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Biomarkers 

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  1. Open Access 01-12-2024 | OriginalPaper

    Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma

    Within the global context, the incidence of thyroid cancer has been incrementally rising, establishing it as the most prevalent malignancy in the head and neck region [ 1 , 2 ]. Papillary thyroid carcinoma (PTC), constituting 80% of all thyroid …

  2. 12-04-2024 | Alzheimer's Disease | Panel Discussion | Article
    Experts in Conversation

    Implementing AD biomarkers and amyloid-targeting therapies

    Dorota Religa and Robert Perneczky walk us through the most exciting findings from the AD/PD™ and CONy 2024 conferences. Their discussion focuses on existing and emerging biomarkers and new amyloid-targeting therapies in Alzheimer's disease.

    Lilly
  3. 25-04-2024 | Pancreatic Cancer | Online First

    The role of biomarkers in the early detection of pancreatic cancer

    Pancreatic surveillance can detect early-stage pancreatic cancer and achieve long-term survival, but currently involves annual endoscopic ultrasound and MRI/MRCP, and is recommended only for individuals who meet familial/genetic risk criteria. To …

  4. Open Access 01-12-2024 | Biomarkers | OriginalPaper

    Clinical significance of urinary inflammatory biomarkers in patients with IgA nephropathy

    IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide [ 1 ]. Its clinical course is variable and can progress to end-stage kidney disease (ESKD) in approximately 40% of patients within 20–30 years of diagnosis …

  5. 10-04-2024 | Alzheimer's Disease | Panel Discussion | Teaser

    Implementing AD biomarkers and amyloid-targeting therapies

    Dorota Religa and Robert Perneczky walk us through the most exciting findings from the AD/PD™ and CONy 2024 conferences. Their discussion focuses on existing and emerging biomarkers and new amyloid-targeting therapies in Alzheimer's disease.

  6. Open Access 01-12-2024 | OriginalPaper

    Energy expenditure related biomarkers following bariatric surgery: a prospective six-month cohort study

    Bariatric surgery is considered an effective way for weight loss in the short and long term. It can help patients decrease the risk of obesity-related diseases [ 1 , 2 ]. There are strong evidences supporting the safety and effectiveness of …

  7. Open Access 01-12-2024 | Stroke | OriginalPaper

    The role of blood protein biomarkers in acute ischemic stroke prognosis

    Stroke is a common global cause of disability and mortality [ 1 ]. It has a diverse etiology that include unmodifiable risk factors, such as age, genetics, and sex in addition to risk factors that can be modified as, hypertension, Diabetes …

  8. Open Access 21-04-2024 | Hypotension | Online First

    Non-invasive biomarkers for spontaneous intracranial hypotension (SIH) through phase-contrast MRI

    Spontaneous intracranial hypotension (SIH) is an underdiagnosed disease caused by spinal CSF leaks, manifesting at any age [ 1 ]. The annual incidence rate of 4–5/100,000 is estimated [ 2 – 4 ]. Typically, clinical manifestation entails, but is not …

  9. Open Access 01-12-2024 | Prostate Cancer | OriginalPaper

    Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer

    Prostate cancer (PCa) has become one of the major malignant tumors that threatens men’s health and survival due to its aggressive metastasis [ 1 ]. Previous clinical studies suggest that PCa advances to castration-resistant prostate cancer (CRPC) …

  10. Open Access 01-12-2024 | Biomarkers | OriginalPaper

    Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in pulmonary arterial hypertension

    Pulmonary arterial hypertension (PAH) is a fatal pulmonary vascular disease which is marked by elevated pressure and the failure of the right ventricle [ 1 , 2 ]. Despite the significant progress in enhancing survival through the advancement of …

  11. Open Access 01-12-2024 | Gastric Cancer | OriginalPaper

    Biomarkers of lipid metabolism in gastric cancer: a case control study

    Gastric cancer is a common malignant tumor. In the global malignant tumors, the incidence of gastric cancer ranks sixth and the mortality rate ranks the third [ 1 ] . It has high incidence in east Asia, especially in China, the incidence and …

  12. Open Access 14-03-2024 | Biomarkers | ReviewPaper

    Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials

    Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by …

  13. 18-03-2024 | Alzheimer's Disease | Video | Article
    Breakfast Bite

    Latest research on fluid biomarkers

    Charlotte Teunissen highlights some of the research presented on AD biomarkers, including a novel assay for multiphosphorylated tau and the impact of confounding factors.

    Lilly
  14. Open Access 01-12-2024 | Cervical Cancer | OriginalPaper

    High-throughput metabolomics identifies new biomarkers for cervical cancer

    Cervical cancer (CC) is an important global public health issue, which ranks as one of the most common cancers and the top leading cause of cancer death in middle-aged women [ 1 , 2 ]. CC has multiple risk factors including high-risk human …

  15. Open Access 01-12-2024 | OriginalPaper

    Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review

    Clinical trials in Alzheimer’s disease (AD) historically have had high failure rates due to several reasons, one of which is the lack of tools to measure target engagement and other biologically relevant modulations to inform drug development [ 1 …

  16. 23-02-2024 | Glioblastoma | Letter

    Harnessing imaging biomarkers for glioblastoma metastasis diagnosis: a correspondence

  17. 27-04-2024 | Online First

    Periprocedural Changes of Serum Biomarkers in Predicting Complications Following Bariatric Surgery for Obesity: Systematic Review and Meta-analysis

    Bariatric surgery is an effective treatment for severe obesity, but complications and peri-operative monitoring are important considerations. We conducted a comprehensive review of studies assessing pre-operative biomarkers and complications in …

  18. Open Access 01-12-2024 | Aortic Dissection | OriginalPaper

    Inflammation in aortic surgery: postoperative evolution of biomarkers according pathologies and segments of the aorta

    Open aortic surgery poses a major insult to the body due to the associated long cardiopulmonary bypass and ischaemia to different organs; this translates into a general inflammatory response that it is usually exarcerbated by the need of …

  19. Open Access 26-03-2024 | Edema | OriginalPaper

    Enhancing Diabetic Macular Edema Treatment Outcomes: Exploring the ESASO Classification and Structural OCT Biomarkers

    Diabetes mellitus continues to pose a significant global health challenge, with an alarming rise in the number of affected individuals. In 2019, the International Diabetes Federation reported that approximately 240 million people worldwide had …

  20. Open Access 01-12-2024 | Metastasis | ReviewPaper

    Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer

    Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates. Nevertheless, the swift advancement of contemporary technology has not seamlessly aligned with the evolution …

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