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Giant Cell Arteritis 

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  1. 20-05-2024 | Giant Cell Arteritis | News | Article

    Temporal artery ultrasound efficient for diagnosis of giant cell arteritis

    An ultrasound-first strategy can diagnose giant cell arteritis rapidly and effectively, and avoid the need for temporal artery biopsy in around two-fifths of cases.

  2. Open Access 13-05-2024 | Giant Cell Arteritis | Online First

    Cranial and extracranial manifestations of giant cell arteritis: a single-center observational study

    Giant cell arteritis (GCA) belongs to the group of large vessel vasculitis according to the 2012 International Chapel Hill Consensus Conference nomenclature [ 1 ]. The pooled incidence of GCA is 10 cases per 100,000 individuals aged 50 years and …

  3. 13-03-2024 | Giant Cell Arteritis | Online First

    Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis

    Immunological mechanisms through the activation of CD4-positive T-cells have been assumed to be involved in the pathogenesis of giant cell arteritis (GCA). Many studies employing frozen tissues of temporal artery biopsy, peripheral blood …

  4. 19-03-2024 | Giant Cell Arteritis | Online First

    Giant cell arteritis: insights from a monocentric retrospective cohort study

    Giant cell arteritis (GCA), more common in Northern European populations, has limited data in Arabcountries. Our study reports GCA’s clinical manifestations in Jordan and reviews published research on GCA across Arab nations. In this retrospective …

  5. Open Access 01-12-2024 | Giant Cell Arteritis | OriginalPaper

    Apolipoproteins and the risk of giant cell arteritis—a nested case–control study

    The etiology of giant cell arteritis (GCA) is not fully understood. Studies of predictors are therefore of major interest. A meta-analysis of observational studies demonstrated that patients with GCA have a significantly reduced prevalence of …

  6. Open Access 01-02-2024 | Giant Cell Arteritis | OriginalPaper

    Glucocorticoid discontinuation rate and risk factors for relapses in a contemporary cohort of patients with giant cell arteritis

    The rates of relapses and therapy discontinuation in patients with giant cell arteritis (GCA) in the modern therapeutic era have not been defined. We aimed to evaluate the glucocorticoid (GC) discontinuation rate and the factors associated with …

  7. Open Access 05-01-2024 | Giant Cell Arteritis | OriginalPaper

    Trends in health care of patients with vasculitides, including giant cell arteritis, Takayasu arteritis, ANCA-associated vasculitis and Behçet’s disease: cross-sectional data of the German National Database 2007–2021

    The aim of this study is to present the current care situation of patients with giant cell arteritis (GCA), Takayasu arteritis (TAK), ANCA-associated vasculitis (AAV) and Behçet’s disease (BD). Trends over the last 15 years will reflect …

  8. Open Access 01-12-2024 | Giant Cell Arteritis | OriginalPaper

    Usefulness of 18F-FDG PET-CT for assessing large-vessel involvement in patients with suspected giant cell arteritis and negative temporal artery biopsy

    Current evidence shows that giant cell arteritis (GCA) is much more than a cranial disease, as it has a much broader and heterogeneous clinical spectrum than previously thought. Generally, it exhibits a typical clinical picture consisting of …

  9. Open Access 15-05-2023 | Giant Cell Arteritis | Case Study

    Tongue necrosis secondary to giant cell arteritis, successfully treated with tocilizumab: a case report

    The first case study of a patient with refractory giant cell arteritis, presenting with tongue necrosis that had rapid improvement with tocilizumab.

