Issue 1/2024
Content (126 Articles)
Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease
Deng Wu, Xiaoman Bi, Kim Hei-Man Chow
Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study
Dong Ji, Wen-Zhu Chen, Lei Zhang, Zhi-Hua Zhang, Li-Jian Chen
Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation
Kasey R. Keever, Kui Cui, Jared L. Casteel, Sanjay Singh, Donald B. Hoover, David L. Williams, Valentin A. Pavlov, Valentin P. Yakubenko
Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity
Fabiola Paciello, Anna Pisani, Rolando Rolesi, Raffaele Montuoro, Veronica Mohamed-Hizam, Giammarco Boni, Cristian Ripoli, Jacopo Galli, Renata Sisto, Anna Rita Fetoni, Claudio Grassi
Peripheral blood amyloid-β involved in the pathogenesis of Alzheimer’s disease via impacting on peripheral innate immune cells
Mingchao Shi, Fengna Chu, Feiqi Zhu, Jie Zhu
Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice
Ya-Jing Zhu, Jing Huang, Ru Chen, Yu Zhang, Xin He, Wen-Xin Duan, Yuan-Lei Zou, Meng-Mei Sun, Hui-Li Sun, Si-Min Cheng, Hao-Chuan Wang, Hao Zhang, Wen-Ning Wu
iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie, Sarah R. Ball, Margaret Sunde, G. Gregory Neely, Cesar L. Moreno, Alexandra Maximova, Eryn L. Werry, Michael Kassiou
MIF contribution to progressive brain diseases
Agata Matejuk, Gil Benedek, Richard Bucala, Szymon Matejuk, Halina Offner, Arthur A. Vandenbark
Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia
Kimberly C. Olney, Camila de Ávila, Kennedi T. Todd, Lauren E. Tallant, J. Hudson Barnett, Katelin A. Gibson, Piyush Hota, Adithya Shyamala Pandiane, Pinar Cay Durgun, Michael Serhan, Ran Wang, Mary Laura Lind, Erica Forzani, Naomi M. Gades, Leslie F. Thomas, John D. Fryer
Impaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
Yue Hao, Yinchun Su, Yifan He, Wenyuan Zhang, Yang Liu, Yu Guo, Xingfan Chen, Chunhan Liu, Siyu Han, Buyi Wang, Yushuang Liu, Wei Zhao, Lili Mu, Jinghua Wang, Haisheng Peng, Junwei Han, Qingfei Kong
Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response
Emily J. Koller, Caleb A. Wood, Zoe Lai, Ella Borgenheimer, Kristi L. Hoffman, Joanna L. Jankowsky
Autoimmune demyelination alters hypothalamic transcriptome and endocrine function
Jonathan J. Carver, Kristy M. Lau, Alexandra E. Puckett, Alessandro Didonna
The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress
Xueying Li, Pusheng Quan, Yao Si, Fei Liu, Yuwei Fan, Feifan Ding, Lina Sun, Han Liu, Shuo Huang, Linlin Sun, Fan Yang, Lifen Yao
A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice
Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice
Xue Bai, Bing Wang, Yiduo Cui, Siqi Tian, Yi Zhang, Linhao You, Yan-Zhong Chang, Guofen Gao
Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates
Josef Newman, Xiaoying Tong, April Tan, Toni Yeasky, Vanessa Nunes De Paiva, Pietro Presicce, Paranthaman S. Kannan, Kevin Williams, Andreas Damianos, Marione Tamase Newsam, Merline K. Benny, Shu Wu, Karen C. Young, Lisa A. Miller, Suhas G. Kallapur, Claire A. Chougnet, Alan H. Jobe, Roberta Brambilla, Augusto F. Schmidt
CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Shir Zaccai, Anna Nemirovsky, Livnat Lerner, Leenor Alfahel, Ekaterina Eremenko, Adrian Israelson, Alon Monsonego
Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation
Izhar Livne-Bar, Shubham Maurya, Karsten Gronert, Jeremy M. Sivak
Taming microglia: the promise of engineered microglia in treating neurological diseases
Echo Yongqi Luo, Rio Ryohichi Sugimura
Correction: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders
Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte, Ramon Velazquez
Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?
