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Graft-Versus-Host Disease 

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  1. Open Access 01-12-2024 | Graft-Versus-Host Disease | OriginalPaper

    Diagnostic prediction of gastrointestinal graft-versus-host disease based on a clinical- CT- signs nomogram model

    Hematopoietic stem cell transplantation (HSCT) helps counteract the effects of tumor and disease, and thus, it is essential for the management of several life-threatening hematological diseases [ 1 , 2 ]. Graft-versus-host disease (GVHD) can occur …

  2. Open Access 01-12-2024 | Graft-Versus-Host Disease | OriginalPaper

    A phase II study of belumosudil for chronic graft-versus-host disease in patients who failed at least one line of systemic therapy in China

    Chronic graft-versus-host disease (cGVHD), an immune-related disorder characterized by inflammation and fibrosis, is a common cause of morbidity and non-relapse mortality following allogenic hematopoietic stem cell transplant (allo-HSCT) [ 1 – 3 ].

  3. Open Access 29-01-2024 | Pleural Effusion | OriginalPaper

    Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid

    Isolated pleural effusion is a rare manifestation of chronic graft versus host disease (cGVHD) after hematopoietic stem cell transplantation (HSCT). We herein report a 58-year-old woman presenting with massive pleural effusion approximately 1 year …

  4. Open Access 01-12-2024 | Basiliximab | OriginalPaper

    Mesenchymal stromal cells plus basiliximab improve the response of steroid-refractory acute graft-versus-host disease as a second-line therapy: a multicentre, randomized, controlled trial

    Severe acute graft-versus-host disease (aGVHD) strongly predicts the poor prognosis of allogeneic haemopoietic stem cell transplantation (allo-HSCT) [ 1 , 2 ] and causes death in 16–19% of adult allo-HSCT patients [ 3 ]. Steroids are a recognized …

  5. Open Access 06-12-2023 | Graft-Versus-Host Disease | OriginalPaper

    A New Treatment for Recalcitrant Neurotrophic Keratopathy of Ocular Graft-Versus-Host Disease with Virus Infection

    Neurotrophic keratopathy (NK), also known as neurotrophic keratitis, is a rare degenerative ocular disease. When the trigeminal innervation of the cornea is damaged, morphological and metabolic epithelial abnormalities progress, leading to NK [ 1 …2

  6. 06-11-2023 | Graft-Versus-Host Disease | OriginalPaper

    Non-viral pathogens of infectious diarrhoea post-allogeneic stem cell transplantation are associated with graft-versus-host disease

    Infectious diarrhoea is common post-allogeneic haematopoietic stem-cell transplantation (alloHSCT). While the epidemiology of Clostridioides difficile infection (CDI) post-alloHSCT has been described, the impact of other diarrhoeal pathogens is …

  7. Open Access 01-12-2023 | Graft-Versus-Host Disease | Letter

    Advances in graft-versus-host disease prevention strategies: latest updates from the 2022 ASH annual meeting

    This review summarizes the significant advancements in prophylaxis against graft-versus-host disease (GvHD) presented at the 2022 ASH Annual Meeting. The use of innovative agents and regimens, along with the conventional prophylactic approach of …

  8. 20-07-2023 | Ruxolitinib | OriginalPaper

    Ruxolitinib versus basiliximab for steroid-refractory acute graft-versus-host disease: a retrospective study

    Acute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic hematopoietic stem cell transplantation; not all patients respond to standard glucocorticoids treatment. This study retrospectively evaluated the effects of …

  9. Open Access 01-12-2023 | Ruxolitinib | OriginalPaper

    Real-world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC-FFM in ruxolitinib-refractory acute graft-versus-host disease

    Acute graft-versus-host disease (aGvHD) remains the leading cause of treatment-related morbidity and mortality after allogeneic haematopoietic stem cell transplantation (HSCT) [ 1 – 3 ]. The incidence of Grade II–IV aGvHD has decreased over recent …

  10. 22-07-2023 | Graft-Versus-Host Disease | Letter

    The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive

    Hematopoietic stem cell transplantation is increasing in frequency with graft-versus-host disease affecting many recipients. When the skin is involved, biopsy is routinely performed but often does not aid in definitive diagnosis. Here, we examine …

  11. Open Access 25-07-2023 | Graft-Versus-Host Disease | OriginalPaper

    The graft-versus-leukemia effect of prophylactic donor lymphocyte infusions after allogeneic stem cell transplantation is equally effective in relapse prevention but safer compared to spontaneous graft-versus-host disease

    Therapeutic donor lymphocyte infusions (tDLI) are used to reinforce the graft-versus-leukemia (GvL) effect in relapse after allogeneic stem cell transplantation (alloSCT). In contrast, the role of prophylactic DLI (proDLI) in preventing leukemia …

  12. Open Access 03-10-2023 | Graft-Versus-Host Disease | OriginalPaper

    Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use

    Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic …

  13. 16-02-2023 | Graft-Versus-Host Disease | OriginalPaper

    Readability of Online Patient Education Materials for Graft-Versus-Host Disease

    Graft-versus-host disease (GVHD) is a complex systemic diagnosis which is associated with significant symptom distress in patients. Patient education has shown to mitigate uncertainty and distress, but to our knowledge, no studies have evaluated …

  14. 07-06-2023 | Ruxolitinib | OriginalPaper

    Ruxolitinib Treatment of Steroid-Refractory Graft-versus-Host Disease in Children: A Case Series and Review of the Literature

    In recent decades, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been used to treat many high-risk or relapsed hematologic malignancies, hereditary diseases, and solid tumors. However, graft-versus-host disease (GVHD) is a …

  15. 21-01-2023 | Glucocorticoid | ReviewPaper

    Graft-Versus-Host Disease: an Update on Functional Implications and Rehabilitation Interventions

    Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially life-saving intervention to treat hematologic malignancies that can result in significant morbidity, reducing function and quality of life. One of the most severe …

  16. 12-09-2023 | OriginalPaper

    Protocol for a feasibility trial (EXPRESS-C-GVHD) for an expressive helping intervention within a support group for cutaneous graft-versus-host-disease

    Graft-versus-host-disease (GVHD) is an immune system-mediated complication of hematopoietic stem cell transplant (HSCT). It is a disease phenomenon that occurs when immune cells of the donor recognize and attack healthy tissue within the …

  17. Open Access 01-12-2023 | Graft-Versus-Host Disease | OriginalPaper

    Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination

    Graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). Grafted immune cells attack the host tissue, including the skin, mouth, eyes, lungs, liver, gastrointestinal tract, genitalia …

  18. Open Access 01-10-2023 | Graft-Versus-Host Disease | OriginalPaper

    Identification of single nucleotide polymorphisms (SNPs) associated with chronic graft-versus-host disease in patients undergoing allogeneic hematopoietic cell transplantation

    Each year thousands of patients suffering from blood disorders, hematological cancers, or immunodeficiency complete conditioning therapy prior to undergoing allogeneic hematopoietic stem cell transplant (HCT) in the USA [ 1 ]. In allogeneic HCT …

  19. Open Access 01-12-2022 | Graft-Versus-Host Disease | OriginalPaper

    IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity

    Allo-HSCT is an effective method for the treatment of hematologic malignancies. However, cGVHD is a major complication of allo-HSCT, occurring in approximately 50% of patients [ 1 – 4 ]. Similar to aGVHD, donor T cells play a critical pathogenic …

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