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Carbapenem Antibiotic 

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  1. Open Access 22-03-2023 | Imipenem | OriginalPaper

    Carbapenem Antibiotics Versus Other Antibiotics for Complicated Intra-abdominal Infections: a Systematic Review and Patient-Level Meta-analysis of Randomized Controlled Trials (PROSPERO CRD42018108854)

    Complicated intra-abdominal infections (CII) and secondary peritonitis (SP) are characterized by a loss of bowel wall integrity and subsequent abscess formation and/or spread into the peritoneal cavity. The etiology is either spontaneous due to …

  2. Open Access 01-12-2022 | Antibiotic | OriginalPaper

    Initial empirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children: a retrospective medical record review

    Enterobacteriaceae are important opportunistic pathogens and common microflora, but can cause severe diseases including meningitis, pneumonia, pyelonephritis, intra-abdominal infection, and septicemia ( 1 ). Antibiotic resistant has been increased …

  3. Open Access 01-12-2022 | Nosocomial Infection | OriginalPaper

    Active surveillance of carbapenem-resistant gram-negative bacteria to guide antibiotic therapy: a single-center prospective observational study

    Carbapenem-resistant gram-negative bacteria (CRGNB) are one of the most serious multidrug-resistant bacteria (MDR) globally, accounting for a significant portion of Hospital Acquired Infections (HAI) and are associated with increased mortality and …

  4. Open Access 01-07-2021 | Amikacin | OriginalPaper

    Fast-track identification of CTX-M-extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacterales in bloodstream infections: implications on the likelihood of deduction of antibiotic susceptibility in emergency and internal medicine departments

    This study aims at presenting a reliable fast-track diagnostics for the detection of CTX-M ESBL- (CTX-M-p) and carbapenemase-producers (CA-p) directly from blood cultures (BCs) of patients with Enterobacterales (EB) bloodstream infections (BSIs) …

  5. 01-12-2017 | OriginalPaper

    Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics

    Drug–drug interactions (DDIs) are known to be a common clinical issue [ 1 ]. The DDI potential of investigational drugs is now evaluated before initiation of clinical studies mainly using in vitro human liver samples and in vivo testing in animal …

  6. 01-12-2018 | OriginalPaper

    Antimicrobial stewardship in an Internal Medicine ward: effects on antibiotic consumption and on the use of carbapenems

    Assessing the effects of an antimicrobial stewardship program (ASP) implemented in a 78-bed Internal Medicine ward of an Italian mid-sized acute care hospital of 296 beds (26,820 bed days/year in 2015 and 26,653 in 2016). The ASP, implemented in …

  7. Open Access 01-12-2018 | OriginalPaper

    Association between antibiotic consumption and the rate of carbapenem-resistant Gram-negative bacteria from China based on 153 tertiary hospitals data in 2014

    Carbapenem is a beta-lactam antibiotic with a broad antimicrobial spectrum and effective antibacterial activity. It is generally administered as a last resort for treating drug-resistant Gram-negative bacterial infections. However, in recent …

  8. 01-02-2018 | OriginalPaper

    Findings from an outbreak of carbapenem-resistant Klebsiella pneumoniae emphasize the role of antibiotic treatment for cross transmission

    Carbapenem-resistant Klebsiella pneumoniae (CKP) initially were described in the 1990s in Japan and the USA [ 1 – 3 ]. Today, the bacteria are present all over the world, especially affecting hospitalized patients. Carbapenem resistance is …

  9. 01-10-2017 | OriginalPaper

    Synergistic activity of synthetic N-terminal peptide of human lactoferrin in combination with various antibiotics against carbapenem-resistant Klebsiella pneumoniae strains

    The spread of multi-drug resistant (MDR) Klebsiella pneumoniae strains producing carbapenemases points to a pressing need for new antibacterial agents. To this end, the in-vitro antibacterial activity of a synthetic N-terminal peptide of human …

  10. Open Access 01-12-2016 | Letter

    Rapid detection of carbapenem resistance: targeting a zero level of inadequate empiric antibiotic exposure?