Jelle Y. Broos, Rianne T. M. van der Burgt, Julia Konings, Merel Rijnsburger, Oliver Werz, Helga E. de Vries, Martin Giera, Gijs Kooij
Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration
Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Michel Paques, Torben Lykke Sørensen, Olaf Strauss, Xavier Guillonneau, Cécile Delarasse, Florian Sennlaub
Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome
Beate Hartmannsberger, Sabrina Scriba, Carolina Guidolin, Juliane Becker, Katharina Mehling, Kathrin Doppler, Claudia Sommer, Heike L. Rittner
Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
Matthew D. Cain, N. Rubin Klein, Xiaoping Jiang, Hamid Salimi, Qingping Wu, Mark J. Miller, William B. Klimstra, Robyn S. Klein
Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi, Hiroshi Kiyama
Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity
Milica Lazarević, Goran Stegnjaić, Bojan Jevtić, Sanja Despotović, Đurđica Ignjatović, Suzana Stanisavljević, Neda Nikolovski, Miljana Momčilović, Graeme L. Fraser, Mirjana Dimitrijević, Đorđe Miljković
Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice
Shutian Zhang, Dajun Zhao, Zhaohua Yang, Fanshun Wang, Shouguo Yang, Chunsheng Wang
Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis
Peng-Fei Wang, Fei Jiang, Qiu-Ming Zeng, Wei-Fan Yin, Yue-Zi Hu, Qiao Li, Zhao-Lan Hu
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis
Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang, Xing Li
Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease
Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Carla Palleis, Sabrina Katzdobler, Lena Burow, Carolin Kurz, Mirlind Zaganjori, Lena-Katharina Trappmann, Oliver Goldhardt, Timo Grimmer, Jan Haeckert, Daniel Keeser, Sophia Stoecklein, Estrella Morenas-Rodriguez, Peter Bartenstein, Johannes Levin, Günter U. Höglinger, Mikael Simons, Robert Perneczky, Matthias Brendel
Synergistic effect of sildenafil combined with controlled hypothermia to alleviate microglial activation after neonatal hypoxia–ischemia in rats
Pansiot Julien, Manuela Zinni, Natacha Bonnel, Marina El Kamouh, Felipe Odorcyk, Lea Peters, Emilie-Fleur Gautier, Marjorie Leduc, Cédric Broussard, Olivier Baud
Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases
Wendy Balestri, Ruchi Sharma, Victor A. da Silva, Bianca C. Bobotis, Annabel J. Curle, Vandana Kothakota, Farnoosh Kalantarnia, Maria V. Hangad, Mina Hoorfar, Joanne L. Jones, Marie-Ève Tremblay, Jehan J. El-Jawhari, Stephanie M. Willerth, Yvonne Reinwald
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice
Anna M. Pfaller, Lew Kaplan, Madalena Carido, Felix Grassmann, Nundehui Díaz-Lezama, Farhad Ghaseminejad, Kirsten A. Wunderlich, Sarah Glänzer, Oliver Bludau, Thomas Pannicke, Bernhard H. F. Weber, Susanne F. Koch, Boyan Bonev, Stefanie M. Hauck, Antje Grosche
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agnès Gruart, José M. Delgado-García, Lesley Probert, Vasiliki Kyrargyri
SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury
Yi Qian, Lixuan Yang, Jian Chen, Chao Zhou, Ningning Zong, Yang Geng, Shengnan Xia, Haiyan Yang, Xinyu Bao, Yan Chen, Yun Xu
Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice
Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li, Wenjie Jin
Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease
Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate, Jonathan M. Levenson
Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures
Ahmad S. Rashidi, Diana N. Tran, Caithlin R. Peelen, Michiel van Gent, Werner J. D. Ouwendijk, Georges M. G. M. Verjans
Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring
Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Pernilla Svedin, Thomas Jansson, Carina Mallard, Maryam Ardalan
Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury
Erwin K. Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J. Pridham, Michelle L. Olsen, Michelle H. Theus
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina
Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash, Astrid E. Cardona
Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner
Chong He, Kun Peng, Xiong Zhu, Zuo Wang, Wenbo Xiu, Gao Zhang, Yang Chen, Chaonan Sun, Xiao Xiao, Donghua Liu, An Li, Yanping Gao, Jinxia Wang, Ping Shuai, Yilian Chen, Ling Yu, Fang Lu
