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780 search results for:

Cutaneous Mastocytosis 

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  1. 01-06-2019 | Mastocytosis | OriginalPaper

    Higher prevalence of vertebral fractures in systemic mastocytosis, but not in cutaneous mastocytosis and idiopathic mast cell activation syndrome

    Mast cell disorders (MCDs) are rare conditions associated with mast cell activation, abnormal growth, and/or accumulation in different organs. Among MCDs, SM is known to frequently involve bone with secondary osteoporosis, fragility fractures, and …

  2. 01-08-2011 | ReviewPaper

    Diagnosis and Treatment of Cutaneous Mastocytosis in Children

    Practical Recommendations

    Cutaneous mastocytosis in children is a generally benign disease that can present at birth and is often associated with mast cell mediator-related symptoms including pruritus, flushing, and abdominal pain with diarrhea. The most common form of …

  3. 01-05-2015 | ReviewPaper

    Cutaneous and Systemic Mastocytosis in Children: A Risk Factor for Anaphylaxis?

    Childhood mastocytosis is usually a clonal mast cell disease related to activating mutations in KIT. The symptoms in childhood mastocytosis are typically cutaneous in nature although systemic symptoms including anaphylaxis due to the release of …

  4. Open Access 01-06-2015 | OriginalPaper

    Cutaneous Mastocytosis with Persistent Blistering: Successful Treatment with Methylprednisolone and 3-Year Follow-Up Management

    Mastocytosis comprises a heterogeneous spectrum of diseases characterized by a range of local and systemic symptoms. The current World Health Organization (WHO) classification, updated in 2008, differentiates one exclusively cutaneous form from …

  5. Open Access 01-03-2014 | OriginalPaper

    PD34 - Childhood mastocytosis: serum baseline total tryptase levels and extent of cutaneous disease as predictors of mast cell mediator release symptoms

    Pediatric mastocytosis has generally a benign prognosis. However some patients suffer from severe mast cell (MC) mediator-associated symptoms including anaphylaxis.

  6. Open Access 01-12-2023 | Mastocytosis | OriginalPaper

    Comprehensive mastocytosis data analysis from a single center

    Mastocytosis is a very rare disorder and is divided into three prognostically distinct variants by World Health Organization: Cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma or localized mast cell (MC) tumors. The …

  7. 19-07-2023 | Mastocytosis | OriginalPaper

    Perioperative management of mastocytosis

    Mastocytosis represents a group of rare hematologic disorders characterized by abnormal mast cell clonal proliferation [ 1 ]. Cutaneous mastocytosis (CM) is restricted to the skin and more frequently diagnosed in children. Systemic mastocytosis

  8. 25-04-2024 | Petechiae | Online First

    Dermatologic manifestations of hematologic disorders

    Distinguishing key morphologic features and understanding the pathophysiology of common cutaneous manifestations of hematologic disorders is essential to ensure prompt and appropriate treatment. In fact, classic cutaneous signs may provide the …

  9. 25-01-2024 | Mastocytosis | ReviewPaper

    Predictors of Clonality and Underlying Mastocytosis in Mast Cell Activation Syndromes

    Mast cells (MC) are cells of the immune system that originate from a CD34 + hematopoietic precursor present in bone marrow (BM), blood, and umbilical cord [ 1 , 2 ]. They are preferentially found in connective tissue and are more numerous in …

  10. Open Access 20-01-2024 | Anaphylaxis | ReviewPaper

    Using the Right Criteria for MCAS

    Mast cells (MCs) are granulated, multifunctional immune cells with diverse functions [ 1 ]. They can adjust their responses, depending on the stimulus encountered and the tissue in which they are stimulated [ 1 – 4 ]. MCs can be activated by …

  11. 01-04-2024 | Systemic Mastocytosis | News

    Dasatinib/Imatinib/Prednisone

    Various toxicities and lack of efficacy
  12. Open Access 01-12-2024 | Urticaria | OriginalPaper

    Sustained control of recalcitrant chronic spontaneous urticaria after initiation of inflammatory airway diseases treatment: two case reports

    Chronic Urticaria (CU) can be subdivided into several causal categories ranging from physical (pressure), allergic, hereditary (mastocytosis, hereditary angioedema, and cryopyrin-associated periodic syndromes, and gender), and autoimmune (anti-F c …

  13. 10-10-2022 | Mastocytosis | ReviewPaper

    The international consensus classification of mastocytosis and related entities

    Mastocytosis is a neoplasm characterized by a clonal proliferation of mast cells, which accumulate in one or multiple organs, associated with an extremely heterogeneous clinical presentation. The disease can be limited to the skin (cutaneous

  14. 09-03-2024 | Anaphylaxis | ReviewPaper

    Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions

    Tryptases, in their mature form, are serine proteases expressed almost exclusively by human mast cells and have been demonstrated to be important biomarkers and mediators of anaphylaxis. Large amounts of mature tryptases are released into …

  15. 14-02-2024 | Mastocytosis | Review

    Unmasking mast cell activation syndrome

    A comprehensive overview of mast cell activation syndrome, with a focus on the prominent gastrointestinal manifestations, some of which can mimic irritable bowel syndrome.

  16. Open Access 01-12-2024 | Anaphylaxis | OriginalPaper

    Anaphylaxis-induced premature uterine contractions: a case report and literature review

    Preterm birth is the leading cause of neonatal mortality globally [ 1 – 7 ]. Multiple pathological mechanisms, such as intra-amniotic inflammation, intra-amniotic infection, vascular disorders, cervical disease, decidual senescence, and breakdown …

  17. 01-03-2024 | Systemic Mastocytosis | News

    Midostaurin

    Haematologic toxicity
  18. 13-01-2024 | Tyrosine Kinase Inhibitors | ReviewPaper

    Mast Cell–Targeting Therapies in Mast Cell Activation Syndromes

    Mast cell activation syndrome (MCAS) is a condition encompassing a broad spectrum of clinical manifestations caused by a pathological spontaneous or triggered activation/degranulation of mast cells (MCs) [ 1 – 5 ].

  19. Open Access 03-02-2024 | Anaphylaxis | ReviewPaper

    Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?

    Mast cells (MC) are multi-functional leukocytes that reside in various organs and tissues and play an important role in diverse immunological processes and pathologies [ 1 – 3 , 4 •, 5 •]. In common with other leukocytes, including tissue-resident …

  20. 01-03-2024 | Systemic Mastocytosis | News

    Tozinameran

    Various toxicities

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