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Cancer Therapy 

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  1. 01-05-2024 | Cancer Therapy | ReviewPaper

    Ferroptosis is an effective strategy for cancer therapy

    Ferroptosis is a form of intracellular iron-dependent cell death that differs from necrosis, autophagy and apoptosis. Intracellular iron mediates Fenton reaction resulting in lipid peroxidation production, which in turn promotes cell death.

  2. Open Access 01-12-2024 | Breast Cancer | OriginalPaper

    Cost-effectiveness of intraoperative radiation therapy versus intensity-modulated radiation therapy for the treatment of early breast cancer: a disinvestment analysis

    Early-stage breast cancer paradigm treatment consists of lumpectomy followed by adjuvant whole breast irradiation (WBI) [ 1 ]. This is a successful and well-tolerated treatment that has demonstrated non-inferiority to radical mastectomy, with an …

  3. 28-04-2024 | Breast Cancer | Online First

    Determining individual suitability for neoadjuvant systemic therapy in breast cancer patients through deep learning

    Breast cancer stands as the most prevalent malignant tumor in women worldwide [ 1 ]. Contemporary treatment strategies employ a multimodal approach integrating surgery, endocrine therapy, chemotherapy, and radiotherapy [ 2 ]. Beyond selecting the …

  4. 01-04-2024 | CAR T-Cell Therapy | News

    FDA requires warnings for T-cell cancer after CAR T-cell therapy

  5. 23-04-2024 | Breast Cancer | Online First

    Perspectives for the clinical application of ctDNA analysis to breast cancer drug therapy

    Circulating tumor DNA (ctDNA) consists of DNA fragments released from cancer cells into the blood circulation with quick clearance. Analysis of ctDNA can enable real-time assessment of the presence of cancer cells and their genomic …

  6. Open Access 01-12-2024 | ReviewPaper

    Targeting inflammation as cancer therapy

    Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and …

  7. Open Access 01-12-2024 | Panitumumab | OriginalPaper

    Cancer therapy related cardiac dysfunction as a result of Panitumumab

    Panitumumab is a human immunoglobulin monoclonal antibody designed to target the epidermal growth factor receptor (EGFR) which is used in the treatment of metastatic colorectal cancer alone or in combination with chemotherapy. In this report, we …

  8. Open Access 08-03-2024 | Breast Cancer | OriginalPaper

    Arterial Stiffness May Predict Subsequent Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer Patients

    Cancer therapy-related cardiac dysfunction (CTRCD) is still a serious problem. Existing risk scores are insufficient for risk classification, especially in low and medium-risk patients. This study aims to evaluate if arterial stiffness (AS) …

  9. 13-04-2024 | Cancer Therapy | Online First

    The role of cardiovascular magnetic resonance in cancer therapy-related cardiotoxicity

  10. 04-04-2024 | Prostate Cancer | Online First

    Role of Metastasis-Directed Therapy in Genitourinary Cancers

    The treatment of oligometastatic genitourinary cancers is a rapidly advancing field with ablative radiotherapy as one of the critical treatment components. The oligometastatic disease state, which can be defined as 1–5 metastatic sites with a …

  11. Open Access 01-12-2024 | Checkpoint Inhibitors | OriginalPaper

    Non–small cell lung cancer and immune checkpoint inhibitor therapy: does non-alcoholic fatty liver disease have an effect?

    Over the past decade, the introduction of immunotherapy has had a profound impact on the outlook for individuals diagnosed with non-small cell lung cancer (NSCLC) [ 1 ]. Immune checkpoint inhibitors (ICIs) such as PD-1 and PD-L1 have emerged as key …

  12. 09-04-2024 | Prostate Cancer | Online First

    Current Systemic Therapy in Men with Metastatic Castration-Sensitive Prostate Cancer

    Prostate cancer (PC) is the second most frequent cancer in men worldwide with an incidence of 1,414,259 new cases and 375,304 deaths in 2020 [ 1 ]. Although the majority of men are diagnosed with localised disease in Western countries, up to …

  13. Open Access 01-12-2024 | Osimertinib | OriginalPaper

    Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer

    Lung cancer mortality is the highest among all cancers [ 1 ]. In the past decade, non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, such as exon 19 deletions and exon 21 L858R point mutations, have …

  14. 04-04-2024 | Cancer Therapy | Online First

    In vivo safety evaluation method for nanomaterials for cancer therapy

    Nanomaterials are extensively used in the diagnosis and treatment of cancer and other diseases because of their distinctive physicochemical properties, including the small size and ease of modification. The approval of numerous nanomaterials for …

  15. Open Access 11-04-2024 | Targeted Therapy | Online First

    Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy

    Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major component of TME and exhibit heterogeneous properties in their …

  16. 02-04-2024 | Pediatric Cancer | OriginalPaper

    Magnesium supplementation therapy to prevent cisplatin-induced acute nephrotoxicity in pediatric cancer: a randomized phase-2 trial

    Cisplatin is one of the most important chemotherapeutic agents against pediatric cancers. Long-term survival recently increased to 50–90% across diseases, making countermeasures against acute and chronic toxicity increasingly important for young …

  17. Open Access 01-12-2024 | Sorafenib | OriginalPaper

    Assessment of disease control rate and safety of sorafenib in targeted therapy for advanced liver cancer

    Liver cancer (LC) is a malignant tumor that occurs in liver cells. It is commonly classified into two types: primary LC and metastatic LC [ 1 , 2 ]. The etiology of LC is diverse, but the most common risk factors include chronic viral hepatitis …

  18. Open Access 01-12-2024 | Breast Cancer | OriginalPaper

    Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients

    Adjuvant endocrine therapy (AET) roughly halves the risk of recurrence among the two-thirds of premenopausal breast cancer patients whose tumors over-express the estrogen receptor (i.e., estrogen receptor positive [ER+]) [ 1 , 2 ]. Breast cancer

  19. Open Access 01-12-2024 | Targeted Therapy | OriginalPaper

    Clinical impact of panel gene sequencing on therapy of advanced cancers of the digestive system: a retrospective, single center study

    Cancers of the digestive system represent a major fraction of the global tumor burden [ 1 , 2 ]. Despite their high incidence, the therapeutic options for most advanced and metastatic cancers of the digestive system are still limited. Molecular …

  20. 28-04-2024 | Esophageal Cancer | Online First

    The real-world data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study

    Esophageal cancer ranks ninth most common among cancers globally, and fifth leading cause of cancer-related death [ 1 ]. Despite the widespread use of fluoropyrimidine plus platinum-based chemotherapy as the standard first-line treatment for …

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