Mitochondrial stress: a key role of neuroinflammation in stroke
Ling Gao, Li Peng, Jian Wang, John H. Zhang, Ying Xia
Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits
Gjinovefa Kola, Caitlyn W. Clifford, Cara K. Campanaro, Rishi R. Dhingra, Mathias Dutschmann, Frank J. Jacono, Thomas E. Dick
Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project
Suzan van Amerongen, Surya V. Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D. Cherry, Charles Bernick, Yonas E. Geda, Jennifer V. Wethe, Douglas I. Katz, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H. Daneshvar, Elizabeth A. Colasurdo, Jeffrey J. Iliff, Gail Li, Elaine R. Peskind, Martha E. Shenton, Eric M. Reiman, Jeffrey L. Cummings, Robert A. Stern, Kewei Chen, Hillary Protas, Eric Reiman, Yi Su, Connie Boker, Michael L. Alosco, Rhoda Au, Robert C. Cantu, Lindsay Farrer, Robert Helm, Douglas I. Katz, Neil Kowall, Jesse Mez, Gustavo Mercier, James Otis, Robert A. Stern, Jason Weller, Tahlia Bragg, Irene Simkin, Diana Trujillo-Rodriguez, Suzan van Amerongen, Alondra Andino, Shannon Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hunt, Nicole Gullotti, Bailey Kossow, Carrie Kugelmass, Megan Mariani, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Marty DiPopolo, Taylor Platt, Surya Pulukuri, Fiona Rice, Madison Sestak, Irene Simkin, Michael McClean, Yorghos Tripodis, Douglas Annis, Christine Chaisson, Diane B. Dixon, Carolyn Finney, Kerrin Gallagher, Kaitlin Hartlage, Jun Lu, Brett Martin, Emmanuel Ojo, Joseph N. Palmisano, Brittany Pine, Janani Ramachandran, Zachary Baucom, Fatima Tuz-Zahra, Eukyung Yhang, Sylvain Bouix, Jennifer Fitzsimmons, Alexander P. Lin, Inga K. Koerte, Ofer Pasternak, Martha E. Shenton, Hector Arciniega, Tashrif Billah, Elena Bonke, Katherine Breedlove, Holly Carrington, Eduardo Coello, Michael J. Coleman, Omar John, Leonard Jung, Huijun Liao, Maria Loy, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Tim L. T. Wiegand, Sarah Banks, Charles Bernick, Jason Miller, Aaron Ritter, Marwan Sabbagh, Raelynn de la Cruz, Jan Durant, Morgan Golceker, Nicolette Harmon, Jaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Miranda Staples, Robert W. Turner, Emma F. Clark, Kenneth L. Marek, Andrew Serrano, Charles H. Adler, David W. Dodick, Yonas Geda, Jennifer V. Wethe, Amy Duffy, Bryce Falk, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, Patrick Bellgowan, Laura Balcer, William Barr, Judith Goldberg, Binu Joseph, Ivan Kirov, Yvonne Lui, Charles Marmar, Thomas Wisniewski, Alhassan Al-Kharafi, Allan George, Lisena Hasanaj, Sammie Martin, Edward Riley, William Runge, Liliana Serrano, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Jeffrey L. Cummings, Jeffrey Iliff, Gail Li, Deidre Janssen, James Meabon, Elaine R. Peskind, Juan Piantino, Abigail Schindler, Ronald Thomas, Elizabeth Colasurdo, Jane Shofer, Daniel S. Marcus, Jenny Gurney, Richard Greenwald, Keith A. Johnson
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim
The role of CD56bright NK cells in neurodegenerative disorders
Carla Rodriguez-Mogeda, Chaja M. J. van Ansenwoude, Lennart van der Molen, Eva M. M. Strijbis, Reina E. Mebius, Helga E. de Vries
Intracerebellar injection of monocytic immature myeloid cells prevents the adverse effects caused by stereotactic surgery in a model of cerebellar neurodegeneration
Carlos del Pilar, Lucía Garrido-Matilla, Lucía del Pozo-Filíu, Rafael Lebrón-Galán, Raúl F. Arias, Diego Clemente, José Ramón Alonso, Eduardo Weruaga, David Díaz
Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease
Carla Cuní-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek
The insular cortex is not insular in thyroid eye disease: neuroimaging revelations of central–peripheral system interaction
Haiyang Zhang, Yuting Liu, Duojin Xia, Mengda Jiang, Yinwei Li, Jing Sun, Haixia Guan, Ling Zhu, Xuefei Song, Jue Wang, Xianqun Fan, Huifang Zhou
Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes
Eleftheria Kodosaki, W. John Watkins, Sam Loveless, Karim L. Kreft, Aidan Richards, Valerie Anderson, Lisa Hurler, Neil P. Robertson, Wioleta M. Zelek, Emma C. Tallantyre
Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson’s disease
Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon, Sang Myun Park
