The systemic toxicity of the Eutectic Mixture of Local Anesthetics (EMLA) cream is mediated by the active ingredients of the cream, the local anesthetics lidocaine and prilocaine, which are both present at a concentration of 2.5%. Systemic …

Venous leg ulcers (VLUs) affect mainly older adults, incidence and prevalence seem to increase [ 1 ], which can be assumed to be associated with an increased number of older people. A recent study points out that there is inaccuracy in the …

Venous leg ulcers (VLU) are common, recurring open wounds on the lower leg, caused by impaired blood flow in diseased or damaged leg veins. Sluggish blood flow increases venous pressure, which can severely impair wound healing [ 1 ]. VLUs are a …

Chronic venous disease (CVD) is a common pathology of the circulation system and is characterized by symptoms and signs as a result of structural or functional abnormalities of the veins. The most common symptoms and signs include pain, tightness …

Note: the numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

Mistake on the part of methods on the preparation with the name of manufacturer of the centrifugation was written as Regenlab but it was Zimmer Biomet. So the correct text should be as below.

Venous leg ulcers (VLUs) have a prevalence of 1–2% of the population in developed countries and account for up to 70% of chronic leg ulcerations [ 1 , 2 ]. Even with the best treatment, wound healing may take several months, and affected patients …

A wound is defined as damage to the integrity of the integument, mucosa or an organ [ 1 , 2 ]. Wounds are classified as superficial, which are limited to the skin and subcutaneous tissues, and deep, which reach the fascia, muscles and neurovascular …

In developed countries, venous leg ulcers (VLUs) have a prevalence of 1–2% of the population and account for approximately 70% of chronic leg ulcerations [ 1 , 2 ]. Due to rising age and comorbidity a steadily growing prevalence can be expected [ 3 …]. With an estimated mean prevalence of up to 0.64, approximately up to 1.8 million people in Germany are affected [

Venous leg ulcers (VLUs) are open lesions of the lower limb and represent between 60 and 80% of all leg ulcerations that occur in the presence of venous disease [ 1 , 2 ]. Healing rates are protracted with only 60% on average healed by 12 weeks …

It is well established that individuals with chronic wounds, particularly those with chronic venous leg ulcers (CVLUs), have substantially reduced quality of life [ 1 – 3 ]. A wound is defined as chronic when it fails to reduce in size by 50% for …

Venous leg ulcers (VLU) are long-lasting wounds of the lower leg. They are usually formed after an injury, with slow healing due to increased blood pressure in the leg veins [ 1 ]. Typically, ulcers take 3–4 months to heal with appropriate …

Chronic venous leg ulcers (CVLUs) are open skin lesions of the lower legs arising in areas affected by venous hypertension that have been present for at least 6 weeks [ 1 ]. These common conditions affect 1% of the adult population and 3.6% of …

Venous leg ulcers (VLUs) are the most severe manifestation of chronic venous disease (CVD). Due to their chronic nature, high recurrence rate and slow healing time, VLUs account for 80% of all leg ulcers seen in patients with CVD. VLUs impose a …

Chronic venous leg ulcers (VLUs) are open wounds which can be large and frequently become infected and leak exudates, leading to significant pain and reduction in quality of life [ 1 , 2 ]. They are the result of an impaired venous return related …

Venous leg ulcers (VLU) are poorly healing wounds caused by chronic venous insufficiency (CVI) [ 1 ]. CVI is a form of peripheral vascular disease that originates from an obstruction of the venous system or a defective venous valve, leading to …