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Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Reactions Weekly

Issue 1/2023

Content (387 Articles)

Vasculitis News item

Azacitadine-related cutaneous vasculitis

Semaglutide News item

Falsified Ozempic pens in the EU and UK

COVID-19 Vaccination News item

ICMRA statement on safety of COVID-19 vaccines

Botulinum Toxin News item

Warning against Haytox in Australia

SCLC Clinical study

Chemotherapy + ICIs in extensive-stage small-cell lung cancer: risk of interstitial lung disease

Gastric Cancer Clinical study

Long-term PPIs after H. pylori eradication increases risk of gastric cancer

Neonatal Seizures Clinical study

No causal association between in utero levothyroxine exposure and seizures

Lurasidone Clinical study

Novel method for deriving AE prevalence in RCTs

Oxycodone Clinical study

Oxycodone allergies/intolerances: risk of worse postoperative pain, longer length of stay

NSCLC Clinical study

PD-1/PD-L1 inhibitor use for NSCLC: more irAEs with first-line therapy

Postpartum Depression Clinical study

Postmarketing safety profile of brexanolone: many safety signals

Inflammatory Rheumatic Diseases Clinical study

Risk of serious infections increases with tofacitinib versus bDMARDs

Crizotinib News item

Other adverse reaction research

Tenofovir Case report

Abacavir/dolutegravir/lamivudine/cobicistat/elvitegravir/emtricitabine/tenofovir-alafenamide

Aciclovir Case report

Aciclovir

Adalimumab Case report

Acitretin/adalimumab/ciclosporin

Basalioma Case report

Acitretin/nicotinamide

Adalimumab Case report

Adalimumab

Scrofuloderma Case report

Adalimumab

Vulgar Psoriasis Case report

Adalimumab/ciclosporin/risankizumab

Folliculitis Decalvans Case report

Afatinib/ciprofloxacin/tetracycline

Esophagitis Case report

Alendronic-acid

Foreign Body Aspiration Case report

Alprazolam/oxycodone

Pergolide Case report

Amantadine/levodopa/pergolide

Pulmonary Hemorrhage Case report

Amfetamine/enoxaparin-sodium

Thoracotomy Case report

Amfetamine/phencyclidine

Hypotension Case report

Aminolevulinic-acid

Ventricular Tachycardia Case report

Amiodarone

Hyperthyroidism Case report

Amiodarone

Cholestyramine Case report

Amiodarone/colestyramine

Ventricular Tachycardia Case report

Amiodarone/lidocaine/magnesium-sulfate

Amitriptyline Case report

Amitriptyline

Amitriptyline Case report

Amitriptyline

Flucytosine Case report

Amphotericin-B/flucytosine

Cushing's Syndrome Case report

Angelica-sinensis/cistanche/codonopsis-pilosula/eucommiae-ulmoides/ginseng/lycium-barbarum/paeonia-lactiflora/radix-angelicae-tuho/rhizoma-atractylodis/dexamethasone

