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Plaque Psoriasis 

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  1. Open Access 04-04-2024 | Vulgar Psoriasis | Report

    Improvements in Psoriasis-Related Work Productivity with Tildrakizumab: Results from a Phase 4 Real-World Study in Patients with Moderate-to-Severe Plaque Psoriasis

    Psoriasis is a chronic inflammatory disorder with an overall prevalence of approximately 3% among US individuals 20 years of age and older, making it one of the most common immune-mediated diseases in the US [ 1 , 2 ]. The overall economic burden …

  2. Open Access 23-03-2024 | Ixekizumab | OriginalPaper

    Comparing Achievement of National Psoriasis Foundation Treatment Targets among Patients with Plaque Psoriasis Treated with Ixekizumab versus Other Biologics in Clinical and Real-World Studies

    The NPF’s treatment targets for plaque psoriasis provide a comprehensive treat-to-target (T2T) strategy to guide therapeutic approaches for clinical practice in the USA, with the goal of reducing disease burden and improving patient outcomes [ 1 ].

  3. Open Access 22-04-2024 | Vulgar Psoriasis | Online First

    Baseline Characteristics and mNAPSI Change from Baseline Scores Through Month 12 for Patients with Moderate-to-Severe Plaque Psoriasis and Concomitant Nail Psoriasis Treated with Biologics from PSoHO

    Nail psoriasis (NP) is a chronic, difficult-to-treat condition affecting around half of patients with psoriasis. It is associated with considerable social stigma and impairment of patients’ quality of life [ 1 ]. The presence of nail changes not …

  4. Open Access 10-05-2024 | Online First

    OPT-In; Optimized Patient Treatment Outcomes in Plaque Psoriasis: A 3-Year State-Transition Treatment-Sequencing Model in the Italian Setting

    Psoriasis is a chronic, relapsing, immune-mediated skin disease. In Europe, the prevalence of psoriasis ranges from 0.73% in Scotland to 2.9% in Italy [ 1 ], which is roughly equal to 1,500,000 Italians [ 2 ].

  5. Open Access 30-04-2024 | Ixekizumab | Online First

    The Safety of Ixekizumab in Chinese Adults with Moderate-to-Severe Plaque Psoriasis: Analyses from a Prospective, Single-Arm, Multicenter, 12-Week Observational Study

    Approximately 6 million people in China have psoriasis [ 1 ], an incurable, immune-mediated, chronic, recurrent inflammatory disease [ 2 ], the majority of whom have moderate-to-severe plaque psoriasis [ 3 ]. The estimated age-standardized …

  6. Open Access 27-03-2024 | Vulgar Psoriasis | OriginalPaper

    Effectiveness of Ixekizumab in Chinese Patients with Moderate-Severe Plaque Psoriasis with Special Area Involvement: Subanalysis of a Prospective, Multicenter, Observational Real-World Study

    Psoriasis is a chronic, incurable inflammatory skin disease characterized by red, scaly plaques that can develop across different body areas as a result of complex gene-environmental-mediated epidermal hyperproliferation [ 1 , 2 ]. In China, more …

  7. 22-03-2024 | Psoriatic Arthritis | OriginalPaper

    Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials

    Psoriasis is a chronic skin condition marked by inflammation mediated by the immune system and intricate underlying physiological mechanisms. A common presentation is chronic plaque psoriasis, accounting for 80 to 90% of the various clinical …

  8. 24-10-2023 | Vulgar Psoriasis | OriginalPaper

    Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study

    TOB/BTG is a family of antiproliferative proteins that play an important role in the regulation of immune responses, acting as lymphocyte activators and macrophage-mediated cytotoxicity. No previous studies have explored their role in patients …

  9. Open Access 15-02-2024 | Vulgar Psoriasis | Report

    Improvements in Plaque Psoriasis Associated with Calcipotriol/Betamethasone Aerosol Foam Treatment: A Post Hoc Analysis of Non-interventional Studies and Clinical Experience

    Plaque psoriasis (hereinafter psoriasis) is a chronic relapsing inflammatory skin disease characterized by red, scaly plaques and pruritus, which often requires long-term therapy. Topical therapies are commonly used to treat psoriasis given their …

  10. Open Access 15-03-2024 | Guselkumab | OriginalPaper

    Response Types and Factors Associated with Response Types to Biologic Therapies in Patients with Moderate-to-Severe Plaque Psoriasis from Two Randomized Clinical Trials

    Psoriasis is a chronic inflammatory skin disease that can significantly affect patients’ quality of life [ 1 , 2 ]. In recent years, as the pathogenesis of the disease has become better understood, a variety of novel targeted treatments have become …

  11. Open Access 10-02-2024 | Vulgar Psoriasis | ReviewPaper

    The Efficacy and Safety of Bimekizumab for Plaque Psoriasis: An Expert Consensus Panel

    Plaque psoriasis is an immune-mediated inflammatory condition affecting skin, joints, and several other systems [ 1 ]. As a result of its chronic relapsing–remitting course, psoriasis has a considerable effect on quality of life [ 1 , 2 ].