Parkinson’s disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Cansu Yildirim-Balatan, Alexis Fenyi, Pierre Besnault, Lina Gomez, Julia E. Sepulveda-Diaz, Patrick P. Michel, Ronald Melki, Stéphane Hunot
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C. Saido, Takashi Saito, Koji Yamanaka
Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury
Josef Biber, Yassin Jabri, Sarah Glänzer, Aaron Dort, Patricia Hoffelner, Christoph Q. Schmidt, Oliver Bludau, Diana Pauly, Antje Grosche
SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
Chenglong Wang, Yitong Xu, Miao Xu, Cong Sun, Xiaojiao Zhang, Xueshu Tao, Tao Song
Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia
Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry
Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington’s disease
Ian D. Gaudet, Hongyuan Xu, Emily Gordon, Gianna A. Cannestro, Michael L. Lu, Jianning Wei
IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
Ning Yu, Huan Cui, Sixuan Jin, Penghao Liu, Yehong Fang, Fengrun Sun, Yan Cao, Bo Yuan, Yikuan Xie, Wanru Duan, Chao Ma
Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang
Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Pretty Garg, Franziska Würtz, Fabian Hobbie, Klemens Buttgereit, Abhishek Aich, Kristian Leite, Peter Rehling, Sebastian Kügler, Mathias Bähr
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Ellen R. Gillespie, Laura F. Grice, Isabel G. Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A. Brown, James Walsham, Kristen J. Radford, Quan H. Nguyen, Marc J. Ruitenberg
The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
Alice Brandli, Kirstan A. Vessey, Erica L. Fletcher
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Rami A. Shahror, Carol A. Morris, Aya A. Mohammed, Melissa Wild, Bushra Zaman, Christian D. Mitchell, Paul H. Phillips, Nancy J. Rusch, Esraa Shosha, Abdelrahman Y. Fouda
TYROBP/DAP12 knockout in Huntington’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby, Michelle E. Ehrlich
Border-associated macrophages in the central nervous system
Rui Sun, Haowu Jiang
Macrophages coordinate immune response to laser-induced injury via extracellular traps
Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt, Volker Enzmann
Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk
Shanshan Song, Helena Oft, Shamseldin Metwally, Satya Paruchuri, John Bielanin, Victoria Fiesler, Chaim Sneiderman, Gary Kohanbash, Dandan Sun
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury
Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng, Jiangang Shen
Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis
Mahesh Chandra Kodali, Jerry Antone, Eric Alsop, Rojashree Jayakumar, Khushi Parikh, Aude Chiot, Paula Sanchez-Molina, Bahareh Ajami, Steven E. Arnold, Kendall Jensen, Sudeshna Das, Marc S. Weinberg
Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
Cathrin E. Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van het Hof, Ruud D. Fontijn, Susanne M. A. van der Pol, Laura Michalick, Wolfgang M. Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Britta Engelhardt, Gijs Kooij, Maarten E. Witte, Helga E. de Vries
P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation
Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang, Xiuju Chen
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager, David N Zacks
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu, Jingfa Zhang
Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Ling’en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao, Jing Ye
Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer’s disease
Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E. Alexander, Aimin Xu, Koon-Ho Chan
Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies
Dominika Olešová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký, Andrej Kováč
The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks
Milena Rodriguez Alvarez, Hussam Alkaissi, Aja M. Rieger, Guillem R. Esber, Manuel E. Acosta, Stacy I. Stephenson, Allison V. Maurice, Laura Melissa Rodríguez Valencia, Christopher A. Roman, Juan Marcos Alarcon
Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease
Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yongtao He, Jiayin Zhao, Zishan Wang, Jinghui Wang, Qing Li, Guangchun Fan, Zhaolin Liu, Chenye Shen, Yunhe Zhang, Mei Yu, Jian Fei, Fang Huang
