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1110 search results for:

Tiotropium 

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  1. Open Access 01-12-2024 | Tiotropium | OriginalPaper

    A placebo-controlled, crossover trial to investigate the efficacy of tiotropium bromide or placebo added to usual care in stable symptomatic post-hematopoietic stem cell transplantation (HSCT) bronchiolitis obliterans syndrome (BOS)

    Pulmonary complications account for more than 90% of mortality after bone marrow transplant (BMT). Bronchiolitis obliterans syndrome (BOS) is one of them, which is defined as the pulmonary form of graft-versus-host disease (GVHD). Due to post-bone …

  2. Open Access 01-12-2024 | Tiotropium | OriginalPaper

    Cost-utility of tiotropium in patients with severe asthma

    Asthma is a disease that affects more than 300 million people worldwide [ 1 ]. Trends suggest increasing asthma prevalence globally, with an anticipated 100 million new cases in the next decade, principally in developing countries [ 2 ]. For …

  3. Open Access 01-12-2021 | Umeclidinium | OriginalPaper

    Time-to-first exacerbation, adherence, and medical costs among US patients receiving umeclidinium/vilanterol or tiotropium as initial maintenance therapy for chronic obstructive pulmonary disease: a retrospective cohort study

    In patients with chronic obstructive pulmonary disease (COPD), exacerbations are associated with increased disease burden and higher healthcare costs [ 1 ]. As such, reducing the risk of exacerbations is an important goal of maintenance therapy in …

  4. Open Access 01-06-2021 | Umeclidinium | OriginalPaper

    Hospital Admission and Readmission Among US Patients Receiving Umeclidinium/Vilanterol or Tiotropium as Initial Maintenance Therapy for Chronic Obstructive Pulmonary Disease

    This article is published with digital features, including a summary slide and plain language summary, to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.13953734 .

  5. Open Access 01-12-2020 | Olodaterol | OriginalPaper

    Physical Functioning in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium/Olodaterol Respimat in Routine Clinical Practice in Italy

    Inactivity has a crucial role in the development of extra-pulmonary effects of chronic obstructive pulmonary disease (COPD), including skeletal muscle weakness, osteoporosis, and cardiovascular disease, and leads to an accelerated decline of lung …

  6. 07-02-2023 | Bronchiectasis | OriginalPaper

    Tiotropium in Patients with Bronchiectasis: A Prospective Cohort Study

    Bronchiectasis is characterized by permanent pathological airway dilatation and pulmonary impairment, often accompanied by cough, production purulent sputum, hemoptysis and progressive dyspnea [ 1 ]. Bronchiectasis leading to chronic airway …

  7. Open Access 01-12-2020 | Tiotropium | OriginalPaper

    In Vitro Effect of Different Airflow Rates on the Aerosol Properties of Nebulized Glycopyrrolate in the eFlow® Closed System and Tiotropium Delivered in the HandiHaler®

    Chronic obstructive pulmonary disease (COPD) is one of the most common pulmonary diseases in the United States and globally [ 1 – 3 ]. COPD is most commonly treated by inhalation of bronchodilators, with or without corticosteroids [ 1 ]. Inhalation …

  8. Open Access 01-06-2019 | Umeclidinium | OriginalPaper

    Tiotropium/Olodaterol: A Review in COPD

    Tiotropium/olodaterol (Stiolto® Respimat®; Spiolto® Respimat®) is an inhaled fixed-dose combination of the long-acting muscarinic antagonist tiotropium bromide (hereafter referred to as tiotropium) and the long-acting β2-adrenergic agonist …

  9. Open Access 01-12-2021 | Bronchial Asthma | OriginalPaper

    Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience

    Tiotropium bromide (Spiriva®) is a long-acting muscarinic antagonist (LAMA) interfering with muscarinic M3 post-synaptic receptors; its use in asthma in adults has been associated with bronchodilation and decreased bronchial secretions, although …

  10. Open Access 01-10-2020 | Olodaterol | OriginalPaper

    Tiotropium/Olodaterol Decreases Exacerbation Rates Compared with Tiotropium in a Range of Patients with COPD: Pooled Analysis of the TONADO®/DYNAGITO® Trials