  11. 01-09-1999 | OriginalPaper

    Estimation of outer membrane permeability of carbapenem antibiotics to Pseudomonas aeruginosa

    The outer membrane permeability of carbapenems (imipenem [IPM], panipenem [PAPM], meropenem [MEPM], and biapenem [BIPM]) and ceftazidime (CAZ) to Pseudomonas aeruginosa was determined by the Zimmermann and Rosselet method. The permeability …

  12. 01-09-1999 | OriginalPaper

    Comparative in vitro activity of carbapenem antibiotics against respiratory pathogens isolated in recent years

    We investigated the antibacterial activity of 12 antibiotics, including 4 carbapenems, against 200 strains of respiratory pathogens isolated in 1997, and compared the results with those obtained in 1993. The strains examined were 38 strains of …

  13. 01-06-2007 | OriginalPaper

    Relationship between the usage of carbapenem antibiotics and the incidence of imipenem-resistant Pseudomonas aeruginosa

    Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolates are resistant to almost all broadspectrum β-lactams and carbapenems. We investigated 389 P. aeruginosa isolates, collected from 29 hospitals in the Tohoku area of Japan, to …

  14. 01-12-2001 | OriginalPaper

    Comparative in-vitro activity of carbapenem antibiotics against respiratory pathogens isolated between 1999 and 2000

    We investigated the antibacterial activity of 12 antibiotics, inclusive of four carbapenems, against 167 strains of respiratory pathogens isolated between 1999 and 2000. Thirty strains of methicillin-susceptible Staphylococcus aureus (MSSA), 28 …

  15. 01-12-1998 | OriginalPaper

    Evaluation of the antimicrobial activity of carbapenem and cephem antibiotics againstPseudomonas aeruginosa isolated from hospitalized patients

    Pseudomonas aeruginosa is an opportunistic pathogen that infects compromised hosts. It is therefore important to clarify the bactericidal activity of antimicrobial agents against this bacterium. We evaluated the antimicrobial potency of several …

  16. 01-05-2010 | Report

    Prevalence of antibiotics resistance and OXA carbapenemases genes in multidrug-resistant Acinetobacter baumannii isolates in central Taiwan

    This study analyzed the prevalence of antibiotics resistance and the distribution of genes responsible for carbapenems resistance in Acinetobacter baumannii isolates. Clinical A. baumannii isolates were cultured, identified, and collected during …

  17. 01-09-1997 | OriginalPaper

    Sequential in vitro effects and analysis using simulators of in vivo blood and urinary antimicrobial concentrations on the endotoxin release from bacteria exposed to carbapenem antibiotics

    Endotoxin release fromPseudomonas aeruginosa exposed to an antimicrobial agent was examined using cytotoxicity assays and simulators of blood and urinary antimicrobial concentrations. The antibiotics included imipenem (IPM), panipenem (PAPM) …

  18. 01-06-2008 | OriginalPaper

    Susceptibility of clinical isolates of Pseudomonas aeruginosa in the Northern Kyushu district of Japan to carbapenem antibiotics, determined by an integrated concentration method: evaluation of the method based on Monte Carlo simulation

    In empirical antibacterial therapy, regional surveillance is expected to yield important information for the determination of the class and dosage regimen of antibacterial agents to be used when dealing with infections with organisms such as …

  19. Open Access 01-12-2018 | OriginalPaper

    Clonal diversity and genetic profiling of antibiotic resistance among multidrug/carbapenem-resistant Klebsiella pneumoniae isolates from a tertiary care hospital in Saudi Arabia

    Klebsiella pneumoniae ( KP ), a member of the Enterobacteriaceae family of Gram-negative bacteria, is an important human and animal pathogen [ 1 ]. High mortality rates are associated with infection with carbapenemase-producing KP [ 2 ]. Various …

  20. Open Access 01-12-2024 | Carbapenem Antibiotic | OriginalPaper

    Development of a risk prediction model for subsequent infection after colonization with carbapenem-resistant Enterobacterales: a retrospective cohort study

    As one of the antibiotic-resistant bacteria from World Health Organization priority list, carbapenem-resistant Enterobacterale (CRE), which could cause a variety of intractable infections, has been regarded as a fatal medical threat with high …

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