Asthmatic Status Case report

Antiasthmatics/magnesium

Carbapenem Antibiotic Case report

Antibacterials

Doxycycline Case report

Antibacterials

Daptomycin Case report

Antibacterials

Amoxicillin Case report

Antibacterials

Amphotericin B Case report

Antibacterials/antifungals

ANCA-Associated Vasculitis Case report

Antibacterials/immunosuppressants/steroids

Paliperidone Case report

Antidepressants/antipsychotics/otilonium-bromide

Sitagliptin Case report

Antihyperglycaemics

Nevi Case report

Antineoplastic

NSCLC Case report

Antineoplastics

Bullous Pemphigoid Case report

Antineoplastics

Gefitinib Case report

Antineoplastics

Axitinib Case report

Antineoplastics

Afatinib Case report

Antineoplastics

Bevacizumab Case report

Antineoplastics

Pleural Effusion Case report

Antineoplastics

Melanoma Case report

Antineoplastics/immune globulin

Clozapine Case report

Antipsychotics

Clozapine Case report

Antipsychotics/scopolamine

Human Immunodeficiency Virus Case report

Antiretrovirals/prednisone

Eptifibatide Case report

Antithrombotics/aspirin/eptifibatide

Tenofovir Case report

Antituberculars

Apixaban Case report

Apixaban/warfarin

Heparin Case report

Argatroban/ceftriaxone/heparin

Stuttering Case report

Aripiprazole

Aripiprazole Case report

Aripiprazole/clozapine

Malaria Case report

Artesunate

COVID-19 Case report

Aspirin

Clopidogrel Case report

Aspirin/clopidogrel

Clopidogrel Case report

Aspirin/clopidogrel

Clopidogrel Case report

Aspirin/clopidogrel/ticagrelor

Pancreatitis Case report

Atezolizumab

Hepatocellular Carcinoma Case report

Atezolizumab

Atorvastatin Case report

Atorvastatin

Ceftazidime Case report

Avibactam/ceftazidime

Azathioprine Case report

Azathioprine

Azathioprine Case report

Azathioprine

Azathioprine Case report

Azathioprine

Aspergillosis Case report

Azathioprine/hydroxychloroquine

Infliximab Case report

Azathioprine/infliximab/steroids

Azathioprine Case report

Azathioprine/mesalazine

Headache Case report

Azd-1222/tozinameran

Arthritis Case report

Azd-1222/tozinameran

Uveitis Case report

AZD1222/ranibizumab/tozinameran

Suicide Case report

Baclofen

Ringworm of the hair Case report

Baricitinib

Shingles Case report

Baricitinib/tofacitinib/upadacitinib

Soft Tissue Ultrasound Case report

BBIBP-CorV

Cardiogenic Shock Case report

Belimumab

Case report

Betamethasone

Lupus Erythematosus Case report

Betamethasone dipropionate

Bevacizumab Case report

Bevacizumab/pralsetinib

Bicalutamide Case report

Bicalutamide

Tenofovir Case report

Bictegravir/emtricitabine/tenofovir-alafenamide/glucose

Denosumab Case report

Bisphosphonates/denosumab

Melanoma Case report

Bleomycin

Daratumumab Case report

Bortezomib/daratumumab/dexamethasone

Bosutinib Case report

Bosutinib

Quetiapine Case report

Bromazepam/quetiapine

Bromocriptine Case report

Bromocriptine

Joint Infection Case report

Budesonide/formoterol/piperacillin/tazobactam

Hypotension Case report

Bupivacaine overdose

Posterior Reversible Encephalopathy Syndrome Case report

Bupivacaine/morphine

Bupropion Case report

Bupropion/nicotine/varenicline

Acute Lymphoblastic Leukemia Case report

Busulfan

Basalioma Case report

Cabazitaxel

Hyperparathyroidism Case report

Calcitriol/calcium carbonate/lanthanum carbonate

Lung Cancer Case report

Camrelizumab

Case report

Camrelizumab

Hyperthyroidism Case report

Camrelizumab

Thrombocytopenia Case report

Camrelizumab

Hyperglycemia Case report

Capecitabine/cisplatin/gemcitabine

Clonazepam Case report

Carbamazepine/clonazepam

Oropharyngeal Cancer Case report

Carboplatin/cisplatin/paclitaxel

Lenvatinib Case report

Carboplatin/lenvatinib/paclitaxel

Neutropenia Case report

Carboplatin/paclitaxel

Leukopenia Case report

Carboplatin/paclitaxel/sintilimab

Pneumonia Case report

Carfilzomib/prednisone

Cefazolin Case report

Cefazolin

Ciprofloxacin Case report

Cefiderocol/ciprofloxacin/colistin

Ceftriaxone Case report

Ceftriaxone

Ceftriaxone Case report

Ceftriaxone

Ceftriaxone Case report

Ceftriaxone

COVID-19 Case report

Cilgavimab/tixagevimab

COVID-19 Case report

Cilgavimab/tixagevimab

