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Gout 

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  1. 06-12-2023 | Gout | OriginalPaper

    Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation

    Gout is a self-limiting form of inflammatory arthropathy caused by the formation of urate crystals due to hyperuricemia. The resolution of gout involves the transition of proinflammatory M1-type macrophages to anti-inflammatory M2-type …

  2. 30-04-2024 | Gout | News | Article

    SGLT2 inhibitors show gout prevention benefit over sulfonylureas

    SGLT2 inhibitors reduce the risk of incident gout and gout flares in patients with type 2 diabetes and offer cardiovascular benefits, compared with sulfonylureas.

  3. 31-10-2023 | Gout | OriginalPaper

    Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities

    Gout flares are extremely painful episodes of acute joint inflammation induced by monosodium urate crystals, characterized by sudden onset of joint pain, erythema, heat, swelling, and dysfunction [ 1 ].

  4. Open Access 01-12-2024 | Gout | OriginalPaper

    Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice

    Gout is caused by monosodium urate (MSU) crystals deposition and characterized by recurrent self-limiting attacks of acute arthritis [ 1 ]. MSU crystals were viewed as a “danger signal” that could be recognized by Toll-like receptors (TLR) 2/4 to …

  5. 06-05-2024 | Gout | Online First

    Empagliflozin and Risk of Incident Gout: Analysis from the EMPagliflozin Comparative Effectiveness and SafEty (EMPRISE) Cohort Study

    Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a newer class of oral glucose-lowering medications that lower serum glucose independent of insulin by blocking glucose reabsorption in the proximal tubule to induce glucosuria. In addition …

  6. 01-03-2024 | Interferon | Letter

    Neuropathologic Impacts of JAK Inhibitor Treatment in Aicardi-Goutières Syndrome

    Aicardi-Goutières syndrome (AGS) is a genetic interferonopathy characterized by upregulation of type I interferon response. It is associated with increased mortality and severe disabilities. Janus Kinase (JAK) inhibitors have shown effectiveness …

  7. Open Access 01-12-2024 | Gout | OriginalPaper

    The association between Helicobacter pylori infection and the risk for gout in hyperuricemia patients in China – A cross-sectional study

    Helicobacter pylori ( H. pylori ) is a gram-negative spiral bacterium that colonizes in the gastric mucosa persistently, infecting approximately 4.4 billion people worldwide and varying considerably according to geographic region [ 1 ]. H. pylori …

  8. Open Access 16-03-2024 | Gout | OriginalPaper

    The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target

    In gout, flares of severely painful inflammatory arthritis intersect with metabolism, and macrophage activation [ 1 – 3 ]. Gout represents a major public health problem, and severe flares commonly lead to physical incapacity, emergency department …

  9. 04-04-2024 | Gout | ReviewPaper

    Get on top of gout with a fresh look at treatment options

    Managing increasingly prevalent gout, which stems from hyperuricaemia, is not easy. Flare management and long-term serum urate-lowering (ULT) therapy, largely with xanthine oxidase inhibitors (XOIs) or uric acid transporter 1 inhibitors (URAT1Is) …

  10. Open Access 01-12-2024 | Gout | OriginalPaper

    Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation

    Gout is an inflammatory arthritis initially treated with oral urate-lowering therapy (ULT), such as xanthine oxidase inhibitors (XOIs) or uricosuric agents [ 1 – 3 ]. However, some patients are unable to tolerate oral ULTs, have gout that is …

  11. 16-04-2024 | Gout | Online First

    CD8 T cell-derived perforin regulates macrophage-mediated inflammation in a murine model of gout

    Gout is a spontaneous inflammatory disease based on hyperuricemia [ 1 ]. It has become the most common inflammatory arthritis worldwide [ 2 ]. It is estimated that among every 1000 individuals, 1.4 women and 4.0 men suffer from gout, and the number …

  12. 28-02-2024 | ReviewPaper

    The Effects of Pharmacological Urate-Lowering Therapy on Cardiovascular Disease in Older Adults with Gout

    Cardiovascular disease is an important cause of mortality in older patients. In addition to the traditional risk factors for cardiovascular disease, hyperuricemia has been increasingly associated with an elevated risk of cardiovascular disease.

  13. Open Access 06-04-2024 | Gout | Online First

    Cardiovascular safety of using non-steroidal anti-inflammatory drugs for gout: a Danish nationwide case-crossover study

    Gout attacks are treated with uric-lowering and anti-inflammatory drugs. In patients with gout, non-steroidal anti-inflammatory drugs (NSAIDs) could be both cardiovascular beneficial, due to their anti-inflammatory actions, and cardiovascular …

  14. Open Access 01-12-2024 | Gout | ReviewPaper

    Correlation between gout and dry eye disease

    Gouty arthritis is the most common type of inflammatory arthritis in adults, and its incidence and prevalence have been increasing in recent years [ 1 ]. Gout is an inflammatory arthritis caused by the deposition of monosodium urate crystals in …

  15. 16-03-2024 | Febuxostat | OriginalPaper

    Comparison of the efficacy and safety of benzbromarone and febuxostat in gout and hyperuricemia: a systematic review and meta-analysis

    Gout is an inflammatory arthritis that commonly affects both small and large bone joints. It is one of the most prevalent forms of arthritis in developed countries and also one of the most common inflammatory bone joint diseases in some developing …

  16. 31-03-2024 | Gout | Online First

    Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice

    Gout is a metabolic condition characterized by the accumulation of urate crystals in the synovial joints. These crystal depositions result in joint swelling and increased concentration of serum uric acid in blood. The commercially available drugs …

  17. 06-03-2024 | Gout | OriginalPaper

    Coffee intake reduced gout risk by decreasing urate and urea while increasing SHBG levels in plasma: a mediation Mendelian randomization study

    Gout, a form of inflammatory arthritis, has become increasingly prevalent, posing a significant public health challenge [ 1 ]. Characterized by the deposition of urate crystals in joints, it often manifests as recurrent painful attacks [ 2 ]. The …

  18. Open Access 01-12-2024 | Colchicine | OriginalPaper

    Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial

  19. 19-03-2024 | Gout | Online First

    Exposure to alcohol or lead? Chronic gout in baroque depictions of obese Silenus and Bacchus

  20. 22-12-2023 | Gout | ReviewPaper

    Pipeline Therapies for Gout

    Although present treatments for gout are effective, there are many unmet needs remaining, for which the gout pipeline is expanding. The ever-growing list of associated comorbidities with gout (e.g., renal disease [ 1 ], hypertension [ 2 ] …

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