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Heparin-Induced Thrombocytopenia 

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  1. 12-01-2024 | Carotid Endarterectomy | Letter

    Bolus-only bivalirudin for carotid endarterectomy in a patient with heparin-induced thrombocytopenia

  2. Open Access 01-12-2023 | Cerebral Sinus Venous Thrombosis | OriginalPaper

    Cerebral venous sinus thrombosis associated with SRA-negative heparin-induced thrombocytopenia: case report

    Immune-mediated heparin-induced thrombocytopenia (HIT), an infrequent complication of heparin administration, is caused by the production of antibodies directed against heparin-platelet protein factor 4 (PF4) and is considered to be a …

  3. 21-02-2023 | Heart Surgery | OriginalPaper

    Acute heparin-induced thrombocytopenia (HIT) without thrombocytopenia post aortocoronary bypass grafting

    Heparin-induced thrombocytopenia (HIT) after cardiac surgery is a clinical condition associated with increased incidence of thromboembolic events and mortality. HIT without thrombocytopenia is a rare clinical entity poorly reported in the …

  4. 12-08-2023 | Heparin-Induced Thrombocytopenia | OriginalPaper

    Incidence and clinical outcomes of heparin-induced thrombocytopenia: 11 year experience in a tertiary care university hospital

    Heparin-induced thrombocytopenia (HIT) is a rare immuno-mediated adverse reaction with high thrombotic and mortality risk. To evaluate incidence and outcomes of HIT cases diagnosed at a tertiary care hospital from 2007 to 2018. A retrospective …

  5. Open Access 01-12-2023 | Heparin-Induced Thrombocytopenia | OriginalPaper

    How to assess hypercoagulability in heparin-induced thrombocytopenia? Biomarkers of potential value to support therapeutic intensity of non-heparin anticoagulation

    Heparin induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction that occurs during heparin administration. It does not expose per se to bleeding risk as other drug-induced thrombocytopenias do, but to thrombotic risk. In the …

  6. 23-05-2023 | SARS-CoV-2 | ReviewPaper

    Significance of heparin induced thrombocytopenia (HIT) in COVID-19: a systematic review and meta-analysis

    Heparin-induced thrombocytopenia (HIT) occurs in approximately 3% of patients receiving heparinoids. About 30–75% of patients with type 2 of HIT develop thrombosis as a result of platelet activation. The most important clinical symptom is …

  7. Open Access 01-12-2022 | Angiography | OriginalPaper

    Heparin-induced thrombocytopenia post-cardiovascular interventional therapy: a case report

    Heparin-induced thrombocytopenia (HIT) is a rare but important cause of morbidity and mortality in patients exposed to heparin [ 1 ]. As an immunologic condition, HIT is induced by IgG antibodies recognizing complexes of platelet factor 4 (PF4) and …

  8. 22-08-2022 | Insulins | BriefCommunication

    Skin changes in heparin-induced thrombocytopenia

  9. Open Access 01-12-2022 | Escherichia Coli | OriginalPaper

    Heparin-induced thrombocytopenia following Shiga-toxin-associated hemolytic uremic syndrome: a case report

    Hemolytic uremic syndrome (HUS) associated with Shiga-toxin-producing Escherichia coli (STEC HUS) is the most common form of HUS, with 50% of cases occurring in adults [ 1 – 3 ]. The classical clinical manifestation is diarrhea (bloody in about 60% …

  10. Open Access 01-12-2022 | COVID-19 | OriginalPaper

    The potential impact of Covid-19 on the capacity of routine laboratory tests to detect heparin-induced thrombocytopenia

    In Covid-19, anticoagulation with heparin is often administered to prevent or treat thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a severe complication of heparin treatment, caused by heparin-dependent, platelet activating …

  11. 01-12-2021 | Thrombocytopenia | Review

    Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

    Heparin is an essential life-saving drug and is extensively used as an anticoagulant [ 1 ]. Approximately 175 metric tons of heparin are used annually worldwide. Pharmaceutical heparin is animal-sourced and extracted from the porcine intestinal …