COVID-19 Case report

Cilgavimab/tixagevimab/dexamethasone

Ciprofloxacin Case report

Ciprofloxacin

Moxifloxacin Case report

Ciprofloxacin/levofloxacin/moxifloxacin

Colostomy Case report

Cisplatin/gemcitabine/sintilimab

Ponesimod Case report

Cladribine/ponesimod

Clonidine Case report

Clonidine/labetalol/nicardipine

Prazosin Case report

Clonidine/potassium chloride/prazosin

COVID-19 Case report

Corticosteroid/prednisone

Levofloxacin Case report

Cotrimoxazole/levofloxacin

Morphine Case report

Cotrimoxazole/morphine/phenazopyridine

Azithromycin Case report

Cotrimoxazole/prednisone/primaquine

COVID-19 Case report

COVID-19-vaccine

Leukocytoclastic Vasculitis Case report

Covid-19-vaccine/methotrexate

Uveitis Case report

COVID-19-vaccines

Ultrasound Case report

Cyanoacrylate

Glomerulonephritis Case report

Cyclophosphamide/prednisolone

Dabigatran Case report

Dabigatran-etexilate

Olanzapine Case report

Dantrolene/lithium/olanzapine

Thalassemia Case report

Deferoxamine

Denosumab Case report

Denosumab

Denosumab Case report

Denosumab

Diseases of the neuromuscular synapses and muscles Case report

Dexamethasone

Multiple Myeloma Case report

Dexamethasone/ixazomib/lenalidomide

Cryptococcosis Case report

Dexamethasone/tocilizumab

Hypoxemia Case report

Dexmedetomidine

Dextromethorphan Case report

Dexmethylphenidate/dextromethorphan

Haloperidol Case report

Diazepam/haloperidol

Digoxin Case report

Digoxin

Leg Ulcer Case report

Dimeticone

Tocilizumab Case report

Disease modifying antirheumatics/tocilizumab

Neutropenia Case report

Docetaxel

NSCLC Case report

Docetaxel

Case report

Docetaxel/paclitaxel

Tremor Case report

Donepezil

Sarcoma Case report

Doxorubicin

Pleural Effusion Case report

Doxorubicin

Doxycycline Case report

Doxycycline

Guillain-Barré Syndrome Case report

DTaP vaccine

Dupilumab Case report

Dupilumab

Myocarditis Case report

Durvalumab

Vaccination Case report

Elasomeran

Nephrotic Syndrome Case report

Elasomeran

Tick Case report

Elasomeran/influenza-virus-vaccine/tick-borne-encephalitis-vaccine

Tendinosis Case report

Elasomeran/tozinameran

Hemophilia Case report

Emicizumab

Neurofibromatosis Case report

Enoxaparin-sodium

Chronic Lymphocytic Leukemia Case report

Epigallocatechin-gallate

Escitalopram Case report

Escitalopram

Escitalopram Case report

Escitalopram

Menorrhagia Case report

Estradiol

Etanercept Case report

Etanercept/methotrexate

Ventricular Tachycardia Case report

Ethacizin/sotalol interaction

Tranexamic Acid Case report

Factor-VIII-inhibitor-bypassing-fraction/tranexamic-acid

Clindamycin Case report

Favipiravir

Fentanyl Case report

Fentanyl abuse

Fentanyl Case report

Fentanyl/methadone

Cutaneous Mastocytosis Case report

Fentanyl/morphine

Fingolimod Case report

Fingolimod

Fingolimod Case report

Fingolimod/prednisolone

Right Bundle Branch Block Case report

Flecainide

Atrial Fibrillation Case report

Flecainide/methylprednisolone

Fluconazole Case report

Fluconazole

Fluconazole Case report

Fluconazole

Thrombocytopenia Case report

Flumbatinib

Tramadol Case report

Flunitrazepam/tramadol

Urticaria Case report

Fluorouracil/folinic acid/oxaliplatin

Hepatitis Case report

Fluorouracil/folinic-acid/oxaliplatin

Rectal Cancer Case report

Fluorouracil/folinic-acid/oxaliplatin

Salmeterol Case report

Fluticasone-propionate/prednisone/salmeterol

Neutropenia Case report

Folinic-acid/oxaliplatin

Fremanezumab Case report

Fremanezumab

Furosemide Case report

Furosemide

Spironolactone Case report

Furosemide/spironolactone/tolvaptan

Gabapentin Case report

Gabapentin

Disseminated Intravascular Coagulation Case report

Gemcitabine/paclitaxel/plasma

Avoidant Restrictive Food Intake Disorder Case report

Glucose/potassium-chloride/sodium-chloride

Golimumab Case report

Golimumab

Leukopenia Case report

GPC3-CAR-T

Haloperidol Case report

Haloperidol/lorazepam

Heparin-Induced Thrombocytopenia Case report

Heparin

Heparin Case report

Heparin

Heparin Case report

Heparin

Heparin Case report

Heparin/prednisone

Heparin Case report

Heparin/rivaroxaban

