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Pediatrics Neonatology

Neonatology

Outcomes no better with CGM vs self-monitored glucose in gestational diabetes

Perinatal and neonatal outcomes in women with gestational diabetes are not improved with real-time continuous glucose monitoring versus self-monitoring of blood glucose.

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Editor's Choice

Breakthrough gene-editing therapy helps infant with rare disorder

A customized gene-editing approach has been used for the first time to treat a rare genetic condition in an infant.

Lung ultrasound to manage neonatal respiratory distress: guidelines

Consensus recommendations from an international panel of experts on the use of lung ultrasound to optimize the management of neonatal respiratory distress.

Sequential oral agents do not equal insulin in gestational diabetes

Sequential oral metformin and glyburide is not equivalent to insulin for gestational diabetes with respect to the proportion of infants born large for gestational age.

Handheld ultra-widefield OCT device may improve ROP examination

An ultra-widefield optical coherence tomography device can provide high-quality images for use in diagnosing retinopathy of prematurity without the need for scleral depression.

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Case Studies

Aciclovir extravasation in a newborn

Neonates have higher risk of extravasation as their tiny and fragile vessels make catheterization difficult, but there’s no treatment protocol. How would you manage aciclovir extravasation?

Neonatal meningitis: new and old lessons

A premature infant presented with extensive CNS injury from recurrent E. coli infection, requiring non-traditional methods to identify and clear the infection.

Treating type V aplasia cutis congenita

ACC is a rare congenital disorder characterized by absence of skin. In this newborn with large abdominal skin defects, more than 60% of the skin completed epithelization after 5 weeks of conservative treatment.

Current Reviews

Advances in Neonatal Seizures (2024): An Update for Pediatricians

Seizures are more common in the neonatal period than any other time due to the greater propensity of the immature brain to develop seizures, making them the most common neurological emergency in the neonatal period. The unique attribute of …

Exploring the long-term impacts of neonatal hypoglycemia to determine a safe threshold for glucose concentrations

Hypoglycemia and impaired metabolic transition are frequently observed in neonates during the first 24–48 h after birth [1, 2]. Severe (< 36 mg/dL or 2 mmol/L) and recurrent (3 or more episodes) hypoglycemia can cause neurological injury and …

Economic evaluation of newborn screening for congenital cytomegalovirus infection: A systematic review

Congenital cytomegalovirus (cCMV) infection occurs through placental transmission from mother to fetus. Of infected infants, 10%−15% are symptomatic while 85%−90% are asymptomatic [ 1 , 2 ]. The main clinical manifestation is sensorineural hearing …

Further Reading

Phototherapy modifies hematologic markers without inducing inflammation in neonates: a retrospective observational study

Phototherapy is the standard treatment for neonatal hyperbilirubinemia. However, its impact on hematologic indices related to oxidative stress and systemic inflammation, particularly in preterm infants, remains insufficiently understood. In this …

First in-human pilot study of wearable phototherapy for neonatal hyperbilirubinaemia

This pilot study aimed to assess the effectiveness and safety of the first wearable phototherapy device in (near-)term neonates with unconjugated hyperbilirubinaemia. This prospective single-arm intervention pilot study was conducted in the …

Cost-effectiveness of treatments for presymptomatic newborn patients with spinal muscular atrophy and two or three copies of the survival motor neuron 2 gene in Italy

Spinal muscular atrophy (SMA) is a rare, inherited, autosomal, recessive neuromuscular disease typically caused by the loss of survival motor neuron 1 ( SMN1 ) gene from chromosome 5q, which leads to reduced SMN protein function and progressive …

Genotypic and phenotypic characteristics of Turkish patients with phenylalanine metabolism disorders

Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine metabolism, in which especially high phenylalanine concentrations cause brain dysfunction. If untreated, this brain dysfunction results in severe intellectual disability …