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling
Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma, Ren-Hong Du
Cranial irradiation disrupts homeostatic microglial dynamic behavior
Alexandra O. Strohm, Carl Johnston, Eric Hernady, Brian Marples, M. Kerry O’Banion, Ania K. Majewska
Bi-directional neuro-immune dysfunction after chronic experimental brain injury
Rodney M. Ritzel, Yun Li, Yun Jiao, Sarah J. Doran, Niaz Khan, Rebecca J. Henry, Kavitha Brunner, David J. Loane, Alan I. Faden, Gregory L. Szeto, Junfang Wu
Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Hanyou Liu, Jingying Li, Xue Wang, Shiqi Luo, Dan Luo, Wei Ge, Chao Ma
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
Xiaowei Fei, Li Wang, Ya-nan Dou, Fei Fei, Yanyu Zhang, Weihao Lv, Xin He, Xiuquan Wu, Wangshu Chao, Hongqing Chen, Jialiang Wei, Dakuan Gao, Zhou Fei
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi, Hong Liao
Impact of microglia isolation and culture methodology on transcriptional profile and function
Mark Mizrachi, Betty Diamond
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord
Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing, Li Cheng
Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting, Chaim Putterman
Correction: Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease
Carla Cuní‑López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek
Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
Maria T. Cencioni, Roberta Magliozzi, Ilaria Palmisano, Keittisak Suwan, Antonella Mensi, Laura Fuentes-Font, Luisa M. Villar, José I. Fernández-Velasco, Noelia Villarrubia Migallón, Lucienne Costa-Frossard, Enric Monreal, Rehiana Ali, Marina Romozzi, Nicholas Mazarakis, Richard Reynolds, Richard Nicholas, Paolo A. Muraro
Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz, Esther Luquin, Pedro Clavero, Elisa Mengual, Sandra Hervás-Stubbs, Maria S. Aymerich
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease
Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman, Eliezer Masliah
Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Terry Dean, Andrew S. Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga, Katerina Akassoglou, Jae Kyu Ryu
A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies
Ogochukwu J. Uweru, Akhabue K. Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S. Thomas, Georgia Davidson, Kendall Cox, Ukpong B. Eyo
GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
Qun Fu, Yi-Bao Zhang, Chang-Xi Shi, Ming Jiang, Kai Lu, Zi-Hui Fu, Jia-Ping Ruan, Jing Wu, Xiao-Ping Gu
LXR agonism for CNS diseases: promises and challenges
Ruiyi Zhang, Emily Wuerch, V. Wee Yong, Mengzhou Xue
Complement propagates visual system pathology following traumatic brain injury
Davis M. Borucki, Baerbel Rohrer, Stephen Tomlinson
Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain
Yidan Tang, Jiahui Wu, Changliang Liu, Lu Gan, Hai Chen, Ya-Lan Sun, Jin Liu, Yuan-Xiang Tao, Tao Zhu, Chan Chen
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
Kevin Budding, Jeroen W. Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Eva M. Zekveld, Ewout J.N. Groen, Bart C. Jacobs, Ruth Huizinga, H. Stephan Goedee, Elisabeth A. Cats, Jeanette H.W. Leusen, Leonard H. van den Berg, C. Erik Hack, W. Ludo van der Pol
Microbiota-derived acetate attenuates neuroinflammation in rostral ventrolateral medulla of spontaneously hypertensive rats
Xiaopeng Yin, Changhao Duan, Lin Zhang, Yufang Zhu, Yueyao Qiu, Kaiyi Shi, Sen Wang, Xiaoguang Zhang, Huaxing Zhang, Yinchao Hao, Fang Yuan, Yanming Tian
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng, Yujie Chen
CSF1R antagonism results in increased supraspinal infiltration in EAE
Marilyn Wang, Sofia E. Caryotakis, Glendalyn G. Smith, Alan V. Nguyen, David E. Pleasure, Athena M. Soulika
Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis
Xiangyi Kong, Wenyuan Lyu, Xiaojie Lin, Chunlong Lin, Hao Feng, Lin Xu, Kaiyue Shan, Penghui Wei, Jianjun Li
Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway
Xin Shi, Panpan Li, Marc Herb, Hanhan Liu, Maoren Wang, Xiaosha Wang, Yuan Feng, Tim van Beers, Ning Xia, Huige Li, Verena Prokosch