  10. Open Access 01-12-2024 | Giant Cell Arteritis | OriginalPaper

    The Meteoritics Trial: efficacy of methotrexate after remission-induction with tocilizumab and glucocorticoids in giant cell arteritis—study protocol for a randomized, double-blind, placebo-controlled, parallel-group phase II study

  11. 11-01-2024 | Giant Cell Arteritis | Online First

    Reproducibility and accuracy of vessel wall MRI in diagnosing giant cell arteritis: a study with readers of varying expertise

    Giant cell arteritis (GCA) is an idiopathic medium- and large-vessel vasculitis that commonly affects individuals over 50 years, particularly women, with a peak incidence between 70 and 80 years old [ 1 , 2 ]. It typically involves the branches of …

  12. 11-10-2023 | Giant Cell Arteritis | OriginalPaper

    The impact of month and season on the incidence of giant cell arteritis: an Intelligent Research in Sight (IRIS) Registry analysis

    Giant cell arteritis (GCA) is an idiopathic vasculitis of the medium and large arteries, and, given its risk for irreversible vision loss, represents a true ophthalmic emergency [ 1 ]. In the hopes of clarifying the etiology and facilitating …

  13. Open Access 01-08-2023 | Giant Cell Arteritis | OriginalPaper

    Assessment and comparison of probability scores to predict giant cell arteritis

    Giant cell arteritis (GCA) is the most common primary systemic vasculitis in adult patients [ 1 ]. GCA usually occurs over the age of 50 years, with a peak incidence at 80 years of age [ 2 , 3 ]. The lifetime risk of developing GCA is 1% in women …

  14. Open Access 31-08-2023 | Giant Cell Arteritis | BriefCommunication

    Diagnostic delay in patients with giant cell arteritis: results of a fast-track clinic

    Giant cell arteritis (GCA) can lead to severe complications if left untreated. The aim of this study was to describe time from onset of symptoms to diagnosis and treatment in GCA suspected patients in a fast-track clinic (FTC), and secondarily to …

  15. Open Access 01-12-2023 | Giant Cell Arteritis | OriginalPaper

    Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis

    Giant cell arteritis (GCA) is a systemic inflammatory vasculitis of unknown etiology that occurs in the elderly and causes a wide variety of systemic, neurologic, and ophthalmologic symptoms. The Chapel Hill Consensus Conference 2012 definition [ 1 …] classifies GCA as a primary large-vessel vasculitis (LVV), along with Takayasu arteritis (TAK). The clinical characteristics of GCA and TAK are distinct; GCA develops in people over the age of 50 years and is common in Western countries, whereas TAK usually develops in those below 40 years and is common in Japan, China, India, Turkey, Mexico, and South America. Moreover, GCA is related to human leukocyte antigen (HLA)-class I and II alleles, while TAK relates to HLA-class I alleles [

  16. Open Access 01-12-2023 | Arteritis | OriginalPaper

    [18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis

    Giant-cell arteritis (GCA) is the most frequent systemic vasculitis among people over 50 years of age [ 1 ]. This disease is estimated to affect more than 3 million people by 2050 [ 2 ]. Aortitis is diagnosed in 40–80% of GCA patients and is …

  17. 13-11-2023 | Giant Cell Arteritis | Online First

    Simultaneous pericardial and pleural effusion as a rare first manifestation of giant cell arteritis

    A 62-year-old male was admitted to our clinic with complaints of stabbing chest pain and progressive dyspnea for 2 weeks. The patient’s medical history was unremarkable. Physical examination revealed diminished bibasilar lung sounds on …

  18. 15-08-2023 | Cough | Letter

    PET FDG CT is useful for giant-cell arteritis with isolated cough

    Giant cell arteritis (GCA) is a chronic vasculitis of large- and medium-sized vessels. The most frequent symptoms are temporal headaches, scalp tenderness, jaw claudication and polymyalgia rheumatica in 35% of patients. Atypical presentation with …

  19. Open Access 01-12-2023 | Giant Cell Arteritis | OriginalPaper

    A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of sarilumab in patients with giant cell arteritis

    Giant cell arteritis (GCA) is the most common primary systemic vasculitis in people above 50 years of age and is more frequently reported in Caucasians and in females [ 1 , 2 ]. More than 3 million people are expected to be diagnosed with GCA by …

  20. 01-07-2023 | Giant Cell Arteritis | OriginalPaper

    Giant cell arteritis: the skin as the key to the diagnosis

    An 82-year-old male patient with HIV-1 infection with undetectable viral load was seen at the Neurology Outpatient clinic due to fluctuating binocular diplopia and difficulty in feeding interpreted as dysphagia. An initial diagnosis of ocular and …

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