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Septic Shock 

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  1. Open Access 01-12-2024 | Esophageal Rupture | OriginalPaper

    Mediastinitis and septic shock complicating spontaneous esophageal rupture “Boerhaave’s syndrome”: a case report

    Boerhaave’s syndrome, also known as spontaneous esophageal rupture, is a rare but life-threatening condition characterized by a tear in the esophagus. It is most commonly caused by a sudden increase in intraesophageal pressure, often due to severe …

  2. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23

    In the last decade, sepsis and septic shock have shown a continuously growing incidence and persistently elevated mortality rates, higher than 20% for sepsis and 50% for septic shock, despite general improvements in the application of specific …

  3. 18-03-2024 | Septic Shock | EditorialNotes

    Monitoring capillary refill time in septic shock

    CRT measures the amount of time, in seconds, necessary for the skin to return to baseline color after applying a pressure on a soft tissue, generally a fingertip. CRT is influenced by various factors such as room temperature and lighting, skin …

  4. 02-04-2024 | Septic Shock | OriginalPaper

    Septic Shock After Endoscopic Sleeve Gastroplasty: A Post-procedural Complication?

    ESG is a safe and effective technique in the obesity management, usually indicated in class I and II obesity. It is also an acceptable treatment in patients with class III obesity who have high surgical risk or refuse surgery [ 1 , 2 ]. This …

  5. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department

    Fever is one of the most common symptom in the pediatric emergency department (PED). Among patients with febrile presentation in the PED, only some were hospitalized with sepsis. However, sepsis remains the leading cause of pediatric mortality and …

  6. Open Access 01-12-2024 | Septicemia | ReviewPaper

    Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines

    Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and …

  7. 26-01-2024 | Septic Shock | OriginalPaper

    Echocardiographic characteristics in neonates with septic shock

    Clinical parameters used for hemodynamic assessment and titration of vasopressor therapy in neonates with septic shock have several limitations. Functional echocardiography is an emerging tool for bedside assessment of cardiac function and may be …

  8. 15-02-2024 | Septic Shock | BriefCommunication

    Vasoconstriction in septic shock

    Through various mechanisms, sepsis decreases vascular tone, inducing hypotension and decreasing tissue perfusion. In addition, regional blood flow distribution may be impaired. Regional perfusion is regulated by modulating regional arterial tone …

  9. 28-03-2024 | Septic Shock | OriginalPaper

    Venous congestion in septic shock quantified with point-of-care ultrasound: a pilot prospective multicentre cohort study

    We conducted a pilot prospective multicentre cohort study of patients with septic shock admitted to the ICU. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement 18 provided guidance on the design and …

  10. Open Access 10-04-2024 | Septic Shock | OriginalPaper

    Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial

    In patients with sepsis, hyperlactatemia is associated with increased mortality and morbidity [ 1 ]. Traditionally, hyperlactatemia has been viewed as a marker of hypoperfusion leading to tissue hypoxia. But adrenergic stress response, increased …

  11. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    The use of thermal imaging for evaluation of peripheral tissue perfusion in surgical patients with septic shock

    Evaluation and maintenance of peripheral tissue perfusion is essential during management of septic shock [ 1 , 2 ]. Classically, resuscitation of septic shock patients targets macro-circulatory parameters such as mean arterial pressure and cardiac …

  12. Open Access 01-12-2024 | Septic Shock | ReviewPaper

    Administration of methylene blue in septic shock: pros and cons

    Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their use to counteract life-threatening hypotension comes with potential adverse effects, so that …

  13. Open Access 01-12-2024 | Meningitis | OriginalPaper

    Rare case of septic shock combined with meningitis caused by Pasteurella multocida without a history of cat and dog bites

    Pasteurella multocida is a small Gram-negative, facultative anaerobic coccobacillus and one of the main zoonotic pathogens; it is present in the oral cavity and gastrointestinal tract of many domestic animals, wildlife, and birds [ 1 ]. The highest …

  14. Open Access 01-12-2024 | Shock | ReviewPaper

    Angiotensin ii therapy in refractory septic shock: which patient can benefit most? A narrative review

    Patients with septic shock who experience refractory hypotension despite adequate fluid resuscitation and high-dose noradrenaline have high mortality rates. To improve outcomes, evidence-based guidelines recommend starting a second vasopressor …

  15. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    Thiamine administration in septic shock: a post hoc analysis of two randomized trials

    Thiamine has been proposed as a mitochondrial resuscitator that may attenuate organ injury and lessen mortality in septic shock [ 1 , 2 ]. Kidney injury is frequently seen in patients with septic shock and has been associated with poor clinical …

  16. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    The prehospital NEW score to assess septic shock in-hospital, 30-day and 90-day mortality

    During the last twenty years, despite research on prevention and treatments, the mortality and the morbidity rates of sepsis remain stable [ 1 , 2 ]. To date, whatever the initial stage of sepsis, this latter one is responsible of 20% of all deaths …

  17. 14-12-2023 | Lung Ultrasound | OriginalPaper

    Lung ultrasound–guided fluid resuscitation in neonatal septic shock: A randomized controlled trial

    This randomized controlled trial aimed to determine whether lung ultrasound–guided fluid resuscitation improves the clinical outcomes of neonates with septic shock. Seventy-two patients were randomly assigned to undergo treatment with lung …

  18. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    The prognostic importance of the pan-immune-inflammation value in patients with septic shock

    Sepsis is a life-threatening organ dysfunction deriving from a dysregulated host response to infection [ 1 ]. The incidence of sepsis and septic shock have risen continually since the first consensus definition in 1991, reaching approximately 49 …

  19. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    The use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study

    Septic shock, a critical condition characterized by organ failure, presents a substantial mortality risk in intensive care units (ICUs), with the 28-day mortality rate possibly reaching 40% [ 1 ]. The conventional management of septic shock

  20. Open Access 01-12-2024 | Septic Shock | OriginalPaper

    Association between left ventricular systolic function parameters and myocardial injury, organ failure and mortality in patients with septic shock

    Septic cardiomyopathy (SCM) occurs commonly among critically ill patients with sepsis, with prevalences ranging from 20 to 65% [ 1 , 2 ]. Patients with SCM have a 2–3 times increased risk of mortality [ 1 , 2 ]. Although no consensus exists for the …

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