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Pediatrics Pediatric Hematology and Oncology

Pediatric Hematology and Oncology

Neuroblastoma mimicking Bell’s palsy

A high degree of suspicion is required to identify neuroblastoma presenting in an atypical manner. Here the child initially exhibited just left-sided facial paralysis, mimicking Bell’s palsy.

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Editor's Choice

Melanoma risk doubled in childhood cancer survivors

Compared with the general population, childhood cancer survivors have a twofold increased risk for melanoma, with substantially worse survival for those who develop invasive melanoma.

How do you identify children with cancer predisposition syndromes?

CPS are genetic disorders that significantly increase the risk of developing malignancies. The malignant features of CPS are well-studied, but recognizing their non-malignant features is crucial for early diagnosis in children and adolescents.

Beti-cel promising for severe β-thalassemia

Gene therapy with betibeglogene autotemcel leads to high rates of transfusion independence in patients with severe transfusion-dependent β-thalassemia.

Total resection via right mini-thoracotomy of a left atrial myxoma in a child

Carney complex is a rare syndrome characterized by skin pigmentation, endocrine disorders, and myxomas. This case presents a 13 year old girl diagnosed with Carney complex who underwent a successful right lateral mini-thoracotomy.

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Case Studies

Neuroblastoma mimicking Bell’s palsy

A high degree of suspicion is required to identify neuroblastoma presenting in an atypical manner. Here the child initially exhibited just left-sided facial paralysis, mimicking Bell’s palsy.

Total resection via right mini-thoracotomy of a left atrial myxoma in a child

Carney complex is a rare syndrome characterized by skin pigmentation, endocrine disorders, and myxomas. This case presents a 13 year old girl diagnosed with Carney complex who underwent a successful right lateral mini-thoracotomy.

Atypical presentation of PJP

Typical symptoms of Pneumocystis jirovecii pneumonia include dyspnea, cough, and low-grade fever. But this patient, an allogeneic stem cell transplant recipient, presented with hypercalcemia and kidney injury.

Current Reviews

Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro models

  • Open Access
  • Alzheimer's Disease
  • Neurology and Preclinical Neurological Studies - Review Article

Neurodegenerative diseases raise public health concerns. Recent evidence indicates that Alzheimer’s disease (AD) sufferers will triple by 2050. The rising incidence of dementia diagnoses raises concerns about the socio-economical and emotional …

Psychosocial situation, burden, and unmet needs among informal caregivers prior to hematopoietic stem cell transplantation: a systematic review of quantitative and qualitative data

Hematopoietic stem cell transplantation (HSCT) involves transplanting hematopoietic stem cells from different donor types and sources, aiming to completely or partially replenish and replace the patients’ hematopoietic system [ 1 ]. HSCT presents …

The psychological effects of protective isolation on haematological stem cell transplant patients: an integrative, descriptive review

Haematopoietic stem cell transplantation (HSCT) is a complex and specialised medical procedure. It is used to treat haematological malignancies which are now the 5th most common cancer in the UK. Approximately 37,320 cases are diagnosed every year …

Hematopoietic stem cell transplantation and immunosuppressive therapy: implications of clonal haematopoiesis

Aplastic anemia (AA) is a life-threatening bone marrow failure syndrome. The advent of next-generation sequencing (NGS) has shed light on the link between somatic mutations (SM) and the efficacy of immunosuppressive therapy (IST) in AA patients.

Further Reading

Efficacy and safety of the thiotepa–busulfan conditioning regimen as for autologous stem cell transplantation in relapsed/refractory systemic diffuse large B cell lymphoma: a single-center retrospective study

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard treatment for relapsed diffuse large B cell lymphoma (DLBCL). The BEAM regimen is widely used, but the MEAM regimen is more common in Japan due to the …

Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro models

  • Open Access
  • Alzheimer's Disease
  • Neurology and Preclinical Neurological Studies - Review Article

Neurodegenerative diseases raise public health concerns. Recent evidence indicates that Alzheimer’s disease (AD) sufferers will triple by 2050. The rising incidence of dementia diagnoses raises concerns about the socio-economical and emotional …

The impact of experiential avoidance on anxiety and depressive disorders in hematological cancer patients

Anxiety disorders and/or depressive disorders co-occurring with hematological cancer are an additional burden for patients. Experiential avoidance (EA; efforts to avoid negative emotions, thoughts, or memories) is an empirically evident …

A cross-sectional survey on health care professionals’ approaches, challenges, and support needs when addressing life threat with recipients of an allogeneic hematopoietic stem cell transplantation and with their relatives

Patients treated with an allogeneic hematopoietic stem cell transplantation (allo-SCT) face a significant mortality risk, which might trigger existential distress. We aimed to investigate how hematology health care professionals (HCPs) address …