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Chronic Myeloid Leukemia 

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  1. 24-04-2024 | Chronic Myeloid Leukemia | Online First

    Cytogenetic and epidemiological profile of chronic myeloid leukemia in Morocco

    Chronic myeloid leukemia (CML) is a neoplastic disease of genetic origin resulting from clonal proliferation of hematopoietic stem cells (HSCs). The reciprocal translocation t(9;22)(q34;q11) is the main chromosomal abnormality involved in this …

  2. 01-04-2024 | Dasatinib | Online First

    Palmoplantar Keratoderma in a Patient of Chronic Myeloid Leukemia on Dasatinib

  3. 26-04-2024 | Online First

    Priapism as an initial manifestation in an adult patient with chronic myeloid leukemia in Japan: case report and review of the literature

    We report the first documented Japanese case in the English literature of chronic myeloid leukemia (CML) in which priapism was the presenting symptom. Priapism, a rare manifestation in CML patients, is particularly uncommon in Japan. This can be …

  4. 23-04-2024 | Tyrosine Kinase Inhibitors | Online First

    A Retrospective Analysis of BCR-ABL-1 Kinase Domain Mutations in Frontline TKI Resistant Chronic Myeloid Leukemia Patients: A Single Centre Experience

    CML is a commonly diagnosed myeloproliferative neoplasm in India. Tyrosine kinase inhibitors (TKIs) are the current standard of care for management of CML. Mutations in Tyrosine kinase Domain (TKD) result in resistance to TKIs. The aim of this …

  5. 05-04-2024 | Chronic Myeloid Leukemia | Online First

    Maternal and Foetal Outcomes of Newly Diagnosed Chronic Myeloid Leukemia During Pregnancy and its Long-Term Impact

    Diagnosing Chronic Myeloid Leukemia (CML) during pregnancy presents challenges for both haematologists and obstetricians. Limited data exists regarding the management of pregnancy-associated CML in low- and middle-income countries (LMICs). This …

  6. Open Access 01-12-2024 | OriginalPaper

    Hematological, clinical, cytogenetic and molecular profiles of confirmed chronic myeloid leukemia patients at presentation at a tertiary care teaching hospital in Addis Ababa, Ethiopia: a cross-sectional study

    Chronic myeloid leukemia (CML) is a hematopoietic stem cell (HSC)-derived myeloproliferative disorder caused by chromosomal translocation (9; 22). The formation of the Philadelphia (Ph) chromosome and the expression of the breakpoint cluster …

  7. Open Access 01-04-2024 | Imatinib | OriginalPaper

    Oral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes

    Chronic myeloid leukemia (CML) is characterized by the BCR::ABL1 oncoprotein, which produces a constitutively active tyrosine kinase that leads to pathogenesis (Heisterkamp et al. 1983 ). Tyrosine kinase inhibitors (TKIs) can inhibit the activity …

  8. 03-04-2024 | Bosutinib | Online First

    Hepatotoxicity as dose-limiting toxicity of the combination of bosutinib and atezolizumab in patients with chronic myeloid leukemia. Results of the ZEROLMC study

    In the field of chronic myeloid leukemia (CML), new strategies are needed to increase the rate of successful treatment discontinuations, a crucial goal in this disease. Anti-PD-L1 checkpoint inhibitors are a promising therapeutic approach in CML …

  9. Open Access 05-03-2024 | Imatinib | Online First

    Predictive performance of population pharmacokinetic models of imatinib in chronic myeloid leukemia patients

    Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm associated with the specific chromosomal translocation in chromosomes 9 and 22, which is known as the Philadelphia chromosome (Ph). Around 95% of the patients with CML are detected …

  10. 08-04-2024 | Imatinib | Online First

    Changes in chronic myeloid leukemia treatment modalities and outcomes after introduction of second-generation tyrosine kinase inhibitors as first-line therapy: a multi-institutional retrospective study by the CML Cooperative Study Group

    This study investigated changes in treatment modalities and outcomes of chronic myeloid leukemia in the chronic phase (CP-CML) after the approval of second-generation tyrosine kinase inhibitors (2G-TKIs) for first-line therapy. Patients were …

