPaper

    Management of Hepatitis B in Pregnancy

    Hepatitis B virus (HBV) remains a significant public health problem, with an estimated 296 million people worldwide living with chronic hepatitis B (CHB) and 1.5 million new cases each year [ 1 ]. Within this population, approximately 65 million …

  3. Open Access 01-12-2024 | Diffuse Large B-Cell Lymphoma | OriginalPaper

    Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma

    About 16% of human cancers are linked to infectious agents, predominantly due to viral and bacterial infections [ 1 ]. Chronic hepatitis C (CHC) virus infection, primarily affecting the liver, also poses systemic risks, significantly increasing the …

  4. 01-05-2024 | Hepatitis B | OriginalPaper

    miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2

    Transcription of the covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is subject to dual regulation by host factors and viral proteins. MicroRNAs (miRNAs) can regulate the expression of target genes at the post-transcriptional …

  5. Open Access 01-12-2024 | OriginalPaper

    Hepatitis B virus infection among illegal drug users in Enugu State, Nigeria: prevalence, immune status, and related risk factors

    Hepatitis B virus infection is a global health challenge that jeopardizes public health and security. An estimated 296 million people worldwide are living with chronic HBV infection, and each year 1.5 million new infections and 1.2 million …

  6. 24-04-2024 | Hepatitis B | Online First

    Inpatient Cost Burdens of Treating Chronic Hepatitis B in US Hospitals: A Weighted Analysis of a National Database

    Hepatitis B is a vaccine-preventable illness that constitutes a relatively smaller proportion of liver disease in the United States compared to other liver disease etiologies [ 1 ]. Despite the relatively low incidence of chronic hepatitis B (CHB) …

  7. Open Access 01-12-2024 | Hepatitis B | OriginalPaper

    Hepatitis B virus reactivation in hepatocellular carcinoma patients after hepatic arterial infusion chemotherapy combined with and without immunotherapy

    Liver cancer is a frequently occurring malignant tumor worldwide, with approximately 70% of new cases found in Asia alone [ 1 ]. The most prevalent form of liver tumor is hepatocellular carcinoma (HCC), which makes up 80% of cases and is typically …

  8. 23-04-2024 | Autoimmune Hepatitis | Online First

    Hepatic and Extrahepatic Characteristics of Autoimmune Hepatitis: A 23-year Hospital-Based Cohort Study

    Autoimmune hepatitis (AIH) is a necroinflammatory liver disease that occurs in patients of all ages [ 1 ]. AIH is a prototypical autoimmune disease with a female predominance. The etiology of AIH remains mostly unresolved but likely results from …

  9. Open Access 01-12-2024 | Hepatitis B | OriginalPaper

    Characteristics and clinical treatment outcomes of chronic hepatitis B children with coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg

    Despite the implementation of universal vaccination programs, hepatitis B virus (HBV) infection of children remains a significant global public health challenge [ 1 – 3 ]. According to the report from WHO in 2015, the prevalence of hepatitis B

  10. Open Access 01-05-2024 | Hepatitis B | OriginalPaper

    Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022

    Missense mutations in certain small envelope proteins diminish the efficacy of antibodies. Consequently, tracking the incidence and types of vaccine-escape mutations (VEMs) was crucial both before and after the introduction of universal hepatitis

  11. 23-02-2024 | Hepatitis B | ReviewPaper

    When to Stop Antiviral Therapy in HBeAg-Negative Patients with Chronic Hepatitis B?

    Chronic hepatitis B virus (HBV) infection is a serious global health issue with a potential risk of adverse sequelae, including hepatic decompensation, cirrhosis, and/or hepatocellular carcinoma (HCC). Hepatitis activity and related events in …

  12. Open Access 10-02-2024 | Hepatitis B | ReviewPaper

    Perspective on Emerging Therapies to Achieve Functional Cure of Chronic Hepatitis B

    Despite the availability of a safe and effective vaccine for over four decades, the global health burden of hepatitis B virus (HBV) infection remains high. Recent estimates suggest there are ~ 300 million people with chronic infection resulting in …

  13. Open Access 01-12-2024 | Hepatitis B | OriginalPaper

    A care coordination program to support patients with hepatitis B virus at Kaiser Permanente Mid-Atlantic States

    Hepatitis B is a vaccine-preventable infection of the liver which impacts > 880,000 people within the United States and 296 million people worldwide [ 1 ]. The hepatitis B virus (HBV) can be transmitted perinatally, through blood-to-blood contact …

  14. Open Access 01-12-2024 | Hepatitis B | OriginalPaper

    Survey of lived experiences and challenges in hepatitis B management and treatment

    Almost 300 million people are living with chronic hepatitis B infection worldwide and most remain undiagnosed and at risk for liver cancer. In 2015 the World Health Organization (WHO) developed guidelines for the prevention, care, and treatment of …

  15. 28-02-2024 | Hepatitis C | Report

    Birth Outcomes Among People with Hepatitis C in Pregnancy — Three U.S. States, 2018–2021

    The incidence of hepatitis C virus (HCV) infection in reproductive-aged adults in the United States has risen in parallel with injection drug use associated with the opioid crisis.(Centers for Disease Control and Prevention, 2023 ) Universal …

  16. Open Access 28-02-2024 | Hepatitis B | ReviewPaper

    A Review of Hepatitis B Reactivation Risk on Immunosuppressants with a Focus on Newer Immunomodulators

    Hepatitis B virus (HBV) infection is a public health threat worldwide that can result in chronic hepatitis with progression to liver cirrhosis and/or cancer [ 1 ]. It is estimated that 3.2% of the global population lives with chronic HBV, amounting …

  17. 13-04-2024 | Autoimmune Hepatitis | Online First

    Succinic Acid Ameliorates Concanavalin A-Induced Hepatitis by Altering the Inflammatory Microenvironment and Expression of BCL-2 Family Proteins

    Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease that currently lacks feasible drug treatment methods. Our study aimed to evaluate the protective effect of succinic acid against AIH and provide a reliable method …

  18. Open Access 08-04-2024 | Hepatitis C | Online First

    Reactivation of hepatitis C virus caused by steroid monotherapy for sudden deafness

    Hepatitis C virus (HCV) reactivation has been reported to be caused due to several anticancer drugs and immunosuppressive agents; however, HCV reactivation after steroid monotherapy has rarely been reported. Here, we report the case of a …

  19. Open Access 01-12-2024 | Hepatitis B Vaccination | OriginalPaper

    Peg-IFNα combined with hepatitis B vaccination contributes to HBsAg seroconversion and improved immune function

    Hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma (HCC), posing a serious global public health problem [ 1 ]. Previous findings showed that hepatitis B surface antigen (HBsAg) seroclearance resulted in …

  20. Open Access 01-12-2024 | Entecavir | OriginalPaper

    Hepatitis B relapse after entecavir or tenofovir alafenamide cessation under anti-viral prophylaxis for cancer chemotherapy

    Because the covalently closed circular DNA of HBV serves as a template for viral replication, patients with both cancer and HBV are at risk of HBV reactivation (HBVr) when they undergo cytotoxic or immunosuppressive therapy, and this risk is …

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