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Acute Liver Failure 

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  1. 09-05-2024 | Acute Liver Failure | Online First

    Overview of acute liver failure in India

    Acute liver failure (ALF) is an infrequent, but serious complication subsequent to severe acute liver injury (sALI) due to various hepatotoxic agents such as hepatotropic virus(es) and drugs such as anti-tubercular medications, paracetamol …

  2. 01-05-2024 | Acute Liver Failure | Online First

    Acute liver failure in pregnancy

    Liver function abnormalities are noted in a minority of pregnancies with multiple causes for the same. A small proportion of these develop severe liver injury and progress to acute liver failure (ALF). There is a discrete set of etiology for ALF …

  3. 07-05-2024 | Acute Liver Failure | Online First

    Acute liver failure histopathology: A 5-year retrospective study

    As per the American Association for the Study of Liver Disease (AASLD), acute liver failure (ALF) in adults is defined as a severe liver injury characterized by evidence of coagulation abnormality and encephalopathy, in a patient who does not have …

  4. 27-04-2024 | Acute Liver Failure | Online First

    Changing etiological spectrum of acute liver failure

    Acute liver failure (ALF) is an uncommon but potentially dramatic syndrome characterized by massive hepatic necrosis and has a very high mortality rate of 50% to 75% without liver transplantation (LT) [ 1 , 2 ]. In the Indian perspective …

  5. 30-04-2024 | Acute Liver Failure | Online First

    Dengue-related acute liver failure—A scoping review

    Infection by dengue virus is common in tropical countries. Hepatic involvement in dengue can range from asymptomatic elevation of transaminases to life-threatening acute liver failure (ALF). Dengue-related ALF (DALF) is responsible for significant …

  6. 05-04-2024 | Acute Liver Failure | Online First

    Acute kidney injury in acute liver failure: A narrative review

    Acute kidney injury (AKI) is a frequent complication of acute liver failure (ALF) and it worsens the already worse prognoses of ALF. ALF is an uncommon disease, with varying etiologies and varying definitions in different parts of the world. There …

  7. 11-03-2024 | Acute Kidney Injury | ReviewPaper

    Acute Kidney Injury in Acute on Chronic Liver Failure Versus Decompensated Cirrhosis—What Is the Difference?

    Cirrhosis and acute on chronic liver failure (ACLF) often complicates with development of acute kidney injury (AKI). Spectrum of AKI include hepatorenal syndrome AKI (HRS AKI) and non AKI hepatorenal syndrome (HRS-NAKI). NAKI HRS is further …

  8. Open Access 01-12-2024 | OriginalPaper

    Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice

    Hepatic encephalopathy (HE) is a neuropsychiatric abnormality in patients with acute or chronic liver diseases. These patients develop a progressive hypokinetic rigid syndrome that is termed as “hepatic parkinsonism or cirrhosis-related …

  9. Open Access 30-04-2024 | Acute Liver Failure | Online First

    Clinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China

    Neonatal acute liver failure (NALF), as a rare disease with high mortality, has limited relevant literature reports in China. We attempted to analyze a NALF cohort to improve the prognosis of this disease. We included all patients diagnosed with …

  10. 26-04-2024 | Acute Liver Failure | Online First

    Difficult transplant decisions in acute liver failure —Benefit versus futility, where to draw a line

    A 39-year-old lady presented with history of jaundice for two days and altered sensorium for one day. Initial testing demonstrated a deranged liver function (LF) with coagulopathy and raised arterial ammonia (Table 1 ). Parameters Received in ICU …

  11. 05-04-2024 | Acute Liver Failure | Online First

    Critical care management of acute liver failure

    The management of acute liver failure (ALF) in modern hepatology intensive care units (ICU) has improved patient outcomes. Critical care management of hepatic encephalopathy, cerebral edema, fluid and electrolytes; prevention of infections and …

  12. 27-04-2024 | Acute Liver Failure | Online First

    Difficult extubation following recovery from acute liver failure: Use of point-of-care critical care assessment

  13. Open Access 01-12-2024 | Acute Liver Failure | OriginalPaper

    The burden and predictors of 30-day unplanned readmission in patients with acute liver failure: a national representative database study

    Acute liver failure (ALF) is the generic term used to describe the rapid development of severe liver dysfunction in the absence of preexisting liver diseases, mainly manifesting as coagulopathy and hepatic encephalopathy (HE) [ 1 ]. Paracetamol …

  14. 05-04-2024 | Acute Kidney Injury | Online First

    APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure

    Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are …

  15. 26-03-2024 | Amlodipine | OriginalPaper

    Acute High-Output Heart Failure with Pulmonary Hypertension and Severe Liver Injury Caused by Amlodipine Poisoning: A Case Report

    Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring …

  16. 01-05-2024 | Acute Liver Failure | Online First

    Plasma exchange improves survival in acute liver failure - An updated systematic review and meta-analysis focussed on comparing within single etiology

    Acute liver failure (ALF) leads to systemic inflammation and organ failures resulting in high mortality [ 1 ]. Although urgent liver transplantation (LT) improves survival, it may not always be available or feasible [ 1 ]. Therapeutic plasma …

  17. Open Access 25-03-2024 | Acute Kidney Injury | Online First

    Intraoperative kidney replacement therapy in acute liver failure

    Paediatric acute liver failure (PALF) is often characterised by its rapidity of onset and potential for significant morbidity and even mortality. Patients often develop multiorgan dysfunction/failure, including severe acute kidney injury (AKI).

  18. 26-03-2024 | Acute Liver Failure | Online First

    Extra-corporeal non-liver transplant therapies for acute liver failure: Focus on plasma exchange and continuous renal replacement therapy

    The acute inflammatory milieu in patients with acute liver failure (ALF) results in ‘toxic’ blood in these patients. In vitro experiments have shown that the plasma obtained from ALF patients is toxic to rabbit hepatocytes and inhibits …

  19. 17-04-2024 | Liver Transplantation | Online First

    Prediction of mortality from hepatitis A virus-related acute liver failure in children—Do we have the perfect prognostic model?

  20. 22-02-2024 | Liver Transplantation | OriginalPaper

    A novel prognostic model to predict mortality in patients with acute-on-chronic liver failure in intensive care unit

    Acute-on-chronic liver failure (ACLF) implies high short-term mortality rates and usually requires intensive care unit (ICU) admission. Proper prognosis for these patients is crucial for early referral for liver transplantation. The superiority of …

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