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Xiangyang Deng, Junwei Ren, Kezhu Chen, Jin Zhang, Quan Zhang, Jun Zeng, Tianwen Li, Qisheng Tang, Jian Lin, Jianhong Zhu
Neuroinflammation driven by human immunodeficiency virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of neurogranin in vivo and in vitro
Roberta S. dos Reis, Marc C. E. Wagner, Savannah McKenna, Velpandi Ayyavoo
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell
Chronic immunosuppression across 12 months and high ability of acute and subacute CNS-injury biomarker concentrations to identify individuals with complicated mTBI on acute CT and MRI
Gerard Janez Brett Clarke, Turid Follestad, Toril Skandsen, Henrik Zetterberg, Anne Vik, Kaj Blennow, Alexander Olsen, Asta Kristine Håberg
Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Ziying Feng, Cheng Fang, Yinzhong Ma, Junlei Chang
Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
Guanqiao Liu, Wen Shu, Yingqi Chen, Yong Fu, Shuai Fang, Haonan Zheng, Weike Cheng, Qingrong Lin, Yanjun Hu, Nan Jiang, Bin Yu
Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing
Lei Zhu, He Li, Xuening Peng, Zhaohuai Li, Sichen Zhao, Dongting Wu, Jialing Chen, Si Li, Renbing Jia, Zuohong Li, Wenru Su
Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction
Rebecca J. Henry, James P. Barrett, Maria Vaida, Niaz Z. Khan, Oleg Makarevich, Rodney M. Ritzel, Alan I. Faden, Bogdan A. Stoica
Maternal immunoglobulin G affects brain development of mouse offspring
Mizuki Sadakata, Kazuki Fujii, Ryosuke Kaneko, Emi Hosoya, Hisako Sugimoto, Reika Kawabata-Iwakawa, Tetsuhiro Kasamatsu, Shoko Hongo, Yumie Koshidaka, Akinori Takase, Takatoshi Iijima, Keizo Takao, Tetsushi Sadakata
Inhibition of NADPH oxidase 2 enhances resistance to viral neuroinflammation by facilitating M1-polarization of macrophages at the extraneural tissues
Jin Young Choi, Hee Won Byeon, Seong Ok Park, Erdenebileg Uyangaa, Koanhoi Kim, Seong Kug Eo
Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation
Junhui Chen, Zhonghua Shi, Chunlei Zhang, Kun Xiong, Wei Zhao, Yuhai Wang
Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain
Pauline Beckers, Inês Belo Do Nascimento, Mathilde Charlier, Nathalie Desmet, Ann Massie, Emmanuel Hermans
Impact of maternal immune activation and sex on placental and fetal brain cytokine and gene expression profiles in a preclinical model of neurodevelopmental disorders
Hadley C. Osman, Rachel Moreno, Destanie Rose, Megan E. Rowland, Annie Vogel Ciernia, Paul Ashwood
Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria
Yi Wang, Yan Shen, Jiao Liang, Shubiao Wang, Yuxiao Huang, Qinghao Zhu, Xizhi Zhang, Kangjie Yu, Guodong Tong, Chao Yang, Yinghui Li, Jun Wang, Ya Zhao
The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study
Sophia C. Morandi, Elio L. Herzog, Marion Munk, Marco Kreuzer, Carlo R. Largiadèr, Sebastian Wolf, Martin Zinkernagel, Denise C. Zysset-Burri
Early administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale
Nhi T. Tran, Tayla R. Penny, Kyra YY. Chan, Tanya Tang, Paris C. Papagianis, Tara Sepehrizadeh, Lakshmi Nekkanti, Valerie A. Zahra, Yen Pham, Tamara Yawno, Ilias Nitsos, Sharmony B. Kelly, Alison M. Thiel, Michael de Veer, Dhafer M. Alahmari, Michael C. Fahey, Graham Jenkin, Suzanne L. Miller, Robert Galinsky, Graeme R. Polglase, Courtney A. McDonald
Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury
Ali Shad, Sarah S. J. Rewell, Matthew Macowan, Natasha Gandasasmita, Jiping Wang, Ke Chen, Ben Marsland, Terence J. O’Brien, Jian Li, Bridgette D. Semple
Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
Dan Li, Shu-fang Yu, Lin Lin, Jie-ru Guo, Si-mei Huang, Xi-lin Wu, Han-lin You, Xiao-juan Cheng, Qiu-yang Zhang, Yu-qi Zeng, Xiao-dong Pan
Dysregulated brain-gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies
Mahmoud G. El Baassiri, Zachariah Raouf, Sarah Badin, Alejandro Escobosa, Chhinder P. Sodhi, Isam W. Nasr
Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer’s disease
Qiang Li, Bing Li, Li Liu, Kang-Ji Wang, Ming-Yue Liu, Yu Deng, Ze Li, Wei-Dong Zhao, Li-Yong Wu, Yu-Hua Chen, Ke Zhang
Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis
İlayda Altınönder, Mustafa Kaya, Sibel P. Yentür, Arman Çakar, Hacer Durmuş, Gülçin Yegen, Berker Özkan, Yeşim Parman, Amr H. Sawalha, Guher Saruhan-Direskeneli