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Lupus Nephritis 

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  1. 12-04-2024 | Lupus Nephritis | Online First

    Do we really need cyclophosphamide for lupus nephritis?

    A 14-year-old patient presents with hematuria and proteinuria. Clinical evaluation reveals a positive anti-nuclear antibody titer, positive anti-double stranded DNA antibody and hypocomplementemia. Systemic lupus erythematosus (SLE) is diagnosed …

  2. Open Access 01-12-2024 | Mycophenolate Mofetil | OriginalPaper

    Mycophenolate-induced colitis in a patient with lupus nephritis: a case report and review of the literature

    Mycophenolate mofetil (MMF) is widely used as an immunosuppressive agent for various inflammatory and/rheumatic conditions, including lupus nephritis and organ transplantation. Mycophenolic acid is an active metabolite of MMF that reversibly …

  3. Open Access 01-12-2024 | Lupus Nephritis | OriginalPaper

    Analysis of m6A-regulated genes and subtype classification in lupus nephritis

    Lupus nephritis (LN) is one of the most common and serious complications of systemic lupus erythematosus (SLE) with high morbidity and mortality rates [ 1 ]. The global annual incidence of SLE ranges from 1/100,000 to 8.7/100,000, and 40-60% of …

  4. Open Access 01-12-2024 | Lupus Nephritis | OriginalPaper

    Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study

    Juvenile systemic lupus erythematosus (JSLE) is a systemic heterogeneous autoimmune disease characterized by various clinical manifestations involving different tissues [ 1 ]. Lupus nephritis (LN), which is considered one of the most severe …

  5. 15-04-2024 | Systemic Lupus Erythematosus | Online First

    A more detailed description of study methods could be needed: Comments on “Clinico-serological associations of urinary activated leukocyte cell adhesion molecule in systemic lupus erythematosus and lupus nephritis

  6. Open Access 01-12-2024 | Lupus Nephritis | OriginalPaper

    Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis

    Lupus nephritis (LN) is a lethal complication of the autoimmune disease, systemic lupus erythematosus. Glucocorticosteroids and immunosuppressants are the cornerstones of treatment for this disease; however, long-term treatment can be toxic and …

  7. 13-04-2024 | Lupus Nephritis | Online First

    Efficacy and safety of telitacicept in patients with lupus nephritis: a single-center, real-world retrospective study

    When systemic lupus erythematosus (SLE) disease involves the kidneys, patients may present with symptoms such as hematuria, proteinuria, edema, hypertension, and anemia, indicating SLE nephritis [ 1 ]. The kidneys are the most commonly affected …

  8. 15-04-2024 | Lupus Nephritis | Online First

    A rebuttal letter as regards: A more detailed description of study methods could be needed—comments on “Clinico-serological associations of urinary activated leukocyte cell adhesion molecule in systemic lupus erythematosus and lupus nephritis

  9. 12-12-2023 | Lupus Nephritis | OriginalPaper

    Blockade of Notch1 Signaling Alleviated Podocyte Injury in Lupus Nephritis Via Inhibition of NLRP3 Inflammasome Activation

    To explore the role of Notch1 pathway in the pathogenesis of podocyte injury, and to provide novel strategy for podocyte repair in lupus nephritis (LN). Bioinformatics analysis and immunofluorescence assay were applied to determine the expression …

  10. Open Access 01-12-2024 | Lupus Nephritis | OriginalPaper

    LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis

    Systemic lupus erythematosus (SLE) is an autoimmune disease with an unknown cause, various clinical manifestations, and multiorgan involvement [ 1 , 2 ]. Lupus nephritis (LN) occurs in more than 60% of SLE patients during disease progression and …

  11. Open Access 01-12-2024 | Lupus Nephritis | OriginalPaper

    Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network

    The Accelerating Medicines Partnership (AMP) RA/SLE Network was established with the goal of applying new technologies, such as single-cell RNA sequencing of diseased kidney tissue, to improve diagnostic and therapeutic tools that would ultimately …

  12. Open Access 28-03-2024 | Lupus Nephritis | Online First

    Clinical and laboratory characteristics of early-onset and delayed-onset lupus nephritis patients: A single-center retrospective study

    Systemic lupus erythematosus (SLE), commonly referred to as lupus, is a multifaceted autoimmune disease that affects multiple organs. SLE is characterized by its diverse clinical manifestations and varied organ involvement. Common symptoms include …

  13. 26-02-2024 | Systemic Lupus Erythematosus | OriginalPaper

    Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity

    Lupus nephritis (LN) is one of the most serious and life-threating manifestations of SLE and is associated with high morbidity and mortality[ 1 ]. Despite improved survival rates and development of new targeted therapeutics, patients with SLE …

  14. 03-03-2024 | Lupus Nephritis | Online First

    Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway

    Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly expressed in the serum of patients with LN. Renal PTX3 deposition is directly related to clinical …

  15. Open Access 31-01-2024 | Lupus Nephritis | OriginalPaper

    Clinico-serological associations of urinary activated leukocyte cell adhesion molecule in systemic lupus erythematosus and lupus nephritis

    The hallmarks of SLE include a vast array of autoantibodies that stimulate the immune system to attack the body's tissues, causing damage to several systems and organs [ 1 ]. Lupus nephritis is one of the major complications of SLE that primarily …

  16. Open Access 01-12-2024 | Lupus Nephritis | OriginalPaper

    Macrophage subpopulations in pediatric patients with lupus nephritis and other inflammatory diseases affecting the kidney

    Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogeneous clinical picture. Lupus nephritis (LN) is manifested in 50–80% of all SLE patients, with varying degrees of severity [ 1 ]. The International Society of …

  17. 26-03-2024 | Lupus Nephritis | Online First

    Class V lupus nephritis recurrence with histologic resolution in a kidney transplant recipient on a pregnancy-adapted immunosuppression protocol: a lesson for the clinical nephrologist

    A kidney transplant recipient of Cambodian ethnicity was diagnosed with systemic lupus erythematosus in her teens. She had initially reported cutaneous and musculoskeletal manifestations and was diagnosed with class IV lupus nephritis (LN) at the …

  18. 20-12-2023 | Lupus Nephritis | ReviewPaper

    Managing Lupus Nephritis in Children and Adolescents

    Lupus nephritis is an important manifestation of systemic lupus erythematosus, which leads to chronic kidney disease, kidney failure, and can result in mortality. About 35%–60% of children with systemic lupus erythematosus develop kidney …

  19. Open Access 01-12-2024 | Lupus Nephritis | Letter

    Evaluating inter-rater reliability in the context of “Sysmex UN2000 detection of protein/creatinine ratio and of renal tubular epithelial cells can be used for screening lupus nephritis”: a statistical examination

    When delving into the examination of nominal and categorical data, researchers commonly turn to classical statistical techniques such as the Kappa statistic and its iterations like Cohen’s Kappa. These metrics are instrumental in gauging the …

  20. 27-10-2023 | Lupus Nephritis | OriginalPaper

    Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency

    Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. The activation of both the adaptive and innate immune systems leads to the overproduction of autoantibodies and the tissue deposition of immune complexes [ 1 ].

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