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Hepatocellular Carcinoma 

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  1. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Cyclovirobuxine D inhibits hepatocellular carcinoma growth by inducing ferroptosis of hepatocellular carcinoma cells

    Predominantly hepatocellular carcinoma (HCC), liver cancer is the sixth most often diagnosed cancer and the third major cause of cancer mortality globally [ 1 , 2 ]. HCC is closely associated with viral hepatitis, nonalcoholic steatohepatitis …

  2. Open Access 01-12-2024 | Hepatocellular Carcinoma | ReviewPaper

    The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is still a public health disease with its high prevalence and morbidity. Short of early diagnosis biomarkers and effective therapy, the treatment of HCC patients hasn’t achieved ideal effect. Hypoxia is a hallmark of …

  3. 07-04-2024 | Hepatocellular Carcinoma | Online First

    Patients undergoing liver resection for non-alcoholic fatty liver disease-related hepatocellular carcinoma and those for viral hepatitis-related hepatocellular carcinoma have similar survival outcomes

    Numerous studies have compared outcomes of liver resection (LR) of patients with non-alcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) to those of patients with non-NAFLD-related HCC. However, results have been …

  4. Open Access 01-05-2024 | Hepatocellular Carcinoma | OriginalPaper

    GALAD score as a prognostic model for recurrence of hepatocellular carcinoma after local ablation

    Hepatocellular carcinoma (HCC) represents the sixth most prevalent cancer and the third leading cause of cancer-related death worldwide. Approximately 906,000 new HCC cases, as well as an estimated 830,000 HCC deaths, occurred in 2020 (Sung et al.

  5. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Prognostic analysis of hepatocellular carcinoma based on cuproptosis -associated lncRNAs

    Hepatocellular carcinoma (HCC) constitutes around 90% of all primary liver cancer instances and ranks as the second leading cause of cancer-related mortality worldwide, with an annual incidence of 850,000 new cases. The principal risk factors for …

  6. Open Access 01-12-2024 | Hepatocellular Carcinoma | ReviewPaper

    Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives

    Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. In recent years, immunotherapies such as immune checkpoint inhibitors (ICIs) have made great progress in the systemic …

  7. 07-05-2024 | Hepatocellular Carcinoma | Online First

    The Prognostic Value of Preoperative Serum Markers and Risk Classification in Patients with Hepatocellular Carcinoma

  8. 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Longitudinal analysis of liver transplant candidates for hepatocellular carcinoma in a single center

    Hepatocarcinogenesis results from a permissive microenvironment created by chronic liver disease [ 1 ]. Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically develops against a background of chronic liver disease …

  9. Open Access 30-04-2024 | Hepatocellular Carcinoma | Online First

    Managing hepatocellular carcinoma across the stages: efficacy and outcomes of stereotactic body radiotherapy

    A retrospective study

    Liver cancer, ranking as the 6th most prevalent malignancy globally and standing as the third leading cause of cancer-related death, is a challenging malignancy and is surpassed only by lung and colorectal cancer [ 1 ]. Hepatocellular carcinoma

  10. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study

    The most frequent causes of hepatocellular carcinoma (HCC) are chronic infection with hepatitis B or C virus and alcoholic liver disease [ 1 ]. Nevertheless, the most frequent causes of mortality among HCC patients in recent decades have become …

  11. Open Access 23-04-2024 | Hepatocellular Carcinoma | Online First

    Metabolomic Analysis of Human Cirrhosis and Hepatocellular Carcinoma: A Pilot Study

    Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide [ 1 ]. The majority of HCC develops in patients with underlying liver cirrhosis (LC) which provides the opportunity to closely monitor those patients at risk [ 2 , 3 ].

  12. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Laparoscopic-assisted microwave ablation in treatment of small hepatocellular carcinoma: safety and efficacy in comparison with laparoscopic hepatectomy

    Laparoscopic-assisted microwave ablation (LAMWA), as one of the locoregional therapies, has been employed to treat hepatocellular carcinoma (HCC). This study aims to compare the efficacy and safety of LAMWA and laparoscopic hepatectomy in the …

  13. 04-05-2024 | Hepatocellular Carcinoma | Online First

    Interpretable machine learning based on CT-derived extracellular volume fraction to predict pathological grading of hepatocellular carcinoma

    Currently, there are two main methods for pathological grading (PG) of hepatocellular carcinoma (HCC): the Edmondson-Steiner grading system and the World Health Organization grading system. The Edmondson-Steiner system categorizes HCC into Grade …

  14. 26-04-2024 | Hepatocellular Carcinoma | Online First

    Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma

    Hepatocellular carcinoma (HCC), one of the most prevalent cancers globally, is closely associated with tumor-associated macrophages (TAMs), including monocyte-derived macrophages and liver-resident Kupffer cells. Understanding TAM heterogeneity at …

  15. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Prognostic analysis of radiation-induced liver damage following carbon-ion radiotherapy for hepatocellular carcinoma

    External beam radiotherapy (EBRT) and stereotactic body radiotherapy (SBRT) are viable treatment options for patients with unresectable or inoperable hepatocellular carcinoma (HCC) [ 1 ]. Current guidelines suggest that SBRT is an advanced EBRT …

  16. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway

    Liver cancer is one of the most fatal malignancies, with a 5-year survival rate of only 21% [ 1 ]. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for approximately 90% of the total [ 2 ]. Despite the constantly …

  17. Open Access 01-12-2024 | Hepatocellular Carcinoma | OriginalPaper

    Metabolic dysfunction-associated fatty liver disease increases the risk of complications after radical resection in patients with hepatocellular carcinoma

    The prevalence of nonalcoholic fatty liver disease (NAFLD) has progressively increased over the past few decades, reaching a level almost equivalent to that of obesity and has emerged as the foremost chronic liver disease in contemporary times …

  18. 05-05-2024 | Hepatocellular Carcinoma | Online First

    Regulatory effect of Yinchenhao decoction on bile acid metabolism to improve the inflammatory microenvironment of hepatocellular carcinoma in mice

    Hepatocellular carcinoma (HCC) is a malignant tumor with extremely high mortality. The tumor microenvironment is the “soil” of its occurrence and development, and the inflammatory microenvironment is an important part of the “soil”. Bile acid is …

  19. Open Access 01-12-2024 | Hepatitis B | OriginalPaper

    Hepatitis B virus reactivation in hepatocellular carcinoma patients after hepatic arterial infusion chemotherapy combined with and without immunotherapy

    Liver cancer is a frequently occurring malignant tumor worldwide, with approximately 70% of new cases found in Asia alone [ 1 ]. The most prevalent form of liver tumor is hepatocellular carcinoma (HCC), which makes up 80% of cases and is typically …

  20. 04-05-2024 | Hepatocellular Carcinoma | Online First

    Current role and perspectives of living donor liver transplantation for hepatocellular carcinoma: systematic review of the past 20 years

    Hepatocellular carcinoma (HCC) poses a significant global health challenge, and liver transplantation (LT) remains the best curative option. Living donor liver transplantation (LDLT) emerged as a potential solution to organ scarcity, reducing …

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