  12. 01-07-2022 | Dabigatran | OriginalPaper

    A Multicenter Retrospective Evaluation of Direct Oral Anticoagulants for the Treatment of Heparin-Induced Thrombocytopenia

    Heparin-induced thrombocytopenia (HIT) is a rare immune-mediated complication that may occur following exposure to unfractionated and low-molecular-weight heparins. The resulting procoagulant state is associated with the development of potentially …

  13. Open Access 01-12-2022 | Heparin-Induced Thrombocytopenia | OriginalPaper

    Importance of gradual induction in oral anticoagulation therapy in a patient with heparin-induced thrombocytopenia with a left ventricular assist device: a case report

    Heparin-induced thrombocytopenia (HIT) is a condition in which thrombocytopenia and thromboembolism are triggered due to platelet activation via immunological mechanisms [ 1 , 2 ]. The frequency of HIT is reported to be high in patients with an …

  14. Open Access 01-12-2021 | Ventricular Flutter | OriginalPaper

    Near fatal stent thrombosis in an aneurysmatic RCX as first manifestation of heparin induced thrombocytopenia (HIT) without thrombocytopenia

    The incidence of heparin-induced thrombocytopenia (HIT) is approximately 1 in 5000 hospitalized patients [ 1 ], with a higher proportion of 0.5% after cardiac surgery [ 2 ]. Any new onset thrombocytopenia doubles the risk of early stent thrombosis …

  15. Open Access 01-12-2021 | Heart Surgery | OriginalPaper

    Heparin-induced thrombocytopenia presenting as splenic hemorrhage following cardiac surgery: a case report

    HIT-associated antibodies are frequently detected after cardiac surgery We report a case of atraumatic splenic hemorrhage due to HIT following coronary artery bypass grafting. HIT should be suspected for any patient with congestive hemorrhage …

  16. Open Access 01-12-2021 | Thrombosis | OriginalPaper

    Research on clinical characteristics and prognostic analysis of heparin-induced thrombocytopenia after surgery for acute type a aortic dissection

    Heparin-induced thrombocytopenia (HIT) is an iatrogenic disease that potentially threatens the lives of people exposed to heparin or low-molecular-weight heparin. Because of the use of heparin during cardiopulmonary bypass, patients undergoing …

  17. 01-08-2021 | Anticoagulant

    Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis

    Background Argatroban, lepirudin, desirudin, bivalirudin, and danaparoid are commonly used to manage heparin-induced thrombocytopenia related complications. However, the most suitable drug for this condition still remains controversial. Aim of the …

  18. 01-04-2021 | Warfarin | OriginalPaper

    Treatment and outcomes of heparin-induced thrombocytopenia (HIT) in patients with neoplasm, a case series

    Heparin-induced thrombocytopenia (HIT) is a highly thrombogenic condition. Cancer patients are already at high risk of thrombosis. The treatment and outcomes of HIT in cancer patients are not well established. We retrospectively identified …

  19. 01-06-2021 | Central Nervous System Trauma | OriginalPaper

    Intravenous Immunoglobulin (IVIG) in Severe Heparin-Induced Thrombocytopenia (HIT) in a Traumatic Brain Injury (TBI) Patient with Cerebral Venous Sinus Thrombosis (CVST)

    There is an absence of literature discussing heparin-induced thrombocytopenia (HIT) management in traumatic brain injury (TBI) patients with post-traumatic cerebral venous sinus thrombosis (CVST).

  20. 01-04-2021 | Endarterectomy | OriginalPaper

    Platelet count trends and response to fondaparinux in a cohort of heparin-induced thrombocytopenia suspected patients after pulmonary endarterectomy

    A definitive diagnosis of heparin-induced thrombocytopenia (HIT) is difficult to make, especially in patients undergoing cardiac surgery. In this retrospective cohort study, we assessed the platelet count trends and the response to fondaparinux in …

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