Nitroglycerin Case report

Hydralazine/metoprolol/nitroglycerin

Hydroxychloroquine Case report

Hydroxychloroquine

Ibuprofen Case report

Ibuprofen/mupirocin

Imatinib Case report

Imatinib

Respiratory Syncytial Virus Infection Case report

Immune-globulin

Myasthenia Gravis Case report

Immune-globulin/pembrolizumab

Leukocytosis Case report

Immunosuppressants

Ulcerative Colitis Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab

Infliximab Case report

Infliximab/prednisolone

Autoimmune Hemolytic Anemia Case report

Inotersen

Insulin Glargine Case report

Insulin-glargine

Encephalopathy Case report

Iohexol

Encephalopathy Case report

Iohexol/iopamidol

Sorafenib Case report

Ipilimumab/nivolumab/sorafenib

Case report

Isavuconazole

Psoriatic Arthritis Case report

Ixekizumab

Vulgar Psoriasis Case report

Ixekizumab/methotrexate

Lacosamide Case report

Lacosamide

Lacosamide Case report

Lacosamide

Lamotrigine Case report

Lamotrigine

Lamotrigine Case report

Lamotrigine/quetiapine

Lenvatinib Case report

Lenvatinib

Phenobarbital Case report

Levetiracetam/midazolam/phenobarbital

Levofloxacin Case report

Levofloxacin

Affective Disorder Case report

Levonorgestrel

Hypotension Case report

Lidocaine overdose

Propranolol Case report

Lithium/propranolol

Ulcerative Colitis Case report

Lymecycline/mesalazine

Tetany Case report

Magnesium-sulfate/nifedipine

Mepolizumab Case report

Mepolizumab

Metformin Case report

Metformin

Methotrexate Case report

Methotrexate

Methotrexate Case report

Methotrexate

Methotrexate Case report

Methotrexate

Methotrexate Case report

Methotrexate

Methotrexate Case report

Methotrexate

Atopic Dermatitis Case report

Methotrexate

Methotrexate Case report

Methotrexate

Methotrexate Case report

Methotrexate

Methotrexate Case report

Methotrexate/prednisone

Hypokalemia Case report

Methylprednisolone

Case report

Methylprednisolone/pembrolizumab

Tocilizumab Case report

Methylprednisolone/tisagenlecleucel/tocilizumab

Cyanosis Case report

Methylthioninium-chloride/propofol

Erythema Exsudativum Multiforme Case report

Molnupiravir

Streptokinase Case report

Multiple drug

Voriconazole Case report

Multiple drug

Amoxicillin Case report

Multiple drugs

Dystonia Case report

Multiple drugs

Fentanyl Case report

Multiple drugs

Naltrexone Case report

Multiple drugs

Tiotropium Case report

Multiple drugs

Aspergillosis Case report

Multiple drugs

Metronidazole Case report

Multiple drugs

Mirtazapine Case report

Multiple drugs

Remifentanil Case report

Multiple drugs

Mantle Cell Lymphoma Case report

Multiple drugs

Prednisolone Case report

Multiple drugs

Erythema Exsudativum Multiforme Case report

Multiple drugs

Cefepime Case report

Multiple drugs

Anakinra Case report

Multiple drugs

Ramipril Case report

Multiple drugs

Spironolactone Case report

Multiple drugs

Minoxidil Case report

Multiple drugs

Gabapentin Case report

Multiple drugs

Duloxetine Case report

Multiple drugs

Cytostatic Therapy Case report

Multiple drugs

Case report

Multiple drugs

Graft-Versus-Host Disease Case report

Multiple drugs

Hydromorphone Case report

Multiple drugs

Bevacizumab Case report

Multiple drugs

Ruxolitinib Case report

Multiple drugs

Psoriatic Arthritis Case report

Multiple drugs

Lupus Nephritis Case report

Multiple drugs

Malignant Hyperthermia Case report

Multiple drugs

Metformin Case report

Multiple drugs

Pulmonary Hemorrhage Case report

Multiple drugs

Sulfasalazine Case report

Multiple drugs

Common Pemphigus Case report

Multiple drugs

Perampanel Case report

Multiple drugs

Vulgar Psoriasis Case report

Multiple drugs

Dronabinol Case report

Multiple drugs

Celiac Disease Case report

Multiple drugs

Valaciclovir Case report

Multiple drugs

Systemic Lupus Erythematosus Case report

Multiple drugs

Acne Inversa Case report

Multiple drugs

Fluphenazine Case report

Multiple drugs

Pyoderma Gangrenosum Case report

Multiple drugs

Vitiligo Case report

Multiple drugs

Polymyalgia Arteritica Case report

Multiple drugs

Quetiapine Case report

Multiple drugs

Taste Disorder Case report

Multiple drugs