  11. 16-03-2024 | Chronic Myeloid Leukemia | Online First

    The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia

    In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of a Philadelphia chromosome (Ph). However, a subset of CML patients display variant complex translocations, characterized by …

  12. Open Access 07-02-2024 | Chronic Myeloid Leukemia | OriginalPaper

    Late relapse of chronic myeloid leukemia after allogeneic bone marrow transplantation points to KANSARL (KANSL1::ARL17A) alteration: a case report with insights on the molecular landscape

    Chronic myeloid leukemia is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome and the consequent BCR::ABL1 oncoprotein. In the era before the introduction of tyrosine kinase inhibitors (TKIs), the only …

  13. 23-02-2024 | Chronic Myeloid Leukemia | Online First

    Tyrosine Kinase Inhibitor Discontinuation in Chronic Myeloid Leukemia: Strategies to Optimize Success and New Directions

    Chronic myeloid leukemia (CML) is caused by the occurrence in the hematopoietic stem cell (HSC) pool of a reciprocal translocation between chromosome 9 and 22, the t(9;22)(q34;q11) [ 1 ]. This translocation generates a fusion between the BCR and …

  14. Open Access 01-12-2024 | Chronic Myeloid Leukemia | OriginalPaper

    Erythroid variant evolving from chronic myeloid leukemia resistant to multiple tyrosine kinase inhibitors: a rare case report

    CML originates from a pluripotent hematopoietic stem cell and is defined by the Philadelphia (Ph) chromosome with t(9;22) (q34.1;q11.2) reciprocal translocation [ 1 ]. This abnormality leads to constitutive tyrosine kinase activity, triggering …

  15. Open Access 16-12-2023 | Chronic Myeloid Leukemia | OriginalPaper

    Patient Versus Physician Perspective in the Management of Chronic Myeloid Leukemia During Treatment with Tyrosine Kinase Inhibitors

    Achieving an optimal outcome in chronic myeloid leukemia (CML) requires both prolonged adherence to oral tyrosine kinase inhibitor (TKI) therapy by patients and careful monitoring of treatment responses by their physicians [ 1 , 2 ]. Nevertheless …

  16. 01-02-2024 | Chronic Myeloid Leukemia | ReviewPaper

    Role of miRNAs to control the progression of Chronic Myeloid Leukemia by their expression levels

    Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder distinguished by a specific genetic anomaly known as a reciprocal translocation between chromosomes 9 and 22. This translocation causes fusion between the BCR and ABL regions.

  17. 09-01-2024 | Chronic Myeloid Leukemia | Letter

    Philadelphia chromosome-positive B cell acute lymphoblastic phase arising 24 years after treatment-free remission for chronic myeloid leukemia with identical BCR-ABL fusion transcript

    We would like to follow-up on the case reported by Bloch et al. [ 3 ] to complete the surprising history of our patient. He was diagnosed at the age of 40 years with a low risk CML in the pre-TKI era. The BCR::ABL1 e14a2 fusion transcript was found …

  18. 05-01-2024 | Tyrosine Kinase Inhibitors | ReviewPaper

    Maximizing the Value of Chronic Myeloid Leukemia Management Using Tyrosine Kinase Inhibitors in the USA: Potential Determinants and Consequences of Healthcare Resource Utilization and Costs, with Proposed Optimization Approaches

    With the advent and increasing use of effective, safe, and well-tolerated tyrosine kinase inhibitors (TKIs) in the past 20 years, the mortality rate ascribed to chronic myeloid (myelogenous) leukemia (CML) has declined markedly, from approximately …

  19. 01-02-2024 | Chronic Myeloid Leukemia | OriginalPaper

    Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway

    The aberrant expression of the long non-coding RNA (lncRNA) Small Nucleolar RNA Host Gene 29 (SNHG29) has been associated with various human cancers. However, the role of SNHG29 in chronic myeloid leukemia (CML) remains elusive. Therefore, this …

  20. Open Access 01-12-2023 | Chronic Myeloid Leukemia | OriginalPaper

    Chronic myeloid leukemia with sleep-related painful erections as a first symptom: a case report

    Sleep-related painful erections (SRPE) is an uncommon parasomnia making up of nocturnal penile tumescence accompanied by pain that awakens the individual. SRPE has normal non-painful erections and no penile anatomic abnormalities are present when …

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