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Pediatrics Pediatric Hematology and Oncology

Pediatric Hematology and Oncology

Open Access Metabolic Disease in Childhood Case Study

Severe cobalamin C deficiency

Nephrotic syndrome is usually caused by primary renal disorders, but you should consider metabolic diseases in atypical cases. This 7-month-old presented with nephrotic syndrome, malignant hypertension, and hemolytic anemia.

Editor's Choice

Hodgkin’s lymphoma masquerading as ocular inflammation

Open Access Hodgkin Lymphoma Case Study

A 17-year-old presented with non-necrotizing scleritis, anterior uveitis, vitritis, yellowish chorioretinal lesions, papillitis, and vasculitis. Would you consider Hodgkin’s lymphoma in the differential diagnosis?

Early detection in children predisposed to cancer

Standardized surveillance protocols aid the early detection of tumors in children and young adults with a cancer predisposition syndrome.

Phoenix Sepsis Score assesses infection risk in pediatric cancer

20-06-2024 Pediatric Cancer News

The Phoenix Sepsis Score accurately predicts definitely attributable mortality in children undergoing cancer treatment who have a suspected infection.

What is decidual cast?

Abnormal uterine bleeding combined with imaging features of genital tract obstruction produced a confusing picture in a post-menarchal adolescent girl.

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Case Studies

Severe cobalamin C deficiency

Open Access Metabolic Disease in Childhood Case Study

Nephrotic syndrome is usually caused by primary renal disorders, but you should consider metabolic diseases in atypical cases. This 7-month-old presented with nephrotic syndrome, malignant hypertension, and hemolytic anemia.

Hodgkin’s lymphoma masquerading as ocular inflammation

Open Access Hodgkin Lymphoma Case Study

A 17-year-old presented with non-necrotizing scleritis, anterior uveitis, vitritis, yellowish chorioretinal lesions, papillitis, and vasculitis. Would you consider Hodgkin’s lymphoma in the differential diagnosis?

What is decidual cast?

Abnormal uterine bleeding combined with imaging features of genital tract obstruction produced a confusing picture in a post-menarchal adolescent girl.

Current Reviews

Current Status on Management of Primary Plasma Cell Leukemia

Plasma Cell Leukemia (PCL) is a very rare and highly aggressive form of plasma cell dyscrasia, distinguished by the presence of circulating clonal plasma cells (PC) in the peripheral blood [ 1 , 2 •]. It accounts for 2–4% (i.e. 0.04 cases per 100 …

Thymus transplantation as immunotherapy for the enhancement and/or correction of T cell function

The thymus is where T cells, among the most important immune cells involved in biological defense and homeostasis, are produced and developed. The thymus plays an important role in the defense against infection and cancer as well as the prevention …

Desensitization Strategies for Donor-Specific Antibodies in HLA-Mismatched Stem Cell Transplantation Recipients: What We Know and What We Do Not Know

Open Access Stem Cell Transplantation Review

In human leukocyte antigen (HLA)-mismatched allogeneic stem cell transplantation settings, donor-specific anti-HLA antibodies (DSAs) can independently lead to graft failure, including both primary graft rejection and primary poor graft function.

Neurological involvement in hematopoietic stem cell transplantation-associated thrombotic microangiopathy

Open Access Thrombotic Microangiopathy Review Article

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a well-recognized serious complication of hematopoietic stem cell transplantation (HSCT). The understanding of TA-TMA pathophysiology has expanded in recent years. Dysregulation of …

CME & eLearning

eLearning | Interviews (Link opens in a new window)

This independent educational program aims to highlight advances in the diagnosis, treatment, and management of patients with hemophilia that have the potential to improve patients’ outcomes and quality of life.

Supported by:
  • Sanofi
Developed by: Springer Healthcare IME

Further Reading

Increased risk of hip and major osteoporotic fractures in 8463 patients who have undergone stem cell transplantation, a Swedish population-based study

Open Access Graft-Versus-Host Disease Original Article

Osteoporosis is a disease characterized by loss of bone mineral density (BMD), resulting in an increased risk of fracture. Osteoporosis does not display any symptoms prior to fracture. Consequently, the manifestation of osteoporosis is …

Health professionals’ perceptions of prehabilitation before haematopoietic cell transplantation to optimise candidacy in older adults

Open Access Stem Cell Transplantation Research

Therapeutic advances for haematological cancers have improved survival rates; however, treatment is often associated with significant toxicity and prolonged hospitalisation, which may negatively affect patients’ quality of life and physical …

Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma

Open Access Neuroblastoma Research

Neuroblastoma (NB) is the most common and deadliest extracranial solid tumor in children. Targeting tumor-associated macrophages (TAMs) is a strategy for attenuating tumor-promoting states. The crosstalk between cancer cells and TAMs plays a …

Real-World Safety and Effectiveness of Letermovir in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation: Final Results of Post-Marketing Surveillance in Japan

Open Access Graft-Versus-Host Disease Original Research Article

Cytomegalovirus (CMV) is one of the most common opportunistic infections in patients undergoing hematopoietic stem cell transplantation (HSCT) [ 1 ] that usually occurs as a result of reactivation in patients with seropositivity for CMV. Notably …