Lisinopril Case report

Multiple drugs

Cholangiocarcinoma Case report

Multiple drugs

Thrombocytopenia Case report

Multiple drugs

Brigatinib Case report

Multiple drugs

Anakinra Case report

Multiple drugs

Methotrexate Case report

Multiple drugs

Paroxetine Case report

Multiple drugs

Acute Lymphoblastic Leukemia Case report

Multiple drugs

Neutropenia Case report

Multiple drugs

Campylobacter Case report

Mycophenolate mofetil, sirolimus and prednisone

Ophthalmoparesis Case report

Mycophenolate-mofetil

Pancreatitis Case report

Mycophenolate-mofetil/nivolumab/pembrolizumab

Histoplasmosis Case report

Mycophenolate-mofetil/prednisone/tacrolimus

Secondary Syphilis Case report

Mycophenolate-sodium/prednisone/tacrolimus

Tacrolimus Case report

Mycophenolate/prednisone/tacrolimus

Pneumonia Case report

Mycophenolate/tacrolimus

Nilotinib Case report

Nilotinib

Ruxolitinib Case report

Nirmatrelvir+ritonavir/ruxolitinib interaction

Status Epilepticus Case report

Nivolumab/prednisone

Septic Shock Case report

Norepinephrine/phenylephrine/vasopressin

Hypotension Case report

Norepinephrine/sodium-chloride

Ocrelizumab Case report

Ocrelizumab

Cephalexin Case report

Ocrilate

Olanzapine Case report

Olanzapine

Oseltamivir Case report

Oseltamivir

Psychotherapy Case report

Oxytocin

Pregabalin Case report

Ozone/pregabalin

Ovarian Cancer Case report

Paclitaxel

Case report

Paclitaxel

Multiple Myeloma Case report

Panobinostat

Paracetamol Case report

Paracetamol

Paracetamol Case report

Paracetamol overdose

Lichen Planus Case report

Pembrolizumab

NSCLC Case report

Pembrolizumab

Polymyalgia Arteritica Case report

Pembrolizumab

Cholangiocarcinoma Case report

Pembrolizumab

Lichen Planus Case report

Pembrolizumab

Myocarditis Case report

Pembrolizumab

Bullous Pemphigoid Case report

Pembrolizumab/enfortumab-vedotin

Cholangiocarcinoma Case report

Pemigatinib

Cystitis Case report

Phenazopyridine

Intoxication Case report

Phenibut

Phenytoin Case report

Phenytoin

Phenytoin Case report

Phenytoin

Piperacillin Case report

Piperacillin/tazobactam

Piperacillin Case report

Piperacillin/tazobactam

Acute Kidney Injury Case report

Polyvalent-antivenom

Case report

Posaconazole

Hyperthyroidism Case report

Potassium-chloride

Dermatofibroma Case report

Prednisolone/mycophenolate-mofetil/ciclosporin

Candidiasis Case report

Prednisone

Supraventricular Tachycardia Case report

Propafenone

Sternum Fracture Case report

Radium-223-chloride

Furosemide Case report

Radix-glycyrrhizae

Idiopathic Intracranial Hypertension Case report

Retinol

Acute Kidney Injury Case report

Ringers-lactate/sodium-bicarbonate/sodium-chloride

Systemic Sclerosis Case report

Rituximab

Rituximab Case report

Rituximab/steroids

Rivaroxaban Case report

Rivaroxaban

Rosuvastatin Case report

Rosuvastatin

Choroidal Melanoma Case report

Ruthenium-106

Spironolactone Case report

Sodium-chloride/spironolactone

Coma Case report

Sodium-oxybate/alcohol

Sulfasalazine Case report

Sulfasalazine

Case report

Tepotinib

Autoimmune Hemolytic Anemia Case report

Thalidomide

Erythema Nodosum Case report

Thiamazole

Tocilizumab Case report

Tocilizumab

Tocilizumab Case report

Tocilizumab

Lymphoma Case report

Tofacitinib

Torasemide Case report

Torasemide

Churg-Strauss Syndrome Case report

Tozinameran

Bullous Pemphigoid Case report

Tozinameran

Case report

Tozinameran

Vaccination Case report

Tozinameran

COVID-19 Vaccination Case report

Tozinameran

Pityriasis Rubra Pilaris Case report

Tozinameran

Lupus Erythematosus Case report

Tozinameran

Atopic Dermatitis Case report

Tralokinumab

Case report

Trametinib

Landau-Kleffner Syndrome Case report

Valproic-acid

Chronic Inflammatory Bowel Disease Case report

Vedolizumab

Chronic Lymphocytic Leukemia Case report

Venetoclax

Warfarin Case report

Warfarin

Warfarin Case report

Warfarin

Warfarin Case report

Warfarin overdose

Hepatocellular Carcinoma Case report

Yttrium-90

Headache News item

Non-serious case reports

Oct 23
Issue: 1/2023
Nov 23
Issue: 1/2023

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