  12. Open Access 03-02-2024 | Psoriatic Arthritis | OriginalPaper

    Etanercept in Axial Spondyloarthritis, Psoriatic Arthritis, and Plaque Psoriasis: Real-World Outcome Data from German Non-interventional Study ADEQUATE

    For patients with chronic diseases such as axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and plaque psoriasis (PsO), treatment goals usually include attaining remission preferably within the first 12 weeks of treatment [ 1 – 3 ]. In …

  13. Open Access 19-02-2024 | Vulgar Psoriasis | OriginalPaper

    Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

    This article is published with digital features, including a graphical abstract to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.24893724 .

  14. Open Access 09-02-2024 | Ixekizumab | OriginalPaper

    Speed and Cumulative Responses According to Body Regions in Patients with Moderate-to-Severe Plaque Psoriasis Treated with Ixekizumab (Interleukin-17A Antagonist) versus Guselkumab (Interleukin-23p19 Inhibitor)

    An interactive infographic provided for this article: https://vahub.lilly.com/gooderham_dermatologyandtherapy_2024 .

  15. Open Access 21-12-2023 | Pruritus | OriginalPaper

    Rapid Improvements in Itch with Tapinarof Cream 1% Once Daily in Two Phase 3 Trials in Adults with Mild to Severe Plaque Psoriasis

    Psoriasis is a chronic, inflammatory skin disease that affects approximately 2% of people worldwide [ 1 ]. Pruritus affects 60–90% of patients with psoriasis and substantially impacts health-related quality of life [ 2 – 5 ]. Itching can negatively …

  16. Open Access 30-11-2023 | OriginalPaper

    Management of Moderate to Severe Plaque Psoriasis with Brodalumab in Daily Practice: Real-World Evidence from the LIBERO Study in the Czech Republic

    Psoriasis is a chronic, immune-mediated inflammatory skin disease, characterized by proliferation of keratinocytes and accumulation of immune cells in the affected skin, with an estimated prevalence of 2% in the European adult population [ 1 ].

  17. Open Access 07-10-2023 | Vulgar Psoriasis | OriginalPaper

    Guselkumab-Treated Patients with Plaque Psoriasis Who Achieved Complete Skin Clearance for ≥ 156 Consecutive Weeks: A Post-Hoc Analysis From the VOYAGE 1 Clinical Trial

    Plaque psoriasis is the most common form of psoriasis [ 1 ] and the concept of this highly prevalent disease [ 2 , 3 ] involving accumulating disease memory and increasing impact of chronification is now well established [ 4 ]. However, further …

  18. 01-11-2023 | Plaque Psoriasis | ReviewPaper

    Deucravacitinib in plaque psoriasis: a profile of its use

    Deucravacitinib (SOTYKTU™) is a tyrosine kinase 2 (TYK2) inhibitor that expands the availability of effective oral treatments for the management of moderate to severe plaque psoriasis in adults. In contrast to Janus kinase inhibitors that target …

  19. Open Access 14-10-2023 | Hydrotherapy | OriginalPaper

    Efficacy of Avène Hydrotherapy on Chronic Pruritus in Patients with Plaque Psoriasis

    Psoriasis is one of the most common chronic inflammatory skin diseases, and plaque psoriasis is by far the most common clinical form of psoriasis [ 1 , 2 ]. Management of psoriasis is challenging, particularly in pediatric and elderly patients …

  20. Open Access 22-11-2023 | Ustekinumab | OriginalPaper

    Efficacy and Safety of Candidate Biosimilar CT-P43 Versus Originator Ustekinumab in Moderate to Severe Plaque Psoriasis: 28-Week Results of a Randomised, Active-Controlled, Double-Blind, Phase III Study

    Plaque psoriasis is a chronic, immune-mediated inflammatory disease, with an estimated prevalence of ≥ 1.5% in regions such as Australasia and Western and Central Europe, and in areas of North America [ 1 ]. Ustekinumab is a monoclonal antibody …

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