    Chronic obstructive pulmonary disease (COPD) is a multidimensional, progressive condition characterised by persistent airflow obstruction, worsening dyspnoea and respiratory failure [ 1 , 2 ]. Exacerbations, defined as periods of acute worsening of …

  11. Open Access 01-08-2020 | Olodaterol | OriginalPaper

    Benefits of Tiotropium/Olodaterol Compared with Tiotropium in Patients with COPD Receiving only LAMA at Baseline: Pooled Analysis of the TONADO® and OTEMTO® Studies

    Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity [ 1 – 4 ]. In 2016, COPD was the third leading cause of death worldwide, a trend that is anticipated to continue through 2020 [ 5 , 6 ]. Additionally …

  12. Open Access 01-05-2021 | Olodaterol | OriginalPaper

    Effectiveness and Safety of COPD Maintenance Therapy with Tiotropium/Olodaterol versus LABA/ICS in a US Claims Database

    There are several different inhaled medicines for people with chronic obstructive pulmonary disease (COPD), including long-acting muscarinic antagonists (LAMAs), long-acting β 2 -agonists (LABAs), and inhaled corticosteroids (ICS). These medicines …

  13. Open Access 01-12-2020 | Olodaterol | ReviewPaper

    Tiotropium in chronic obstructive pulmonary disease – a review of clinical development

    Bronchodilators are the mainstay of pharmacological treatment in chronic obstructive pulmonary disease (COPD) [ 1 ]. The 2020 update of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy document includes a model for …

  14. 01-05-2024 | Tiotropium | News

    Budesonide/formoterol/prednisone/tiotropium-bromide

    Lack of efficacy
  15. Open Access 10-08-2022 | Olodaterol | OriginalPaper

    Effectiveness of Tiotropium/Olodaterol in the Real World: A Post Hoc Subgroup Analysis After the First Year of Use

    Bronchodilation, using an inhaled long-acting muscarinic antagonist (LAMA) and/or an inhaled long-acting β 2 -adrenoceptor agonist (LABA), is the backbone of maintenance pharmacotherapy for stable chronic obstructive pulmonary disease (COPD).

  16. 01-12-2021 | Olodaterol

    Real-world effectiveness of early intervention with fixed-dose tiotropium/olodaterol vs tiotropium in Japanese patients with COPD: a high-dimensional propensity score–matched cohort analysis

    Chronic obstructive pulmonary disease (COPD) is a preventable and highly prevalent respiratory disease that is associated with substantial morbidity and mortality worldwide [ 1 ]. In Japan, the prevalence of COPD among individuals aged ≥ 40 years …

  17. Open Access 01-02-2021 | Olodaterol | ReviewPaper

    Effects of Tiotropium/Olodaterol on Activity-Related Breathlessness, Exercise Endurance and Physical Activity in Patients with COPD: Narrative Review with Meta-/Pooled Analyses

    This article is published with digital features, including a summary slide and graphical abstract, to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.13160231 .

  18. Open Access 01-04-2019 | Olodaterol | Report

    Dose Determination for a Fixed-Dose Drug Combination: A Phase II Randomized Controlled Trial for Tiotropium/Olodaterol Versus Tiotropium in Patients with COPD

    Tiotropium/olodaterol 5/5 μg, delivered via the Respimat ® , is an approved maintenance treatment for chronic obstructive pulmonary disease (COPD) that has been rigorously tested in a large clinical trial program [ 1 – 5 ]. Before the phase III …

  19. Open Access 01-12-2020 | Budesonide | OriginalPaper

    A comparison of tiotropium, long-acting β2-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma

    Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite treatment. Selecting the most appropriate pharmacological treatment to add onto inhaled corticosteroids …

  20. Open Access 01-12-2020 | Bronchial Asthma | BriefCommunication

    Forced Expiratory Flow (FEF25–75%) as a Clinical Endpoint in Children and Adolescents with Symptomatic Asthma Receiving Tiotropium: A Post Hoc Analysis

    Assessment of standard measures of lung function can be more challenging in children and adolescents compared with adults. Whilst forced expiratory volume in 1 s (FEV 1 ) is accepted as a standard measure of lung function in adults with asthma, it …

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