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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2024

Open Access 01-12-2024 | Stroke | Review

Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke

Authors: Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng, Yujie Chen

Published in: Journal of Neuroinflammation | Issue 1/2024

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Abstract

The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous system and the peripheral immune system, both in the healthy state and after ischemic and hemorrhagic stroke. Although primary injury after stroke is certainly important, the limited therapeutic efficacy, poor neurological prognosis and high mortality have led researchers to realize that secondary injury and damage may also play important roles in influencing long-term neurological prognosis and mortality and that the neuroinflammatory process in secondary injury is one of the most important influences on disease progression. Here, we summarize the interactions of the central nervous system with the peripheral immune system after ischemic and hemorrhagic stroke, in particular, how the central nervous system activates and recruits peripheral immune components, and we review recent advances in corresponding therapeutic approaches and clinical studies, emphasizing the importance of the role of the peripheral immune system in ischemic and hemorrhagic stroke.
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Metadata
Title
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
Authors
Mingxu Duan
Ya Xu
Yuanshu Li
Hua Feng
Yujie Chen
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2024
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-024-03101-y

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