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Type 1 Diabetes in Children 

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  1. Open Access 25-04-2024 | Type 1 Diabetes | Online First

    The psychosocial outcomes of advanced hybrid closed-loop system in children and adolescents with type 1 diabetes

    The study was carried out to determine the psychosocial outcomes of advanced hybrid closed-loop (AHCL) systems in children and adolescents with type 1 diabetes (T1D). Single-center and cohort study with a duration 6 months consisted of 60 children

  2. Open Access 01-12-2024 | Type 1 Diabetes | OriginalPaper

    Evaluation of cardiac autonomic dysfunctions in children with type 1 diabetes mellitus

    Type 1 Diabetes Mellitus (T1DM) is a prevalent chronic disorder affecting children and adolescents. Clinical symptoms typically peak between 5 and 7 years old and during early puberty. These peaks are attributed to increased infection rates during …

  3. 19-04-2024 | Hypoglycemia | Online First

    Beyond HbA1c: Identifying Gaps in Glycemic Control Among Children and Young People with Type 1 Diabetes Using Continuous Glucose Monitoring

    Type 1 diabetes is a chronic disease leading to long-term complications. Based on the results from the DCCT study, modern-day insulin regimens aim to achieve normoglycemia to minimize risk of long-term complications [ 1 ]. Glycosylated hemoglobin …

  4. Open Access 22-03-2024 | Type 1 Diabetes | OriginalPaper

    The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

    Type 1 diabetes results from an autoimmune response that leads to destruction of the pancreatic beta cells, consequent insulin deficiency and life-long need for exogenous insulin [ 1 , 2 ].

  5. 21-02-2024 | Type 1 Diabetes | OriginalPaper

    Use of teplizumab in children and adolescents at risk of type 1 diabetes: perspectives of parents and caregivers from an Italian Pediatric Diabetes Center

    Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive T cell-mediated destruction of pancreatic beta cells, resulting in absolute insulin deficiency, derangement of glucose metabolism, and the need for insulin replacement …

  6. Open Access 18-04-2024 | Type 1 Diabetes | Online First

    Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes

    Complications from diabetes mellitus such as retinopathy, nephropathy, and neuropathy are related to hyperglycaemia, diabetes duration, age, blood pressure, and albuminuria [ 1 , 2 ]. Glycosylated haemoglobin (HbA1c) is a good biomarker for …

  7. Open Access 01-12-2024 | Type 1 Diabetes | ReviewPaper

    Humanistic burden of pediatric type 1 diabetes on children and informal caregivers: systematic literature reviews

    T1D is a chronic disease that is incurable and needs nearly permanent attention due to frequent injections or dose adjustments, the use of devices to monitor blood glucose, and different applications related to T1D management [ 1 ]. Having a child …

  8. Open Access 12-04-2024 | Hypoglycemia | Online First

    Evaluation of the possible impact of the fear of hypoglycemia on diabetes management in children and adolescents with type 1 diabetes mellitus and their parents: a cross-sectional study

    Hypoglycemia constitutes the commonest acute complication of type 1 diabetes mellitus (T1DM) [ 1 ]. Aggressive HbA1c goals may increase the frequency of hypoglycemia, which represents a major limiting factor in the glycemic control of T1DM [ 2 ].

  9. Open Access 01-12-2024 | Hypoglycemia | OriginalPaper

    Long-term assessment of the NHS hybrid closed-loop real-world study on glycaemic outcomes, time-in-range, and quality of life in children and young people with type 1 diabetes

    Hybrid closed-loop (HCL) systems seamlessly interface continuous glucose monitoring (CGM) with insulin pumps, employing specialised algorithms and user-initiated automated insulin delivery. This study aimed to assess the efficacy of HCLs at 12 …

  10. Open Access 01-12-2024 | Vitamin D Deficiency | OriginalPaper

    Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: a systematic review and meta-analysis

    Type 1 diabetes (T1D), an autoimmune disease that affects pancreatic beta cells, is one of the most common endocrine disorders affecting children and young adults worldwide [ 1 – 3 ]. According to statistics, 2.15 out of every 1,000 people that are …

  11. 07-03-2024 | Obesity | OriginalPaper

    Soluble urokinase plasminogen activator receptor (suPAR) in children with obesity or type 1 diabetes as a marker of endothelial dysfunction: a cross-sectional study

    Pediatric obesity and type 1 diabetes mellitus (T1DM) represent two common chronic diseases associated with chronic inflammation, endothelial dysfunction and long-term complications. The aim of the present study was to assess the possible …

  12. 19-10-2023 | Type 1 Diabetes | OriginalPaper

    Early lung diffusion abnormalities and airways’ inflammation in children with type 1 diabetes

    Intensive glycemic controls have contributed over the last decades to an overall improvement in glycometabolic management in children with type 1 diabetes (T1D) [ 1 , 2 ]. However, the aforementioned approach was deemed elusive in controlling …

  13. Open Access 21-12-2023 | Type 1 Diabetes | OriginalPaper

    Adaptation and validation of an artificial intelligence based digital radiogrammetry tool for assessing bone health of indian children and youth with type-1 diabetes

    The International Society for Paediatric and Adolescent Diabetes (ISPAD) clinical practice consensus guidelines 2022 enlists poor bone health in ‘other complications’ and ‘associated conditions’ in children and adolescents with type 1 diabetes

  14. Open Access 12-01-2024 | Type 1 Diabetes | OriginalPaper

    Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children

    Type 1 diabetes is an autoimmune disorder that is characterised by inflammatory damage to pancreatic beta cells by autoreactive T lymphocytes [ 1 ]. Decades of studies have shown that, in genetically susceptible individuals, the disease is a …

  15. Open Access 13-10-2023 | Type 1 Diabetes | OriginalPaper

    Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease

    Diabetes with its two major types, type 1 (T1DM) and type 2 (T2DM), has long been recognized as a major risk factor for the development of vascular disease [ 1 ]. In adults, macrovascular complications are the leading cause of diabetes-related …

  16. Open Access 01-12-2024 | OriginalPaper

    Prevalence of celiac-related antibodies and its impact on metabolic control in Egyptian children with type 1 diabetes mellitus

    Type 1 diabetes mellitus (T1DM) is among the most recognizable chronic autoimmune diseases present at a young age, involving numerous genetic and environmental risk factors in its pathological process [ 1 ]. Children with T1DM face a higher risk of …

  17. 22-09-2023 | Insulins | OriginalPaper

    Practice of complementary and alternative medicine use in North Indian children with type 1 diabetes: an exploratory study

    Type 1 Diabetes (T1DM) is a chronic metabolic disorder that is mostly diagnosed in childhood [ 1 ]. According to the 2019 IDF atlas, India is leading the world in the number of new T1DM cases, and adds more than 20,000 new cases every year in the …

  18. 01-02-2024 | OriginalPaper

    School-time Hyperglycemia and Prolonged Night-Time Hypoglycemia on Continuous Glucose Monitoring in Children With Type 1 Diabetes

  19. Open Access 12-01-2024 | COVID-19 | OriginalPaper

    Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes

    The COVID-19 pandemic has been linked to increases in the incidence of both type 1 and type 2 diabetes [ 1 – 3 ]. SARS-CoV-2 infection may have contributed to the observed increase [ 1 ], but lifestyle changes that occurred during the pandemic may …

  20. Open Access 28-02-2024 | Type 1 Diabetes | Online First

    Correction to: Factors affecting the prolongation of glycemic time in range among children with type 1 diabetes using continuous glucose monitoring systems: A case control study

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