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Stevens-Johnson Syndrome 

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  1. Open Access 01-12-2024 | Stevens-Johnson Syndrome | OriginalPaper

    The outcomes of corneal sight rehabilitating surgery in Stevens-Johnson syndrome: case series

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute blistering disorders of the skin and mucous membrane [ 1 ]. These disorders commonly affect the ocular surface as well [ 2 ]. In the acute stage, ocular tissues undergo …

  2. Open Access 17-05-2024 | Stevens-Johnson Syndrome | Online First

    Evaluation of the Factors Influencing Mortality in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Multicenter Study of 166 Patients

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening conditions that belong to the same disease spectrum. Clinically, they are characterized by widespread erythematous targetoid plaques accompanied by …

  3. 01-07-2024 | Stevens-Johnson Syndrome | Letter

    Diagnostic discordance of Stevens-Johnson syndrome and toxic epidermal necrolysis between dermatologists and primary inpatient teams: a single-institution retrospective chart review

  4. Open Access 20-03-2024 | Stevens-Johnson Syndrome | OriginalPaper

    Clinical Characteristics and Treatment of Ophthalmic Sequelae of StevensJohnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Eyecare Centre in Hungary

    StevensJohnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN), constitute a spectrum of diseases that are life-threatening immunologic dermatological disorders affecting the skin and mucous membranes [ 1 ]. The incidence of …

  5. Open Access 01-12-2024 | Stevens-Johnson Syndrome | Letter

    Comment on: Proposal for a new diagnostic classification of photodistributed StevensJohnson syndrome and toxic epidermal necrolysis

    StevensJohnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap (SJS/TEN), collectively referred to SJS/TEN, form a spectrum of severe life-threatening adverse drug reactions whose pathomechanism is not fully understood. The …

  6. 01-01-2024 | Stevens-Johnson Syndrome | Report

    Pregnancies complicated by StevensJohnson syndrome and toxic epidermal necrolysis: a nationwide study

    StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous diseases that have been scarcely studied in pregnancy [ 1 , 2 ]. The goal of this study is to describe SJS/TEN in pregnant women and investigate the risk …

  7. Open Access 01-12-2023 | Osimertinib | OriginalPaper

    Osimertinib tolerance in a patient with Stevens Johnson syndrome during osimertinib therapy after treatment with pembrolizumab

    Osimertinib, a third-generation epidermal growth factor receptor- tyrosine kinase inhibitor (EGFR-TKI), has emerged as an important treatment for non-small cell lung cancer (NSCLC). Compared to other EGFR-TKIs, Osimertinib has been associated with …

  8. Open Access 04-05-2023 | Stevens-Johnson Syndrome | ReviewPaper

    Ophthalmic Aspects of StevensJohnson Syndrome and Toxic Epidermal Necrolysis: A Narrative Review

    The aim of our review article was to summarize the current literature on StevensJohnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN). SJS/TEN is a serious, rare multi-system, immune-mediated, mucocutaneous disease with a …

  9. 20-10-2022 | Stevens-Johnson Syndrome | Report

    Pediatric StevensJohnson Syndrome and Toxic Epidermal Necrolysis: a national analysis of 2016 Kids’ Inpatient Database

    Pediatric-specific studies on StevensJohnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are lacking. The objective of this study was to characterize demographics, comorbidities, and outcomes of pediatric SJS and TEN patients on a …

  10. Open Access 01-12-2023 | Stevens-Johnson Syndrome | ReviewPaper

    Photodistributed StevensJohnson syndrome and toxic epidermal necrolysis: a systematic review and proposal for a new diagnostic classification

    StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare cutaneous reactions with epidermal necrosis, vesiculobullous formation, epidermal detachment, and mucous membrane involvement. The classification is determined by the …

  11. Open Access 01-12-2023 | Stevens-Johnson Syndrome | OriginalPaper

    Ocular surface involvement and histopathologic changes in the acute stage of Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional study

    Stevens-Johnson syndrome (SJS) and its much more severe form, toxic epidermal necrolysis (TEN), are primarily drug-induced life-threatening immunologic dermatological disorders characterized by a sudden high fever, necrosis and detachment of skin …

  12. 01-07-2022 | Stevens-Johnson Syndrome | ReviewPaper

    Management of Drug-Induced Epidermal Necrolysis (DEN) in Pediatric Patients: Moving from Drug-Induced StevensJohnson Syndrome, Overlap and Toxic Epidermal Necrolysis to a Single Unifying Diagnosis of DEN

    Pediatric StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threating blistering diseases triggered by medications that affect the skin and mucosae. Drug-induced epidermal necrolysis is a better term for …

  13. Open Access 13-05-2023 | Etanercept | OriginalPaper

    Biologic TNF-α Inhibitors for StevensJohnson Syndrome, Toxic Epidermal Necrolysis, and TEN-SJS Overlap: A Study-Level and Patient-Level Meta-Analysis

    StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening cutaneous adverse reactions primarily caused by certain medications [ 1 ]. SJS and TEN are considered different severities of the same disease …

  14. Open Access 01-12-2020 | Stevens-Johnson Syndrome | OriginalPaper

    Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report

    Since the World Health Organization declared a global pandemic due to the coronavirus disease 2019 (COVID-19), there have been targeted efforts to establish management modalities. Aminoquinolines, such as chloroquine and hydroxychloroquine, have …

  15. Open Access 01-12-2022 | Streptococci | OriginalPaper

    Matrix metalloproteinase 9 is associated with conjunctival microbiota culture positivity in Korean patients with chronic Stevens-Johnson syndrome

    Stevens-Johnson syndrome (SJS) is caused by an abnormal immune-response to drugs or other risk factors and is characterized with extensive exfoliation of the mucocutaneous tissue which can be fatal [ 1 , 2 ]. Acute and chronic ocular manifestations …

  16. Open Access 01-12-2019 | Stevens-Johnson Syndrome | OriginalPaper

    Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study

    Stevens-Johnson syndrome (SJS) and its more severe variant, toxic epidermal necrolysis (TEN), are acute blistering diseases of the skin and mucus membranes. They were first reported in 1922 [ 1 ] and 1956 [ 2 ], respectively. To date, there has …

  17. 01-03-2022 | Stevens-Johnson Syndrome | OriginalPaper

    Culprit Medications and Risk Factors Associated with StevensJohnson Syndrome and Toxic Epidermal Necrolysis: Population-Based Nested Case–Control Study

    StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare mucocutaneous adverse drug reactions, with estimated incidence rates from 1 to 12 per million person-years, and reported mortality ranges of 1–9% for SJS and 30–50% for …

  18. 01-02-2021 | Bullous Pemphigoid | News

    Sofosbuvir increases risk of Stevens-Johnson syndrome

  19. 01-03-2020 | Wound Debridement | ReviewPaper

    Wound Management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are uncommon, acute, life-threatening mucocutaneous adverse reactions associated with a potentially high mortality rate. They are characterized by a cytokine-mediated keratinocyte …

  20. 23-04-2022 | Stevens-Johnson Syndrome | OriginalPaper

    Cytokeratin profile and keratinocyte gene expression in keratinized lid margins of patients with chronic Stevens-Johnson syndrome

    Stevens-Johnson syndrome (SJS) is a drug-induced, immune-mediated hypersensitive reaction that affects the skin and mucous membranes [ 1 ]. Ocular involvement in the acute stage presents as inflammation and ulceration of the ocular surface, which …

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